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Brain expressed X-linked 2

X-linked protein, brain expressed X-linked-2
This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] (from NCBI)
Top mentioned proteins: RAD54, Bex1, CAN, Daxx, ACID
Papers on X-linked protein
5-Methoxytryptophan-dependent inhibition of oral squamous cell carcinoma metastasis.
Chou et al., Taiwan. In Electrophoresis, Sep 2015
Some of the differentially regulated proteins such as amadillo-repeat-containing X-linked protein 1, phosphoglycerate kinase 1, tropomyosin alpha-1, and tropomyosin alpha-4 may be associated with the 5-MTP-dependent inhibition of oral cancer growth and metastasis.
Pcdh11x Negatively Regulates Dendritic Branching.
Xu et al., Beijing, China. In J Mol Neurosci, Aug 2015
Our previous research found that protocadherin 11 X-linked protein (Pcdh11x) is predominantly expressed in neurons and has an influence on dendritic branching.
Mecp2 regulates neural cell differentiation by suppressing the Id1 to Her2 axis in zebrafish.
Xiong et al., Beijing, China. In J Cell Sci, Jul 2015
Rett syndrome (RTT) is a progressive neurological disorder caused by mutations in the X-linked protein methyl-CpG-binding protein 2 (MeCP2).
ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons.
Allis et al., Beijing, China. In Proc Natl Acad Sci U S A, Jul 2015
ATRX (the alpha thalassemia/mental retardation syndrome X-linked protein) is a member of the switch2/sucrose nonfermentable2 (SWI2/SNF2) family of chromatin-remodeling proteins and primarily functions at heterochromatic loci via its recognition of "repressive" histone modifications [e.g., histone H3 lysine 9 tri-methylation (H3K9me3)].
Impending Impact of Molecular Pathology on Classifying Adult Diffuse Gliomas.
Macaulay, Tampa, United States. In Cancer Control, Apr 2015
The codeletion of 1p/19q distinguishes OD from FA, which, by contrast, shows frequent loss of the α thalassemia/mental retardation syndrome X-linked protein.
Biophysical Studies on BEX3, the p75NTR-Associated Cell Death Executor, Reveal a High-Order Oligomer with Partially Folded Regions.
Almeida et al., Rio de Janeiro, Brazil. In Plos One, 2014
BEX3 (Brain Expressed X-linked protein 3) is a member of a mammal-specific placental protein family.
Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) activation requires phosphorylation of serine 412 by protein kinase A catalytic subunit α (PKACα) and X-linked protein kinase (PRKX).
Xia et al., Hangzhou, China. In J Biol Chem, 2014
In vitro kinase and shRNA-based knockdown assays reveal that TAK1 Ser-412 phosphorylation is regulated by cAMP-dependent protein kinase catalytic subunit α (PKACα) and X-linked protein kinase (PRKX), which is essential for proper signaling and proinflammatory cytokine induction by TLR/IL-1R activation.
Faster-X adaptive protein evolution in house mice.
Keightley et al., Edinburgh, United Kingdom. In Genetics, 2014
In this study, we have analyzed genome-wide nucleotide polymorphism data from the house mouse subspecies Mus musculus castaneus and nucleotide divergence from Mus famulus and Rattus norvegicus to compare rates of adaptive evolution for autosomal and X-linked protein-coding genes.
Clinicopathologic significance of immunostaining of α-thalassemia/mental retardation syndrome X-linked protein and death domain-associated protein in neuroendocrine tumors.
Sasano et al., Sendai, Japan. In Hum Pathol, 2013
α-Thalassemia/mental retardation syndrome X-linked protein (ATRX) and death domain-associated protein (DAXX) genes are tumor suppressors whose mutations have been identified in sporadic pancreatic neuroendocrine tumors as well as in patients with MEN1.
The X-linked intellectual disability protein PHF6 associates with the PAF1 complex and regulates neuronal migration in the mammalian brain.
Bonni et al., Boston, United States. In Neuron, 2013
Mutations of the X-linked protein PHF6 cause the intellectual disability disorder Börjeson-Forssman-Lehmann syndrome (BFLS).
Coupling hippocampal neurogenesis to brain pH through proneurogenic small molecules that regulate proton sensing G protein-coupled receptors.
Zhang et al., Dallas, United States. In Acs Chem Neurosci, 2012
Isx and GPR68 coregulated neuronal target genes such as Bex1 (brain-enriched X-linked protein-1) in hippocampal neural progenitors (HCN cells), which further amplified GPR68 signaling by producing metabolic acid in response to Isx.
[BEX2 regulates cell cycle through the interaction with INI1/hSNF5].
Han et al., Shijiazhuang, China. In Yi Chuan, 2012
Both BEX2 and INI1/hSNF5 mainly localized in cell nucleus.
A feedback loop between BEX2 and ErbB2 mediated by c-Jun signaling in breast cancer.
Francis et al., Brisbane, Australia. In Int J Cancer, 2012
BEX2 overexpression was associated with breast cancer.
Nrk, an X-linked protein kinase in the germinal center kinase family, is required for placental development and fetoplacental induction of labor.
Komada et al., Yokohama, Japan. In J Biol Chem, 2011
The complete mechanism of labor induction in eutherian mammals remains unclear.
Role of ATRX in chromatin structure and function: implications for chromosome instability and human disease.
Viveiros et al., Athens, United States. In Reproduction, 2011
Among these, α-thalassemia mental retardation X-linked protein (ATRX) has recently emerged as a critical factor involved in heterochromatin formation at mammalian centromeres and telomeres as well as facultative heterochromatin on the murine inactive X chromosome.
BEX2 has a functional interplay with c-Jun/JNK and p65/RelA in breast cancer.
Hughes-Davies et al., Brisbane, Australia. In Mol Cancer, 2009
BEX2 has a functional interplay with c-Jun and p65/RelA in breast cancer.
Galectin 1 proangiogenic and promigratory effects in the Hs683 oligodendroglioma model are partly mediated through the control of BEX2 expression.
Kiss et al., Brussels, Belgium. In Neoplasia, 2009
BEX2 is implicated in oligodendroglioma biology.
Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in acute myeloid leukemia.
Quentmeier et al., Braunschweig, Germany. In Mol Cancer, 2008
These results suggest that the conspicuous expression of the tumor suppressor genes BEX2, IGSF4 and TIMP3 in MLLmu acute myeloid leukemias cell lines is the consequence of altered epigenetic properties of MLL fusion proteins.
ATRX and sex differentiation.
Harley et al., Melbourne, Australia. In Trends Endocrinol Metab, 2004
Most interest in the gene encoding the alpha-thalassemia, mental retardation, X-linked protein (ATRX) has traditionally been focused on its role in brain development and globin regulation.
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