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Wingless-related MMTV integration site 1

Wnt1, int-1
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, int-2, HAD, ACID, c-Myc
Papers using Wnt1 antibodies
Expression analysis of E-cadherin, Slug and GSK3beta in invasive ductal carcinoma of breast
Farias Eduardo F et al., In Breast Cancer Research : BCR, 2008
... wnt1 transgenic, until sufficient mice for ...
P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from β-catenin
Oshima Masanobu et al., In The EMBO Journal, 2005
... K19-Wnt1 transgenic mice were euthanized at ...
An entire functional mammary gland may comprise the progeny from a single cell.
Blagosklonny Mikhail V., In PLoS ONE, 1997
... MMTV-Wnt1 (FVB/N) transgenic mice, have been previously ...
Tumor angiogenesis in node-negative breast carcinomas–relationship with epidermal growth factor receptor, estrogen receptor, and survival.
Blagosklonny Mikhail V., In PLoS ONE, 1993
... Wnt1 tumors used for transplantations were from MMTV-Wnt1 transgenic mice that were passaged ...
More powerful procedures for multiple significance testing.
Schmidt Harald H. H. W., In PLoS ONE, 1989
... phospho- and total Lrp6 (#2568 and #2560, respectively; all from Cell Signaling Technology, Beverly, MA), Wnt1 (ab15251, Abcam, Cambridge, UK), Wnt3a (38-2700, ...
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Papers on Wnt1
Identification of the WNT1 residues required for palmitoylation by Porcupine.
Burrus et al., San Francisco, United States. In Febs Lett, 20 Dec 2014
We show that WNT1 residues 214-234 are sufficient for PORCN-dependent palmitoylation of Ser224.
Efficient Differentiation of Human Embryonic Stem Cells Toward Dopaminergic Neurons Using Recombinant LMX1A Factor.
Baharvand et al., Tehrān, Iran. In Mol Biotechnol, 08 Dec 2014
The results obtained revealed that the treatment of hESCs with recombinant LMX1A (rLMX1A) protein along with dual SMAD inhibition led to higher expression of LMX1B, LMX1A, FOXA2, PITX3, EN1, and WNT1 effector endogenous genes and two-fold expression of PITX3.
Effect of genotype and environment on five bioactive components of cultivated licorice (Glycyrrhiza uralensis FISCH.) populations in northern China.
Wang et al., In Biol Pharm Bull, 30 Nov 2014
Biplot of the principal component analysis showed that for quality breeding, G2 (WNT-1) and G3 (JX-1) are two relatively preferable genotypes, and E2 (Chifeng) location is suitable for accumulation of the bioactive components of these two genotypes.
Mutations in patients with osteogenesis imperfecta from consanguineous Indian families.
Phadke et al., Lucknow, India. In Eur J Med Genet, 24 Nov 2014
As WNT1 gene was not properly covered in exome sequencing in one patient, the gene was sequenced and a homozygous in-frame deletion of four amino acids (p.Phe176_Leu179del) was identified.
Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity.
Karantza et al., United States. In Autophagy, Sep 2014
We now report that, while it delays or does not alter mammary tumorigenesis driven by Palb2 loss or ERBB2 and PyMT overexpression, monoallelic Becn1 loss promotes mammary tumor development in 2 specific contexts, namely following parity and in association with wingless-type MMTV integration site family, member 1 (WNT1) activation.
Wnt1 inducible signalling pathway protein-2 (WISP‑2/CCN5): roles and regulation in human cancers (review).
Jiang et al., Beijing, China. In Oncol Rep, Feb 2014
Wnt1 inducible signalling pathway protein-2 (WISP‑2), also known as CCN5, CT58, CTGF-L, CTGF-3, HICP and Cop1, is one of the 3 WNT1 inducible proteins that belongs to the CCN family.
Canonical wnt signaling activity in early stages of chick lung development.
Correia-Pinto et al., Braga, Portugal. In Plos One, Dec 2013
The present work characterizes, for the first time, the expression pattern of several Wnt signaling members, such as wnt-1, wnt-2b, wnt-3a, wnt-5a, wnt-7b, wnt-8b, wnt-9a, lrp5, lrp6, sfrp1, dkk1, β-catenin and axin2 at early stages of chick lung development.
A descriptive analysis of 14 cases of progressive-psuedorheumatoid-arthropathy of childhood from south India: review of literature in comparison with juvenile idiopathic arthritis.
Gibikote et al., Vellore, India. In Semin Arthritis Rheum, Jun 2013
The gene attributed to its cause is WNT1-inducible-signaling pathway protein3 (WISP3).
WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta.
Mäkitie et al., Helsinki, Finland. In N Engl J Med, Jun 2013
This report identifies human skeletal diseases associated with mutations in WNT1.
WNT signalling pathways as therapeutic targets in cancer.
Moon et al., Seattle, United States. In Nat Rev Cancer, 2013
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically.
Critical roles of Notch and Wnt/β-catenin pathways in the regulation of hyperplasia and/or colitis in response to bacterial infection.
Umar et al., Kansas City, United States. In Infect Immun, 2012
The balancing act between cell proliferation and mucus production to restore barrier integrity seems to depend upon the interplay between the Wnt/beta-catenin and Notch pathways in the transmissible murine colonic hyperplasia model.
Transcriptional integration of Wnt and Nodal pathways in establishment of the Spemann organizer.
Kessler et al., Philadelphia, United States. In Dev Biol, 2012
Data show taht combined Wnt and Nodal signaling synergistically activates transcription of Spemann organizer genes.
Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning.
Jho et al., Seoul, South Korea. In Embo J, 2012
The authors propose that these dual functions of DP1 can promote and stabilize biphasic Wnt-on and Wnt-off states in response to a gradual gradient of Wnt/beta-catenin signalling to determine differential cell fates.
Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.
Robinson et al., Slough, United Kingdom. In J Biol Chem, 2012
peptide derived from the loop 2 region of sclerostin blocked the interaction of sclerostin with LRP5/6 and also inhibited Wnt1 but not Wnt3A or Wnt9B signaling. This suggests that these Wnts interact with LRP6 in different ways
Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.
Wu et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2012
Dickkopf2 is a Wnt antagonist involved in regulation of glucose metabolism
Ancient deuterostome origins of vertebrate brain signalling centres.
Lowe et al., Chicago, United States. In Nature, 2012
Fgf8/17/18 (a single gene homologous to vertebrate Fgf8, Fgf17 and Fgf18), sfrp1/5, hh and wnt1 are expressed in vertebrate-like arrangements in hemichordate ectoderm, and homologous genetic mechanisms regulate ectodermal patterning in both animals.
The role of the adenomatous polyposis coli (APC) in oral squamous cell carcinoma.
García-García et al., Santiago de Compostela, Spain. In Oral Oncol, 2012
The goal of this paper is to describe the role of the APC gene, and its derivatives, in the carcinogenicity pathway of WNT-1, identifying its role as a tumor suppressor gene in OSCC, while describing the genetic (loss of heterozygosity and mutations) and epigenetic alterations that modulate its expression and evaluate its relationship with the clinicopathological parameters of this type of tumors.
Integrating care for patients with lower risk myelodysplastic syndrome.
Garcia-Manero, Houston, United States. In Semin Oncol, 2011
Patients with lower risk myelodysplastic syndrome (MDS) are those with low or intermediate-1 (INT-1) risk disease by the International Prognostic Scoring System (IPSS) index.
Wnt/beta-catenin signaling in development and disease.
Clevers, Utrecht, Netherlands. In Cell, 2006
A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades.
Generation of a functional mammary gland from a single stem cell.
Visvader et al., Australia. In Nature, 2006
In support of a potential role for MaSCs in breast cancer, the stem-cell-enriched subpopulation was expanded in premalignant mammary tissue from MMTV-wnt-1 mice and contained a higher number of MaSCs.
More papers using Wnt1 antibodies
Marked alteration at midblastula transition in the effect of lithium on formation of the larval body pattern of Xenopus laevis
Czerny Thomas et al., In Development Genes and Evolution, 1988
... Wnt1-transgenic embryos were carried out ...
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
Rapraeger Alan C. et al., In The Journal of Experimental Medicine, 1969
... Alexander (University of Wisconsin-Madison, Madison, WI); tumors were from mice overexpressing Wnt-1 under control of the MMTV-LTR (31, 62) or from FVB MMTV–ΔN89β-catenin transgenic mice ( ...
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