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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Xenotropic and polytropic retrovirus receptor 1

X receptor
Top mentioned proteins: ACID, beta 2-adrenoceptor, CAN, V1a, CYP3A4
Papers on X receptor
Nuclear receptors and drug metabolism for the personalization of cancer therapy.
Toffoli et al., Italy. In Expert Opin Drug Metab Toxicol, Feb 2016
The study of the host genetic background of Pregnane X Receptor (PXR; NR1I2) and Constitutive Androstane Receptor (CAR; NR1I3 and NR1I4), represents a new and attractive strategy to discern variability in ADME of antineoplastic drugs.
Cross-talk between EPAS-1/HIF-2α and PXR Signaling Pathway Regulates Multi-drug Resistance of Stomach Cancer Cell.
Xu et al., Beijing, China. In Int J Biochem Cell Biol, Feb 2016
Our results revealed that EPAS-1 interacts with Pregnane X Receptor (PXR), a nuclear receptor that regulates multiple genes' transcription involved in multi-drugs resistance (MDR) process.
Transcriptional regulation of the human Liver X Receptor α gene by Hepatocyte Nuclear Factor 4α.
Kardassis et al., Irákleion, Greece. In Biochem Biophys Res Commun, Feb 2016
Liver X Receptors (LXRs) are sterol-activated transcription factors that play major roles in cellular cholesterol homeostasis, HDL biogenesis and reverse cholesterol transport.
Sterol O-Acyltransferase 2-Driven Cholesterol Esterification Opposes Liver X Receptor-Stimulated Fecal Neutral Sterol Loss.
Brown et al., Cleveland, United States. In Lipids, Feb 2016
Although it is well known that SOAT2-driven cholesterol esterification can alter both the packaging and retention of atherogenic apoB-containing lipoproteins, here we set out to determine whether SOAT2-driven cholesterol esterification can also impact basal and liver X receptor (LXR)-stimulated fecal neutral sterol loss.
Dietary procyanidins selectively modulate intestinal farnesoid X receptor-regulated gene expression to alter enterohepatic bile acid recirculation: elucidation of a novel mechanism to reduce triglyceridemia.
Ricketts et al., Reno, United States. In Mol Nutr Food Res, Jan 2016
METHODS: To determine whether modulation of bile acid (BA) homeostasis contributes to the hypotriglyceridemic action of grape seed procyanidin extract (GSPE) we examined the effect on genes regulating BA absorption, transport and synthesis in vitro, in Caco-2 cells, and in vivo, in wild type (C57BL/6) and farnesoid x receptor knockout (Fxr(-/-) ) mice.
Hepatocyte-specific Keap1 deletion reduces liver steatosis but not inflammation during non-alcoholic steatohepatitis development.
Streetz et al., Aachen, Germany. In Free Radic Biol Med, Jan 2016
In parallel to reduced expression of genes involved in lipid droplet formation, protein expression of Liver X Receptor (LXRα/β) and Peroxisome proliferator-activated receptor α (PPARα) was significantly decreased.
Excess Nitric Oxide Activates TRPV1-Ca(2+)-Calpain Signaling and Promotes PEST-dependent Degradation of Liver X Receptor α.
Lee et al., Taipei, Taiwan. In Int J Biol Sci, Dec 2015
Excess nitric oxide (NO) deregulates cholesterol metabolism in macrophage foam cells, yet the underlying molecular mechanism is incompletely understood.
Re-adopting classical nuclear receptors by cholesterol metabolites.
Umetani, Houston, United States. In J Steroid Biochem Mol Biol, Dec 2015
In addition to the identification of 27HC as a SERM, oxysterols have been recently demonstrated as indirect modulators of ER through interaction with the nuclear receptor Liver X Receptor (LXR) β.
Changes seen in gut bacteria content and distribution with obesity: causation or association?
Bell, Birmingham, United States. In Postgrad Med, Nov 2015
These changes could either be due to the dramatic change in the composition of the diet which occurs following this surgery or due to down-regulation of the Farnesoid X Receptor which causes a decrease in bile acid production and an elevation of the gut pH which in turn allows the regrowth of bacteria associated with weight loss which were previously unable to grow in the acidic intestinal environment caused by excess production of bile acids.
Farnesoid x receptor in human metabolism and disease: the interplay between gene polymorphisms, clinical phenotypes and disease susceptibility.
Giaginis et al., Athens, Greece. In Expert Opin Drug Metab Toxicol, Apr 2015
INTRODUCTION: Farnesoid x receptor (FXR) belongs to the group of nuclear receptors (NRs), which regulate the expression of various genes by binding to DNA either as a monomer or a heterodimer with retinoid x receptor.
Recent advances in understanding/management of non-alcoholic steatohepatitis.
Sanyal et al., Richmond, United States. In F1000prime Rep, 2014
Recently, the FLINT (Farnesoid X Receptor [FXR] Ligand Obeticholic Acid in NASH Treatment) trial provided promising results of the efficacy of obeticholic acid, a farnesoid X receptor agonist, in improving histological features of NASH and fibrosis.
Role of Liver X Receptor in AD Pathophysiology.
Arboleda et al., Bogotá, Colombia. In Plos One, 2014
Alzheimer's disease (AD) is the major cause of dementia worldwide.
CCR7 Receptor Expression in Mono-MAC-1 Cells: Modulation by Liver X Receptor α Activation and Prostaglandin E 2.
Dumais et al., Sherbrooke, Canada. In Int J Inflam, 2014
Here, we explore the role of the liver X receptor α (LXRα) activation on CCR7 expression in Mono-Mac-1 (MM-1) cells in the presence of PGE2.
O-GlcNAcylation Links ChREBP and FXR to Glucose-Sensing.
Postic et al., Paris, France. In Front Endocrinol (lausanne), 2013
Among them, the nuclear Farnesoid X Receptor (FXR), a key transcription factor of bile acid metabolism involved in the gut-liver axis homeostasis was recently shown to directly interact with ChREBP, acting as a repressor on the ChoRE of glycolytic genes.
Evaluation of cellular determinants required for in vitro xenotropic murine leukemia virus-related virus entry into human prostate cancer and noncancerous cells.
Ly et al., Atlanta, United States. In J Virol, 2010
These studies suggest that the expression of Xpr1 and certain genotypes of the RNASEL gene, which could restrict XMRV infection, may play important roles in defining XMRV tropisms in certain cell types.
Regulation of cyp3a gene transcription by the pregnane x receptor.
Kliewer et al., United States. In Annu Rev Pharmacol Toxicol, 2001
The pregnane X receptor (PXR) is a promiscuous nuclear receptor that has evolved to protect the body from toxic chemicals.
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