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Wingless-related MMTV integration site 4

Wnt4
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SRY, CAN, Wnt5a, HAD, SF-1
Papers on Wnt4
WNT4-like protein is a cortical granule component in mouse oocytes and functions in regulating preimplantation embryogenesis.
New
Yang et al., Taipei, Taiwan. In Syst Biol Reprod Med, Feb 2016
In the present study, a 66 kDa wingless-type MMTV integration site family, member 4 (WNT4)-like protein, with mouse CG origin was identified.
Lens regeneration from the cornea requires suppression of Wnt/β-catenin signaling.
New
Henry et al., Urbana, United States. In Exp Eye Res, Feb 2016
wnt3a, wnt4, wnt5a, wnt5b, wnt6, wnt7b, wnt10a, wnt11, and wnt11b) are expressed in the cornea epithelium, demonstrating that this tissue is transcribing many of the ligands and receptors of the Wnt signaling pathway.
Polymorphisms in Wnt signaling pathway genes are associated with peak bone mineral density, lean mass, and fat mass in Chinese male nuclear families.
New
Zhang et al., Shanghai, China. In Osteoporos Int, Feb 2016
Our study identified that WNT5B and CTNNBL1 for both BMD and body composition, and WNT4 and CTNNB1 gene polymorphisms contribute to the variation in BMD and body composition in young Chinese men, respectively.
Photoperiodic and diurnal regulation of WNT signalling in the arcuate nucleus of the female Djungarian hamster, Phodopus sungorus.
New
Tups et al., Dunedin, New Zealand. In Endocrinology, Jan 2016
We detected elevated expression of the genes WNT-4, Axin-2, Cyclin-D1 and SFRP-2, in the hypothalamic arcuate nucleus, a key energy balance integration site, during LD compared with SD, as well as a diurnal regulation of Axin-2, Cyclin-D1 and DKK-3.
Ovarian development and disease: The known and the unexpected.
Review
New
Chaboissier et al., Fribourg, Switzerland. In Semin Cell Dev Biol, Sep 2015
WNT4, one of a few factors with a demonstrated function in the ovarian-determination pathway, has been found to be involved in sexual differentiation by suppressing male sexual differentiation, promoting Müllerian ducts differentiation and maintaining oocyte health.
Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
New
Impact
Consortium of Investigators of Modifiers of BRCA1 and BRCA2 et al., Los Angeles, United States. In Nat Genet, Feb 2015
Variants at 1p36 (nearest gene, WNT4), 4q26 (SYNPO2), 9q34.2 (ABO) and 17q11.2
Swyer syndrome.
Review
Conway et al., London, United Kingdom. In Curr Opin Endocrinol Diabetes Obes, 2014
In 46,XY gonadal dysgenesis, lack of testis development may be triggered by sex determining region Y, NR5A1, DHH or testis-determining gene loss-of-function mutations, DAX1 or WNT4 duplication or MAP3K1 gain-of-function mutations.
R-spondin1, WNT4, and the CTNNB1 signaling pathway: strict control over ovarian differentiation.
Review
Chaboissier et al., Nice, France. In Reproduction, 2014
Molecular mechanisms governing ovarian differentiation remained unknown for a long time, until the discovery of the roles of R-spondin1 (RSPO1) and WNT4.
Dysfunction of Liver Receptor Homolog-1 in Decidua: Possible Relevance to the Pathogenesis of Preeclampsia.
Zhang et al., Shanghai, China. In Plos One, 2014
Knocking down of NR5A2 in human endometrial stromal cells (hESC) resulted in a significant reduction in their expression of decidualization markers (IGFBP1 and PRL) and signaling pathway molecules (WNT4 and BMP2) (P < 0.05).
Proteomic analysis of cerebrospinal fluid: toward the identification of biomarkers for gliomas.
Review
Zhou et al., Shanghai, China. In Neurosurg Rev, 2014
Further functional and protein-protein interaction assessments were performed by using Protein Analysis Through Evolutionary Relationships (PANTHER) website and Ingenuity Pathway Analysis (IPA) software, which revealed several important protein networks (e.g., IL-6/STAT-3) and four novel focus proteins (IL-6, galanin (GAL), HSPA5, and WNT4) that might be involved in glioma pathogenesis.
Characterising novel pathways in testis determination using mouse genetics.
Review
Greenfield et al., United Kingdom. In Sex Dev, 2013
Studies in 2 broad areas have been especially revealing: (i) identification of pathways required for the appropriate expression of Sry, and (ii) characterisation of the antagonistic interactions between the core testis- (SRY-SOX9-FGF9) and ovary- (RSPO1-WNT4-CTNNB1-FOXL2) determining gene regulatory networks.
Genome-wide association meta-analysis identifies new endometriosis risk loci.
Impact
Montgomery et al., Brisbane, Australia. In Nat Genet, 2012
previously found to associate with disease in Europeans, replicates in Japanese (P = 3.6 × 10(-3)), and we confirm association of rs7521902 at 1p36.12 near WNT4.
Testis development requires the repression of Wnt4 by Fgf signaling.
GeneRIF
Capel et al., Durham, United States. In Dev Biol, 2012
The repression of many female genes including Wnt4 is necessary for the bipotential gonad to adopt the male testicular fate.
WT1 and Sox11 regulate synergistically the promoter of the Wnt4 gene that encodes a critical signal for nephrogenesis.
GeneRIF
Vainio et al., Oulu, Finland. In Exp Cell Res, 2012
Sox11 represents a synergistic factor for WT1 in regulating the Wnt4 gene expression that is critical for nephrogenesis during kidney ontogeny.
Mutations in WNT4 are not responsible for Müllerian duct abnormalities in Chinese women.
GeneRIF
Chen et al., China. In Reprod Biomed Online, 2012
Mutations in WNT4 are not responsible for Mullerian duct abnormalities in Chinese women.
Initiation of synapse formation by Wnt-induced MuSK endocytosis.
GeneRIF
Granato et al., Philadelphia, United States. In Development, 2012
Data show that in vivo, wnt11r and wnt4a initiate MuSK translocation from muscle membranes to recycling endosomes and that this transition is crucial for AChR accumulation at future synaptic sites.
Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway.
GeneRIF
Albrecht et al., Boston, United States. In Plos Genet, 2011
Our analyses show that Wt1, Sf1, and Wnt4 can be dosage-sensitive in mice, depending on the genetic background, and provide insights into the mechanisms of B6 XY sex reversal
Wnt signaling and Dupuytren's disease.
Impact
BSSH-GODD Consortium et al., Groningen, Netherlands. In N Engl J Med, 2011
Six of these loci contain genes known to be involved in the Wnt-signaling pathway: WNT4 (rs7524102) (P=2.8×10(-9);
A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese.
Impact
Nakamura et al., Tokyo, Japan. In Nat Genet, 2010
A SNP, rs16826658, in the LD block including WNT4 on chromosome 1p36, which is considered to play an important role in the development of the female genital tract, revealed a possible association with endometriosis (P = 1.66 x 10(-6), odds ratio = 1.20).
A WNT4 mutation associated with Müllerian-duct regression and virilization in a 46,XX woman.
Impact
Schoenle et al., Zürich, Switzerland. In N Engl J Med, 2004
WNT4, a secreted protein that suppresses male sexual differentiation, is thought to repress the biosynthesis of gonadal androgen in female mammals.
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