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Wingless-related MMTV integration site 1

Wnt1, int-1
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, int-2, HAD, ACID, V1a
Papers using Wnt1 antibodies
Expression analysis of E-cadherin, Slug and GSK3beta in invasive ductal carcinoma of breast
Farias Eduardo F et al., In Breast Cancer Research : BCR, 2008
... wnt1 transgenic, until sufficient mice for ...
P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from β-catenin
Oshima Masanobu et al., In The EMBO Journal, 2005
... K19-Wnt1 transgenic mice were euthanized at ...
An entire functional mammary gland may comprise the progeny from a single cell.
Blagosklonny Mikhail V., In PLoS ONE, 1997
... MMTV-Wnt1 (FVB/N) transgenic mice, have been previously ...
Tumor angiogenesis in node-negative breast carcinomas–relationship with epidermal growth factor receptor, estrogen receptor, and survival.
Blagosklonny Mikhail V., In PLoS ONE, 1993
... Wnt1 tumors used for transplantations were from MMTV-Wnt1 transgenic mice that were passaged ...
More powerful procedures for multiple significance testing.
Schmidt Harald H. H. W., In PLoS ONE, 1989
... phospho- and total Lrp6 (#2568 and #2560, respectively; all from Cell Signaling Technology, Beverly, MA), Wnt1 (ab15251, Abcam, Cambridge, UK), Wnt3a (38-2700, ...
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Papers on Wnt1
MicroRNA-148a inhibits breast cancer migration and invasion by directly targeting WNT-1.
Wei et al., Shenyang, China. In Oncol Rep, Jan 2016
Furthermore, we demonstrated that WNT-1, one of the ligands of Wnt/β-catenin signaling pathway, was a direct target of miR-148a.
Notch Signaling in Pancreatic Development.
Teng et al., Harbin, China. In Int J Mol Sci, Dec 2015
Here, we review the current knowledge of the Notch signaling pathway in pancreatic development and its crosstalk with the Wingless and INT-1 (Wnt) and fibroblast growth factor (FGF) pathways.
[Long- term outcome of thalidomide and cyclosporine in patients with IPSS low/intermediate- 1 myelodysplastic syndromes].
Xiao et al., Tianjin, China. In Zhonghua Xue Ye Xue Za Zhi, Dec 2015
CONCLUSION: CsA combined with thalidomide regime could improve the anemia symptom in low/int-1 risk MDS patients without del(5q).
Grano et al., Bari, Italy. In J Biol Regul Homeost Agents, Oct 2015
Wnt1 is one of the several glycoproteins activating Wnt signaling, critical for normal skeletal development and bone homeostasis.
CCN4/WISP1 (WNT1 inducible signaling pathway protein 1): a focus on its role in cancer.
Chiquet-Ehrismann et al., Basel, Switzerland. In Int J Biochem Cell Biol, May 2015
It is induced by WNT1 and is a downstream target of β-catenin.
Interaction of sonic hedgehog (SHH) pathway with cancer stem cell genes in gastric cancer.
Akhavan-Niaki et al., Bābol, Iran. In Med Oncol, Mar 2015
Correspondingly, KLF5, CDX1/2, WNT1 and FEM1A are considerable genes in gastric cancer, although many researches and studies have illustrated that sonic hedgehog and expression of its signaling cascade proteins are related in gastric cancer.
Role of WNT1-inducible-signaling pathway protein 1 in etoposide resistance in lung adenocarcinoma A549 cells.
Lu et al., Shanghai, China. In Int J Clin Exp Med, 2014
OBJECT: The aim of this study was to explore the role of WNT1-inducible-signaling Pathway Protein 1 (WISP-1) in etoposide resistance in lung adenocarcinoma A549 cells.
New Genetic Forms of Childhood-Onset Primary Osteoporosis.
Mäkitie et al., Stockholm, Sweden. In Horm Res Paediatr, 2014
This Mini Review discusses monogenetic forms of childhood-onset primary osteoporosis, with the main focus on osteoporosis caused by mutations in WNT1 and PLS3, two of the most recently discovered genes underlying early-onset osteoporosis.
Restoration of BRG1 inhibits proliferation and metastasis of lung cancer by regulating tumor suppressor miR-148b.
Fa et al., Zhengzhou, China. In Onco Targets Ther, 2014
Additionally, we suggested that miR-148b suppressed cell proliferation, metastasis, and EMT in lung cancer cells by directly binging to 3'-untranslated region of WNT1, blocking the WNT1/β-catenin signaling pathway.
Role of HIPK2 in kidney fibrosis.
He et al., Shanghai, China. In Kidney Int Suppl (2011), 2014
We found that HIPK2 regulates pro-apoptotic, pro-fibrotic, and pro-inflammatory pathways including p53, transforming growth factor β (TGF-β)-SMAD family member 3 (Smad3), Notch, Wingless and INT-1 (Wnt)/β-catenin, and nuclear factor kappa-light-chain-enhancer of activated B cells in renal tubular epithelial cells.
WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta.
Mäkitie et al., Helsinki, Finland. In N Engl J Med, 2013
This report identifies human skeletal diseases associated with mutations in WNT1.
WNT signalling pathways as therapeutic targets in cancer.
Moon et al., Seattle, United States. In Nat Rev Cancer, 2013
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically.
Critical roles of Notch and Wnt/β-catenin pathways in the regulation of hyperplasia and/or colitis in response to bacterial infection.
Umar et al., Kansas City, United States. In Infect Immun, 2012
The balancing act between cell proliferation and mucus production to restore barrier integrity seems to depend upon the interplay between the Wnt/beta-catenin and Notch pathways in the transmissible murine colonic hyperplasia model.
Transcriptional integration of Wnt and Nodal pathways in establishment of the Spemann organizer.
Kessler et al., Philadelphia, United States. In Dev Biol, 2012
Data show taht combined Wnt and Nodal signaling synergistically activates transcription of Spemann organizer genes.
Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning.
Jho et al., Seoul, South Korea. In Embo J, 2012
The authors propose that these dual functions of DP1 can promote and stabilize biphasic Wnt-on and Wnt-off states in response to a gradual gradient of Wnt/beta-catenin signalling to determine differential cell fates.
Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.
Robinson et al., Slough, United Kingdom. In J Biol Chem, 2012
peptide derived from the loop 2 region of sclerostin blocked the interaction of sclerostin with LRP5/6 and also inhibited Wnt1 but not Wnt3A or Wnt9B signaling. This suggests that these Wnts interact with LRP6 in different ways
Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.
Wu et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2012
Dickkopf2 is a Wnt antagonist involved in regulation of glucose metabolism
Ancient deuterostome origins of vertebrate brain signalling centres.
Lowe et al., Chicago, United States. In Nature, 2012
Fgf8/17/18 (a single gene homologous to vertebrate Fgf8, Fgf17 and Fgf18), sfrp1/5, hh and wnt1 are expressed in vertebrate-like arrangements in hemichordate ectoderm, and homologous genetic mechanisms regulate ectodermal patterning in both animals.
Wnt/beta-catenin signaling in development and disease.
Clevers, Utrecht, Netherlands. In Cell, 2006
A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades.
Generation of a functional mammary gland from a single stem cell.
Visvader et al., Australia. In Nature, 2006
In support of a potential role for MaSCs in breast cancer, the stem-cell-enriched subpopulation was expanded in premalignant mammary tissue from MMTV-wnt-1 mice and contained a higher number of MaSCs.
More papers using Wnt1 antibodies
Marked alteration at midblastula transition in the effect of lithium on formation of the larval body pattern of Xenopus laevis
Czerny Thomas et al., In Development Genes and Evolution, 1988
... Wnt1-transgenic embryos were carried out ...
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
Rapraeger Alan C. et al., In The Journal of Experimental Medicine, 1969
... Alexander (University of Wisconsin-Madison, Madison, WI); tumors were from mice overexpressing Wnt-1 under control of the MMTV-LTR (31, 62) or from FVB MMTV–ΔN89β-catenin transgenic mice ( ...
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