Integrated analysis of gene expression and genomic aberration data in osteosarcoma (OS).
Chongqing, China. In Cancer Gene Ther, Nov 2015
Comparing genomic aberrations and DGEs, we found 41 SNP-associated DEGs and 124 CNV-associated DEGs, in which 7 DGEs were associated with both SNPs and CNVs, including WWP1, EXT1, LDHB, C8orf59, PLEKHA5, CCT3 and VWF.
WWP1: a versatile ubiquitin E3 ligase in signaling and diseases.
Kunming, China. In Cell Mol Life Sci, 2012
WWP1 may function as the E3 ligase for several PY motif-containing proteins, such as Smad2, KLF5, p63, ErbB4/HER4, RUNX2, JunB, RNF11, SPG20, and Gag, as well as several non-PY motif containing proteins, such as TbetaR1, Smad4, KLF2, and EPS15. Review.
The Nedd4-like family of E3 ubiquitin ligases and cancer.
Albany, United States. In Cancer Metastasis Rev, 2007
The assertion that Nedd4-like E3s play a role in cancer is supported by the overexpression of Smurf2 in esophageal squamous cell carcinoma, WWP1 in prostate and breast cancer, Nedd4 in prostate and bladder cancer, and Smurf1 in pancreatic cancer.