The WSB1 gene is involved in pancreatic cancer progression.
Marseille, France. In Plos One, 2007
Data on WSB1 regulation support the hypothesis that activation of stress-response mechanisms helps cancer cells establishing metastases and suggest relevance to cancer development of other genes overexpressed in xenografts
Raising the curtains on interchromosomal interactions.
Cambridge, United Kingdom. In Trends Genet, 2006
By introducing an adaptation of this technique, Ling and colleagues have identified an unexpected coassociation between two loci on separate chromosomes in mouse nuclei, the imprinted Igf2-H19 locus of chromosome 7 and the Wsb1-Nf1 locus of chromosome 11.
CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1.
Palo Alto, United States. In Science, 2006
Using a modification of chromosome conformation capture (3C) and fluorescence in situ hybridization, we found that one allele of the insulin-like growth factor 2 (Igf2)/H19 imprinting control region (ICR) on chromosome 7 colocalized with one allele of Wsb1/Nf1 on chromosome 11.