Lens regeneration from the cornea requires suppression of Wnt/β-catenin signaling.
Urbana, United States. In Exp Eye Res, Feb 2016
wnt3a, wnt4, wnt5a, wnt5b, wnt6, wnt7b, wnt10a, wnt11, and wnt11b) are expressed in the cornea epithelium, demonstrating that this tissue is transcribing many of the ligands and receptors of the Wnt signaling pathway.
Photoperiodic and diurnal regulation of WNT signalling in the arcuate nucleus of the female Djungarian hamster, Phodopus sungorus.
Dunedin, New Zealand. In Endocrinology, Jan 2016
We detected elevated expression of the genes WNT-4, Axin-2, Cyclin-D1 and SFRP-2, in the hypothalamic arcuate nucleus, a key energy balance integration site, during LD compared with SD, as well as a diurnal regulation of Axin-2, Cyclin-D1 and DKK-3.
Ovarian development and disease: The known and the unexpected.
Fribourg, Switzerland. In Semin Cell Dev Biol, Sep 2015
WNT4, one of a few factors with a demonstrated function in the ovarian-determination pathway, has been found to be involved in sexual differentiation by suppressing male sexual differentiation, promoting Müllerian ducts differentiation and maintaining oocyte health.
London, United Kingdom. In Curr Opin Endocrinol Diabetes Obes, 2014
In 46,XY gonadal dysgenesis, lack of testis development may be triggered by sex determining region Y, NR5A1, DHH or testis-determining gene loss-of-function mutations, DAX1 or WNT4 duplication or MAP3K1 gain-of-function mutations.
Proteomic analysis of cerebrospinal fluid: toward the identification of biomarkers for gliomas.
Shanghai, China. In Neurosurg Rev, 2014
Further functional and protein-protein interaction assessments were performed by using Protein Analysis Through Evolutionary Relationships (PANTHER) website and Ingenuity Pathway Analysis (IPA) software, which revealed several important protein networks (e.g., IL-6/STAT-3) and four novel focus proteins (IL-6, galanin (GAL), HSPA5, and WNT4) that might be involved in glioma pathogenesis.
Characterising novel pathways in testis determination using mouse genetics.
United Kingdom. In Sex Dev, 2013
Studies in 2 broad areas have been especially revealing: (i) identification of pathways required for the appropriate expression of Sry, and (ii) characterisation of the antagonistic interactions between the core testis- (SRY-SOX9-FGF9) and ovary- (RSPO1-WNT4-CTNNB1-FOXL2) determining gene regulatory networks.
Wnt signaling and Dupuytren's disease.
Groningen, Netherlands. In N Engl J Med, 2011
Six of these loci contain genes known to be involved in the Wnt-signaling pathway: WNT4 (rs7524102) (P=2.8×10(-9);