Structure of the HECT domain of human WWP2.
China. In Acta Crystallogr Sect F Struct Biol Commun, Oct 2015
WWP2 is a HECT-domain ubiquitin ligase of the Nedd4 family, which is involved in various important biological processes, such as protein degradation, membrane-protein sorting and transportation, the immune response, pluripotency of embryonic stem cells, tumourigenesis and metastasis.
WWP2: a multifunctional ubiquitin ligase gene.
Nanchong, China. In Pathol Oncol Res, 2014
WWP2, a recently identified ubiquitin E3 ligase, has been proved a multifunctional gene by degradation a series of targets via ubiquitin-dependent proteasome system, including PETN, Smads, Oct4, EGR2, TIRF and so.
Unraveling the transcriptional regulatory machinery in chondrogenesis.
Kyoto, Japan. In J Bone Miner Metab, 2011
Sox9 possesses a potent transactivation domain and thereby recruits diverse transcriptional co-activators, histone-modifying enzymes, subunits of the mediator complex, and components of the general transcriptional machinery, such as CBP/p300, Med12, Med25, and Wwp2.