Renal mechanisms of salt-sensitive hypertension: contribution of two steroid receptor-associated pathways.
Tokyo, Japan. In Am J Physiol Renal Physiol, Jan 2015
Recent studies revealed the involvement of two important signaling pathways in renal tubules that play key roles in electrolyte balance and the maintenance of normal blood pressure: the β2 adrenergic stimulant-GR-WNK4-NCC pathway, which is active in distal convoluted tubules 1 (DCT1); and the Rac1-MR pathway, which is active in distal convoluted tubules 2 (DCT2), connecting tubules (CNT), and collecting ducts (CD).
Gordon Syndrome: a continuing story.
Cambridge, United Kingdom. In Pediatr Nephrol, Jan 2015
In 2001, mutations in genes encoding two serine/threonine kinases, WNK1 and WNK4, were identified as causing GS.
Renal nerves, WNK4, glucocorticoids, and salt transport.
Portland, United States. In Cell Metab, 2011
A study in Nature Medicine (Mu et al., 2011) shows that dietary salt excess, coupled with β-adrenergic stimulation, increases arterial pressure via glucocorticoid receptors and WNK4, suggesting interactions between these systems in the pathogenesis of hypertension.