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proteins. Page last changed on 14 Mar 2013.
Wingless-related MMTV integration site 1
Wnt1, int-1
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008] (from
NCBI)
Papers using
Wnt1
antibodies
Expression analysis of E-cadherin, Slug and GSK3beta in invasive ductal carcinoma of breast
Supplier
In Breast Cancer Research : BCR, 2008
... wnt1 transgenic, until sufficient mice for ...
P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from β-catenin
Supplier
In The EMBO Journal, 2005
... K19-Wnt1 transgenic mice were euthanized at ...
An entire functional mammary gland may comprise the progeny from a single cell.
Supplier
In PLoS ONE, 1997
... MMTV-Wnt1 (FVB/N) transgenic mice, have been previously ...
Tumor angiogenesis in node-negative breast carcinomas–relationship with epidermal growth factor receptor, estrogen receptor, and survival.
Supplier
In PLoS ONE, 1993
... Wnt1 tumors used for transplantations were from MMTV-Wnt1 transgenic mice that were passaged ...
More powerful procedures for multiple significance testing.
more suppliersSupplier
In PLoS ONE, 1989
... phospho- and total Lrp6 (#2568 and #2560, respectively; all from Cell Signaling Technology, Beverly, MA), Wnt1 (ab15251, Abcam, Cambridge, UK), Wnt3a (38-2700, ...
Papers on
Wnt1
Sema4d Is Required for the Development of the Hindbrain boundary and Skeletal Muscle in Zebrafish.
New
Wuhan, China. In Biochem Biophys Res Commun, 02 Apr 2013
In addition, these phenotypes appeared to be associated with the abnormal expression of three hindbrain rhombomere boundary markers, wnt1, epha4a and foxb1.2, and two myogenic regulatory factors, myod and myog.
Mutations in WNT1 are a cause of osteogenesis imperfecta.
New
Montréal, Canada. In J Med Genet, 23 Mar 2013
RESULTS: WNT1 mutations were found in four children from three families.
Xenopus Nkx6.1 and Nkx6.2 are required for mid-hindbrain boundary development.
New
Kunming, China. In Dev Genes Evol, 20 Mar 2013
In Xenopus embryos, nkx6.1 and nkx6.2 are expressed in the MHB, and knockdown of either nkx6.1 or nkx6.2 by specific morpholinos disrupts the MHB expression of en2 as well as wnt1, a key regulator for vertebrate MHB formation.
Hormone-sensing cells require Wip1 for paracrine stimulation in normal and premalignant mammary epithelium.
New
In Breast Cancer Res, 03 Mar 2013
For instance, mice lacking the Wip1 phosphatase (also known as PPM1D; Protein Phosphatase magnesium-dependent 1D) have a delay in HER2/neu (human epidermal growth factor 2)- but not Wnt1-induced mammary tumour formation.
WNT signalling pathways as therapeutic targets in cancer.
Review
New
Impact
Seattle, United States. In Nat Rev Cancer, Jan 2013
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically.
Prediction of Structure of Human WNT-CRD (FZD) Complex for Computational Drug Repurposing.
New
Islamabad, Pakistan. In Plos One, Dec 2012
The observed genetic alterations of various extracellular and intracellular WNT (Wingless, Int-1 proto-oncogene) signaling components can result in an increase or decrease in gene expression, and hence can be obstructed proficiently.
[Experimental study on delta-tocotrienol inhibits the Wnt pathway in the colon cancer cell SW620].
New
Tianjin, China. In Wei Sheng Yan Jiu, Nov 2012
Detected the expressions level of the factors related to Wnt signal pathway via Western bloting and immunocytochemistry, to observe the influence of delta-tocotrienol on Wnt-1, beta-catenin, c-jun, cylin D1.
Ancient deuterostome origins of vertebrate brain signalling centres.
New
Impact
Chicago, United States. In Nature, Apr 2012
Fgf8/17/18 (a single gene homologous to vertebrate Fgf8, Fgf17 and Fgf18), sfrp1/5, hh and wnt1 are expressed in vertebrate-like arrangements in hemichordate ectoderm, and homologous genetic mechanisms regulate ectodermal patterning in both animals.
The role of the adenomatous polyposis coli (APC) in oral squamous cell carcinoma.
Review
Santiago de Compostela, Spain. In Oral Oncol, 2012
The goal of this paper is to describe the role of the APC gene, and its derivatives, in the carcinogenicity pathway of WNT-1, identifying its role as a tumor suppressor gene in OSCC, while describing the genetic (loss of heterozygosity and mutations) and epigenetic alterations that modulate its expression and evaluate its relationship with the clinicopathological parameters of this type of tumors.
Shh and Gli3 regulate formation of the telencephalic-diencephalic junction and suppress an isthmus-like signaling source in the forebrain.
GeneRIF
Chicago, United States. In Dev Biol, 2011
Data show that in Shh;Gli3 mutants, adjacent rings of Fgf8 and Wnt3a expression are induced in the diencephalon at the ZLI, reminiscent of the Fgf8/Wnt1-expressing isthmic organizer.
HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain.
GeneRIF
London, United Kingdom. In Development, 2011
transcriptional profiling of anterior forebrain precursors from mouse embryos expressing eGFP from the Hesx1 locus provides molecular evidence supporting a novel function of Hesx1 in mediating repression of Wnt/beta-catenin target activation.
Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3.
GeneRIF
Bethesda, United States. In Development, 2011
Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.
Genome-wide analysis of a Wnt1-regulated transcriptional network implicates neurodegenerative pathways.
GeneRIF
Los Angeles, United States. In Sci Signal, 2011
a connection between Wnt1 signaling and the transcriptional regulation of neurodegenerative disease genes
Integrating care for patients with lower risk myelodysplastic syndrome.
Review
Houston, United States. In Semin Oncol, 2011
Patients with lower risk myelodysplastic syndrome (MDS) are those with low or intermediate-1 (INT-1) risk disease by the International Prognostic Scoring System (IPSS) index.
Wnt signaling in amygdala-dependent learning and memory.
GeneRIF
Atlanta, United States. In J Neurosci, 2011
data suggest that dynamic modulation of Wnt/beta-catenin signaling during consolidation is critical for the structural basis of long-term memory formation
WNT1 inducible signaling pathway protein 1 (WISP1): a novel mediator linking development and disease.
Review
München, Germany. In Int J Biochem Cell Biol, 2011
WISP1 is a secreted, matricellular protein allocated to the CCN protein family.
Insights into the cell of origin in breast cancer and breast cancer stem cells.
Review
Melbourne, Australia. In Asia Pac J Clin Oncol, 2010
Our group has found that the luminal epithelial progenitor marker CD61/beta3 integrin identified a CSC population in mammary tumors from MMTV-wnt-1 mice.
Wnt/beta-catenin signaling in development and disease.
Review
Impact
Utrecht, Netherlands. In Cell, 2006
A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades.
Generation of a functional mammary gland from a single stem cell.
Impact
Australia. In Nature, 2006
In support of a potential role for MaSCs in breast cancer, the stem-cell-enriched subpopulation was expanded in premalignant mammary tissue from MMTV-wnt-1 mice and contained a higher number of MaSCs.
Activation of cellular gene by mouse mammary tumour virus may occur early in mammary tumour development.
More papers using
Wnt1
antibodies
Impact
In Nature, 1984
Thus, a high percentage of virally induced tumours contain an acquired MMTV provirus in either of two defined integration regions, termed int-1 and int-2, and provirus insertion is accompanied by expression of specific RNA transcripts from these regions.
Marked alteration at midblastula transition in the effect of lithium on formation of the larval body pattern of Xenopus laevis
Supplier
In Development Genes and Evolution, 1988
... Wnt1-transgenic embryos were carried out ...
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
Supplier
In The Journal of Experimental Medicine, 1969
... Alexander (University of Wisconsin-Madison, Madison, WI); tumors were from mice overexpressing Wnt-1 under control of the MMTV-LTR (31, 62) or from FVB MMTV–ΔN89β-catenin transgenic mice ( ...
