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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

WWOX WW domain containing oxidoreductase

WW domain-containing oxidoreductase
Top mentioned proteins: oxidoreductase, WWOX, V1a, p53, HAD
Papers on WW domain-containing oxidoreductase
Adenovirus-delivered wwox inhibited lung cancer growth in vivo in a mouse model.
New
You et al., Wuxi, China. In Cancer Gene Ther, Jan 2016
This study investigated the possibility of inhibiting lung cancer in vivo with adenovirus-delivered WW domain-containing oxidoreductase (wwox).
Pleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer Cells.
Review
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Aqeilan et al., Jerusalem, Israel. In J Biol Chem, Jan 2016
WW domain-containing oxidoreductase (WWOX), originally marked as a likely tumor suppressor gene, has over the years become recognized for its role in a much wider range of cellular activities.
Pc2-mediated SUMOylation of WWOX is essential for its suppression of DU145 prostate tumorigenesis.
New
Oh et al., Taejŏn, South Korea. In Febs Lett, Jan 2016
Tumor suppressor WW domain-containing oxidoreductase (WWOX) is depleted in various cancer types.
WWOX modulates the ATR-mediated DNA damage checkpoint response.
New
Aqeilan et al., Jerusalem, Israel. In Oncotarget, Jan 2016
Role of the tumor suppressor WWOX (WW domain-containing oxidoreductase) in DNA damage response upon double strand breaks has been recently revealed.
Identification of a possible susceptibility locus for UVB-induced skin tanning phenotype in Korean females using genomewide association study.
New
Lee et al., Taejŏn, South Korea. In Exp Dermatol, Dec 2015
We found that a novel SNP in the intron of the WW domain-containing oxidoreductase (WWOX) gene yielded significant replicated associations with skin tanning ability (P-value = 1.16 × 10(-4) ).
Allostery mediates ligand binding to WWOX tumor suppressor via a conformational switch.
New
Farooq et al., Miami, United States. In J Mol Recognit, Apr 2015
While being devoid of the ability to recognize ligands itself, the WW2 domain is believed to aid ligand binding to the WW1 domain in the context of a WW1-WW2 tandem module of WW domain-containing oxidoreductase (WWOX) tumor suppressor.
Ectopic expression of the WWOX gene suppresses stemness of human ovarian cancer stem cells.
New
Han et al., Xuzhou, China. In Oncol Lett, Apr 2015
UNASSIGNED: The present study aimed to investigate the effects of the WW domain-containing oxidoreductase (WWOX) gene on the stem cell properties of human ovarian cancer stem cells.
Structural insights into the functional versatility of WW domain-containing oxidoreductase tumor suppressor.
Review
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Farooq, Miami, United States. In Exp Biol Med (maywood), Mar 2015
Recent work on WW domain-containing oxidoreductase (WWOX) tumor suppressor is beginning to shed new light on both the molecular mechanism of action of its WW domains as well as the contiguous catalytic domain.
Regulation of cell signaling and apoptosis by tumor suppressor WWOX.
Review
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Hsu et al., Tainan City, Taiwan. In Exp Biol Med (maywood), Mar 2015
Human fragile WWOX gene encodes a tumor suppressor WW domain-containing oxidoreductase (named WWOX, FOR, or WOX1).
WWOX: a fragile tumor suppressor.
Review
New
Huebner et al., Columbus, United States. In Exp Biol Med (maywood), Mar 2015
WWOX, the WW domain-containing oxidoreductase gene at chromosome region 16q23.3-q24.1,
Introduction to a thematic issue for WWOX.
New
Chang, Tainan City, Taiwan. In Exp Biol Med (maywood), Mar 2015
Since its discovery in 2000, WW domain-containing oxidoreductase (WWOX, FOR or WOX1) has been considered as a tumor suppressor protein.
WW domain-containing oxidoreductase in neuronal injury and neurological diseases.
Review
Sze et al., Tainan City, Taiwan. In Oncotarget, 2015
The human and mouse WWOX/Wwox gene encodes a candidate tumor suppressor WW domain-containing oxidoreductase protein.
WWOX suppresses prostate cancer cell progression through cyclin D1-mediated cell cycle arrest in the G1 phase.
Lu et al., Tainan City, Taiwan. In Cell Cycle, 2014
WW domain-containing oxidoreductase (WWOX) has been reported to be a tumor suppressor in multiple cancers, including prostate cancer.
Expression of WW domain-containing oxidoreductase WWOX in pterygium.
Tseng et al., Tainan City, Taiwan. In Mol Vis, 2014
The human WWOX gene, encoding the WW domain containing oxidoreductase (WWOX, FOR, or WOX1), is a candidate tumor suppressor gene.
Tumor Suppressor WWOX inhibits osteosarcoma metastasis by modulating RUNX2 function.
Aqeilan et al., Jerusalem, Israel. In Sci Rep, 2014
We recently demonstrated that WW domain-containing oxidoreductase (WWOX) is frequently inactivated in human OS and that WWOX restoration in WWOX-negative OS cells suppresses tumorigenicity.
Comparative mapping and genomic annotation of the bovine oncosuppressor gene WWOX.
GeneRIF
Ferretti et al., Pavia, Italy. In Cytogenet Genome Res, 2008
data show that the chromosomal location of WWOX is conserved between man and 4 major domesticated species. Moreover, the annotation of the bovine gene also suggests a highly conserved genomic arrangement, including number and size of introns
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