Changes seen in gut bacteria content and distribution with obesity: causation or association?
Birmingham, United States. In Postgrad Med, Nov 2015
These changes could either be due to the dramatic change in the composition of the diet which occurs following this surgery or due to down-regulation of the Farnesoid X Receptor which causes a decrease in bile acid production and an elevation of the gut pH which in turn allows the regrowth of bacteria associated with weight loss which were previously unable to grow in the acidic intestinal environment caused by excess production of bile acids.
O-GlcNAcylation Links ChREBP and FXR to Glucose-Sensing.
Paris, France. In Front Endocrinol (lausanne), 2013
Among them, the nuclear Farnesoid X Receptor (FXR), a key transcription factor of bile acid metabolism involved in the gut-liver axis homeostasis was recently shown to directly interact with ChREBP, acting as a repressor on the ChoRE of glycolytic genes.