WNK3 is a putative chloride-sensing kinase.
Mexico. In Cell Physiol Biochem, 2010
The with-no-lysine kinase 3 (WNK3) is a serine/threonine kinase that modulates the activity of the electroneutral cation-coupled chloride cotransporters (CCC).
Emerging roles for WNK kinases in cancer.
Lisbon, Portugal. In Cell Mol Life Sci, 2010
Although most research has focussed on the role of WNK1, WNK3 and WNK4 in regulating different ion transporters in both the kidney and extrarenal tissues, there is growing evidence for additional roles of WNK kinases in various signalling cascades related to cancer.
Molecular physiology of the WNK kinases.
New Haven, United States. In Annu Rev Physiol, 2007
The related kinase WNK3 has reciprocal actions on the primary mediators of cellular Cl(-) influx and efflux, effects that can serve to regulate cell volume during growth and in response to osmotic stress as well as to modulate neuronal responses to GABA.