Inducible brown adipose tissue, or beige fat, is anabolic for the skeleton.
Toledo, United States. In Endocrinology, Aug 2013
Immunodepletion of CM with antibodies against wingless related MMTV integration site 10b (WNT10b) and insulin-like growth factor binding protein 2 (IGFBP2) resulted in the loss of pro-osteoblastic activity, and the loss of increase in the levels of phospho-AKT and β-catenin.
Wnt signaling and osteoblastogenesis.
United States. In Rev Endocr Metab Disord, 2006
Studies of knockout and transgenic mouse models for Wnt pathway components like Wnt-10b, LRP-5/6, secreted frizzled-related protein-1, dickkopf-2, Axin-2 and beta-catenin have demonstrated that canonical signaling modulates most aspects of osteoblast physiology including proliferation, differentiation, bone matrix formation/mineralization and apoptosis as well as coupling to osteoclastogenesis and bone resorption.
New insights into inhibitors of adipogenesis.
Chapel Hill, United States. In Curr Opin Lipidol, 2004
Intracellular signaling molecules, which negatively regulate adipogenesis, include Pref-1, Foxo1, Foxa2, SMAD-3, WNT-10b, GATA-2 and GATA-3.