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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Wilms tumor 1b

wt1b
Top mentioned proteins: CAN, ACID, NTR, GST, FATE
Papers on wt1b
Evaluation of the teratogenic effects of three traditional Chinese medicines, Si Jun Zi Tang, Liu Jun Zi Tang and Shenling Baizhu San, during zebrafish pronephros development.
New
Chen et al., I-lan, Taiwan. In J Toxicol Pathol, Jul 2015
We used the transgenic zebrafish line Tg(wt1b:EGFP) to assess the teratogenic effects using 12 different protocols, which comprised combinations of 4 doses (0, 25, 250, 1,250 ng/mL) and 3 exposure methods [methods I, 12-36 hours post fertilization (hpf), II, 24-48 hpf, and III, 24-36 hpf].
Development of the zebrafish mesonephros.
New
Davidson et al., Cambridge, United States. In Genesis, Mar 2015
These nephrons, arising from proliferating progenitor cells that express the renal transcription factor genes wt1b, pax2a, and lhx1a, form on top of the pronephric tubules and develop a segmentation pattern similar to pronephric nephrons.
Nephroprotective role of resveratrol and ursolic Acid in aristolochic Acid intoxicated zebrafish.
Chen et al., Taipei, Taiwan. In Toxins (basel), 2015
We used two transgenic lines, Tg(wt1b:EGFP) and Tg(gata1:DsRed), to evaluate the nephroprotective effects of Resv and UA by recording subtle changes in the kidney and red blood cell circulation.
Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta.
Wingert et al., United States. In Dev Biol, 2015
Surprisingly, tubule cells in prkcι/ζ morphants displayed ectopic expression of the transcription factor pax2a and the podocyte-associated genes wt1a, wt1b, and podxl, suggesting that prkcι/ζ are needed to maintain renal epithelial identity.
Alternative splicing of Wilms tumor suppressor 1 (Wt1) exon 4 results in protein isoforms with different functions.
Englert et al., Jena, Germany. In Dev Biol, 2014
Most fish including zebrafish and medaka possess two wt1 paralogs, wt1a and wt1b, both lacking exon 5.
A possible zebrafish model of polycystic kidney disease: knockdown of wnt5a causes cysts in zebrafish kidneys.
Lipschutz et al., Virginia, South Africa. In J Vis Exp, 2013
Tg(wt1b:GFP) transgenic zebrafish were used to visualize kidney structure and kidney cysts following wnt5a knockdown.
Development of an automated imaging pipeline for the analysis of the zebrafish larval kidney.
Gehrig et al., Heidelberg, Germany. In Plos One, 2012
The established pipeline was applied in a pilot screen for the analysis of the impact of potentially nephrotoxic drugs on zebrafish pronephros development in the Tg(wt1b:EGFP) transgenic line in which the developing pronephros is highlighted by GFP expression.
Evaluation of nephrotoxic effects of mycotoxins, citrinin and patulin, on zebrafish (Danio rerio) embryos.
Liu et al., T'ai-chung-shih, Taiwan. In Food Chem Toxicol, 2012
In the presence of CTN and PAT, the gross morphology of kidneys from embryos with green fluorescent kidney (wt1b:GFP) was not apparently altered.
Life-long preservation of the regenerative capacity in the fin and heart in zebrafish.
Kawakami et al., In Biol Open, 2012
The expression of epicardial genes, such as wt1b and aldh1a2, in response to heart injury was comparable in two groups.
Inducible podocyte injury and proteinuria in transgenic zebrafish.
Hildebrandt et al., Ann Arbor, United States. In J Am Soc Nephrol, 2012
Moreover, expression of wt1b::GFP, a marker for the developing nephron, extended into the Bowman capsule in response to podocyte injury, suggesting that zebrafish have a podocyte-specific repair process known to occur in mammalian metanephros.
Developmental nephrotoxicity of aristolochic acid in a zebrafish model.
Chen et al., Taipei, Taiwan. In Toxicol Appl Pharmacol, 2012
Whole-mount in situ hybridization studies using cmlc2 and wt1b as riboprobes indicated that the kidney is more sensitive than the heart to AA damage.
Wt1a, Foxc1a, and the Notch mediator Rbpj physically interact and regulate the formation of podocytes in zebrafish.
Davidson et al., Boston, United States. In Dev Biol, 2011
The Wilms' tumor suppressor-1 (Wt1) and the FoxC1/2 transcription factors, as well as Notch signaling, have been implicated as important regulators of podocyte fate.
Characterization of mesonephric development and regeneration using transgenic zebrafish.
Hildebrandt et al., Ann Arbor, United States. In Am J Physiol Renal Physiol, 2010
Utilizing two transgenic zebrafish lines (wt1b::GFP and pod::NTR-mCherry), we characterized the developmental stages of individual mesonephric nephrons and the temporal-spatial pattern of mesonephrogenesis.
Nephrotoxicity assessments of acetaminophen during zebrafish embryogenesis.
Chen et al., Taiwan. In Comp Biochem Physiol C Toxicol Pharmacol, 2010
We used a green fluorescent kidney line, Tg(wt1b:GFP), as a model to access the acetaminophen (AAP)-induced nephrotoxicity dynamically.
A highly conserved retinoic acid responsive element controls wt1a expression in the zebrafish pronephros.
Englert et al., Jena, Germany. In Development, 2009
Here, we have used transgenesis in zebrafish harboring two wt1 genes, wt1a and wt1b, in order to define regulatory elements that drive wt1 expression in the kidney.
The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephros.
GeneRIF
Bollig et al., Jena, Germany. In Dev Biol, 2007
While wt1a has a more fundamental and early role in pronephros development and is essential for the formation of glomerular structures, wt1b functions at later stages of nephrogenesis.
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