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Wingless-related MMTV integration site 1

Wnt1, int-1
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, int-2, HAD, ACID, V1a
Papers using Wnt1 antibodies
Expression analysis of E-cadherin, Slug and GSK3beta in invasive ductal carcinoma of breast
Farias Eduardo F et al., In Breast Cancer Research : BCR, 2008
... wnt1 transgenic, until sufficient mice for ...
P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from β-catenin
Oshima Masanobu et al., In The EMBO Journal, 2005
... K19-Wnt1 transgenic mice were euthanized at ...
An entire functional mammary gland may comprise the progeny from a single cell.
Blagosklonny Mikhail V., In PLoS ONE, 1997
... MMTV-Wnt1 (FVB/N) transgenic mice, have been previously ...
Tumor angiogenesis in node-negative breast carcinomas–relationship with epidermal growth factor receptor, estrogen receptor, and survival.
Blagosklonny Mikhail V., In PLoS ONE, 1993
... Wnt1 tumors used for transplantations were from MMTV-Wnt1 transgenic mice that were passaged ...
More powerful procedures for multiple significance testing.
Schmidt Harald H. H. W., In PLoS ONE, 1989
... phospho- and total Lrp6 (#2568 and #2560, respectively; all from Cell Signaling Technology, Beverly, MA), Wnt1 (ab15251, Abcam, Cambridge, UK), Wnt3a (38-2700, ...
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Papers on Wnt1
New Genetic Forms of Childhood-Onset Primary Osteoporosis.
Mäkitie et al., Stockholm, Sweden. In Horm Res Paediatr, 01 Dec 2015
This Mini Review discusses monogenetic forms of childhood-onset primary osteoporosis, with the main focus on osteoporosis caused by mutations in WNT1 and PLS3, two of the most recently discovered genes underlying early-onset osteoporosis.
Hypoxia-inducible miR-152 suppresses the expression of WNT1 and ERBB3, and inhibits the proliferation of cervical cancer cells.
Tang et al., Beijing, China. In Exp Biol Med (maywood), 28 Nov 2015
A bioinformatic tool predicted that WNT1 and ERBB3 were target genes of miR-152.
WISP1 mediates BMP3-stimulated mesenchymal stem cell proliferation.
Yang et al., London, Canada. In J Mol Endocrinol, 21 Nov 2015
We conducted DNA microarray analysis on MSCs treated with and without BMP3, and identified WNT1-inducible signaling pathway protein 1 (WISP1) as a differentially expressed gene, whose expression was up regulated 3.7-fold by BMP3.
The WNT/β-catenin signaling pathway may be involved in granulosa cell apoptosis from patients with PCOS in North China.
Zhang et al., Taiyuan, China. In J Gynecol Obstet Biol Reprod (paris), 16 Nov 2015
RT-qPCR was used to measure mRNA levels of WNT family members (WNT1, WNT3, WNT4, WNT5, sFRP4 and sFRP5).
High expression of WISP-1 correlates with poor prognosis in pancreatic ductal adenocarcinoma.
Sun et al., Shanghai, China. In Am J Transl Res, Dec 2014
WNT1 inducible signaling pathway protein 1 (WISP-1) is a member of the CCN family of growth factors and reported to possess an important role in tumorigenesis by triggering downstream events via integrin signaling.
What is new in genetics and osteogenesis imperfecta classification?
Zabel et al., Belo Horizonte, Brazil. In J Pediatr (rio J), Nov 2014
After 2006, mutations were identified in the CRTAP, FKBP10, LEPRE1, PLOD2, PPIB, SERPINF1, SERPINH1, SP7, WNT1, BMP1, and TMEM38B genes, associated with recessive OI and mutation in the IFITM5 gene associated with dominant OI.
Role of HIPK2 in kidney fibrosis.
He et al., Shanghai, China. In Kidney Int Suppl (2011), Nov 2014
We found that HIPK2 regulates pro-apoptotic, pro-fibrotic, and pro-inflammatory pathways including p53, transforming growth factor β (TGF-β)-SMAD family member 3 (Smad3), Notch, Wingless and INT-1 (Wnt)/β-catenin, and nuclear factor kappa-light-chain-enhancer of activated B cells in renal tubular epithelial cells.
Osteogenesis imperfecta due to mutations in non-collagenous genes: lessons in the biology of bone formation.
Smith et al., Bethesda, United States. In Curr Opin Pediatr, Aug 2014
Heat shock protein 47 (HSP47) and FK506-binding protein-65 (FKBP65) defects cause types X and XI osteogenesis imperfecta via aberrant collagen crosslinking, folding, and chaperoning, while defects in SP7 transcription factor, wingless-type MMTV integration site family member 1 (WNT1), trimeric intracellular cation channel type b (TRIC-B), and old astrocyte specifically induced substance (OASIS) disrupt osteoblast development.
Genetically engineered ERα-positive breast cancer mouse models.
Furth et al., Washington, D.C., United States. In Endocr Relat Cancer, Jun 2014
ESR1, CCDN1, prolactin, TGFα, AIB1, ESPL1, and WNT1 overexpression, PIK3CA gain of function, as well as loss of P53 (Trp53) or STAT1 are associated with ER+ mammary cancer.
Wnt1 inducible signalling pathway protein-2 (WISP‑2/CCN5): roles and regulation in human cancers (review).
Jiang et al., Beijing, China. In Oncol Rep, Feb 2014
Wnt1 inducible signalling pathway protein-2 (WISP‑2), also known as CCN5, CT58, CTGF-L, CTGF-3, HICP and Cop1, is one of the 3 WNT1 inducible proteins that belongs to the CCN family.
WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta.
Mäkitie et al., Helsinki, Finland. In N Engl J Med, 2013
This report identifies human skeletal diseases associated with mutations in WNT1.
WNT signalling pathways as therapeutic targets in cancer.
Moon et al., Seattle, United States. In Nat Rev Cancer, 2013
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically.
Critical roles of Notch and Wnt/β-catenin pathways in the regulation of hyperplasia and/or colitis in response to bacterial infection.
Umar et al., Kansas City, United States. In Infect Immun, 2012
The balancing act between cell proliferation and mucus production to restore barrier integrity seems to depend upon the interplay between the Wnt/beta-catenin and Notch pathways in the transmissible murine colonic hyperplasia model.
Transcriptional integration of Wnt and Nodal pathways in establishment of the Spemann organizer.
Kessler et al., Philadelphia, United States. In Dev Biol, 2012
Data show taht combined Wnt and Nodal signaling synergistically activates transcription of Spemann organizer genes.
Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning.
Jho et al., Seoul, South Korea. In Embo J, 2012
The authors propose that these dual functions of DP1 can promote and stabilize biphasic Wnt-on and Wnt-off states in response to a gradual gradient of Wnt/beta-catenin signalling to determine differential cell fates.
Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.
Robinson et al., Slough, United Kingdom. In J Biol Chem, 2012
peptide derived from the loop 2 region of sclerostin blocked the interaction of sclerostin with LRP5/6 and also inhibited Wnt1 but not Wnt3A or Wnt9B signaling. This suggests that these Wnts interact with LRP6 in different ways
Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.
Wu et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2012
Dickkopf2 is a Wnt antagonist involved in regulation of glucose metabolism
Ancient deuterostome origins of vertebrate brain signalling centres.
Lowe et al., Chicago, United States. In Nature, 2012
Fgf8/17/18 (a single gene homologous to vertebrate Fgf8, Fgf17 and Fgf18), sfrp1/5, hh and wnt1 are expressed in vertebrate-like arrangements in hemichordate ectoderm, and homologous genetic mechanisms regulate ectodermal patterning in both animals.
Wnt/beta-catenin signaling in development and disease.
Clevers, Utrecht, Netherlands. In Cell, 2006
A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades.
Generation of a functional mammary gland from a single stem cell.
Visvader et al., Australia. In Nature, 2006
In support of a potential role for MaSCs in breast cancer, the stem-cell-enriched subpopulation was expanded in premalignant mammary tissue from MMTV-wnt-1 mice and contained a higher number of MaSCs.
More papers using Wnt1 antibodies
Marked alteration at midblastula transition in the effect of lithium on formation of the larval body pattern of Xenopus laevis
Czerny Thomas et al., In Development Genes and Evolution, 1988
... Wnt1-transgenic embryos were carried out ...
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
Rapraeger Alan C. et al., In The Journal of Experimental Medicine, 1969
... Alexander (University of Wisconsin-Madison, Madison, WI); tumors were from mice overexpressing Wnt-1 under control of the MMTV-LTR (31, 62) or from FVB MMTV–ΔN89β-catenin transgenic mice ( ...
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