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43 documents found
1: Title: Identification of a novel microRNA-mRNA regulatory biomodule in human prostate cancer.
Authors: Zhang, Yanqiong, et.al. .
Journal: Cell death & disease (Cell Death Dis), Vol. 9 (3): 301, 2018 .
Snippet: In addition to the significant clinical relevance, miR-193a-5p- and miR-188-5p-regulated CCND1-RNASEL-CDKN1A-TP73-MDM2-UBE2I signaling may be a novel regulatory biomodule in prostate carcinogenesis.
Affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China. Department of Urology & Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, 510180, China. Urology Key Laboratory of Guangdong Province, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510230, China. Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, 510180, China. zhongwd2009@live.cn. Urology Key Laboratory of Guangdong Province, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510230, China. zhongwd2009@live.cn. Department of Urology & Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. CWU2@mgh.harvard.edu. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China. nlin@icmm.ac.cn. .
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2: Title: Both conditional ablation and overexpression of E2 SUMO-conjugating enzyme (UBC9) in mouse pancreatic beta cells result in impaired beta cell function.
Authors: He, Xiaoyu, et.al. .
Journal: Diabetologia, 2018 .
Snippet: METHODS: Inducible beta cell-specific Ubc9 (also known as Ube2i) knockout (KO; Ubc9Δbeta) and transgenic (Ubc9Tg) mice were employed to address the impact of SUMOylation on beta cell viability and functionality.
Affiliation: The Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Health, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, People's Republic of China. Medical College of Yangtze University, Jingzhou, Hubei, People's Republic of China. Department of Endocrinology and Metabolism, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China. ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium. Diabetes Center, The Second Xiangya Hospital, Institute of Metabolism and Endocrinology, Central South University, Changsha, 410011, People's Republic of China. zhouzg@hotmail.com. The Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Health, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, People's Republic of China. wangcy@tjh.tjmu.edu.cn. .
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3: Title: A framework for exhaustively mapping functional missense variants.
Authors: Weile, Jochen, et.al. .
Journal: Molecular systems biology (Mol Syst Biol), Vol. 13 (12): 957, 2017 .
Snippet: We applied this framework to four proteins corresponding to six human genes: UBE2I (encoding SUMO E2 conjugase), SUMO1 (small ubiquitin-like modifier), TPK1 (thiamin pyrophosphokinase), and CALM1/2/3 (three genes encoding the protein calmodulin).
Affiliation: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada. The Donnelly Centre, University of Toronto, Toronto, ON, Canada. Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Department of Computer Science, University of Toronto, Toronto, ON, Canada. Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden. SeqWell Inc, Boston, MA, USA. Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology, Barcelona, Catalonia, Spain. Invitae Corp., San Francisco, CA, USA. Department of Genome Sciences, University of Washington, Seattle, WA, USA. Fred Hutchinson Research Center, Seattle, WA, USA. Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA. Department of Genetics, Harvard Medical School, Boston, MA, USA. Institució Catalana de Recerca I Estudis Avançats (ICREA), Barcelona, Catalonia, Spain. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada fritz.roth@utoronto.ca. Canadian Institute for Advanced Research, Toronto, ON, Canada. .
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4: Title: High-throughput screening identifies FAU protein as a regulator of mutant cystic fibrosis transmembrane conductance regulator channel.
Authors: Tomati, Valeria, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), 2017 .
Snippet: These proteins included FAU, UBE2I, UBA52, MLLT6, UBA2, CHD4, PLXNA1, and TRIM24, among others.
Affiliation: Istituto Giannina Gaslini, Italy. Telethon Institute for Genetics and Medicine (Tigem), Italy. University of Naples Federico II, Italy. Istituto Giannina Gaslini, Italy; nicoletta.pedemonte@unige.it. .
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5: Title: Assessing predictions of fitness effects of missense mutations in SUMO-conjugating enzyme UBE2I.
Authors: Zhang, Jing, et.al. .
Journal: Human mutation (Hum Mutat), Vol. 38 (9): 1051-1063, 2017 .
Snippet: Here, we present the results of the SUMO conjugase challenge where participants were predicting functional effects of missense mutations in human SUMO-conjugating enzyme UBE2I.
Affiliation: Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas. Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. Department of Computer Science, University of Toronto, Toronto, Ontario, Canada. .
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6: Title: Ensemble variant interpretation methods to predict enzyme activity and assign pathogenicity in the CAGI4 NAGLU (Human N-acetyl-glucosaminidase) and UBE2I (Human SUMO-ligase) challenges.
Authors: Yin, Yizhou, et.al. .
Journal: Human mutation (Hum Mutat), Vol. 38 (9): 1109-1122, 2017 .
Snippet: Here, we report results obtained using newly developed ensemble methods to address two CAGI4 challenges: enzyme activity for population missense variants found in NAGLU (Human N-acetyl-glucosaminidase) and random missense mutations in Human UBE2I (Human SUMO E2 ligase), assayed in a high-throughput competitive yeast complementation procedure.
Affiliation: Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland. Computational Biology, Bioinformatics and Genomics, Biological Sciences Graduate Program, University of Maryland, College Park, Maryland. Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland. .
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7: Title: The mechanism of Jurkat cells apoptosis induced by Aggregatibacter actinomycetemcomitans cytolethal distending toxin.
Authors: Chen, Hui-Ping, et.al. .
Journal: Apoptosis : an international journal on programmed cell death (Apoptosis), Vol. 22 (6): 841-851, 2017 .
Snippet: In the present study we found that: (i) recombinant wild-type CdtA, CdtB and CdtC (CdtA(W), CdtB(W), CdtC(W)) and mutant CdtB (CdtB(M)) were correctly expressed and the purity of each protein was higher than 80%, (ii) the average apoptosis rate in wild-type CDT (CDT(W)) treated groups was 50.54%, which was significantly higher than the controls (4.71%) and mutant CDT (CDT(M)) treated groups (5.58%) (p < 0.05), (iii) morphological changes of apoptosis were observed in CDT(W) treated cells, (iv) the expression of Bax protein was significantly increased in CDT(W) treated cells, while Bcl-2 protein expression was significantly decreased, (v) 17 apoptosis-related proteins were expressed differentially, among which 10 proteins (SMNDC1, TNFRSF10B, UBE2I, ITM2A, CASP3, P53, EIF1, TCF3, HMGN5, CASP8) were up-regulated and 7 proteins (RRM2, TPX2, KIF11, NUCKS1, TOP2A, XRCC1, PTPLAD1, RRM2) were down-regulated, (vi) one possible apoptotic pathway [Ubc9 (UBE2I)/P53/DR5 (TNFRSF10B)/Caspase-8 (CASP8)/ Caspase-3 (CASP3)] was selected and partially proved.
Affiliation: Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, Jiangsu, China. Department of Periodontics, Affiliated Hospital of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, Jiangsu, China. Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, Jiangsu, China. yanxu@njmu.edu.cn. Department of Periodontics, Affiliated Hospital of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, Jiangsu, China. yanxu@njmu.edu.cn. .
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8: Title: Effect of MicroRNA-30e on the Behavior of Vascular Smooth Muscle Cells via Targeting Ubiquitin-Conjugating Enzyme E2I.
Authors: Zong, Yu, et.al. .
Journal: Circulation journal : official journal of the Japanese Circulation Society (Circ J), Vol. 81 (4): 567-576, 2017 .
Snippet: Furthermore, ubiquitin-conjugating enzyme E2I (Ube2i) was identified as the target gene of endogenous miR-30e by luciferase reporter assay, and it was confirmed that overexpression of miR-30e significantly reduced Ube2i and inhibited the phenotypic switch of VSMCs.
Affiliation: Institute of Cardiovascular Disease, Xuzhou Medical University. .
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9: Title: Making the connections: Autophagy and post-translational modifications in cardiomyocytes.
Authors: Gupta, Manish K, et.al. .
Journal: Autophagy, Vol. 12 (11): 2252-2253, 2016 .
Snippet: SUMOylation can have an integral role in controlling flux through the ubiquitin-proteasome system, and expression of the SUMO (small ubiquitin-like modifier) E2 enzyme UBE2I/UBC9 improves cardiac PQC.
Affiliation: a Division of Molecular Cardiovascular Biology, The Heart Institute , Cincinnati Children's Hospital , Cincinnati , OH , USA. .
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10: Title: Alu-miRNA interactions modulate transcript isoform diversity in stress response and reveal signatures of positive selection.
Authors: Pandey, Rajesh, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 6, 2016 .
Snippet: We observed that two miRNAs (miR-15a-3p and miR-302d-3p) elevated in stress response, target RAD1, GTSE1, NR2C1, FKBP9 and UBE2I exclusively within Alu.
Affiliation: CSIR Ayurgenomics Unit - TRISUTRA, CSIR- Institute of Genomics and Integrative Biology (IGIB), Sukhdev Vihar, Mathura Road, New Delhi-110025, INDIA. Genomics and Molecular Medicine Unit, CSIR- IGIB, Sukhdev Vihar, Mathura Road, New Delhi-110025, INDIA. Academy of Scientific and Innovative Research (AcSIR), New Delhi, INDIA. Persistent LABS, Persistent Systems Ltd., Pune-411004, Maharashtra, INDIA. GN Ramachandran Knowledge Centre for Genome Informatics, CSIR-IGIB, Sukhdev Vihar, Mathura Road, New Delhi-110025, INDIA. .
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11: Title: PCGF2 negatively regulates arsenic trioxide-induced PML-RARA protein degradation via UBE2I inhibition in NB4 cells.
Authors: Jo, Sungsin, et.al. .
Journal: Biochimica et biophysica acta (Biochim Biophys Acta), Vol. 1863 (7 Pt A): 1499-509, 2016 .
Snippet: Arsenic trioxide (ATO) is a therapeutic agent for acute promyelocytic leukemia (APL) which induces PML-RARA protein degradation via enhanced UBE2I-mediated sumoylation.
Affiliation: Hanyang Biomedical Research Institute, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea; Department of Biomedical Science, Graduate School of Biomedical Science and Bioengineering, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea. Hanyang Biomedical Research Institute, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea; Department of Biomedical Laboratory Science, College of Health Science, Yonsei University, 1 Yongseidae-gil, Wonju, Gangwon-do 26493, Republic of Korea. Hanyang Biomedical Research Institute, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea; Department of Biomedical Science, Graduate School, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea. Hanyang Biomedical Research Institute, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea; Department of Pathology, College of Medicine, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea. Electronic address: hc2n@hanyang.ac.kr. .
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12: Title: Differential modulation of expression of nuclear receptor mediated genes by tris(2-butoxyethyl) phosphate (TBOEP) on early life stages of zebrafish (Danio rerio).
Authors: Ma, Zhiyuan, et.al. .
Journal: Aquatic toxicology (Amsterdam, Netherlands) (Aquat Toxicol), Vol. 169, 2015 .
Snippet: In contrast, expression of most genes (mr, 11βhsd, ube2i,and adrb2b) associated with the mineralocorticoid receptor (MR) pathway were significantly down-regulated.
Affiliation: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210023, China. Electronic address: zhiyuan_nju@163.com. State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210023, China. Electronic address: yjun.yu@gmail.com. School of Environment and Sustainability, University of Saskatchewan, Saskatoon, SK S7N 5B3, Canada. State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210023, China. Electronic address: hlliu@nju.edu.cn. State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210023, China. State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210023, China; Toxicology Centre, University of Saskatchewan, Saskatoon, SK S7N 5B3, Canada; Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, SK S7N 5B3, Canada; Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong Special Administrative Region. School of Environment and Sustainability, University of Saskatchewan, Saskatoon, SK S7N 5B3, Canada; Toxicology Centre, University of Saskatchewan, Saskatoon, SK S7N 5B3, Canada. .
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13: Title: Gene expression profile of necrotizing enterocolitis model in neonatal mice.
Authors: Jung, Kyuwhan, et.al. .
Journal: International journal of surgery (London, England) (Int J Surg), Vol. 23 (Pt A): 28-34, 2015 .
Snippet: In particular, down-regulated Hist1h2aa and up-regulated Ube2i showed the most significant signals (P = 0.0008 for both genes).
Affiliation: Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, 463-707, Republic of Korea. Research Institute for Basic Science, Sogang University, Seoul, 121-742, Republic of Korea. Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul 153-803, Republic of Korea. Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, 463-707, Republic of Korea. Preclinical Experimental Center, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, 463-707, Republic of Korea. Research Institute for Basic Science, Sogang University, Seoul, 121-742, Republic of Korea; Department of Life Science, Sogang University, Seoul 121-742, Republic of Korea. Electronic address: hdshin@sogang.ac.kr. Department of Surgery, Seoul National University Children's Hospital, Seoul 110-773, Republic of Korea. Electronic address: sejung@snu.ac.kr. .
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14: Title: Systematic identification of factors for provirus silencing in embryonic stem cells.
Authors: Yang, Bin Xia, et.al. .
Journal: Cell, Vol. 163 (1): 230-45, 2015 .
Snippet: Histone chaperones (Chaf1a/b), sumoylation factors (Sumo2/Ube2i/Sae1/Uba2/Senp6), and chromatin modifiers (Trim28/Eset/Atf7ip) are key determinants that establish provirus silencing.
Affiliation: Epigenetics and Cell Fates Laboratory, A(∗)STAR Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Singapore 138673, Singapore. Epigenetics and Cell Fates Laboratory, A(∗)STAR Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Singapore 138673, Singapore; Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore. College of Life Sciences, Nankai University, Tianjin 300071, China. Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Department of Microbiology and Immunology, Columbia University, New York, NY 10032, USA. Membrane Traffic Laboratory, A(∗)STAR Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Singapore 138673, Singapore. Quantitative Proteomics Group, A(∗)STAR Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Singapore 138673, Singapore. Division of Cancer Genetics and Therapeutics, Laboratory of NF-κB Signaling, A(∗)STAR Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Singapore 138673, Singapore. Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Division of Cancer Genetics and Therapeutics, Laboratory of NF-κB Signaling, A(∗)STAR Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Singapore 138673, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore. Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore. Quantitative Proteomics Group, A(∗)STAR Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Singapore 138673, Singapore; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. Department of Biological Engineering, Synthetic Biology Center, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA. Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Department of Microbiology and Immunology, Columbia University, New York, NY 10032, USA; Howard Hughes Medical Institute, New York, NY 10032, USA. Howard Hughes Medical Institute, Boston, MA 02115, USA; Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Boston, MA 02115, USA; Manton Center for Orphan Disease Research, Boston, MA 02115, USA. Center for Individualized Medicine, Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA. Membrane Traffic Laboratory, A(∗)STAR Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Singapore 138673, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore. Epigenetics and Cell Fates Laboratory, A(∗)STAR Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Singapore 138673, Singapore; Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore. Electronic address: yhloh@imcb.a-star.edu.sg. .
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15: Title: Profiling of ubiquitination pathway genes in peripheral cells from patients with frontotemporal dementia due to C9ORF72 and GRN mutations.
Authors: Serpente, Maria, et.al. .
Journal: International journal of molecular sciences (Int J Mol Sci), Vol. 16 (1): 1385-94, 2015 .
Snippet: In particular, in both groups, four genes, UBE2I, UBE2Q1, UBE2E1 and UBE2N, were down-regulated at a statistically significant (p < 0.05) level.
Affiliation: Neurology Unit, Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan 20122, Italy. maria.serpente@policlinico.mi.it. Neurology Unit, Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan 20122, Italy. chiara.fenoglio@unimi.it. Neurology Unit, Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan 20122, Italy. sara.cioffi@unimi.it. Neurology Unit, Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan 20122, Italy. rossana.bonsi@unimi.it. Neurology Unit, Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan 20122, Italy. andrea.arighi@yahoo.it. Neurology Unit, Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan 20122, Italy. giorgiofumagalli@hotmail.com. Neurology Unit, Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan 20122, Italy. lauraghezzi@me.com. Neurology Unit, Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan 20122, Italy. elio.scarpini@unimi.it. Neurology Unit, Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan 20122, Italy. daniela.galimberti@unimi.it. .
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16: Title: NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation.
Authors: Licciardello, M P, et.al. .
Journal: Oncogene, Vol. 34 (29): 3780-90, 2015 .
Snippet: Knockdown of the E2-conjugating enzyme UBC9 (UBE2I) as well as inhibition of the E1-activating complex SAE1/UBA2 using ginkgolic acid impairs the growth of NOTCH1-activated breast epithelial cells.
Affiliation: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. 1] CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria [2] Christian Doppler Laboratory for Chemical Epigenetics and Antiinfectives, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. .
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17: Title: Obesity-linked homologues TfAP-2 and Twz establish meal frequency in Drosophila melanogaster.
Authors: Williams, Michael J, et.al. .
Journal: PLoS genetics (Plos Genet), Vol. 10 (9): e1004499, 2014 .
Snippet: Finally, we show that in this mouse hypothalamic cell line AP-2β and Kctd15 directly interact with Ube2i, a mouse sumoylation enzyme, and that AP-2β may itself be sumoylated.
Affiliation: Functional Pharmacology, Department of Neuroscience, Uppsala University, Uppsala, Sweden. .
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18: Title: Human factors and pathways essential for mediating epigenetic gene silencing.
Authors: Poleshko, Andrey, et.al. .
Journal: Epigenetics, Vol. 9 (9): 1280-9, 2014 .
Snippet: A key finding was that the E1 and E2 enzymes of the small ubiquitin-like modifier (SUMO) pathway (SAE1, SAE2/UBA2, UBC9/UBE2I) are essential for maintenance of epigenetic silencing.
Affiliation: Fox Chase Cancer Center; Philadelphia, PA USA. Center for Systems and Computational Biology; The Wistar Institute; Philadelphia, PA USA. .
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19: Title: The SUMO conjugating enzyme Ubc9 is required for inducing and maintaining stem cell pluripotency.
Authors: Tahmasebi, Soroush, et.al. .
Journal: Stem cells (Dayton, Ohio) (Stem Cells), Vol. 32 (4): 1012-20, 2014 .
Snippet: For sumoylation, this cascade uses Ubc9 (ubiquitin conjugating enzyme 9, now officially named ubiquitin conjugating enzyme E2I [UBE2I]) as the sole E2 enzyme.
Affiliation: The Rosalind & Morris Goodman Cancer Research Center, Montréal, Québec, Canada; Department of Anatomy & Cell Biology, Montréal, Québec, Canada. .
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20: Title: Early gene expression changes in spinal cord from SOD1(G93A) Amyotrophic Lateral Sclerosis animal model.
Journal: Frontiers in cellular neuroscience (Unknown Journal), Vol. 7, 2013 .
Snippet: Ube2i gene expression was evaluated in astrocytes from both transgenic ages, being up regulated in 40 and 80 days astrocytes enriched samples.
Affiliation: Department of Neurology, Neuroregeneration Center, University of São Paulo School of Medicine São Paulo, Brazil. .
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