Humanin and the receptors for humanin.
Tokyo, Japan. In Mol Neurobiol, 2010
Most recently, it has been shown that Humanin inhibits neuronal cell death and dysfunction by binding to a novel IL-6-receptor-related receptor(s) on the cell surface involving CNTFRalpha, WSX-1, and gp130.
[Immune regulation by IL-27 for therapeutic usage].
Saga, Japan. In Nihon Rinsho Meneki Gakkai Kaishi, 2009
In the absence of IL-27-mediated immunosuppression, hyper-production of various pro-inflammatory cytokines concomitant with severe inflammation in affected organs was observed in IL-27 receptor alpha chain (WSX-1)-deficient mice infected with Trypanosoma cruzi.
Interleukin-35: odd one out or part of the family?
Memphis, United States. In Immunol Rev, 2008
All four are heterodimeric cytokines, composed of an alpha chain (p19, p28, or p35) and a beta chain (p40 or Ebi3), and signal through unique pairings of five receptor chains (IL-12Rbeta1, IL-12Rbeta2, IL-23R, gp130, and WSX-1).