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Wingless-related MMTV integration site 6

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Wnt5a, WNT10A, Wnt10b, Wnt1, Wnt3a
Papers on Wnt6
Transcriptome profiling in oral cavity and esophagus tissues from (S)-N'-nitrosonornicotine-treated rats reveals candidate genes involved in human oral cavity and esophageal carcinogenesis.
Kassie et al., Richmond, United States. In Mol Carcinog, Feb 2016
The most significant impact of exposure to (S)-NNN was alteration of genes involved in immune regulation (Aire, Ctla4, and CD80), inflammation (Ephx2 and Inpp5d) and cancer (Cdkn2a, Dhh, Fetub B, Inpp5d, Ly6E, Nr1d1, and Wnt6).
Microarray Analyses Reveal Marked Differences in Growth Factor and Receptor Expression Between 8-Cell Human Embryos and Pluripotent Stem Cells.
Kiessling et al., Athens, Greece. In Stem Cells Dev, Feb 2016
Forty-four gene elements were underdetected on the 8C arrays, including 11 at least 80-fold under the pluripotent cells: two cytokines (IFITM1, TNFRSF8), five TGFBs (BMP7, LEFTY1, LEFTY2, TDGF1, TDGF3), two FGFs (FGF2, FGF receptor 1), plus ING5, and WNT6.
Hydrogen Sulfide Is a Novel Regulator of Bone Formation Implicated in the Bone Loss Induced by Estrogen Deficiency.
Pacifici et al., Bologna, Italy. In J Bone Miner Res, Dec 2015
Mechanistic studies revealed that GYY increases murine osteoblastogenesis by activating Wnt signaling through increased production of the Wnt ligands Wnt16, Wnt2b, Wnt6 and Wnt10b in the BM.
WNT3 involvement in human bladder exstrophy and cloaca development in zebrafish.
Nordenskjöld et al., Stockholm, Sweden. In Hum Mol Genet, Oct 2015
In total 13 variants were identified in WNT3, WNT6, WNT7A, WNT8B, WNT10A, WNT11, WNT16, FZD5, LRP1 and LRP10 genes and predicted as potentially disease causing, of which seven variants were novel.
Suppression of EZH2 Prevents the Shift of Osteoporotic MSC Fate to Adipocyte and Enhances Bone Formation During Osteoporosis.
Jin et al., Xi'an, China. In Mol Ther, Sep 2015
EZH2 directly increased H3K27me3 levels on promoters of Wnt1, Wnt6, and Wnt10a to silence Wnt gene transcription.
Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways.
Mirotsou et al., Durham, United States. In J Mol Cell Cardiol, Aug 2015
Sfrp2 binding to Wnt6 and inhibition of Wnt6 canonical pathway was essential for the inhibition of CPC proliferation.
Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions.
Mundlos et al., Berlin, Germany. In Cell, Jun 2015
We show that distinct human limb malformations are caused by deletions, inversions, or duplications altering the structure of the TAD-spanning WNT6/IHH/EPHA4/PAX3 locus.
Novel missense mutation in WNT6 in 100 couples with unexplained recurrent miscarriage.
Chen et al., Jinan, China. In Hum Reprod, Apr 2015
STUDY QUESTION: Do mutations and/or polymorphisms in coding sequences in Wingless-Type MMTV Integration Site Family, Member 6 (WNT6) play a role in unexplained recurrent miscarriage (unexplained RM) in Chinese couples?
Lv et al., In Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2015
OBJECTIVE: To explore the potential role of WNT6 in the proliferation, differentiation, and migration of bone marrow mesenchymal stem cells (BMSCs).
Increased WNT6 expression in tumor cells predicts unfavorable survival in esophageal squamous cell carcinoma patients.
Yang et al., Xinhui, China. In Int J Clin Exp Pathol, 2014
The expression status of WNT6 in ESCCs and their clinico-prognostic significances remain to be elucidated.
The Protective Effects of Curcumin on Obesity-Related Glomerulopathy Are Associated with Inhibition of Wnt/β-Catenin Signaling Activation in Podocytes.
Dong et al., Beijing, China. In Evid Based Complement Alternat Med, 2014
Furthermore, the experiments in vitro and in vivo both displayed that curcumin could downregulate the mRNA and protein expressions of Wnt1, Wnt2b, Wnt6, and β-catenin and upregulate the phosphorylation level of β-catenin protein in podocytes and renal tissue.
Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism.
MacDougald et al., Ann Arbor, United States. In Bone, 2012
Mechanisms downstream of beta-catenin are required for Wnt6, Wnt10a and Wnt10b to influence differentiation of mesenchymal precursors.
Polymorphisms in WNT6 and WNT10A and colorectal adenoma risk.
Ulrich et al., Seattle, United States. In Nutr Cancer, 2010
The WNT6 rs6747776 homozygous minor allele (CC) was associated with increased risk of colorectal adenoma.
Salmonella regulation of intestinal stem cells through the Wnt/beta-catenin pathway.
Sun et al., Rochester, United States. In Febs Lett, 2010
The mRNA levels of Wnt3, 6, and 9a were significantly upregulated in the intestinal epithelial cells by Salmonella.
Effect of Wnt6 on human dental papilla cells in vitro.
Ye et al., China. In J Endod, 2010
Wnt6 plays an important role in tooth development by promoting human dental papilla cell differentiation, without significant effects on cell proliferation.
Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation.
Stricker et al., Berlin, Germany. In Gene Expr Patterns, 2009
Study revealed new domains of expression for Wnt2, Wnt2b, Wnt5b, Wnt6, Wnt7b, Wnt9a, Wnt10a, Wnt10b, Wnt11 and Wnt16, in the limb.
WNT signaling in stem cell biology and regenerative medicine.
Katoh, Tokyo, Japan. In Curr Drug Targets, 2008
WNT3, WNT5A and WNT10B are expressed in undifferentiated human embryonic stem cells, while WNT6, WNT8B and WNT10B in endoderm precursor cells.
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
Katoh, Tokyo, Japan. In Stem Cell Rev, 2007
From 1996 to 2002, we cloned and characterized WNT2B/WNT13, WNT3, WNT3A, WNT5B, WNT6, WNT7B, WNT8A, WNT8B, WNT9A/WNT14, WNT9B/WNT14B, WNT10A, WNT10B, WNT11, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD10, FRAT1, FRAT2, NKD1, NKD2, VANGL1, RHOU/ARHU, RHOV/ARHV, GIPC2, GIPC3, FBXW11/betaTRCP2, SOX17, TCF7L1/TCF3, and established a cDNA-PCR system for snap-shot and dynamic analyses on the WNT-transcriptome.
WNT and FGF gene clusters (review).
Katoh, Tokyo, Japan. In Int J Oncol, 2002
Among 19 WNT genes, WNT3 and WNT14B genes are clustered in human chromosome 17q21, WNT3A and WNT14 in human chromosome 1q42, WNT10A and WNT6 in human chromosome 2q35, and WNT10B and WNT1 in human chromosome 12q13.
Ectodermal Wnt function as a neural crest inducer.
Bronner-Fraser et al., Pasadena, United States. In Science, 2002
Here, we show that, in avians, Wnt6 is localized in ectoderm and in vivo inhibition of Wnt signaling perturbs neural crest formation.
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