Cell-specific regulation of L-WNK1 by dietary K.
Pittsburgh, United States. In Am J Physiol Renal Physiol, 01 Feb 2016
This disorder is linked to mutations in genes encoding with-no-lysine kinase 1 (WNK1), WNK4, and Kelch-like 3/Cullin 3, two components of an E3 ubiquitin ligase complex that degrades WNKs.
FGF23 regulation of renal tubular solute transport.
Vienna, Austria. In Curr Opin Nephrol Hypertens, Sep 2015
Moreover, it was recently established that FGF23 signaling in the distal renal tubule targets with-no-lysine kinase-4 (WNK4), a key molecule in the regulation of solute transport in the distal nephron.
Renal nerves, WNK4, glucocorticoids, and salt transport.
Portland, United States. In Cell Metab, 2011
A study in Nature Medicine (Mu et al., 2011) shows that dietary salt excess, coupled with β-adrenergic stimulation, increases arterial pressure via glucocorticoid receptors and WNK4, suggesting interactions between these systems in the pathogenesis of hypertension.