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11 documents found
1: Title: The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity.
Authors: McMichael, Temet M, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 292 (52): 21517-21526, 2017 .
Snippet: Unlike knock-out of individual ZDHHCs, siRNA-mediated knockdown of both ZDHHC3 and ZDHHC7 in ZDHHC20 knock-out cells decreased endogenous IFITM3 palmitoylation.
Affiliation: From the Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio 43210 and. Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, New York 10065. From the Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio 43210 and yount.37@osu.edu. .
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2: Title: S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration.
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 292 (13): 5325-5334, 2017 .
Snippet: JAM-C has been implicated in leukocyte transendothelial migration, angiogenesis, cell adhesion, cell polarity, spermatogenesis, and metastasis.
Affiliation: From the Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853. From the Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853 hl379@cornell.edu. .
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3: Title: Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry.
Authors: Greaves, Jennifer, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 114 (8): E1365-E1374, 2017 .
Snippet: This difference in selectivity was apparent even for highly related enzymes, such as zDHHC3 and zDHHC7, which displayed a marked difference in their ability to use C18:0 acyl-CoA as a substrate.
Affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, United Kingdom. WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1XL, United Kingdom. Biomedical Sciences Research Complex, Schools of Biology and Chemistry, University of St. Andrews, St. Andrews, Fife KY16 9ST, United Kingdom. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, United Kingdom; Luke.Chamberlain@strath.ac.uk. .
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4: Title: ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity.
Authors: Chen, Baoen, et.al. .
Journal: Nature chemical biology (Nat Chem Biol), Vol. 12 (9): 686-93, 2016 .
Snippet: In summary, we demonstrated that ZDHHC7-mediated SCRIB palmitoylation is critical for SCRIB membrane targeting, cell polarity and tumor suppression, providing new mechanistic insights of how dynamic protein palmitoylation regulates cell polarity and tumorigenesis.
Affiliation: Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA. .
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5: Title: ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation.
Journal: Molecular and cellular biology (Mol Cell Biol), Vol. 36 (17): 2208-25, 2016 .
Snippet: Previous in vitro studies revealed that palmitoylation of NCAM is required for fibroblast growth factor 2 (FGF2)-stimulated neurite outgrowth and identified the zinc finger DHHC (Asp-His-His-Cys)-containing proteins ZDHHC3 and ZDHHC7 as specific NCAM-palmitoylating enzymes.
Affiliation: Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genoa, Italy Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics, University of Verona, Verona, Italy. Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genoa, Italy St. Petersburg State University, St. Petersburg, Russia. Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genoa, Italy. Department of Cellular Neurophysiology, Hannover Medical School, Hannover, Germany. Department of Physiological Chemistry, Hannover Medical School, Hannover, Germany. Department of Cellular Neurophysiology, Hannover Medical School, Hannover, Germany ponimaskin.evgeni@mh-hannover.de alexander.dityatev@dzne.de. Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genoa, Italy Molecular Neuroplasticity Group, DZNE, Magdeburg, Germany Medical Faculty, Otto von Guericke University, Magdeburg, Germany Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany ponimaskin.evgeni@mh-hannover.de alexander.dityatev@dzne.de. .
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6: Title: Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability.
Authors: Rossin, A, et.al. .
Journal: Cell death and differentiation (Cell Death Differ), Vol. 22 (4): 643-53, 2015 .
Snippet: In order to better understand the role of this post-translational modification in the regulation of the Fas-mediated apoptosis pathway, we performed a screen that allowed the identification of DHHC7 as a Fas-palmitoylating enzyme.
Affiliation: Université de Nice, Institut de Biologie Valrose, CNRS UMR 7277, INSERM UMR 1091, Nice, France. .
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7: Title: The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity.
Authors: Lemonidis, Kimon, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), Vol. 25 (24): 3870-83, 2014 .
Snippet: Despite this, zDHHC3/zDHHC7 could S-acylate SNAP25/CSP more efficiently than zDHHC17, whereas zDHHC13 lacked S-acylation activity toward these proteins.
Affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, United Kingdom. ZMBP Developmental Genetics, D-72076 Tuebingen, Germany. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, United Kingdom Luke.Chamberlain@strath.ac.uk. .
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8: Title: S-palmitoylation regulates biogenesis of core glycosylated wild-type and F508del CFTR in a post-ER compartment.
Authors: McClure, Michelle L, et.al. .
Journal: The Biochemical journal (Biochem J), Vol. 459 (2): 417-25, 2014 .
Snippet: PATs (protein acyl transferases) comprise a family of 23 gene products that contain a DHHC motif and mediate palmitoylation.
Affiliation: *Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A. .
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9: Title: DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors.
Authors: Pedram, Ali, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), Vol. 23 (1): 188-99, 2012 .
Snippet: From DHHC-7 and -21 knockdown studies, the PATs are required for endogenous ER, PR, and AR palmitoylation, membrane trafficking, and rapid signal transduction in cancer cells.
Affiliation: Division of Endocrinology, Department of Medicine, University of California, Irvine, Irvine, CA 92717, USA. .
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10: Title: Influence of whole arm loss of chromosome 16q on gene expression patterns in oestrogen receptor-positive, invasive breast cancer.
Authors: Hungermann, Daniela, et.al. .
Journal: The Journal of pathology (J Pathol), Vol. 224 (4): 517-28, 2011 .
Snippet: Whole-arm chromosome 16q losses, irrespective of other chromosomal changes, are associated with decreased expression of a number of candidate genes located on 16q (eg CDA08, CGI-128, SNTB2, NQO1, SF3B3, KIAA0174, ATBF1, GABARAPL2, KARS, GCSH, MBTPS1 and ZDHHC7) in breast carcinomas with a low degree of genetic instability.
Affiliation: Institute of Pathology, University of M√ľnster, Germany. .
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11: Title: Identification of a novel gene product, Sertoli cell gene with a zinc finger domain, that is important for FSH activation of testicular Sertoli cells.
Authors: Chaudhary, Jaideep, et.al. .
Journal: Endocrinology, Vol. 143 (2): 426-35, 2002 .
Snippet: Both SERZ-alpha and SERZ-beta proteins were detected with specific antibodies to SERZ-beta and the 5'-end open reading frame SERZ-alpha in a Western blot analysis of total Sertoli cell proteins.
Affiliation: Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164-4231, USA. .
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