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XIAP associated factor 1

XAF1, XIAP-associated factor 1
This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: XIAP, PrP, CAN, POLYMERASE, V1a
Papers on XAF1
Detachment-based Equilibrium of Anoikic Cell Death and Autophagic Cell Survival through Adaptor Protein p66(Shc).
Ma et al., Tianjin, China. In Anat Rec (hoboken), Jan 2016
In addition, p66(Shc) knockdown increased the formation of full-length X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1), which enhances anoikis sensitivity.
Granuloma genes in sarcoidosis: what is new?
Rybicki et al., Detroit, United States. In Curr Opin Pulm Med, Sep 2015
With relevance to granuloma formation, genes involved in apoptotic processes and immune cell activation were further confirmed (ANXA11 and BTNL2) in multiple ethnicities; others were newly identified (XAF1).
Epigenetic Role of Histone 3 Lysine Methyltransferase and Demethylase in Regulating Apoptosis Predicting the Recurrence of Atypical Meningioma.
Kim et al., Ch'angwŏn, South Korea. In J Korean Med Sci, Aug 2015
Immunohistochemical staining was performed on archived paraffin-embedded tissues for pro-apoptotic factors (CASP3, IGFBP, TRAIL-R1, BAX, and XAF1), anti-apoptotic factors (survivin, ERK, RAF1, MDM2, and BCL2), and the histone modifying enzymes (MLL2, RIZ, EZH1, NSD2, KDM5c, JMJD2a, UTX, and JMJD5).
XIAP associated factor 1 (XAF1) represses expression of X-linked inhibitor of apoptosis protein (XIAP) and regulates invasion, cell cycle, apoptosis, and cisplatin sensitivity of ovarian carcinoma cells.
Wang et al., Shenyang, China. In Asian Pac J Cancer Prev, 2014
BACKGROUND: X-linked inhibitor of apoptosis protein (XIAP) associated factor 1 (XAF1) exhibits aberrantly low or absent expression in various human malignancies, closely associated with anti-apoptosis and overgrowth of cancer cells.
Epigenetic silencing of the XAF1 gene is mediated by the loss of CTCF binding.
Melendez-Zajgla et al., Mexico. In Sci Rep, 2014
XAF1 is a tumour suppressor gene that compromises cell viability by modulating different cellular events such as mitosis, cell cycle progression and apoptosis.
IFI6 Inhibits Apoptosis via Mitochondrial-Dependent Pathway in Dengue Virus 2 Infected Vascular Endothelial Cells.
Huang et al., Guangzhou, China. In Plos One, 2014
In addition, the pro-apoptotic protein X-linked Inhibitor of Apoptosis (XIAP)-Associated Factor 1(XAF1) expression had been reported to be up-regulated and led to the induction of apoptosis in DENV2-infected VECs,but the relationship between XAF1 and IFI6 dengue virus-induced apoptosis in VECs warrants further study.
GEMMs shine a light on resistance to androgen deprivation therapy for prostate cancer.
Thompson et al., Houston, United States. In Cancer Cell, 2013
The value of genetically engineered mice for coclinical studies is clearly demonstrated in a recent publication that reveals XAF1, XIAP, and SRD5A1 as novel predictive biomarkers and therapeutic targets for ADT resistance.
A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer.
Pandolfi et al., Boston, United States. In Nat Genet, 2013
Mechanistically, the integrated acquisition of data from mouse models and patients identifies the expression patterns of XAF1, XIAP and SRD5A1 as a predictive and actionable signature for CRPC.
XAF1 is frequently methylated in human esophageal cancer.
Guo et al., Zhengzhou, China. In World J Gastroenterol, 2012
XAF1 is frequently methylated in esophageal cancer, and XAF1 expression is regulated by promoter region hypermethylation.
XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification.
Wong et al., Guangzhou, China. In Mol Carcinog, 2012
These findings suggest that a potential novel feedback loop exists between XAF1 and wild-type p53
XAF1 as a prognostic biomarker and therapeutic target in squamous cell lung cancer.
Qian et al., Suzhou, China. In Chin Med J (engl), 2011
The levels of XAF1 protein and mRNA in cancer tissues were significantly lower than those in cancer adjacent and normal lung tissues.
Identification of a functional p53 responsive element within the promoter of XAF1 gene in gastrointestinal cancer cells.
Wang et al., Guangzhou, China. In Int J Oncol, 2010
Demonstrate that p53 could suppress the transcription of XAF1 through interaction with a high affinity responsive element (-95 to -86 nt) within XAF1 promoter in gastrointestinal cancer cells.
XAF1 expression and regulatory effects of somatostatin on XAF1 in prostate cancer cells.
Liu et al., Jinan, China. In J Exp Clin Cancer Res, 2009
XAF1 down-regulation may contribute to the prostate cancer development
The emergence of DNA methylation as a key modulator of aberrant cell death in prostate cancer.
Lawler et al., Dublin, Ireland. In Endocr Relat Cancer, 2008
The most significant advances have involved the discovery of apoptotic gene targets of methylation, including XAF1, (fragile histidine triad (FHIT ), cellular retinol binding protein 1 (CRBP1), decoy receptor 1(DCR1), decoy receptor 2 (DCR2 ), target of methylation-induced silenceing 1 (TMS1), TNF receptor superfamily, member 6 (FAS), Reprimo (RPRM) and GLI pathogenesis-related 1 (GLIPR1).
The role of XAF1 in cancer.
Korneluk et al., Ottawa, Canada. In Curr Opin Investig Drugs, 2007
Studies have demonstrated that XAF1 is strongly pro-apoptotic, is inducible by IFN and is a tumor suppressor.
Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation.
Borden et al., Cleveland, United States. In J Clin Oncol, 2006
siRNA to XAF1 inhibited IFN-induced apoptosis; conversely, overexpression of XAF1 overcame resistance to apoptosis induction by IFN-beta.
Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis.
Borden et al., Cleveland, United States. In Apoptosis, 2003
These include TNF-alpha related apoptosis inducing ligand (TRAIL/Apo2L), Fas/FasL, XIAP associated factor-1 (XAF-1), caspase-4, caspase-8, dsRNA activated protein kinase (PKR), 2'5'A oligoadenylate synthetase (OAS), death activating protein kinases (DAP kinase), phospholipid scramblase, galectin 9, IFN regulatory factors (IRFs), promyelocytic leukemia gene (PML) and regulators of IFN induced death (RIDs).
IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo.
Kato et al., Genève, Switzerland. In Nat Cell Biol, 2002
The anti-apoptotic activity of IAPs is inhibited by second mitochondria-derived activator of caspase (Smac)/DIABLO and XAF1 (ref.
XIAP: apoptotic brake and promising therapeutic target.
Korneluk et al., Ottawa, Canada. In Apoptosis, 2001
In turn, the caspase inhibiting activity of XIAP is negatively regulated by at least two XIAP-interacting proteins, XAF1 and Smac/DIABLO.
Identification of XAF1 as an antagonist of XIAP anti-Caspase activity.
Korneluk et al., Ottawa, Canada. In Nat Cell Biol, 2001
Here we have isolated the protein XIAP-associated factor 1 (XAF1) on the basis of its ability to bind XIAP, a member of the IAP family.
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