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Wingless related MMTV integration site 10b

Wnt10b
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Wnt1, Wnt5a, Wnt3a, HAD, HAIR
Papers on Wnt10b
Olive leaf extract attenuates obesity in high-fat diet-fed mice by modulating the expression of molecules involved in adipogenesis and thermogenesis.
New
Park et al., Seoul, South Korea. In Evid Based Complement Alternat Med, Dec 2013
OLE significantly reversed the HFD-induced upregulation of WNT10b- and galanin-mediated signaling molecules and key adipogenic genes (PPAR γ , C/EBP α , CD36, FAS, and leptin) in the epididymal adipose tissue of HFD-fed mice.
Canonical Wnts, specifically Wnt-10b, show ability to maintain dermal papilla cells.
New
Yoshikawa et al., Kashihara, Japan. In Biochem Biophys Res Commun, Sep 2013
Wnt-10b promoted cell proliferation and trichogenesis, while Wnt-3a showed those abilities to a limited extent, and Wnt-5a and 11 had no effects.
Inducible brown adipose tissue, or beige fat, is anabolic for the skeleton.
New
Lecka-Czernik et al., Toledo, United States. In Endocrinology, Aug 2013
Immunodepletion of CM with antibodies against wingless related MMTV integration site 10b (WNT10b) and insulin-like growth factor binding protein 2 (IGFBP2) resulted in the loss of pro-osteoblastic activity, and the loss of increase in the levels of phospho-AKT and β-catenin.
Heme oxygenase gene targeting to adipocytes attenuates adiposity and vascular dysfunction in mice fed a high-fat diet.
Kappas et al., Beijing, China. In Hypertension, 2012
Transduction of aP2-HO-1 lowered the elevated levels of these proteins and increased Sonic hedgehog, Wnt10b, and β-catenin (P<0.05).
β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis.
Distler et al., Erlangen, Germany. In Ann Rheum Dis, 2012
The accumulation of β-catenin resulted from increased expression of Wnt-1 and Wnt-10b in SSc.
Differential expression of canonical and non-canonical Wnt ligands in ameloblastoma.
Kawakami et al., Kuala Lumpur, Malaysia. In J Oral Pathol Med, 2012
RESULTS: Canonical Wnt proteins (except Wnt-10b) were heterogeneously expressed in ameloblastoma.
Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH.
GeneRIF
Pacifici et al., Atlanta, United States. In Proc Natl Acad Sci U S A, 2012
direct PPR signaling in T cells plays an important role in PTH-induced bone anabolism by promoting T-cell production of Wnt10b
Genetic association between WNT10B polymorphisms and obesity in a Belgian case-control population is restricted to males.
GeneRIF
Van Hul et al., Antwerp, Belgium. In Mol Genet Metab, 2012
common variation in WNT10B was shown to be associated with BMI and weight in a case-control population of Belgian males.
ApoA1: mimetic peptide reverses adipocyte dysfunction in vivo and in vitro via an increase in heme oxygenase (HO-1) and Wnt10b.
Abraham et al., Toledo, United States. In Cell Cycle, 2012
MSC-derived adipocytes treated with L-4F increased WNT10b and decreased Peg 1/Mest.
Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism.
GeneRIF
MacDougald et al., Ann Arbor, United States. In Bone, 2012
Mechanisms downstream of beta-catenin are required for Wnt6, Wnt10a and Wnt10b to influence differentiation of mesenchymal precursors.
Wnt/β-catenin pathway forms a negative feedback loop during TGF-β1 induced human normal skin fibroblast-to-myofibroblast transition.
GeneRIF
Hu et al., Xi'an, China. In J Dermatol Sci, 2012
Wnt/beta-catenin pathway forms a negative feedback loop during TGF-beta1 induced human normal skin fibroblast-to-myofibroblast transition
Wnt-signaling mediates the anti-adipogenic action of lysophosphatidic acid through cross talking with the Rho/Rho associated kinase (ROCK) pathway.
GeneRIF
Ng et al., Toronto, Canada. In Biochem Cell Biol, 2011
Lysophosphatidic acid treatment dose dependently reduces lipid accumulation and PPARgamma mRNA expression and increases Wnt10b ligand mRNA expression in differentiated 3T3-L1 cells.
Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation.
Park et al., Seoul, South Korea. In Ppar Res, 2011
Moreover, cinchonine significantly reversed HFD-induced downregulations of WNT10b and galanin-mediated signaling molecules and key adipogenic genes in the epididymal adipose tissues of mice.
Dermal papilla cells serially cultured with Wnt-10b sustain their hair follicle induction activity after transplantation into nude mice.
Yoshikawa et al., Kashihara, Japan. In Cell Transplant, 2011
The addition of Wnt-10b to the first culture of primary DP cells promoted their proliferation and maintained their Wnt responsiveness and HF induction ability.
Exendin-4 upregulates the expression of Wnt-4, a novel regulator of pancreatic β-cell proliferation.
Schinner et al., Düsseldorf, Germany. In Am J Physiol Endocrinol Metab, 2011
The expression of Wnt-signaling molecules (Wnt-4, Wnt-10b, Frizzled-4, LRP5, TCF7L2) and TNFα was analyzed by semiquantitative PCR and Western blotting.
Lamin A/C deficiency is associated with fat infiltration of muscle and bone.
Duque et al., Sydney, Australia. In Mech Ageing Dev, 2011
From a mechanistic approach, high levels of pro-adipogenic factors PPARγ and C/EBPα were associated with a reduction in myogenic and osteogenic factors from the Wnt-10b/β-catenin signalling pathway in Lmna(-/-) mice.
Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma?
Varga et al., Chicago, United States. In Arthritis Rheum, 2011
OBJECTIVE: Because aberrant Wnt signaling has been linked with systemic sclerosis (SSc) and pulmonary fibrosis, we sought to investigate the effect of Wnt-10b on skin homeostasis and differentiation in transgenic mice and in explanted mesenchymal cells.
Wnt signaling and osteoblastogenesis.
Review
Komm et al., United States. In Rev Endocr Metab Disord, 2006
Studies of knockout and transgenic mouse models for Wnt pathway components like Wnt-10b, LRP-5/6, secreted frizzled-related protein-1, dickkopf-2, Axin-2 and beta-catenin have demonstrated that canonical signaling modulates most aspects of osteoblast physiology including proliferation, differentiation, bone matrix formation/mineralization and apoptosis as well as coupling to osteoclastogenesis and bone resorption.
New insights into inhibitors of adipogenesis.
Review
Harp, Chapel Hill, United States. In Curr Opin Lipidol, 2004
Intracellular signaling molecules, which negatively regulate adipogenesis, include Pref-1, Foxo1, Foxa2, SMAD-3, WNT-10b, GATA-2 and GATA-3.
Inhibition of adipogenesis by Wnt signaling.
Impact
MacDougald et al., Ann Arbor, United States. In Science, 2000
Here we show that Wnt signaling, likely mediated by Wnt-10b, is a molecular switch that governs adipogenesis.
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