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Wingless related MMTV integration site 10b

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Wnt1, Wnt5a, HAIR, Wnt3a, HAD
Papers on Wnt10b
Biologic Roles of Estrogen Receptor- β and Insulin-Like Growth Factor-2 in Triple-Negative Breast Cancer.
Pietras et al., Los Angeles, United States. In Biomed Res Int, Dec 2014
Growth-stimulating effects of ERβ may be due in part to downstream actions that promote VEGF, amphiregulin, and Wnt-10b secretion, other factors associated with tumor promotion.
Oleuropein attenuates visceral adiposity in high-fat diet-induced obese mice through the modulation of WNT10b- and galanin-mediated signalings.
Park et al., Seoul, South Korea. In Mol Nutr Food Res, Nov 2014
Oleuropein also significantly reversed the HFD-induced elevations of adipogenic related gene expression involved in WNT10b- and galanin-mediated signalings in adipose tissue of mice.
Relationship between impaired adipogenesis of retroperitoneal adipose tissue and hypertrophic obesity: role of endogenous glucocorticoid excess.
Giovambattista et al., La Plata, Argentina. In J Cell Mol Med, Aug 2014
The distorted adipogenic capacity was highly conditioned by RPAT-SVF cells displaying a low committed population and both excessive and reduced expression of anti- (Pref-1 and Wnt-10b) and pro-adipogenic (mineralocorticoid receptor) signals respectively.
DAPT in the control of human hair follicle stem cell proliferation and differentiation.
Hu et al., China. In Postepy Dermatol Alergol, Aug 2014
We found that DAPT treatment results in downregulation of Hes1 and p21 and upregulation of Wnt10b.
Modulating hair follicle size with Wnt10b/DKK1 during hair regeneration.
Yang et al., Chongqing, China. In Exp Dermatol, Jun 2014
Here, we showed that in response to prolonged ectopic Wnt10b-mediated β-catenin activation, regenerating anagen hair follicles grew larger in size.
CTLA-4Ig-induced T cell anergy promotes Wnt-10b production and bone formation in a mouse model.
Weitzmann et al., Decatur, United States. In Arthritis Rheumatol, Apr 2014
RESULTS: Pharmacologic disruption of CD28 T cell costimulation in mice significantly increased bone mass and enhanced indices of bone structure, a consequence of enhanced bone formation, concurrent with enhanced secretion of the bone anabolic factor Wnt-10b by T cells.
Decaffeinated green coffee bean extract attenuates diet-induced obesity and insulin resistance in mice.
Park et al., Seoul, South Korea. In Evid Based Complement Alternat Med, 2013
Green coffee bean extract resulted in downregulation of genes involved in WNT10b- and galanin-mediated adipogenesis and TLR4-mediated proinflammatory pathway and stimulation of GLUT4 translocation to the plasma membrane in white adipose tissue.
Olive leaf extract attenuates obesity in high-fat diet-fed mice by modulating the expression of molecules involved in adipogenesis and thermogenesis.
Park et al., Seoul, South Korea. In Evid Based Complement Alternat Med, 2013
OLE significantly reversed the HFD-induced upregulation of WNT10b- and galanin-mediated signaling molecules and key adipogenic genes (PPAR γ , C/EBP α , CD36, FAS, and leptin) in the epididymal adipose tissue of HFD-fed mice.
Canonical Wnts, specifically Wnt-10b, show ability to maintain dermal papilla cells.
Yoshikawa et al., Kashihara, Japan. In Biochem Biophys Res Commun, 2013
Wnt-10b promoted cell proliferation and trichogenesis, while Wnt-3a showed those abilities to a limited extent, and Wnt-5a and 11 had no effects.
Inducible brown adipose tissue, or beige fat, is anabolic for the skeleton.
Lecka-Czernik et al., Toledo, United States. In Endocrinology, 2013
Immunodepletion of CM with antibodies against wingless related MMTV integration site 10b (WNT10b) and insulin-like growth factor binding protein 2 (IGFBP2) resulted in the loss of pro-osteoblastic activity, and the loss of increase in the levels of phospho-AKT and β-catenin.
Heme oxygenase gene targeting to adipocytes attenuates adiposity and vascular dysfunction in mice fed a high-fat diet.
Kappas et al., Beijing, China. In Hypertension, 2012
Transduction of aP2-HO-1 lowered the elevated levels of these proteins and increased Sonic hedgehog, Wnt10b, and β-catenin (P<0.05).
Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH.
Pacifici et al., Atlanta, United States. In Proc Natl Acad Sci U S A, 2012
direct PPR signaling in T cells plays an important role in PTH-induced bone anabolism by promoting T-cell production of Wnt10b
Genetic association between WNT10B polymorphisms and obesity in a Belgian case-control population is restricted to males.
Van Hul et al., Antwerp, Belgium. In Mol Genet Metab, 2012
common variation in WNT10B was shown to be associated with BMI and weight in a case-control population of Belgian males.
Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism.
MacDougald et al., Ann Arbor, United States. In Bone, 2012
Mechanisms downstream of beta-catenin are required for Wnt6, Wnt10a and Wnt10b to influence differentiation of mesenchymal precursors.
Wnt/β-catenin pathway forms a negative feedback loop during TGF-β1 induced human normal skin fibroblast-to-myofibroblast transition.
Hu et al., Xi'an, China. In J Dermatol Sci, 2012
Wnt/beta-catenin pathway forms a negative feedback loop during TGF-beta1 induced human normal skin fibroblast-to-myofibroblast transition
Wnt-signaling mediates the anti-adipogenic action of lysophosphatidic acid through cross talking with the Rho/Rho associated kinase (ROCK) pathway.
Ng et al., Toronto, Canada. In Biochem Cell Biol, 2011
Lysophosphatidic acid treatment dose dependently reduces lipid accumulation and PPARgamma mRNA expression and increases Wnt10b ligand mRNA expression in differentiated 3T3-L1 cells.
Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation.
Park et al., Seoul, South Korea. In Ppar Res, 2011
Moreover, cinchonine significantly reversed HFD-induced downregulations of WNT10b and galanin-mediated signaling molecules and key adipogenic genes in the epididymal adipose tissues of mice.
Wnt signaling and osteoblastogenesis.
Komm et al., United States. In Rev Endocr Metab Disord, 2006
Studies of knockout and transgenic mouse models for Wnt pathway components like Wnt-10b, LRP-5/6, secreted frizzled-related protein-1, dickkopf-2, Axin-2 and beta-catenin have demonstrated that canonical signaling modulates most aspects of osteoblast physiology including proliferation, differentiation, bone matrix formation/mineralization and apoptosis as well as coupling to osteoclastogenesis and bone resorption.
New insights into inhibitors of adipogenesis.
Harp, Chapel Hill, United States. In Curr Opin Lipidol, 2004
Intracellular signaling molecules, which negatively regulate adipogenesis, include Pref-1, Foxo1, Foxa2, SMAD-3, WNT-10b, GATA-2 and GATA-3.
Inhibition of adipogenesis by Wnt signaling.
MacDougald et al., Ann Arbor, United States. In Science, 2000
Here we show that Wnt signaling, likely mediated by Wnt-10b, is a molecular switch that governs adipogenesis.
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