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proteins. Page last changed on 19 Aug 2016.
Werner helicase interacting protein 1
Whip, WRNIP1, Werner helicase interacting protein 1
Werner's syndrome is a rare autosomal recessive disorder characterized by premature aging. The protein encoded by this gene interacts with the N-terminal portion of Werner protein containing the exonuclease domain. This protein shows homology to replication factor C family proteins, and is conserved from E. coli to human. Studies in yeast suggest that this gene may influence the aging process. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
WRN, POLYMERASE, RAD18, Ubiquitin, V1a
Papers on
Whip
Flipping a Lipid-Linked Oligosaccharide? You Must Whip It!
New
Dallas, United States. In Trends Biochem Sci, Dec 2015
Perez et al. now report the structure of the PglK protein of C. jejuni, a flippase for a bacterial lipid-linked oligosaccharide, and reveal an unexpected whip-like mechanism.
RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress.
New
Pavia, Italy. In Oncogene, Dec 2015
Here, we show that monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA), a marker of stalled replication forks, interacts with the ATM cofactor ATMIN via WRN-interacting protein 1 (WRNIP1).
Loss-of-function mutations in PTPN6 promote STAT3 deregulation via JAK3 kinase in diffuse large B-cell lymphoma.
New
Rochester, United States. In Oncotarget, Dec 2015
Consistent with this notion, both the mutants demonstrated increased resistance to JAK3 inhibitor, WHIP-154 relative to WT PTPN6.
Phylogeographic Study of Whip Scorpions (Chelicerata: Arachnida: Thelyphonida) in Japan and Taiwan.
New
Fukuoka, Japan. In Zoolog Sci, Aug 2015
Whip scorpions (Thelyphonida), comprising an order in the class Arachnida, are distributed from tropical to temperate zones.
Structural basis for ubiquitin recognition by ubiquitin-binding zinc finger of FAAP20.
Tokyo, Japan. In Plos One, 2014
Finally, structural comparison among FAAP20-UBZ, WRNIP1-UBZ and RAD18-UBZ revealed distinct modes of ubiquitin binding.
WRNIP1 functions upstream of DNA polymerase η in the UV-induced DNA damage response.
Musashino, Japan. In Biochem Biophys Res Commun, 2014
WRNIP1 (WRN-interacting protein 1) was first identified as a factor that interacts with WRN, the protein that is defective in Werner syndrome (WS).
Werner complex deficiency in cells disrupts the Nuclear Pore Complex and the distribution of lamin B1.
Hoboken, United States. In Biochim Biophys Acta, 2013
In our previous publication, we connected the DNA damage sensor Werner's Helicase Interacting Protein (WHIP), a binding partner of WRN, to the NPC.
Administration of botanicals with the diet regulates gene expression in peripheral blood cells of Sarda sheep during ACTH challenge.
Udine, Italy. In Domest Anim Endocrinol, 2012
At T3, treatment with ACTH caused down-regulation of transcripts (P<0.001) involved in "response to stress" (GADD45A, GADD45B, WRNIP1, and XRCC6) and in "innate immune response" (MAPK3 and NFkBIB).
WRNIP1 accumulates at laser light irradiated sites rapidly via its ubiquitin-binding zinc finger domain and independently from its ATPase domain.
GeneRIF
Sendai, Japan. In Biochem Biophys Res Commun, 2012
Mutated WRNIP1 with a deleted ATPase domain or with mutations in lysine residues accumulated in laser light irradiated sites, suggesting that the ATPase domain of WRNIP1 and ubiquitination of WRNIP1 are dispensable for the accumulation.
The genome maintenance factor Mgs1 is targeted to sites of replication stress by ubiquitylated PCNA.
London, United Kingdom. In Nucleic Acids Res, 2012
Mgs1, the budding yeast homolog of mammalian Werner helicase-interacting protein 1 (WRNIP1/WHIP), contributes to genome stability during undisturbed replication and in response to DNA damage.
Identification of novel CDK9 and Cyclin T1-associated protein complexes (CCAPs) whose siRNA depletion enhances HIV-1 Tat function.
Houston, United States. In Retrovirology, 2011
RESULTS: We examined five CCAPs that contain: 1) PPP1R10/TOX3/WDR82; 2) TTF2; 3) TPR; 4) WRNIP1; 5) FBXO11/CUL1/SKP1.
Werner interacting protein 1 promotes binding of Werner protein to template-primer DNA.
Sendai, Japan. In Biol Pharm Bull, 2010
Werner interacting protein 1 (WRNIP1) that is highly conserved from Escherichia coli to human was originally identified as a protein that interacts with the Werner syndrome responsible gene product (WRN).
Microarray-driven validation of reference genes for quantitative real-time polymerase chain reaction in a rat vocal fold model of mucosal injury.
Madison, United States. In Anal Biochem, 2010
Ablim1, Sptbn1, and Wrnip1 were identified as stably expressed in a model-specific microarray dataset and were further validated as suitable reference genes in an independent qRT-PCR experiment using 2(-DeltaCT) and pairwise comparison-based (geNorm) analyses.
The discovery of a Werner Helicase Interacting Protein (WHIP) association with the nuclear pore complex.
GeneRIF
Hoboken, United States. In Cell Cycle, 2010
WHIP was identified as a partner/component of the nuclear envelope/nuclear pore complex (NPC) and set forth to investigate a role for the protein positioned at the NPC.
Physical and functional interaction between WRNIP1 and RAD18.
GeneRIF
Sendai, Japan. In Genes Genet Syst, 2009
Data show that that WRNIP1 interacts physically with RAD18 and interferes with the binding of RAD18 to forked DNA and to template/primer DNA.
Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner.
GeneRIF
Frankfurt am Main, Germany. In J Biol Chem, 2009
analysis of the composite and regulated topography of Wrnip1 in the human nucleus highlights its potential role in replication and other nuclear transactions
Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain.
GeneRIF
New York City, United States. In J Biol Chem, 2007
Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain
PHOTOREACTIONS OF PARTIALLY BLINDED WHIP-TAIL SCORPIONS.
Cleveland, United States. In J Gen Physiol, 1919
The experiments dealt with in this paper were devised to ascertain (1) the relative effectiveness as photoreceptors of the whip-tail scorpion's median eyes, lateral eye groups, and cutaneous sensitive areas, and (2) the effect on orientation produced by symmetrical and by asymmetrical interference with the photoreceptive mechanism.
