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Wingless-related MMTV integration site 3A

Wnt3a
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, TCF, Frizzled, DKK1, V1a
Papers using Wnt3a antibodies
Wnt expression in the adult rat subventricular zone after stroke.
Supplier
Arai Ken, In PLoS ONE, 2006
... The Wnt3a-HA gene (bearing the HA tag) from the pBSWnt-3aHA cDNA (Addgene, Cambridge, MA, USA) and the AcGFP1 gene from the pIRES2/AcGFP1 cDNA (Clontech) served as the expression ...
Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions
Supplier
Suemori Hirofumi et al., In In Vitro Cellular & Developmental Biology. Animal, 2005
... WNT3ARnD Systems ...
Papers on Wnt3a
Lens regeneration from the cornea requires suppression of Wnt/β-catenin signaling.
New
Henry et al., Urbana, United States. In Exp Eye Res, Feb 2016
wnt3a, wnt4, wnt5a, wnt5b, wnt6, wnt7b, wnt10a, wnt11, and wnt11b) are expressed in the cornea epithelium, demonstrating that this tissue is transcribing many of the ligands and receptors of the Wnt signaling pathway.
WNT/β-catenin Signaling Pathway and Downstream Modulators in Low- and High-grade Glioma.
New
Schiffer et al., Torino, Italy. In Cancer Genomics Proteomics, Feb 2016
MATERIALS AND METHODS: In 74 gliomas of different histological grade and in 24 glioblastoma cell lines, protein expression of WNT member 3a (WNT3a), β-catenin and transcription factor 4 (TCF4) was investigated by immunohistochemistry, western blotting, immunofluorescence and immunocytochemistry.
Rescuing failed oral implants via Wnt activation.
New
Helms et al., Chengdu, China. In J Clin Periodontol, Jan 2016
After fibrous encapsulation was established peri-implant injections of a liposomal formulation of WNT3A protein (L-WNT3A) or liposomal PBS (L-PBS) were then initiated.
All-trans retinoic acid modulates Wnt3A-induced osteogenic differentiation of mesenchymal stem cells via activating the PI3K/AKT/GSK3β signalling pathway.
New
Gao et al., Shanghai, China. In Mol Cell Endocrinol, Jan 2016
Here, we explored whether Wnt3A and all-trans-retinoic acid (ATRA) play synergistic roles in MSC osteogenic differentiation.
Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology.
New
Donowitz et al., Baltimore, United States. In Gastroenterology, Jan 2016
RESULTS: Enteroids differentiated upon withdrawl of WNT3A, yielding decreased crypt markers and increased villus-like characteristics.
Recent developments in β-cell differentiation of pluripotent stem cells induced by small and large molecules.
Review
Higuchi et al., Kuala Selangor, Malaysia. In Int J Mol Sci, 2013
activin A, betacellulin, bone morphogentic protein (BMP4), epidermal growth factor (EGF), fibroblast growth factor (FGF), keratinocyte growth factor (KGF), hepatocyte growth factor (HGF), noggin, transforming growth factor (TGF-α), and WNT3A) are thought to contribute from the initial stages of definitive endoderm formation to the final stages of maturation of functional endocrine cells.
WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation.
Impact
Long et al., Saint Louis, United States. In Cell Metab, 2013
WNT3A induces aerobic glycolysis known as Warburg effect by increasing the level of key glycolytic enzymes.
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage.
Impact
Clevers et al., Utrecht, Netherlands. In Nat Cell Biol, 2012
Cultured Dll1(high) cells form long-lived organoids (mini-guts) on brief Wnt3A exposure.
Wnt3a inhibits proliferation but promotes melanogenesis of melan-a cells.
GeneRIF
Yang et al., Chongqing, China. In Int J Mol Med, 2012
Wnt3a inhibits proliferation but promotes melanogenesis of melan-a cells. Wnt3a plays an important role in melanocyte homeostasis.
Wnt/β-catenin signaling mediates the antitumor activity of magnolol in colorectal cancer cells.
GeneRIF
Lee et al., Seoul, South Korea. In Mol Pharmacol, 2012
Growth inhibition of magnolol against human colon cancer cells can be partly attributed to the regulation of the Wnt3a/beta-catenin signaling pathway.
WNT-3a modulates platelet function by regulating small GTPase activity.
GeneRIF
Maguire et al., Dublin, Ireland. In Febs Lett, 2012
WNT-3a as a novel upstream regulator of small GTPase activity in platelets
Interaction of Wnt3a, Msgn1 and Tbx6 in neural versus paraxial mesoderm lineage commitment and paraxial mesoderm differentiation in the mouse embryo.
GeneRIF
Hadjantonakis et al., New York City, United States. In Dev Biol, 2012
Data suggest that in epiblast cells, Wnt3a is important for epithelial-to-mesenchymal transition and cell ingression through the primitive streak, as well as for promoting neural fate by regulation of Sox2 expression during posterior somite formation.
Multi-level interactions between the nuclear receptor TRα1 and the WNT effectors β-catenin/Tcf4 in the intestinal epithelium.
GeneRIF
Plateroti et al., Lyon, France. In Plos One, 2011
increased beta-catenin/Tcf4 levels i) correlated with reduced TRalpha1 transcriptional activity on its target genes and, ii) were likely responsible for the shift of TRalpha1 binding on WNT targets
Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis.
Review
Chen et al., Rochester, United States. In Ann N Y Acad Sci, 2011
Ex vivo studies with tissue derived from OA patients and in vivo studies with mutant mice have suggested that pathways involving receptor ligands such as TGF-β1, WNT3a, and Indian hedgehog; signaling molecules such as Smads, β-catenin, and HIF-2a; and peptidases such as MMP13 and ADAMTS4/5 are probably involved to some degree.
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
Impact
Clevers et al., Utrecht, Netherlands. In Nature, 2011
In HEK293 cells, RSPO1 enhances canonical WNT signals initiated by WNT3A.
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro.
Impact
Wells et al., Cincinnati, United States. In Nature, 2011
Using this culture system as a model to study human intestinal development, we identified that the combined activity of WNT3A and FGF4 is required for hindgut specification whereas FGF4 alone is sufficient to promote hindgut morphogenesis.
APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex.
Impact
Christiano et al., New York City, United States. In Nature, 2010
We show that APCDD1 is a membrane-bound glycoprotein that is abundantly expressed in human hair follicles, and can interact in vitro with WNT3A and LRP5-two essential components of Wnt signalling.
miR-15a and miR-16-1 in cancer: discovery, function and future perspectives.
Review
Croce et al., Jerusalem, Israel. In Cell Death Differ, 2010
miR-15a and miR-16-1 function by targeting multiple oncogenes, including BCL2, MCL1, CCND1, and WNT3A.
Hear the Wnt Ror: how melanoma cells adjust to changes in Wnt.
Review
Weeraratna et al., Baltimore, United States. In Pigment Cell Melanoma Res, 2009
Canonical Wnt signaling, represented by Wnts such as Wnt1 and Wnt3A, signals via beta-catenin to promote melanocyte differentiation and tumor development.
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
Review
Katoh, Tokyo, Japan. In Stem Cell Rev, 2007
From 1996 to 2002, we cloned and characterized WNT2B/WNT13, WNT3, WNT3A, WNT5B, WNT6, WNT7B, WNT8A, WNT8B, WNT9A/WNT14, WNT9B/WNT14B, WNT10A, WNT10B, WNT11, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD10, FRAT1, FRAT2, NKD1, NKD2, VANGL1, RHOU/ARHU, RHOV/ARHV, GIPC2, GIPC3, FBXW11/betaTRCP2, SOX17, TCF7L1/TCF3, and established a cDNA-PCR system for snap-shot and dynamic analyses on the WNT-transcriptome.
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