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WEE1 homolog

Wee1, Swe1, Swe1p
This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CDC2, PCNA, cdc25, CAN, V1a
Papers using Wee1 antibodies
Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis
Supplier
Sékaly Rafick-Pierre et al., In The Journal of Experimental Medicine, 1998
... The mAbs against caspase-2, caspase-4, and Wee1 were purchased from Transduction Laboratories, Santa Cruz Biotechnology, and StressGen Biotechnologies Corp., ...
Papers on Wee1
A WEE1 Inhibitor Analog of AZD1775 Maintains Synergy with Cisplatin and Demonstrates Reduced Single-Agent Cytotoxicity in Medulloblastoma Cells.
New
Reigan et al., Aurora, United States. In Acs Chem Biol, Feb 2016
We previously identified WEE1 kinase as a new molecular target for medulloblastoma from an integrated genomic analysis of gene expression and a kinome-wide siRNA screen of medulloblastoma cells and tissue.
Expression and prognostic value of the WEE1 kinase in gliomas.
New
Kristensen et al., Odense, Denmark. In J Neurooncol, Feb 2016
WEE1 is a regulator of the G2 checkpoint in glioblastoma (GBM) cells.
Cytotoxicity of Thirdhand Smoke and Identification of Acrolein as a Volatile Thirdhand Smoke Chemical That Inhibits Cell Proliferation.
New
Talbot et al., Riverside, United States. In Toxicol Sci, Jan 2016
At 48 hours, WEE1 expression increased, while ANACP1 expression decreased consistent with blocking entry into and completion of the M phase of the cell cycle.
Genetic variants in cell cycle control pathway confer susceptibility to aggressive prostate carcinoma.
New
Daw et al., Saint Louis, United States. In Prostate, Jan 2016
RESULTS: Eleven variants within 10 genes (CCNC, CCND3, CCNG1, CCNT2, CDK6, MDM2, SKP2, WEE1, YWHAB, YWHAH) in the European-American population and nine variants in 7 genes (CCNG1, CDK2, CDK5, MDM2, RB1, SMAD3, TERF2) in the African-American population were found to be associated with aggressive PCa using at least one model.
Development of cell-cycle checkpoint therapy for solid tumors.
Review
New
Tamura, Tokyo, Japan. In Jpn J Clin Oncol, Dec 2015
These proteins include cyclin-dependent kinase, checkpoint kinase, WEE1 kinase, aurora kinase and polo-like kinase.
Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave.
New
Impact
Sørensen et al., Copenhagen, Denmark. In Cancer Cell, Dec 2015
describe a synthetic lethal interaction where cancer cells deficient in H3K36me3 owing to SETD2 loss-of-function mutation are strongly sensitized to inhibition of WEE1, a cell cycle controlling kinase.
The role and mechanism of WEE1 on the cisplatin resistance reversal of the HepG2/DDP human hepatic cancer cell line.
New
Ren et al., Xinxiang, China. In Oncol Lett, Nov 2015
Accumulating evidence suggests that WEE1 G2 checkpoint kinase (WEE1) is involved in cisplatin resistance, which has been demonstrated to correlate with cancer initiation and progression.
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
New
Impact
Humphrey et al., Oxford, United Kingdom. In Cancer Cell, Nov 2015
Here we identify a synthetic lethal interaction in which H3K36me3-deficient cancers are acutely sensitive to WEE1 inhibition.
New perspectives in ovarian cancer treatment.
Review
Oehler et al., Adelaide, Australia. In Maturitas, 2014
Other approaches target aberrant OC signalling such as the PI3K/Akt/mTOR network, the epidermal growth factor receptor, the WEE1 tyrosine kinase and the folate receptor alpha.
Cardio-miRNAs and onco-miRNAs: circulating miRNA-based diagnostics for non-cancerous and cancerous diseases.
Review
Katoh, Tokyo, Japan. In Front Cell Dev Biol, 2013
ACVR2A, BCL2, CCND1, E2F3, GLUT3, MYB, RAF1, VEGF, WEE1, and WNT7A are representative miR-195 targets.
WEE1 inhibition and genomic instability in cancer.
Review
Würdinger et al., Amsterdam, Netherlands. In Biochim Biophys Acta, 2013
WEE1 kinase is an important regulator of the G2 checkpoint and is overexpressed in various cancer types.
Wee1 kinase as a target for cancer therapy.
Review
Kummar et al., Bethesda, United States. In Cell Cycle, 2013
Wee1, a protein kinase, regulates the G 2 checkpoint in response to DNA damage.
The S. pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1.
Impact
GeneRIF
Hagan et al., Manchester, United Kingdom. In Nat Cell Biol, 2012
Sid2 activation midway through G2 phase promotes Fin1 phosphorylation and mitotic commitment throught pom1/Wee1 cell geometry network.
Integrated genomic analyses identify WEE1 as a critical mediator of cell fate and a novel therapeutic target in acute myeloid leukemia.
GeneRIF
DeGregori et al., Aurora, United States. In Leukemia, 2012
Elevated WEE1 expression is associated with acute myeloid leukemia.
Mouse Wee1 gene is repressed by Krüppel-like factor 3 (KLF3) via interaction with multiple upstream elements.
GeneRIF
Tamura et al., Chiba, Japan. In Gene, 2012
In this study, we found that the chromosomal wee1 gene is also down-regulated by KLF3.
WEE1 inhibition sensitizes basal breast cancer cells to TRAIL-induced apoptosis.
GeneRIF
Lipkowitz et al., Bethesda, United States. In Mol Cancer Res, 2012
Sensitization effects of WEE1 inhibition on TRAIL-mediated apoptosis in breast cancer cell lines.
Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit.
GeneRIF
Grieco et al., Napoli, Italy. In Nat Commun, 2011
Data identify Cdc20, USP44, and Wee1 as relevant Fcp1 targets.
In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma.
Impact
GeneRIF
Würdinger et al., Amsterdam, Netherlands. In Cancer Cell, 2010
WEE1 is a major regulator of the G(2) checkpoint in glioblastoma cells.
Control mechanism of the circadian clock for timing of cell division in vivo.
Impact
GeneRIF
Okamura et al., Kōbe, Japan. In Science, 2003
expression of wee1 was directly regulated by the molecular components of the circadian clockwork in the regenerating liver
Epistatic gene interactions in the control of division in fission yeast.
Impact
Fantes, In Nature, 1979
Suppression by wee1 mutants is almost complete, while the wee2.1 mutation is a less effective suppressor.
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