Lens regeneration from the cornea requires suppression of Wnt/β-catenin signaling.
Urbana, United States. In Exp Eye Res, Feb 2016
wnt3a, wnt4, wnt5a, wnt5b, wnt6, wnt7b, wnt10a, wnt11, and wnt11b) are expressed in the cornea epithelium, demonstrating that this tissue is transcribing many of the ligands and receptors of the Wnt signaling pathway.
The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue.
Campinas, Brazil. In Proteomics Clin Appl, Oct 2015
Furthermore, 32 different molecular functions were found to be associated with these proteins, such as RNA binding, ribosomal functions, transporter activity, receptor activity, serine/threonine phosphatase activity, cell adhesion, cytoskeletal protein binding and catalytic activity.
Steroid Receptor-Associated Immunophilins: A Gateway to Steroid Signalling.
Australia. In Clin Biochem Rev, May 2015
The steroid receptor-associated immunophilins FKBP51, FKBP52, CyP40 and PP5 have specific roles in steroid receptor function that impact steroid hormone-binding affinity, nucleocytoplasmic shuttling and transcriptional activation of target genes in a tissue-specific manner.
Autosomal Dominant Robinow Syndrome
Seattle, United States. In Unknown Journal, Feb 2015
The diagnosis is supported by identification of a heterozygous WNT5A or DVL1 pathogenic variant.