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Wingless-type MMTV integration site family, member 10A

WNT10A, SSPS
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Wnt6, Wnt10b, Wnt3, PAX9, MSX1
Papers on WNT10A
Novel missense mutation in the EDA gene in a family affected by oligodontia.
New
Ruf et al., Gießen, Germany. In J Orofac Orthop, Feb 2016
BACKGROUND: Mutations in the EDA-EDAR-EDARADD genes and more recently, mutations in the WNT10A gene have been described as the cause of syndromic and nonsyndromic tooth agenesis concomitant with diverse abnormalities of ectodermally derived tissues.
Lens regeneration from the cornea requires suppression of Wnt/β-catenin signaling.
New
Henry et al., Urbana, United States. In Exp Eye Res, Feb 2016
wnt3a, wnt4, wnt5a, wnt5b, wnt6, wnt7b, wnt10a, wnt11, and wnt11b) are expressed in the cornea epithelium, demonstrating that this tissue is transcribing many of the ligands and receptors of the Wnt signaling pathway.
A novel initiation codon mutation of PAX9 in a family with oligodontia.
New
Bian et al., Wuhan, China. In Arch Oral Biol, Jan 2016
OBJECTIVE: Recent studies have attributed non-syndromic tooth agenesis to mutations in several genes, including MSX1, PAX9, AXIN2, WNT10A and EDA.
Short communication: Changes in fluorescence intensity induced by soybean soluble polysaccharide-milk protein interactions during acidification.
New
Qiu et al., Hangzhou, China. In J Dairy Sci, Dec 2015
We investigated changes in fluorescence intensity induced by interactions of soybean soluble polysaccharide (SSPS) and milk protein (Mp) during acidification.
GREMLIN 2 Mutations and Dental Anomalies.
New
Ketudat Cairns et al., Chiang Mai, Thailand. In J Dent Res, Dec 2015
It has been associated with mutations in MSX1, PAX9, EDA, AXIN2, EDAR, EDARADD, and WNT10A.
Evaluation of the predictive capacity of DNA variants associated with straight hair in Europeans.
New
EUROFORGEN-NoE Consortium et al., Kraków, Poland. In Forensic Sci Int Genet, Nov 2015
The only genome-wide association study made to date revealed the Trichohyalin gene (TCHH) to be significantly associated with hair morphology in Europeans and reported weaker associations for WNT10A and FRAS1 genes.
Loss-of-Function Mutations in the WNT Co-receptor LRP6 Cause Autosomal-Dominant Oligodontia.
New
van Haaften et al., Utrecht, Netherlands. In Am J Hum Genet, Nov 2015
In this same pathway, WNT10A was recently identified as a major contributor in the etiology of non-syndromic oligodontia.
WNT3 involvement in human bladder exstrophy and cloaca development in zebrafish.
New
Nordenskjöld et al., Stockholm, Sweden. In Hum Mol Genet, Oct 2015
In total 13 variants were identified in WNT3, WNT6, WNT7A, WNT8B, WNT10A, WNT11, WNT16, FZD5, LRP1 and LRP10 genes and predicted as potentially disease causing, of which seven variants were novel.
WNT10A exonic variant increases the risk of keratoconus by decreasing corneal thickness.
New
Mackey et al., Brisbane, Australia. In Hum Mol Genet, Oct 2015
We identified a genome-wide significant exonic variant rs121908120 (P = 6.63 × 10(-10)) in WNT10A.
An aberrant splice acceptor site due to a novel intronic nucleotide substitution in MSX1 gene is the cause of congenital tooth agenesis in a Japanese family.
Tokita et al., Nagoya, Japan. In Plos One, 2014
Congenital tooth agenesis is caused by mutations in the MSX1, PAX9, WNT10A, or AXIN2 genes.
Influence of pea protein aggregates on the structure and stability of pea protein/soybean polysaccharide complex emulsions.
Yao et al., Shanghai, China. In Molecules, 2014
In this study, pea protein isolate (PPI) with poor dispersibility in acidic solution was used to form complexes with soybean soluble polysaccharide (SSPS), and the effects of PPI aggregates on the structure and stability of PPI/SSPS complex emulsions were investigated.
Differentially expressed genes and microRNAs in bladder carcinoma cell line 5637 and T24 detected by RNA sequencing.
Lang et al., Jiujiang, China. In Int J Clin Exp Pathol, 2014
miR-4257, miR-6733 and gene WNT9A and WNT10A were down-regulated in both the cell lines.
Dento-maxillo-facial phenotype and implants-based oral rehabilitation in Ectodermal Dysplasia with WNT10A gene mutation: report of a case and literature review.
Review
Schmittbuhl et al., Strasbourg, France. In J Craniomaxillofac Surg, 2014
PURPOSE: To report the dento-craniofacial phenotype of a family affected by a WNT10A HED and to describe the implant-based oral rehabilitation of a patient presenting a severe oligodontia linked to this mutation.
Mutations in WNT10A are present in more than half of isolated hypodontia cases.
GeneRIF
Ploos van Amstel et al., Utrecht, Netherlands. In J Med Genet, 2012
In a panel of 34 patients with isolated hypodontia, the candidate gene WNT10A and the genes MSX1, PAX9, IRF6 and AXIN2 have been sequenced. WNT10A mutations were identified in 56% of the cases with non-syndromic hypodontia.
Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism.
GeneRIF
MacDougald et al., Ann Arbor, United States. In Bone, 2012
Mechanisms downstream of beta-catenin are required for Wnt6, Wnt10a and Wnt10b to influence differentiation of mesenchymal precursors.
Intra-familial variability of ectodermal defects associated with WNT10A mutations.
GeneRIF
McGrath et al., In Acta Derm Venereol, 2011
Case Reports: Single pedigree study provides a detailed illustration of the phenotypic spectrum of ectodermal abnormalities associated with WNT10A gene pathology.
Polymorphisms in WNT6 and WNT10A and colorectal adenoma risk.
GeneRIF
Ulrich et al., Seattle, United States. In Nutr Cancer, 2010
We observed a marginally significant interaction between WNT10 rs10177996 (intron 1) and an individual's proportion of calories from saturated fat.
Circadian disruption accelerates tumor growth and angio/stromagenesis through a Wnt signaling pathway.
GeneRIF
Kohno et al., Kitakyūshū, Japan. In Plos One, 2009
WNT10A may be a novel angio/stromagenic growth factor
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
Review
Katoh, Tokyo, Japan. In Stem Cell Rev, 2007
From 1996 to 2002, we cloned and characterized WNT2B/WNT13, WNT3, WNT3A, WNT5B, WNT6, WNT7B, WNT8A, WNT8B, WNT9A/WNT14, WNT9B/WNT14B, WNT10A, WNT10B, WNT11, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD10, FRAT1, FRAT2, NKD1, NKD2, VANGL1, RHOU/ARHU, RHOV/ARHV, GIPC2, GIPC3, FBXW11/betaTRCP2, SOX17, TCF7L1/TCF3, and established a cDNA-PCR system for snap-shot and dynamic analyses on the WNT-transcriptome.
WNT and FGF gene clusters (review).
Review
Katoh, Tokyo, Japan. In Int J Oncol, 2002
Among 19 WNT genes, WNT3 and WNT14B genes are clustered in human chromosome 17q21, WNT3A and WNT14 in human chromosome 1q42, WNT10A and WNT6 in human chromosome 2q35, and WNT10B and WNT1 in human chromosome 12q13.
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