gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Wingless-type MMTV integration site family, member 5A

Wnt5a, PP5, tissue factor pathway inhibitor-2, TFPI-2, placental protein 5, Wnt5b
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: CAN, TFPI, ACID, V1a, HAD
Papers using Wnt5a antibodies
Novel approaches for targeted cancer therapy
Supplier
Kawakami Koji et al., In Journal of Translational Medicine, 2003
... Human recombinant FKBP5 and PP5 were purchased from Abnova.
Papers on Wnt5a
WNT-5A: signaling and functions in health and disease.
Review
New
Gosens et al., Groningen, Netherlands. In Cell Mol Life Sci, Feb 2016
WNT-5A plays critical roles in a myriad of processes from embryonic morphogenesis to the maintenance of post-natal homeostasis.
Lens regeneration from the cornea requires suppression of Wnt/β-catenin signaling.
New
Henry et al., Urbana, United States. In Exp Eye Res, Feb 2016
wnt3a, wnt4, wnt5a, wnt5b, wnt6, wnt7b, wnt10a, wnt11, and wnt11b) are expressed in the cornea epithelium, demonstrating that this tissue is transcribing many of the ligands and receptors of the Wnt signaling pathway.
Polymorphisms in Wnt signaling pathway genes are associated with peak bone mineral density, lean mass, and fat mass in Chinese male nuclear families.
New
Zhang et al., Shanghai, China. In Osteoporos Int, Feb 2016
Our study identified that WNT5B and CTNNBL1 for both BMD and body composition, and WNT4 and CTNNB1 gene polymorphisms contribute to the variation in BMD and body composition in young Chinese men, respectively.
WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling.
New
Boerboom et al., Saint-Hyacinthe, Canada. In Faseb J, Jan 2016
Noncanonical WNTs, including WNT5a and WNT11, are expressed in granulosa cells (GCs) and are differentially regulated throughout follicle development, but their physiologic roles remain unknown.
Ectodermal Wnt controls nasal pit morphogenesis through modulation of the BMP/FGF/JNK signaling axis.
New
Zhang et al., Hangzhou, China. In Dev Dyn, Jan 2016
BACKGROUND: Mutations of WNT3, WNT5A, WNT9B, and WNT11 genes are associated with orofacial birth defects, including nonsyndromic CLP (Cleft lip with cleft palate) in humans.
The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue.
Review
New
Turck et al., Campinas, Brazil. In Proteomics Clin Appl, Oct 2015
Furthermore, 32 different molecular functions were found to be associated with these proteins, such as RNA binding, ribosomal functions, transporter activity, receptor activity, serine/threonine phosphatase activity, cell adhesion, cytoskeletal protein binding and catalytic activity.
Steroid Receptor-Associated Immunophilins: A Gateway to Steroid Signalling.
Review
New
Ward et al., Australia. In Clin Biochem Rev, May 2015
The steroid receptor-associated immunophilins FKBP51, FKBP52, CyP40 and PP5 have specific roles in steroid receptor function that impact steroid hormone-binding affinity, nucleocytoplasmic shuttling and transcriptional activation of target genes in a tissue-specific manner.
Autosomal Dominant Robinow Syndrome
Review
New
Chitayat et al., Seattle, United States. In Unknown Journal, Feb 2015
The diagnosis is supported by identification of a heterozygous WNT5A or DVL1 pathogenic variant.
WNT5A transforms intestinal CD8αα(+) IELs into an unconventional phenotype with pro-inflammatory features.
Ran et al., Shanghai, China. In Bmc Gastroenterol, 2014
RESULTS: Non-canonical WNT pathway elements represented by FZD5, WNT5A and NFATc1 were remarkably elevated in colitis IELs.
Therapy for BRAFi-Resistant Melanomas: Is WNT5A the Answer?
Review
Andersson et al., Malmö, Sweden. In Cancers (basel), 2014
Recent studies have shown that WNT5A plays a key role in enhancing the resistance of melanoma cells to BRAFi.
Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer.
Impact
Zhou et al., Lexington, United States. In Cancer Cell, 2014
Here we report a mechanism by which Twist recruits BRD4 to direct WNT5A expression in basal-like breast cancer (BLBC).
Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury.
Impact
GeneRIF
Stappenbeck et al., Saint Louis, United States. In Science, 2012
These findings suggest a Wnt5a-dependent mechanism for forming new colonic crypt units to reestablish homeostasis.
Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis.
GeneRIF
Wang et al., Birmingham, United Kingdom. In Dev Biol, 2012
A Wnt5a--> Dvl PCP signaling cascade may regulate actin polymerization and protrusive cell behavior in the caudal splanchnic mesoderm to promote second heart field deployment, outflow tract lengthening and cardiac looping.
Induced Wnt5a expression perturbs embryonic outgrowth and intestinal elongation, but is well-tolerated in adult mice.
GeneRIF
Smits et al., Rotterdam, Netherlands. In Dev Biol, 2012
These results indicate a role for Wnt5a during a restricted time-frame of embryonic development, but suggest no impact during homeostatic postnatal stages.
Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development.
GeneRIF
Nusse et al., Stanford, United States. In Dev Biol, 2012
A single mammalian Wnt protein can have multiple signaling activities in vivo.
Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration.
GeneRIF
Gu et al., Nanjing, China. In Plos One, 2011
Wnt5a promotes breast cancer cell migration via Dvl2/Daam1/RhoA.
Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response.
Impact
Katsanis et al., Baltimore, United States. In Nat Genet, 2007
Here we show that bbs1, bbs4 and mkks (also known as bbs6), which encode basal body proteins, are required for convergence and extension in zebrafish and interact with wnt11 and wnt5b.
Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5.
Impact
GeneRIF
Dhillon et al., Glasgow, United Kingdom. In Nat Cell Biol, 2006
PP5 is a physiological regulator of Raf-1 signalling pathways.
Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells.
Impact
Benezra et al., New York City, United States. In Science, 2004
Insulin-like growth factor 1, a long-range secreted factor, in combination with WNT5a, a locally secreted factor, likely account for complete reversion of the cardiac phenotype.
Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue.
Impact
GeneRIF
Jones et al., Worcester, United States. In Cancer Cell, 2003
Wnt5a suppresses hematopoietic malignancies
share on facebooktweetadd +1mail to friends