More powerful procedures for multiple significance testing.more suppliers
In PLoS ONE, 1989
... phospho- and total Lrp6 (#2568 and #2560, respectively; all from Cell Signaling Technology, Beverly, MA), Wnt1 (ab15251, Abcam, Cambridge, UK), Wnt3a (38-2700, ...
Cerebellar development in the absence of Gbx function in zebrafish.
Seattle, United States. In Dev Biol, 30 Nov 2013
The genetic hierarchy of gene expression at the MHB is complex, involving multiple positive and negative feedback loops that result in the establishment of non-overlapping domains of Wnt1 and Fgf8 on either side of the boundary and the consequent specification of the cerebellum.
WNT signalling pathways as therapeutic targets in cancer.
Seattle, United States. In Nat Rev Cancer, Jan 2013
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically.
Ancient deuterostome origins of vertebrate brain signalling centres.
Chicago, United States. In Nature, Apr 2012
Fgf8/17/18 (a single gene homologous to vertebrate Fgf8, Fgf17 and Fgf18), sfrp1/5, hh and wnt1 are expressed in vertebrate-like arrangements in hemichordate ectoderm, and homologous genetic mechanisms regulate ectodermal patterning in both animals.
The role of the adenomatous polyposis coli (APC) in oral squamous cell carcinoma.
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Santiago de Compostela, Spain. In Oral Oncol, 2012
The goal of this paper is to describe the role of the APC gene, and its derivatives, in the carcinogenicity pathway of WNT-1, identifying its role as a tumor suppressor gene in OSCC, while describing the genetic (loss of heterozygosity and mutations) and epigenetic alterations that modulate its expression and evaluate its relationship with the clinicopathological parameters of this type of tumors.