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Wingless-type MMTV integration site family, member 3

Wnt3, INT4
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Wnt9b, Wnt3a, Wnt5a, CAN, POLYMERASE
Papers on Wnt3
Ectodermal Wnt controls nasal pit morphogenesis through modulation of the BMP/FGF/JNK signaling axis.
Zhang et al., Hangzhou, China. In Dev Dyn, Jan 2016
BACKGROUND: Mutations of WNT3, WNT5A, WNT9B, and WNT11 genes are associated with orofacial birth defects, including nonsyndromic CLP (Cleft lip with cleft palate) in humans.
Modulating the expression level of secreted Wnt3 influences cerebellum development in zebrafish transgenics.
Wohland et al., Singapore, Singapore. In Development, Dec 2015
Using light and fluorescence microscopy for the overall imaging of the specimen and fluorescence correlation spectroscopy (FCS) to determine Wnt3 dynamics, we demonstrated that Wnt3 regulates cerebellum development during embryogenesis using zebrafish wnt3 transgenics with either tissue-specific expression of an EGFP reporter or a functionally active fusion protein, Wnt3EGFP.
The WNT/β-catenin signaling pathway may be involved in granulosa cell apoptosis from patients with PCOS in North China.
Zhang et al., Taiyuan, China. In J Gynecol Obstet Biol Reprod (paris), Nov 2015
RT-qPCR was used to measure mRNA levels of WNT family members (WNT1, WNT3, WNT4, WNT5, sFRP4 and sFRP5).
Genome-Wide Linkage Analysis Identifies Loci for Physical Appearance Traits in Chickens.
Wen et al., China. In G3 (bethesda), Oct 2015
For beard and wattles traits, an identical region 11 cM/2.23 Mb (0.0-11.0 cM/0.00-2.23 Mb) including WNT3 and GH genes on GGA27 was identified.
Association Between Genes Involved in Craniofacial Development and Nonsyndromic Cleft Lip and/or Palate in the Brazilian Population.
Coletta et al., In Cleft Palate Craniofac J, Oct 2015
DESIGN:   The SNPs rs748044 (TNP1), rs1106514 (MSX1), rs28372960, rs15251 and rs2569062 (TCOF1), rs7829058 (FGFR1), rs1793949 (COL2A1), rs11653738 (WNT3), and rs242082 (TIMP3) were assessed in a family-based transmission disequilibrium test (TDT) and a structured case-control analysis based on the individual ancestry proportions.
WNT16-expressing Acute Lymphoblastic Leukemia Cells are Sensitive to Autophagy Inhibitors after ER Stress Induction.
Denko et al., Pátrai, Greece. In Anticancer Res, Sep 2015
BACKGROUND: Previous work from our group showed hypoxia can induce endoplasmic reticulum (ER) stress and block the processing of the WNT3 protein in cells engineered to express WNT3a.
The D543N polymorphism of the SLC11A1/NRAMP1 gene is associated with treatment failure in male patients with pulmonary tuberculosis.
Sosa-Macías et al., In Drug Metabol Personal Ther, Sep 2015
We assessed the polymorphisms of SLC11A1 in the regions of D543N and INT4 via polymerase chain reaction real-time TaqMan® single nucleotide polymorphism (SNP) genotyping.
An association study of NRAMP1, VDR, MBL and their interaction with the susceptibility to tuberculosis in a Chinese population.
Xu et al., Shanghai, China. In Int J Infect Dis, Sep 2015
Genetic polymorphisms of NRAMP1 (INT4, D543NA and 3'UTR), MBL (HL, PQ, XY and AB) and VDR (FokI and Taq) were analyzed by using PCR-restriction fragment length polymorphism (RFLP) and PCR- single- strand conformation polymorphism (SSCP) techniques.
Variations in WNT3 gene are associated with incidence of non-syndromic cleft lip with or without cleft palate in a northeast Chinese population.
Xu et al., Shenyang, China. In Genet Mol Res, 2014
Two SNPs (rs3809857 and rs9890413) in the WNT3 gene were subjected to case-control and case-parent analysis by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 236 unrelated patients with NSCL/P, including 128 elementary families (185 mothers and 154 fathers), and 400 control individuals from northeast China.
Injury-induced asymmetric cell death as a driving force for head regeneration in Hydra.
Galliot, Genève, Switzerland. In Dev Genes Evol, 2013
In head-regenerating tips (but not in foot ones), a wave of cell death takes place immediately, leading the apoptotic cells to transiently release Wnt3 and activate the β-catenin pathway in the neighboring cycling cells to push them through mitosis.
Clinical review: Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headed.
Kiel et al., Boston, United States. In J Clin Endocrinol Metab, 2012
Among 59 novel BMD GWAS loci that have not been reported by previous candidate gene association studies, some have been shown to be involved in key biological pathways involving the skeleton, particularly Wnt signaling (AXIN1, LRP5, CTNNB1, DKK1, FOXC2, HOXC6, LRP4, MEF2C, PTHLH, RSPO3, SFRP4, TGFBR3, WLS, WNT3, WNT4, WNT5B, WNT16), bone development: ossification (CLCN7, CSF1, MEF2C, MEPE, PKDCC, PTHLH, RUNX2, SOX6, SOX9, SPP1, SP7), mesenchymal-stem-cell differentiation (FAM3C, MEF2C, RUNX2, SOX4, SOX9, SP7), osteoclast differentiation (JAG1, RUNX2), and TGF-signaling (FOXL1, SPTBN1, TGFBR3).
Wnt3 gene expression promotes tumor progression in non-small cell lung cancer.
Yokomise et al., Japan. In Lung Cancer, 2012
The apoptotic index was significantly lower in high-Wnt3 tumors than in low-Wnt3 tumors (P=0.0245).
Polymorphisms in the SLC11A1 gene and tuberculosis risk: a meta-analysis update.
Fan et al., Chengdu, China. In Int J Tuberc Lung Dis, 2012
OBJECTIVE: To comprehensively evaluate the genetic risk of polymorphisms (D543N, 3'UTR TGTG ins/del, INT4, [GT]n) in the SLC11A1 gene for TB.
Genotype and haplotype analysis of WNT genes in non-syndromic cleft lip with or without cleft palate.
Jagodzinski et al., Poznań, Poland. In Eur J Oral Sci, 2012
study confirmed the involvement of polymorphisms in the WNT3 gene in NCL/P aetiology in the tested population.
Routes to the tonoplast: the sorting of tonoplast transporters in Arabidopsis mesophyll protoplasts.
Sauer et al., Erlangen, Germany. In Plant Cell, 2012
C-terminal di-leucine motif in INT1 can reroute other proteins, such as INT4, SUCROSE TRANSPORTER2 (SUC2), or SWEET1, to the tonoplast.
Association studies of candidate genes and cleft lip and palate taking into consideration geographical origin.
Vieira et al., Rīga, Latvia. In Eur J Oral Sci, 2011
The findings of a significant association between lip and/or palate clefts and two markers in the WNT3 and COL11A2 genes were the most consistent and were observed in all groups analysed and stratified.
Wnt3 and Wnt3a are required for induction of the mid-diencephalic organizer in the caudal forebrain.
Scholpp et al., Karlsruhe, Germany. In Neural Dev, 2011
We have identified canonical Wnt signaling as a novel pathway, that is required for proper formation of the mid-diencephalic organizer and consequently for the development of the major relay station of the brain - the thalamus.
SLC11A1 (NRAMP1) polymorphisms and tuberculosis susceptibility: updated systematic review and meta-analysis.
Gao et al., Beijing, China. In Plos One, 2010
for 3' UTR, D543N, INT4, and 5' (GT)n, respectively.
Tetra-Amelia Syndrome
Niemann, Seattle, United States. In Unknown Journal, 2007
WNT3 is the only gene in which mutations are known to cause tetra-amelia syndrome.
Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity.
Holdener et al., Stony Brook, United States. In Cell, 2003
However, phenotypic differences between mesd-deficient and wnt3(-)(/)(-) embryos suggest that MESD may function on related members of the low-density lipoprotein receptor (LDLR) family, whose members mediate diverse cellular processes ranging from cargo transport to signaling.
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