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Wingless-related MMTV integration site 1

Wnt1, int-1
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, int-2, HAD, ACID, c-Myc
Papers using Wnt1 antibodies
Expression analysis of E-cadherin, Slug and GSK3beta in invasive ductal carcinoma of breast
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Farias Eduardo F et al., In Breast Cancer Research : BCR, 2008
... wnt1 transgenic, until sufficient mice for ...
P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from β-catenin
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Oshima Masanobu et al., In The EMBO Journal, 2005
... K19-Wnt1 transgenic mice were euthanized at ...
An entire functional mammary gland may comprise the progeny from a single cell.
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Blagosklonny Mikhail V., In PLoS ONE, 1997
... MMTV-Wnt1 (FVB/N) transgenic mice, have been previously ...
Tumor angiogenesis in node-negative breast carcinomas–relationship with epidermal growth factor receptor, estrogen receptor, and survival.
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Blagosklonny Mikhail V., In PLoS ONE, 1993
... Wnt1 tumors used for transplantations were from MMTV-Wnt1 transgenic mice that were passaged ...
More powerful procedures for multiple significance testing.
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Schmidt Harald H. H. W., In PLoS ONE, 1989
... phospho- and total Lrp6 (#2568 and #2560, respectively; all from Cell Signaling Technology, Beverly, MA), Wnt1 (ab15251, Abcam, Cambridge, UK), Wnt3a (38-2700, ...
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Papers on Wnt1
The WNT/β-catenin signaling pathway and expression of survival promoting genes in luteinized granulosa cells: endometriosis as a paradigm for a dysregulated apoptosis pathway.
New
Panina-Bordignon et al., Milano, Italy. In Fertil Steril, 21 Apr 2014
RESULT(S): Compared with luteinized granulosa cells from control women, cells derived from endometriosis patients had significantly higher transcript levels of the β-catenin-independent molecules WNT4 and WNT5a and lower levels of the β-catenin-dependent molecule WNT1.
The Swaying mouse as a model of Osteogenesis Imperfecta caused by WNT1 mutations.
New
Lee et al., Houston, United States. In Hum Mol Genet, 14 Apr 2014
Here, we show that Swaying (Wnt1(sw/sw)) mice previously reported to carry a spontaneous mutation in Wnt1 share major features of OI including propensity to fractures and severe osteopenia.
Frizzled10 mediates WNT1 and WNT3a signaling in the dorsal spinal cord of the developing chick embryo.
New
Burrus et al., San Francisco, United States. In Dev Dyn, 06 Apr 2014
UNLABELLED: Background: WNT1 and WNT3A drive a dorsal to ventral gradient of β-catenin dependent Wnt signaling in the developing spinal cord.
Abnormal gene expression and gene fusion in lung adenocarcinoma with high-throughput RNA sequencing.
New
Zhang et al., Shenyang, China. In Cancer Gene Ther, 28 Feb 2014
On the basis of the cellular localization analysis of core genes, wnt-1-induced secreted protein 1 (WISP1) and receptor (G protein-coupled) activity modifying protein 1 (RAMP1) identified mainly located in extracellular region and extracellular space.
WNT1 gene expression alters in heterogeneous population of prostate cancer cells; decreased expression pattern observed in CD133+/CD44+ prostate cancer stem cell spheroids.
New
Oktem et al., Manisa, Turkey. In J Buon, Jan 2014
The expression levels of WNT1, FZD1, ADAR, APC, AXIN, BTRC, FRAT1 and PPARD genes were measured by polymerase chain reaction (PCR) array assay and the protein expression levels of WNT1, FZD and AXIN by immunohistochemistry. Results: The expression levels of WNT pathway-related molecules were found to increase in both CSCs and non- CSCs when CSCs were maintained as spheroids.
Wnt/β-catenin pathway as a potential prognostic and predictive marker in patients with advanced ovarian cancer.
New
Lamparska-Przybysz et al., Warsaw, Poland. In J Ovarian Res, Dec 2013
In ovarian carcinoma, abnormal expression of β-catenin, E-cadherin and WNT-1 was observed, but their prognostic and predictive role is unclear.
A descriptive analysis of 14 cases of progressive-psuedorheumatoid-arthropathy of childhood from south India: review of literature in comparison with juvenile idiopathic arthritis.
Review
New
Gibikote et al., Vellore, India. In Semin Arthritis Rheum, Jun 2013
The gene attributed to its cause is WNT1-inducible-signaling pathway protein3 (WISP3).
WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta.
New
Impact
Mäkitie et al., Helsinki, Finland. In N Engl J Med, Jun 2013
This report identifies human skeletal diseases associated with mutations in WNT1.
WNT signalling pathways as therapeutic targets in cancer.
Review
Impact
Moon et al., Seattle, United States. In Nat Rev Cancer, 2013
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically.
Critical roles of Notch and Wnt/β-catenin pathways in the regulation of hyperplasia and/or colitis in response to bacterial infection.
GeneRIF
Umar et al., Kansas City, United States. In Infect Immun, 2012
The balancing act between cell proliferation and mucus production to restore barrier integrity seems to depend upon the interplay between the Wnt/beta-catenin and Notch pathways in the transmissible murine colonic hyperplasia model.
Transcriptional integration of Wnt and Nodal pathways in establishment of the Spemann organizer.
GeneRIF
Kessler et al., Philadelphia, United States. In Dev Biol, 2012
Data show taht combined Wnt and Nodal signaling synergistically activates transcription of Spemann organizer genes.
Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning.
GeneRIF
Jho et al., Seoul, South Korea. In Embo J, 2012
The authors propose that these dual functions of DP1 can promote and stabilize biphasic Wnt-on and Wnt-off states in response to a gradual gradient of Wnt/beta-catenin signalling to determine differential cell fates.
Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.
GeneRIF
Robinson et al., Slough, United Kingdom. In J Biol Chem, 2012
peptide derived from the loop 2 region of sclerostin blocked the interaction of sclerostin with LRP5/6 and also inhibited Wnt1 but not Wnt3A or Wnt9B signaling. This suggests that these Wnts interact with LRP6 in different ways
Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.
GeneRIF
Wu et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2012
Dickkopf2 is a Wnt antagonist involved in regulation of glucose metabolism
Ancient deuterostome origins of vertebrate brain signalling centres.
Impact
Lowe et al., Chicago, United States. In Nature, 2012
Fgf8/17/18 (a single gene homologous to vertebrate Fgf8, Fgf17 and Fgf18), sfrp1/5, hh and wnt1 are expressed in vertebrate-like arrangements in hemichordate ectoderm, and homologous genetic mechanisms regulate ectodermal patterning in both animals.
The role of the adenomatous polyposis coli (APC) in oral squamous cell carcinoma.
Review
García-García et al., Santiago de Compostela, Spain. In Oral Oncol, 2012
The goal of this paper is to describe the role of the APC gene, and its derivatives, in the carcinogenicity pathway of WNT-1, identifying its role as a tumor suppressor gene in OSCC, while describing the genetic (loss of heterozygosity and mutations) and epigenetic alterations that modulate its expression and evaluate its relationship with the clinicopathological parameters of this type of tumors.
Integrating care for patients with lower risk myelodysplastic syndrome.
Review
Garcia-Manero, Houston, United States. In Semin Oncol, 2011
Patients with lower risk myelodysplastic syndrome (MDS) are those with low or intermediate-1 (INT-1) risk disease by the International Prognostic Scoring System (IPSS) index.
WNT1 inducible signaling pathway protein 1 (WISP1): a novel mediator linking development and disease.
Review
Königshoff et al., München, Germany. In Int J Biochem Cell Biol, 2011
WISP1 is a secreted, matricellular protein allocated to the CCN protein family.
Wnt/beta-catenin signaling in development and disease.
Review
Impact
Clevers, Utrecht, Netherlands. In Cell, 2006
A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades.
Generation of a functional mammary gland from a single stem cell.
Impact
Visvader et al., Australia. In Nature, 2006
In support of a potential role for MaSCs in breast cancer, the stem-cell-enriched subpopulation was expanded in premalignant mammary tissue from MMTV-wnt-1 mice and contained a higher number of MaSCs.
More papers using Wnt1 antibodies
Marked alteration at midblastula transition in the effect of lithium on formation of the larval body pattern of Xenopus laevis
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Czerny Thomas et al., In Development Genes and Evolution, 1988
... Wnt1-transgenic embryos were carried out ...
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
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Rapraeger Alan C. et al., In The Journal of Experimental Medicine, 1969
... Alexander (University of Wisconsin-Madison, Madison, WI); tumors were from mice overexpressing Wnt-1 under control of the MMTV-LTR (31, 62) or from FVB MMTV–ΔN89β-catenin transgenic mice ( ...
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