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WNT1 inducible signaling pathway protein 1

WISP-1, CCN4
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011] (from NCBI)
Top mentioned proteins: sorting nexin 9, Wnt1, Cyr61, NOV, connective tissue growth factor
Papers on WISP-1
MECHANICAL VENTILATION AUGMENTS POLY(I:C)INDUCED LUNG INJURY VIA A WISP1-INTEGRIN β3 DEPENDENT PATHWAY IN MICE.
New
Li et al., Shanghai, China. In Mol Med, Feb 2016
The expression level of WNT-induced secreted protein 1 (WISP1) was consistent with lung injury, and the amplification of lung injury by MTV can be alleviated by anti-WISP1 antibody treatment.
Impairment of PI3K/AKT and WNT/β-catenin pathways in bone marrow mesenchymal stem cells isolated from patients with myelodysplastic syndromes.
New
Leone et al., Roma, Italy. In Exp Hematol, Jan 2016
GSK3β impairment translated into decreased β-catenin protein levels and downregulation of several WNT/β-catenin target genes (SOX9, EGR1, WISP1).
RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens.
New
Sarver et al., Minneapolis, United States. In Genome Res, Jan 2016
RNA fusion-based CISs were identified corresponding to both DNA-based CISs (Cdkn2a, Mycl1, Nf2, Pten, Sema6d, and Rere) and additional regions strongly associated with cancer that were not observed by LM-PCR (Myc, Akt1, Pth, Csf1r, Fgfr2, Wisp1, Map3k5, and Map4k3).
Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats.
New
Boyce et al., Thousand Oaks, United States. In Bone, Jan 2016
Expression change of canonical Wnt target genes was similar in all three cell types at d8, including upregulation of Twist1 and Wisp1.
Wnts talking with the TGF-β superfamily: WISPers about modulation of osteoarthritis.
New
van der Kraan et al., Nijmegen, Netherlands. In Rheumatology (oxford), Jan 2016
Therefore, interference with Wnt-induced proteins, such as WISP1, might be an overall more effective and safer therapeutic approach to inhibit the pathological events that take place during OA.
Thymosin β4 Prevents Angiotensin II-Induced Cardiomyocyte Growth by Regulating Wnt/WISP Signaling.
New
Gupta et al., Beijing, China. In J Cell Physiol, Jan 2016
Cell size, hypertrophy marker gene expression and Wnt signaling components, β-catenin and Wnt-induced secreted protein-1 (WISP-1) were evaluated by quantitative real-time PCR, Western blotting and fluorescent microscopy.
CCN4/WISP-1 positively regulates chondrogenesis by controlling TGF-β3 function.
New
Kuboki et al., Okayama, Japan. In Bone, Dec 2015
To understand the role of CCN4 in chondrogenesis, human bone marrow stromal cells (hBMSCs) were transduced with CCN4 adenovirus (adCCN4) or siRNA to CCN4 (siCCN4) in the presence or absence of transforming growth factor-β3 (TGF-β3).
Effect of siRNA on Wisp-1 gene expression, proliferation, migration and adhesion of mouse hepatocellular carcinoma cells.
New
Ren et al., China. In Asian Pac J Trop Med, Oct 2015
OBJECTIVE: To study the inhibition effect of siRNA on the expression of Wisp-1 gene in Hca-F of mouse hepatocellular carcinoma cells strain and also its effect on the proliferation, migration and adhesion of hepatocellular carcinoma cells.
Stem cell guidance through the mechanistic target of rapamycin.
Review
New
Maiese, Newark, United States. In World J Stem Cells, Sep 2015
mTOR can control the programmed cell death pathways of autophagy and apoptosis that can yield variable outcomes in stem cell survival and be reliant upon proliferative pathways that include Wnt signaling, Wnt1 inducible signaling pathway protein 1 (WISP1), silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1), and trophic factors.
CCN4/WISP1 (WNT1 inducible signaling pathway protein 1): a focus on its role in cancer.
Review
New
Chiquet-Ehrismann et al., Basel, Switzerland. In Int J Biochem Cell Biol, May 2015
The matricellular protein WISP1 is a member of the CCN protein family.
Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease.
Review
New
Maiese, Newark, United States. In Neural Regen Res, Apr 2015
Pathways that involve insulin-like growth factor-1, fibroblast growth factor, epidermal growth factor, and erythropoietin can govern glucose homeostasis and are intimately tied to Wnt signaling that involves Wnt1 and Wnt1 inducible signaling pathway protein 1 (CCN4) to foster control over stem cell proliferation, wound repair, cognitive decline, β-cell proliferation, vascular regeneration, and programmed cell death.
FoxO Transcription Factors and Regenerative Pathways in Diabetes Mellitus.
Review
Maiese, Newark, United States. In Curr Neurovasc Res, 2014
cerevisiae) (SIRT1), Wnt, and Wnt1 inducible signaling pathway protein 1 (WISP1).
New Insights for Oxidative Stress and Diabetes Mellitus.
Review
Maiese, Newark, United States. In Oxid Med Cell Longev, 2014
cerevisiae) (SIRT1), and Wnt1 inducible signaling pathway protein 1 (WISP1) are especially justified to be considered treatment targets for DM since these pathways can address the complex relationship between stem cells, trophic factors, impaired glucose tolerance, programmed cell death pathways of apoptosis and autophagy, tissue remodeling, cellular energy homeostasis, and vascular biology that greatly impact the biology and disease progression of DM.
High expression of WISP-1 correlates with poor prognosis in pancreatic ductal adenocarcinoma.
Sun et al., Shanghai, China. In Am J Transl Res, 2014
WNT1 inducible signaling pathway protein 1 (WISP-1) is a member of the CCN family of growth factors and reported to possess an important role in tumorigenesis by triggering downstream events via integrin signaling.
Role of WNT1-inducible-signaling pathway protein 1 in etoposide resistance in lung adenocarcinoma A549 cells.
Lu et al., Shanghai, China. In Int J Clin Exp Med, 2014
OBJECT: The aim of this study was to explore the role of WNT1-inducible-signaling Pathway Protein 1 (WISP-1) in etoposide resistance in lung adenocarcinoma A549 cells.
WISP1 (CCN4) autoregulates its expression and nuclear trafficking of β-catenin during oxidant stress with limited effects upon neuronal autophagy.
GeneRIF
Maiese et al., Newark, United States. In Curr Neurovasc Res, 2012
WISP1/CCN4 autoregulates its expression through the promotion of beta-catenin activity and may employ beta-catenin to have a limited control over autophagy.
Wnt1 inducible signaling pathway protein 1 (WISP1) blocks neurodegeneration through phosphoinositide 3 kinase/Akt1 and apoptotic mitochondrial signaling involving Bad, Bax, Bim, and Bcl-xL.
GeneRIF
Maiese et al., Newark, United States. In Curr Neurovasc Res, 2012
we demonstrate that WISP1 is present in primary hippocampal neurons during oxidant stress
Activation of Notch1 signaling in stromal fibroblasts inhibits melanoma growth by upregulating WISP-1.
GeneRIF
Liu et al., Miami, United States. In Oncogene, 2011
This study shows that constitutive activation of the Notch1 pathway confers fibroblasts with a suppressive phenotype to melanoma growth, partially through WISP-1.
WISP-1 increases MMP-2 expression and cell motility in human chondrosarcoma cells.
GeneRIF
Tang et al., Taipei, Taiwan. In Biochem Pharmacol, 2011
results indicated that WISP-1 enhances the migration of chondrosarcoma cells by increasing MMP-2 expression through the alpha5beta1 integrin receptor, FAK, MEK, ERK, p65 and NF-kappaB signal transduction pathway
Clinical significance of Wnt-induced secreted protein-1 (WISP-1/CCN4) in esophageal squamous cell carcinoma.
GeneRIF
Baba et al., Kumamoto, Japan. In Anticancer Res, 2011
The expression of WISP-1 may play an important role in the progression of esophageal squamous cell carcinoma.
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