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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Wilms tumor 1 associated protein

WTAP, Wilms' tumour 1-associating protein, KIAA0105
The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in three transcript variants, two of which encode the same isoform. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, MUC4, fibrillin-1, HAD, Ott
Papers on WTAP
A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing.
New
Brockdorff et al., Yokohama, Japan. In Cell Rep, Aug 2015
Validation experiments performed on several of the top hits identified the SPOC domain RNA binding proteins Rbm15 and Spen and Wtap, a component of the m6A RNA methyltransferase complex, as playing an important role in the establishment of Xist-mediated silencing.
Carbonic anhydrase IV inhibits colon cancer development by inhibiting the Wnt signalling pathway through targeting the WTAP-WT1-TBL1 axis.
New
Yu et al., Hong Kong, Hong Kong. In Gut, Jul 2015
CA4 interacted with Wilms' tumour 1-associating protein (WTAP) and induced WTAP protein degradation through polyubiquitination.
How mRNA is misspliced in acute myelogenous leukemia (AML)?
Review
Wattel et al., In Oncotarget, 2014
At the protein level, WT1 interacts with the splicing factors U2AF2, WTAP, and RPM4.
The Drosophila Wilms׳ Tumor 1-Associating Protein (WTAP) homolog is required for eye development.
Kumar et al., Bloomington, United States. In Dev Biol, 2014
In this report we have used yeast two-hybrid screens and co-immunoprecipitation assays from Kc167 cells to identify a biochemical complex consisting of So and Fl(2)d, the Drosophila homolog of human Wilms׳ Tumor 1-Associating Protein (WTAP).
Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase.
Yang et al., Beijing, China. In Cell Res, 2014
Here we report two new components of the human m6A methyltransferase complex, Wilms' tumor 1-associating protein (WTAP) and methyltransferase like 14 (METTL14).
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
He et al., Chicago, United States. In Nat Chem Biol, 2014
WTAP, a mammalian splicing factor, can interact with this complex and affect this methylation.
Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle.
Hamakubo et al., In J Biol Chem, 2013
Wilms' tumor 1-associating protein (WTAP) is a putative splicing regulator that is thought to be required for cell cycle progression through the stabilization of cyclin A2 mRNA and mammalian early embryo development.
WTAP regulates migration and invasion of cholangiocarcinoma cells.
Oh et al., Pusan, South Korea. In J Gastroenterol, 2013
BACKGROUND: Wilms' tumor 1-associating protein (WTAP) is a nuclear protein that has been associated with the regulation of proliferation and apoptosis.
Hypospadias and genes related to genital tubercle and early urethral development.
Shaw et al., Stanford, United States. In J Urol, 2013
MATERIALS AND METHODS: We examined 293 relatively common tag single nucleotide polymorphisms in BMP4, BMP7, FGF8, FGF10, FGFR2, HOXA13, HOXD13, HOXA4, HOXB6, SRY, WT1, WTAP, SHH, GLI1, GLI2 and GLI3.
Expression and roles of Wilms' tumor 1-associating protein in glioblastoma.
Oh et al., Yangsan, South Korea. In Cancer Sci, 2012
Wilms' tumor 1-associating protein (WTAP) is a nuclear protein that has been associated with regulation of proliferation and apoptosis.
High glucose-induced proteome alterations in retinal pigmented epithelium cells and its possible relevance to diabetic retinopathy.
Chan et al., Taiwan. In Mol Biosyst, 2012
Further analyses of clinical plasma specimens confirmed that the proteins lamin B2, PUMA, WTAP, ASGR1, and prohibitin 2 showed type 2 diabetic retinopathy-dependent alterations.
Gene expression profiling of peripheral blood leukocytes identifies potential novel biomarkers of chronic obstructive pulmonary disease in current and former smokers.
Murrelle et al., Richmond, United States. In Biomarkers, 2010
This predictor set was reduced to a nine-gene classifier (IL6R, CCR2, PPP2CB, RASSF2, WTAP, DNTTIP2, GDAP1, LIPE and RPL14).
Evaluation of podocyte lesion in patients with diabetic nephropathy: Wilms' tumor-1 protein used as a podocyte marker.
GeneRIF
Liu et al., Nanjing, China. In Diabetes Res Clin Pract, 2010
WTAP level in poodocytes is a valuable alternative technique in the study of podocyte injury in diabetic nephropathy.
Nuclear degradation of Wilms tumor 1-associating protein and survivin splice variant switching underlie IGF-1-mediated survival.
GeneRIF
Pickering et al., London, Canada. In J Biol Chem, 2009
Nuclear degradation of Wilms tumor 1-associating protein and survivin splice variant switching underlie IGF-1-mediated survival
Wtap is required for differentiation of endoderm and mesoderm in the mouse embryo.
GeneRIF
Asano et al., Kanazawa, Japan. In Dev Dyn, 2008
findings indicate that Wtap is indispensable for differentiation of mesoderm and endoderm in the mouse embryo
Vascular biology and the sex of flies: regulation of vascular smooth muscle cell proliferation by wilms' tumor 1-associating protein.
Review
Pickering et al., London, Canada. In Trends Cardiovasc Med, 2007
One gene that has recently been implicated in the acquisition of SMC replicative quiescence is Wilms' tumor 1-associating protein (WTAP).
Analysis of Gene Expression Profile of AGS Cells Stimulated by Helicobacter pylori Adhesion.
Song et al., Seoul, South Korea. In Gut Liver, 2007
Five genes, namely, ARF3, M17S2, DDB2, AWP1, and WTAP were confirmed to be down-regulated.
Wilms' tumor 1-associating protein regulates the proliferation of vascular smooth muscle cells.
GeneRIF
Pickering et al., London, Canada. In Circ Res, 2007
WTAP is a novel regulator of the cell cycle and cell survival and implicate a WTAP-WT1 axis as a novel pathway for controlling vascular smooth muscle cell phenotype.
Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA.
GeneRIF
Kodama et al., Tokyo, Japan. In Proc Natl Acad Sci U S A, 2006
WTAP as an essential factor for the stabilization of cyclin A2 mRNA, thereby regulating G2/M cell-cycle transition
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