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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

WW domain containing oxidoreductase

WWOX, FRA16D, WW domain-containing oxidoreductase, WOX1
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: oxidoreductase, FHIT, CAN, V1a, p53
Papers on WWOX
Adenovirus-delivered wwox inhibited lung cancer growth in vivo in a mouse model.
New
You et al., Wuxi, China. In Cancer Gene Ther, Jan 2016
This study investigated the possibility of inhibiting lung cancer in vivo with adenovirus-delivered WW domain-containing oxidoreductase (wwox).
Pleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer Cells.
Review
New
Aqeilan et al., Jerusalem, Israel. In J Biol Chem, Jan 2016
WW domain-containing oxidoreductase (WWOX), originally marked as a likely tumor suppressor gene, has over the years become recognized for its role in a much wider range of cellular activities.
Pc2-mediated SUMOylation of WWOX is essential for its suppression of DU145 prostate tumorigenesis.
New
Oh et al., Taejŏn, South Korea. In Febs Lett, Jan 2016
Tumor suppressor WW domain-containing oxidoreductase (WWOX) is depleted in various cancer types.
WWOX modulates the ATR-mediated DNA damage checkpoint response.
New
Aqeilan et al., Jerusalem, Israel. In Oncotarget, Jan 2016
Role of the tumor suppressor WWOX (WW domain-containing oxidoreductase) in DNA damage response upon double strand breaks has been recently revealed.
Identification of a possible susceptibility locus for UVB-induced skin tanning phenotype in Korean females using genomewide association study.
New
Lee et al., Taejŏn, South Korea. In Exp Dermatol, Dec 2015
We found that a novel SNP in the intron of the WW domain-containing oxidoreductase (WWOX) gene yielded significant replicated associations with skin tanning ability (P-value = 1.16 × 10(-4) ).
Tumor suppressor WWOX moderates the mitochondrial respiratory complex.
New
Richards et al., Adelaide, Australia. In Genes Chromosomes Cancer, Dec 2015
Fragile site FRA16D exhibits DNA instability in cancer, resulting in diminished levels of protein from the WWOX gene that spans it.
Severe CNS involvement in WWOX mutations: Description of five new cases.
New
Zuccoli et al., Riyadh, Saudi Arabia. In Am J Med Genet A, Dec 2015
Recently, mutations in WWOX have been identified in the setting of central nervous system (CNS) disorders, highlighting a previously unrevealed role of this gene in the normal development and function of the CNS.
A novel gene THSD7A is associated with obesity.
New
Thangaraj et al., Hyderābād, India. In Int J Obes (lond), Nov 2015
It is commonly used for assessing adiposity and obesity-related risk prediction.
[Expressions of WWOX and CD133 in colorectal cancer and their clinical significance].
New
Tao et al., Bengbu, China. In Nan Fang Yi Ke Da Xue Xue Bao, Nov 2015
OBJECTIVE: To investigate the expressions of WWOX and CD133 in colorectal cancer (CRC) and their relationship with the clinicopathologic characteristics of CRC.
Alteration of WWOX in human cancer: a clinical view.
Review
New
Bednarek et al., Łódź, Poland. In Exp Biol Med (maywood), Mar 2015
WWOX gene is located in FRA16D, the highly affected chromosomal fragile site.
Structural insights into the functional versatility of WW domain-containing oxidoreductase tumor suppressor.
Review
New
Farooq, Miami, United States. In Exp Biol Med (maywood), Mar 2015
Recent work on WW domain-containing oxidoreductase (WWOX) tumor suppressor is beginning to shed new light on both the molecular mechanism of action of its WW domains as well as the contiguous catalytic domain.
Regulation of cell signaling and apoptosis by tumor suppressor WWOX.
Review
New
Hsu et al., Tainan City, Taiwan. In Exp Biol Med (maywood), Mar 2015
Human fragile WWOX gene encodes a tumor suppressor WW domain-containing oxidoreductase (named WWOX, FOR, or WOX1).
WWOX, the chromosomal fragile site FRA16D spanning gene: its role in metabolism and contribution to cancer.
Review
New
O'Keefe et al., Adelaide, Australia. In Exp Biol Med (maywood), Mar 2015
Many cancers exhibit FRA16D DNA instability that results in aberrant WWOX expression and is associated with poor prognosis for these cancers.
Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster.
Richards et al., Adelaide, Australia. In Plos One, 2014
WWOX is a >1 Mb gene spanning FRA16D Common Chromosomal Fragile Site, a region of DNA instability in cancer.
Tumor Suppressor WWOX inhibits osteosarcoma metastasis by modulating RUNX2 function.
Aqeilan et al., Jerusalem, Israel. In Sci Rep, 2014
We recently demonstrated that WW domain-containing oxidoreductase (WWOX) is frequently inactivated in human OS and that WWOX restoration in WWOX-negative OS cells suppresses tumorigenicity.
Biophysical basis of the binding of WWOX tumor suppressor to WBP1 and WBP2 adaptors.
GeneRIF
Farooq et al., Miami, United States. In J Mol Biol, 2012
the WW2 domain likely serves as a chaperone to augment the physiological function of WW1 domain within WWOX.
WWOX-mediated apoptosis in A549 cells mainly involves the mitochondrial pathway.
GeneRIF
Ge et al., Shanghai, China. In Mol Med Report, 2012
WWOX induces apoptosis in A549 cells via the mitochondrial pathway.
Aberrant expression of WWOX protein in epithelial ovarian cancer: a clinicopathologic and immunohistochemical study.
GeneRIF
Xiao et al., Jinan, China. In Int J Gynecol Pathol, 2012
loss of WWOX expression in epithelial ovarian carcinomas correlates with advanced International Federation of Gynecology and Obstetrics stages, and lymph node metastases
Roles of the middle domain-specific WUSCHEL-RELATED HOMEOBOX genes in early development of leaves in Arabidopsis.
GeneRIF
Okada et al., Okazaki, Japan. In Plant Cell, 2012
Specific expression of PRS and WOX1 in a domain between the adaxial and abaxial domains is important for lateral-specific blade outgrowth and margin-specific cell fate.
Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study.
GeneRIF
Pan et al., Taipei, Taiwan. In Plos One, 2011
Data identified IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes by gene based association scan and gene expression analysis.
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