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Wingless related MMTV integration site 10b
Wnt10b
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers on
Wnt10b
Canonical Wnts, specifically Wnt-10b, show ability to maintain dermal papilla cells.
New
Kashihara, Japan. In Biochem Biophys Res Commun, Sep 2013
Wnt-10b promoted cell proliferation and trichogenesis, while Wnt-3a showed those abilities to a limited extent, and Wnt-5a and 11 had no effects.
Inducible brown adipose tissue, or beige fat, is anabolic for the skeleton.
New
Toledo, United States. In Endocrinology, Aug 2013
Immunodepletion of CM with antibodies against wingless related MMTV integration site 10b (WNT10b) and insulin-like growth factor binding protein 2 (IGFBP2) resulted in the loss of pro-osteoblastic activity, and the loss of increase in the levels of phospho-AKT and β-catenin.
Heme oxygenase gene targeting to adipocytes attenuates adiposity and vascular dysfunction in mice fed a high-fat diet.
Beijing, China. In Hypertension, 2012
Transduction of aP2-HO-1 lowered the elevated levels of these proteins and increased Sonic hedgehog, Wnt10b, and β-catenin (P<0.05).
β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis.
Erlangen, Germany. In Ann Rheum Dis, 2012
The accumulation of β-catenin resulted from increased expression of Wnt-1 and Wnt-10b in SSc.
Differential expression of canonical and non-canonical Wnt ligands in ameloblastoma.
Kuala Lumpur, Malaysia. In J Oral Pathol Med, 2012
RESULTS: Canonical Wnt proteins (except Wnt-10b) were heterogeneously expressed in ameloblastoma.
ApoA1: mimetic peptide reverses adipocyte dysfunction in vivo and in vitro via an increase in heme oxygenase (HO-1) and Wnt10b.
Toledo, United States. In Cell Cycle, 2012
MSC-derived adipocytes treated with L-4F increased WNT10b and decreased Peg 1/Mest.
Dermal papilla cells serially cultured with Wnt-10b sustain their hair follicle induction activity after transplantation into nude mice.
Kashihara, Japan. In Cell Transplant, 2011
The addition of Wnt-10b to the first culture of primary DP cells promoted their proliferation and maintained their Wnt responsiveness and HF induction ability.
Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation.
Seoul, South Korea. In Ppar Res, 2011
Moreover, cinchonine significantly reversed HFD-induced downregulations of WNT10b and galanin-mediated signaling molecules and key adipogenic genes in the epididymal adipose tissues of mice.
Lamin A/C deficiency is associated with fat infiltration of muscle and bone.
Sydney, Australia. In Mech Ageing Dev, 2011
From a mechanistic approach, high levels of pro-adipogenic factors PPARγ and C/EBPα were associated with a reduction in myogenic and osteogenic factors from the Wnt-10b/β-catenin signalling pathway in Lmna(-/-) mice.
Exendin-4 upregulates the expression of Wnt-4, a novel regulator of pancreatic β-cell proliferation.
Düsseldorf, Germany. In Am J Physiol Endocrinol Metab, 2011
The expression of Wnt-signaling molecules (Wnt-4, Wnt-10b, Frizzled-4, LRP5, TCF7L2) and TNFα was analyzed by semiquantitative PCR and Western blotting.
The influence of Leucine-rich amelogenin peptide on MSC fate by inducing Wnt10b expression.
GeneRIF
Los Angeles, United States. In Biomaterials, 2011
Leucine-rich Amelogenin Peptide (LRAP) treatment elevates the Wnt10b expression level whereas Wnt10b knockdown by siRNA abrogates the effect of LRAP.
Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma?
Chicago, United States. In Arthritis Rheum, 2011
OBJECTIVE: Because aberrant Wnt signaling has been linked with systemic sclerosis (SSc) and pulmonary fibrosis, we sought to investigate the effect of Wnt-10b on skin homeostasis and differentiation in transgenic mice and in explanted mesenchymal cells.
Molecular mechanism of fatty degeneration in rotator cuff muscle with tendon rupture.
GeneRIF
Sendai, Japan. In J Orthop Res, 2011
reduction of Wnt10b in muscle with a rotator cuff tear is a key signal in fatty degeneration of the muscle
Wnt10b activates the Wnt, notch, and NFκB pathways in U2OS osteosarcoma cells.
GeneRIF
Rochester, United States. In J Cell Biochem, 2011
Wnt10b, but not Wnt3a, stimulates the NFkappaB and Notch pathways in U2OS osteosarcoma cells.
A functional promoter polymorphism -607G>C of WNT10B is associated with abdominal fat in Korean female subjects.
GeneRIF
Kwangju, South Korea. In J Nutr Biochem, 2011
This study is the first report of the association of common genetic polymorphism of WNT10B with human fat accumulation.
Expression of Oct4 in HCC and modulation to wnt/β-catenin and TGF-β signal pathways.
Shiyan, China. In Mol Cell Biochem, 2010
Some other genes were also expressed in them with different level including Nanog, Sox2, STAT3 and TCF3, wnt10b, β-catenin, ELF, Smad3 and Smad4.
Homozygous nonsense mutation in WNT10B and sporadic split-hand/foot malformation (SHFM) with autosomal recessive inheritance.
GeneRIF
Aarau, Switzerland. In Am J Med Genet A, 2010
Homozygous nonsense mutation in WNT10B is associated with sporadic split-hand/foot malformation with autosomal recessive inheritance.
Wnt signaling and osteoblastogenesis.
Review
United States. In Rev Endocr Metab Disord, 2006
Studies of knockout and transgenic mouse models for Wnt pathway components like Wnt-10b, LRP-5/6, secreted frizzled-related protein-1, dickkopf-2, Axin-2 and beta-catenin have demonstrated that canonical signaling modulates most aspects of osteoblast physiology including proliferation, differentiation, bone matrix formation/mineralization and apoptosis as well as coupling to osteoclastogenesis and bone resorption.
New insights into inhibitors of adipogenesis.
Review
Chapel Hill, United States. In Curr Opin Lipidol, 2004
Intracellular signaling molecules, which negatively regulate adipogenesis, include Pref-1, Foxo1, Foxa2, SMAD-3, WNT-10b, GATA-2 and GATA-3.
Inhibition of adipogenesis by Wnt signaling.
Impact
Ann Arbor, United States. In Science, 2000
Here we show that Wnt signaling, likely mediated by Wnt-10b, is a molecular switch that governs adipogenesis.
