Genetics of pediatric renal tumors.
Düsseldorf, Germany. In Pediatr Nephrol, 2013
Other genes frequently altered somatically in subsets of WT are CTNNB1 and WTX; both genes influence the Wnt signalling pathway.
Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene.
Houston, United States. In Nat Rev Cancer, 2011
Genes identified as being mutated in Wilms' tumour include TP53, a classic tumour suppressor gene (TSG); CTNNB1 (encoding β-catenin), a classic oncogene; WTX, which accumulating data indicate is a TSG; and WT1, which is inactivated in some Wilms' tumours, similar to a TSG.