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22 documents found
1: Title: MicroRNA-125b-1-3p mediates intervertebral disc degeneration in rats by targeting teashirt zinc finger homeobox 3.
Authors: Meng, Xiaotong, et.al. .
Journal: Experimental and therapeutic medicine (Exp Ther Med), Vol. 15 (3): 2627-2633, 2018 .
Snippet: The present study demonstrated that TSHZ3, as a target gene of miR-125b-1-3p, may serve a protective role in intervertebral disc degeneration and that this protective function may be inhibited by high levels of miR-125b-1-3p.
Affiliation: Department of Orthopedics, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China. .
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2: Title: MiR-338-5p Promotes Glioma Cell Invasion by Regulating TSHZ3 and MMP2.
Authors: Li, Yanyan, et.al. .
Journal: Cellular and molecular neurobiology (Cell Mol Neurobiol), 2017 .
Snippet: The results showed that the expression of miR-338-5p, normalized to hsnRNA U6, was significantly higher in grade III and IV gliomas and glioblastoma cell lines compared to that in NNB and grade II gliomas, whereas TSHZ3 expression, normalized to GAPDH, was inversely related to miR-338-5p (R = -0.636,
Affiliation: Department of Neurosurgery and Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, China. Department of Neurosurgery and Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, China. zhouyouxin@suda.edu.cn. .
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3: Title: A genome-wide siRNA screen for regulators of tumor suppressor p53 activity in human non-small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment.
Journal: Molecular oncology (Mol Oncol), Vol. 11 (5): 534-551, 2017 .
Snippet: Ten genes were validated as inhibitors of p53 activity in multiple NSCLC cell lines: genes encoding the Ras pathway activator SOS1, the zinc finger protein TSHZ3, the mitochondrial membrane protein COX16, and the spliceosome components SNRPD3, SF3A3, SF3B1, SF3B6, XAB2, CWC22, and HNRNPL.
Affiliation: Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands. Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands. Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands. Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands. .
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4: Title: Rare Genetic Variant in SORL1 May Increase Penetrance of Alzheimer's Disease in a Family with Several Generations of APOE-ɛ4 Homozygosity.
Authors: Louwersheimer, Eva, et.al. .
Journal: Journal of Alzheimer's disease : JAD (J Alzheimers Dis), Vol. 56 (1): 63-74, 2017 .
Snippet: Furthermore, three of four affected family members carried a rare variant in the TSHZ3 gene, also associated with AβPP processing.
Affiliation: Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands. Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands. Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands. Delft Bioinformatics Laboratory, Delft University of Technology, Delft, The Netherlands. Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands. Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands. Institutes of Neurology and Healthcare Engineering, UCL, London, UK. Alzheimer Center & Department of Medical Psychology, VU University Medical Center, Amsterdam, The Netherlands. Department of Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, The Netherlands. .
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5: Title: TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons.
Authors: Caubit, Xavier, et.al. .
Journal: Nature genetics (Nat Genet), Vol. 48 (11): 1359-1369, 2016 .
Snippet: TSHZ3, which encodes a zinc-finger transcription factor, was recently positioned as a hub gene in a module of the genes with the highest expression in the developing human neocortex, but its functions remained unknown.
Affiliation: Aix-Marseille Université, CNRS, IBDM, Marseille, France. Institut de Génétique Médicale, Hôpital Jeanne de Flandre, CHRU Lille, Lille, France. Aix-Marseille Université, INSERM, GMGF, Marseille, France. Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut, USA. Molecular and Behavioral Neuroscience Institute (MBNI), Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA. Aix-Marseille Université, CNRS, LPC, Marseille, France. Clinical Genetics Unit, Karolinska University Hospital Solna, Stockholm, Sweden. Department of Pediatrics, Division of Genetics and Genomic Medicine, Washington University School of Medicine, St. Louis, Missouri, USA. Service de Génétique Clinique, Hôpital Jeanne de Flandre, CHRU Lille, Lille, France. Service de Neuropédiatrie, Hôpital Salengro, CHRU Lille, Lille, France. Centre de Cytogénétique, Hôpital Saint Vincent de Paul, GHICL, UCL, Lille, France. Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Science Centre and the Royal Manchester Children's and St Mary's Hospitals, Manchester, UK. UCL Institute of Child Health, London, UK. MGX-Montpellier GenomiX, Institut de Génomique Fonctionnelle, Montpellier, France. Institute of Cell Biology and Neurobiology, Center for Anatomy, Charité University Hospital Berlin, Berlin, Germany. .
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6: Title: Expression patterns of homeobox genes in the mouse vomeronasal organ at postnatal stages.
Authors: Chang, Isabelle, et.al. .
Journal: Gene expression patterns : GEP (Gene Expr Patterns), Vol. 21 (2): 69-80, 2016 .
Snippet: We identified 11 homeobox genes (Dlx3, Dlx4, Emx2, Lhx2, Meis1, Pbx3, Pknox2, Pou6f1, Tshz2, Zhx1, Zhx3) that were expressed exclusively in neurons; 4 homeobox genes (Pax6, Six1, Tgif1, Zfhx3) that were expressed in all non-neuronal cell populations, with Pax6, Six1 and Tgif1 also expressed in some neuronal progenitors and precursors; 12 homeobox genes (Adnp, Cux1, Dlx5, Dlx6, Meis2, Pbx2, Pknox1, Pou2f1, Satb1, Tshz1, Tshz3, Zhx2) with expression in both neuronal and non-neuronal cell populations; and one homeobox gene (Hopx) that was exclusively expressed in the non-sensory epithelium.
Affiliation: Max Planck Research Unit for Neurogenetics, Max-von-Laue-Strasse 4, 60438, Frankfurt, Germany. Electronic address: isabelle.chang@gen.mpg.de. Max Planck Research Unit for Neurogenetics, Max-von-Laue-Strasse 4, 60438, Frankfurt, Germany. .
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7: Title: Sonic hedgehog, TBX18, and TSHZ3 proteins involved in pyeloureteral motility development are overexpressed in ureteropelvic junction obstruction. An immunohistochemical, histopathological, and clinical comparative study.
Authors: Yilmaz, Omer, et.al. .
Journal: Saudi medical journal (Saudi Med J), Vol. 37 (7): 737-43, 2016 .
Snippet: CONCLUSION: Gene product expressions of SHH, TBX18 and TSHZ3 are statistically higher in patients with UPJ obstruction, when compared with control group.
Affiliation: Department of Pediatric Surgery, Faculty of Medicine, Celal Bayar University, Manisa, Turkey. E-mail. omeryilmaz71@gmail.com. .
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8: Title: Whole-genome sequencing of the world's oldest people.
Authors: Gierman, Hinco J, et.al. .
Journal: PloS one, Vol. 9 (11): e112430, 2014 .
Snippet: We followed up on the gene most enriched for rare protein-altering variants in our cohort of supercentenarians, TSHZ3, by sequencing it in a second cohort of 99 long-lived individuals but did not find a significant enrichment.
Affiliation: Depts. of Developmental Biology and Genetics, Stanford University, Stanford, CA, United States of America. Institute for Systems Biology, Seattle, WA, United States of America. Gerontology Research Group, Los Angeles, CA, United States of America; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States of America. .
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9: Title: Altered epigenetic regulation of homeobox genes in human oral squamous cell carcinoma cells.
Journal: Experimental cell research (Exp Cell Res), Vol. 320 (1): 128-43, 2014 .
Snippet: In contrast, IRX1, IRX4, SIX2 and TSHZ3 transcripts are lower in SCC-9 than in OKF6-TERT1R cells.
Affiliation: Department of Pharmacology, Weill Cornell Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA; Department of Pharmacology, Weill Cornell Graduate School of Medical Sciences of Cornell University, 1300 York Avenue, New York, NY 10065, USA. .
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10: Title: A novel OPA3 mutation revealed by exome sequencing: an example of reverse phenotyping.
Authors: Arif, Beenish, et.al. .
Journal: JAMA neurology (Jama Neurol), Vol. 70 (6): 783-7, 2013 .
Snippet: Exome sequencing revealed 2 rare, homozygous variants (c.32 T>A [p.L11Q] in OPA3 and c.941 C>G [p.A314G] in TSHZ3) that segregated with the disease.
Affiliation: Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. .
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11: Title: TSHZ3 and SOX9 regulate the timing of smooth muscle cell differentiation in the ureter by reducing myocardin activity.
Authors: Martin, Elise, et.al. .
Journal: PloS one, Vol. 8 (5): e63721, 2013 .
Snippet: In the mouse ureter, the two transcriptional regulators TSHZ3 and SOX9 are independently required for initiation of smooth muscle differentiation from uncommitted mesenchymal precursor cells.
Affiliation: Aix-Marseille Université, CNRS, IBDM UMR7288, Marseille, France. .
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12: Title: Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes.
Authors: McBride, David J, et.al. .
Journal: The Journal of pathology (J Pathol), Vol. 227 (4): 446-55, 2012 .
Snippet: Recurrent rearrangements of the transcriptional regulator gene, TSHZ3, were found in three of eight serous cases.
Affiliation: Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. david.bowtell@petermac.org .
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13: Title: Functional characterization of the 19q12 amplicon in grade III breast cancers.
Authors: Natrajan, Rachael, et.al. .
Journal: Breast cancer research : BCR (Breast Cancer Res), Vol. 14 (2): R53, 2012 .
Snippet: METHODS: We investigated the presence of 19q12 amplification in a series of 313 frozen primary breast cancers and 56 breast cancer cell lines using microarray comparative genomic hybridisation (aCGH).
Affiliation: Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. .
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14: Title: Genetic loci for blood lipid levels identified by linkage and association analyses in Caribbean Hispanics.
Authors: Dong, Chuanhui, et.al. .
Journal: Journal of lipid research (J Lipid Res), Vol. 52 (7): 1411-9, 2011 .
Snippet: In the association analysis of the linkage peaks, we found that seven SNPs near FLJ45974 were associated with LDL-C/HDL-C with a nominal P < 3.5 × 10(-5), in addition to associations (P < 0.0001) for other lipid traits with SNPs in or near CDH13, SUMF2, TLE3, FAH, ARNT2, TSHZ3, ZNF343, RPL7AL2, and TMC3.
Affiliation: Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA. .
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15: Title: Teashirt-3, a novel regulator of muscle differentiation, associates with BRG1-associated factor 57 (BAF57) to inhibit myogenin gene expression.
Authors: Faralli, Hervé, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 286 (26): 23498-510, 2011 .
Snippet: In the present study, we found that the zinc finger-containing factor Teashirt-3 (TSHZ3) was expressed in quiescent satellite cells of adult mouse skeletal muscles.
Affiliation: Institut de Biologie du Développement de Marseille Luminy, UMR 6216, CNRS-Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France. .
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16: Title: Rare and frequent promoter methylation, respectively, of TSHZ2 and 3 genes that are both downregulated in expression in breast and prostate cancers.
Authors: Yamamoto, Miyako, et.al. .
Journal: PloS one, Vol. 6 (3): e17149, 2011 .
Snippet: The TSHZ3 gene promoter was found to be methylated in all the breast/prostate cancer cell lines and some of the breast cancer clinical specimens analyzed.
Affiliation: Burnham Institute for Medical Research, La Jolla, California, United States of America. fyamamoto@imppc.org .
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17: Title: Teashirt 3 regulates development of neurons involved in both respiratory rhythm and airflow control.
Authors: Caubit, Xavier, et.al. .
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), Vol. 30 (28): 9465-76, 2010 .
Snippet: Tshz3 is expressed in multiple areas of the brainstem involved in respiration, including the pre-Bötzinger complex (preBötC), the embryonic parafacial respiratory group (e-pF), and cranial motoneurons that control the upper airways.
Affiliation: Unité Mixte de Recherche (UMR) 6216, Centre National de la Recherche Scientifique (CNRS), Université de la Méditerranée, Institut de Biologie du Développement de Marseille Luminy, Parc Scientifique de Luminy, Marseille Cedex 9, France. caubit@ibdm.univ-mrs.fr .
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18: Title: Ureter myogenesis: putting Teashirt into context.
Authors: Lye, Claire M, et.al. .
Journal: Journal of the American Society of Nephrology : JASN (J Am Soc Nephrol), Vol. 21 (1): 24-30, 2010 .
Snippet: A signaling pathway can be envisaged, starting with sonic hedgehog secreted by the nascent ureteric urothelium and ending with ureteric smooth muscle cell differentiation, with Tshz3 downstream of bone morphogenetic protein 4 and upstream of myocardin and smooth muscle cell contractile protein synthesis.
Affiliation: UCL Institute of Child Health, London WC1N 1EH, UK. .
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19: Title: Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction.
Authors: Jenkins, Dagan, et.al. .
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (Nephrol Dial Transplant), Vol. 25 (1): 54-60, 2010 .
Snippet: Mice that are null mutant for the Teashirt3 (Tshz3) gene exhibit congenital PUJO with defective smooth muscle differentiation and absent peristalsis in the proximal ureter.
Affiliation: Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK. dagan.jenkins@imm.ox.ac.uk .
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20: Title: FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.
Authors: Kajiwara, Yuji, et.al. .
Journal: PloS one, Vol. 4 (4): e5071, 2009 .
Snippet: We evaluated a case-control cohort and observed evidence for a genetic association between the Teashirt genes TSHZ1 and TSHZ3 and AD, with the TSHZ3 SNP genotype correlating with expression of Teashirt3.
Affiliation: Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, New York, NY, USA. .
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