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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

XPA binding protein 2

XAB2, XPA-binding protein 2, Ntc90, ATH55, SYF1
may play a role in mRNA processing [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: POLYMERASE, CSB, CsA, XPA, STEP
Papers on XAB2
XAB2 tagSNPs contribute to non-small cell lung cancer susceptibility in Chinese population.
Zhang et al., Tangshan, China. In Bmc Cancer, 2014
BACKGROUND: XPA-binding protein 2 (XAB2) interacts with Cockayne syndrome complementation group A (CSA), group B (CSB) and RNA polymerase II to initiate nucleotide excision repair.
Structural requirement of Ntc77 for spliceosome activation and first catalytic step.
Cheng et al., Taipei, Taiwan. In Nucleic Acids Res, 2014
The complex comprises at least eight proteins, among which Ntc90 and Ntc77 contain multiple tetratricopeptide repeat (TPR) elements.
Hematopoietic myeloid cell differentiation diminishes nucleotide excision repair.
Takagi et al., Tokyo, Japan. In Int J Hematol, 2014
XAB2, a molecule involved in nucleotide excision repair (NER), is downregulated during granulocyte differentiation and shows reduced expression in NB4 APL-derived cells in vitro.
DNA damage response and transcription.
Review
Mullenders et al., Leiden, Netherlands. In Dna Repair (amst), 2011
CSB functions as a repair coupling factor to attract NER proteins, chromatin remodelers and the CSA-E3-ubiquitin ligase complex to the stalled RNAPIIo; CSA is dispensable for attraction of NER proteins, yet in cooperation with CSB is required to recruit XAB2, the nucleosomal binding protein HMGN1 and TFIIS.
Identification of novel hub genes associated with liver metastasis of gastric cancer.
Cao et al., Shanghai, China. In Int J Cancer, 2010
NR4A2, NR3C1, ARF3, XAB2, and alternatively spliced variants of NR4A2, SP8 and SP-novel, were significantly down-regulated, whereas CCNE1 significantly up-regulated, in primary GC compared with the normal gastric mucosa.
Ntc90 is required for recruiting first step factor Yju2 but not for spliceosome activation.
Cheng et al., Taipei, Taiwan. In Rna, 2009
The NTC consists of at least eight protein components, including two tetratricopeptide repeat (TPR)-containing proteins, Ntc90 and Ntc77.
Prp45 affects Prp22 partition in spliceosomal complexes and splicing efficiency of non-consensus substrates.
Půta et al., Praha, Czech Republic. In J Cell Biochem, 2009
Using a synthetic lethality screen, we found that prp45(1-169) genetically interacts with alleles of NTC members SYF1, CLF1/SYF3, NTC20, and CEF1, and 2nd step splicing factors SLU7, PRP17, PRP18, and PRP22.
A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity.
Ashworth et al., London, United Kingdom. In Dna Repair (amst), 2009
Novel determinants of PARP inhibitor response were also identified, including the transcription coupled DNA repair (TCR) proteins DDB1 and XAB2.
Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair.
GeneRIF
Tanaka et al., Suita, Japan. In J Biol Chem, 2008
XAB2 complex is a multifunctional factor involved in pre-mRNA splicing, transcription, and transcription-coupled DNA repair.
Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects.
Review
Mullenders et al., Leiden, Netherlands. In Cell Res, 2008
CSA is dispensable for attraction of NER proteins, yet in cooperation with CSB is required to recruit XAB2, the nucleosomal binding protein HMGN1 and TFIIS.
Gene expression profiles in human lymphocytes irradiated in vitro with low doses of gamma rays.
Sakamoto-Hojo et al., Ribeirão Preto, Brazil. In Radiat Res, 2007
A set of 34 significant genes was common for all doses; while SERPINB2 and C14orf104 were up-regulated, CREB3L2, DDX49, STK25 and XAB2 were down-regulated.
Knockdown of XAB2 enhances all-trans retinoic acid-induced cellular differentiation in all-trans retinoic acid-sensitive and -resistant cancer cells.
Mizutani et al., Tokyo, Japan. In Cancer Res, 2007
Xeroderma pigmentosum group A (XPA)-binding protein 2 (XAB2) is composed of 855 amino acids, contains 15 tetratricopeptide repeat motifs, and associates with Cockayne syndrome group A and B proteins and RNA polymerase II, as well as XPA.
Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo.
Mullenders et al., Leiden, Netherlands. In Mol Cell, 2006
CSA is dispensable for attraction of NER proteins to lesion-stalled RNAPIIo, yet in cooperation with CSB is required to recruit XAB2, the nucleosomal binding protein HMGN1, and TFIIS.
Disruption of mouse XAB2 gene involved in pre-mRNA splicing, transcription and transcription-coupled DNA repair results in preimplantation lethality.
GeneRIF
Tanaka et al., Suita, Japan. In Dna Repair (amst), 2005
XAB2 has an essential function in mouse embryogenesis.
A novel rat orthologue and homologue for the Drosophila crooked neck gene in neural stem cells and their immediate descendants.
Nawa et al., Niigata, Japan. In J Biochem, 2003
The other gene, ATH55, encodes an 855 amino acid protein including 21 TPR motifs, which presumably represents a rat crn homologue and an orthologue of human XAB2.
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