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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Wingless-type MMTV integration site family, member 8a

Wnt8, WNT8A
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. It encodes a protein which shows 81% amino acid identity to the mouse Wnt8A protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Wnt3a, Wnt5a, Wnt3, CAN, Wnt8b
Papers on Wnt8
Characterization of Tiki, a new family of WNT-specific metalloproteases.
He et al., Boston, United States. In J Biol Chem, Jan 2016
We also established an in vitro assay for TIKI2 protease activity using FRET peptide substrates derived from the cleavage motifs of Wnt3a and Xenopus wnt8 (Xwnt8).
A multivariate assessment of innate immune-related gene expressions due to exposure to low concentration individual and mixtures of four kinds of heavy metals on zebrafish (Danio rerio) embryos.
Yang et al., Zhenjiang, China. In Fish Shellfish Immunol, Dec 2015
Low concentration heavy metals also affect expression of development-related (wnt8a and vegf) genes.
Specific induction of cranial placode cells from Xenopus ectoderm by modulating the levels of BMP, Wnt, and FGF signaling.
Michiue et al., Tokyo, Japan. In Genesis, Oct 2015
Furthermore, co-injection with either wnt8 or the Wnt inhibitor dkk-1 altered the expression levels of several region-specific genes according to the injected dose.
Kinesin-1 interacts with Bucky ball to form germ cells and is required to pattern the zebrafish body axis.
Marlow et al., United States. In Development, Oct 2015
Interestingly, whereas Syntabulin and wnt8a translocation depend on kif5Ba, grip2a translocation does not, providing evidence for two distinct mechanisms by which DDs might be asymmetrically distributed.
The Chromatin Remodeling Protein Bptf Promotes Posterior Neuroectodermal Fate by Enhancing Smad2-Activated wnt8a Expression.
Wang et al., Beijing, China. In J Neurosci, Jul 2015
Bptf functionally and physically interacts with p-Smad2, which is activated by non-Nodal TGF-β signaling, to promote the expression of wnt8a, a critical gene for neural posteriorization.
Next-generation sequencing of nine atrial fibrillation candidate genes identified novel de novo mutations in patients with extreme trait of atrial fibrillation.
Lin et al., Taipei, Taiwan. In J Med Genet, 2015
Genome-wide association studies (GWAS) have identified common variants in nine genomic regions associated with AF (KCNN3, PRRX1, PITX2, WNT8A, CAV1, C9orf3, SYNE2, HCN4 and ZFHX3 genes); however, the genetic variability of these risk variants does not explain the entire genetic susceptibility to AF. Rare variants missed by GWAS may also contribute to genetic risk of AF.
Both ciliary and non-ciliary functions of Foxj1a confer Wnt/β-catenin signaling in zebrafish left-right patterning.
Lin et al., Rochester, United States. In Biol Open, 2014
We showed that targeted injection of wnt8a mRNA into a single cell at the 128-cell stage is sufficient to induce ectopic foxj1a expression and ectopic cilia.
Cortical depth and differential transport of vegetally localized dorsal and germ line determinants in the zebrafish embryo.
Pelegri et al., Madison, United States. In Bioarchitecture, 2014
We examined the spatial relationship between the proposed dorsal genes wnt8a and grip2a and the PGC factor dazl at the vegetal cortex.
Developmental toxicity in rare minnow (Gobiocypris rarus) embryos exposed to Cu, Zn and Cd.
Wang et al., China. In Ecotoxicol Environ Saf, 2014
Stress and metabolism-related genes (hsp70, cyp1a and mt) were significantly up-regulated, development-related genes (wnt8a, vezf1 and mstn) were significantly down-regulated after the treatment by Cu, Zn and Cd.
Hecate/Grip2a acts to reorganize the cytoskeleton in the symmetry-breaking event of embryonic axis induction.
Pelegri et al., Philadelphia, United States. In Plos Genet, 2014
hecate mutants show defects in the alignment and bundling of microtubules at the vegetal cortex, which result in defects in the asymmetric movement of wnt8a mRNA as well as anchoring of the kinesin-associated cargo adaptor Syntabulin.
Post-transcriptional regulation of wnt8a is essential to zebrafish axis development.
Lekven et al., College Station, United States. In Dev Biol, 2014
wnt8a Is essential for normal patterning during vertebrate embryonic development, and either gain or loss-of-function gene dysregulation results in severe axis malformations.
Biphasic wnt8a expression is achieved through interactions of multiple regulatory inputs.
Lekven et al., College Station, United States. In Dev Dyn, 2012
Wnt8a expression pattern reflects complex interactions of multiple regulatory inputs.
2-O-sulfotransferase regulates Wnt signaling, cell adhesion and cell cycle during zebrafish epiboly.
Yost et al., Salt Lake City, United States. In Development, 2012
2-OST functions within the Wnt pathway, downstream of Wnt ligand signaling and upstream of Gsk3beta and beta-catenin intracellular localization and function
Wnt/β-catenin signaling directly regulates Foxj1 expression and ciliogenesis in zebrafish Kupffer's vesicle.
Lin et al., Rochester, United States. In Development, 2012
It was shown that Wnt3a-Wnt8a/beta-catenin signaling directly regulates ciliogenic transcription factor foxj1a expression and ciliogenesis in zebrafish Kupffer's vesicle.
Identification and mechanism of regulation of the zebrafish dorsal determinant.
Thisse et al., Charlottesville, United States. In Proc Natl Acad Sci U S A, 2011
Data show that the maternal dorsal determinant, Wnt8a, is required to localize the primary dorsal center, and that the extent of this domain is defined by the activity of two maternally provided Wnt antagonists, Sfrp1a and Frzb.
A transgenic wnt8a:PAC reporter reveals biphasic regulation of vertebrate mesoderm development.
Lekven et al., College Station, United States. In Dev Dyn, 2011
wnt8a expression marks Nodal-independent tail mesoderm formation and that Ntl/Bra predominantly regulates wnt8a in paraxial mesoderm progenitors.
Embryonic pattern formation without morphogens.
Bolouri, Seattle, United States. In Bioessays, 2008
In sea urchin embryos, this process begins with blimp1 and wnt8 gene expression at the vegetal pole as soon as embryonic transcription begins.
A gene regulatory network subcircuit drives a dynamic pattern of gene expression.
Davidson et al., Pasadena, United States. In Science, 2007
We show how this dynamic patterning function is encoded in a gene regulatory network (GRN) subcircuit that includes the otx, wnt8, and blimp1 genes, the cis-regulatory control systems of which have all been experimentally defined.
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
Katoh, Tokyo, Japan. In Stem Cell Rev, 2007
From 1996 to 2002, we cloned and characterized WNT2B/WNT13, WNT3, WNT3A, WNT5B, WNT6, WNT7B, WNT8A, WNT8B, WNT9A/WNT14, WNT9B/WNT14B, WNT10A, WNT10B, WNT11, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD10, FRAT1, FRAT2, NKD1, NKD2, VANGL1, RHOU/ARHU, RHOV/ARHV, GIPC2, GIPC3, FBXW11/betaTRCP2, SOX17, TCF7L1/TCF3, and established a cDNA-PCR system for snap-shot and dynamic analyses on the WNT-transcriptome.
Regulation of WNT signaling molecules by retinoic acid during neuronal differentiation in NT2 cells: threshold model of WNT action (review).
Katoh, Tokyo, Japan. In Int J Mol Med, 2002
WNT3A, WNT8A, WNT8B, WNT10B and WNT11 are down-regulated in NT2 cells after ATRA treatment, while WNT2, WNT7B and WNT14B are up-regulated.
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