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60 documents found
1: Title: Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cells.
Authors: Lee, Yura, et.al. .
Journal: Oncotarget, Vol. 8 (25): 41091-41101, 2017 .
Snippet: In addition, we examined the effect on TNIK of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib and whether inhibition of TNIK suppresses the interleukin-6-induced proliferation of multiple myeloma cells.
Affiliation: Department of Biomedical Laboratory Science, School of Medicine, Eulji University, Daejeon 34824, Korea. Present address: Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, College of Medicine, Yonsei University, Seoul 03722, Korea. R&D Center, Peptron, Inc., Daejeon 34054, Korea. Department of Pharmacology, School of Medicine, Eulji University, Daejeon 34824, Korea. .
2: Title: Regulation of glioma migration and invasion via modification of Rap2a activity by the ubiquitin ligase Nedd4-1.
Authors: Wang, Lei, et.al. .
Journal: Oncology reports (Oncol Rep), Vol. 37 (5): 2565-2574, 2017 .
Snippet: To investigate the role of Nedd4-1 and the intracellular pathways involved, we performed pull-down and co-immunoprecipitation assays, and recognized that Nedd4-1, TNIK and Rap2a formed a complex.
Affiliation: Insitute of Nervous System Diseases, Xuzhou Medical University, Xuzhou, Jiangsu, P.R. China. .
3: Title: Genome-wide association study identifies novel susceptible loci and highlights Wnt/beta-catenin pathway in the development of adolescent idiopathic scoliosis.
Authors: Zhu, Zezhang, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), Vol. 26 (8): 1577-1583, 2017 .
Snippet: Furthermore, we observed significantly asymmetric expression of Wnt/beta-catenin pathway in the bilateral paraspinal muscle of AIS patients, including beta-catenin, TNIK, and LBX1.
Affiliation: Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China. Joint Scoliosis Research Center of The Chinese University of Hong Kong and Nanjing University, Nanjing 210008 & Hong Kong 999077, P.R. China. Department of Chemical Pathology and School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, P.R. China. Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, P.R. China. Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun 130116, P.R. China. Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310002, P.R. China. Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, P.R. China. .
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4: Title: The emergence of TNIK as a therapeutic target for colorectal cancer.
Authors: Masuda, Mari, et.al. .
Journal: Expert opinion on therapeutic targets (Expert Opin Ther Targets), Vol. 21 (4): 353-355, 2017 .
No Abstract available.
Affiliation: a National Cancer Center Research Institute , Division of Chemotherapy and Clinical Research , Tokyo , Japan. .
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5: Title: Emergence of TNIK inhibitors in cancer therapeutics.
Authors: Yamada, Tesshi, et.al. .
Journal: Cancer science (Cancer Sci), Vol. 108 (5): 818-823, 2017 .
Snippet: Traf2 and Nck-interacting protein kinase (TNIK) was identified as a regulatory component of the β-catenin and T-cell factor-4 (TCF-4) transcriptional complex.
Affiliation: Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, Japan. .
6: Title: Comprehensive Modeling and Discovery of Mebendazole as a Novel TRAF2- and NCK-interacting Kinase Inhibitor.
Authors: Tan, Zhi, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 6, 2016 .
Snippet: TRAF2- and NCK-interacting kinase (TNIK) represents one of the crucial targets for Wnt-activated colorectal cancer.
Affiliation: Integrated Molecular Discovery Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA. .
7: Title: TNIK inhibition abrogates colorectal cancer stemness.
Authors: Masuda, Mari, et.al. .
Journal: Nature communications (Nat Commun), Vol. 7, 2016 .
Snippet: TNIK is required for the tumour-initiating function of colorectal cancer stem cells.
Affiliation: Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. Carna Biosciences, Inc., BMA 3F 1-5-5 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan. Division of Cancer Differentiation, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. .
8: Title: A null mutation in TNIK defines a novel locus for intellectual disability.
Authors: Anazi, Shams, et.al. .
Journal: Human genetics (Hum Genet), Vol. 135 (7): 773-8, 2016 .
Snippet: Our data strongly implicate TNIK deficiency in the causation of ID in humans.
Affiliation: Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. University Diabetes Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Saudi Human Genome Program, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. University Diabetes Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia. krubeaan@dscenter.org. Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. falkuraya@kfshrc.edu.sa. Department of Anatomy and Cell Biology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. falkuraya@kfshrc.edu.sa. Saudi Human Genome Program, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. falkuraya@kfshrc.edu.sa. .
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9: Title: Traf2- and Nck-interacting kinase (TNIK) is involved in the anti-cancer mechanism of dovitinib in human multiple myeloma IM-9 cells.
Authors: Chon, Hae Jung, et.al. .
Journal: Amino acids, Vol. 48 (7): 1591-9, 2016 .
Snippet: Traf2- and Nck-interacting kinase (TNIK) is a member of the germinal center kinase family.
Affiliation: Department of Biomedical Laboratory Science, School of Medicine, Eulji University, Daejeon, 34824, Korea. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, USA. Department of Pharmacology, School of Medicine, Eulji University, Daejeon, 34824, Korea. Department of Biomedical Laboratory Science, School of Medicine, Eulji University, Daejeon, 34824, Korea. yeon@eulji.ac.kr. .
10: Title: Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia through the TRAF2/TNIK/GluR1 Cascade.
Authors: Lin, Tzer-Bin, et.al. .
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), Vol. 35 (50): 16545-60, 2015 .
Snippet: Tumor necrosis factor receptor-associated factor 2 (TRAF2), which is regulated by spinal F-box protein 3 (Fbxo3)-dependent F-box and leucine-rich repeat protein 2 (Fbxl2) ubiquitination, contributes to SNL-induced allodynia by modifying TNIK/GluR1 phosphorylation-associated GluR1 trafficking.
Affiliation: Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11049, Taiwan, Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan, Department of Biotechnology, Asia University, Taichung 41354, Taiwan. Department of Medicine, Mackay Medical College, New Taipei 25245, Taiwan, Department of Physiology, School of Medicine, College of Medicine, National Taiwan University, Taipei 10617, Taiwan. Department of Medicine, Mackay Medical College, New Taipei 25245, Taiwan, Department of Veterinary Medicine, College of Veterinary Medicine, National Chung-Hsing University, Taichung 40254, Taiwan. Department of Medicine, Mackay Medical College, New Taipei 25245, Taiwan, Department of Anesthesiology, Mackay Memorial Hospital, New Taipei 10449, Taiwan. Department of Medicine, Mackay Medical College, New Taipei 25245, Taiwan. School of Medicine, Fu-Jen Catholic University, New Taipei 24205, Taiwan, and. Department of Obstetrics and Gynecology, Chung-Shan Medical University Hospital, Chung-Shan Medical University, Taichung 40201, Taiwan. Department of Medicine, Mackay Medical College, New Taipei 25245, Taiwan, hsien.yu@gmail.com. .
11: Title: Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK.
Authors: Wang, Qi, et.al. .
Journal: The Journal of pharmacology and experimental therapeutics (J Pharmacol Exp Ther), Vol. 356 (2): 410-23, 2016 .
Snippet: Together, using a TNIK inhibitor and phosphomotif antibody, we identify endogenous substrates of TNIK in neurons, define consensus sequences for TNIK, and suggest signaling pathways by which TNIK influences synaptic development and function linked to psychiatric and neurologic disorders.
Affiliation: Neuroscience & Pain Research Unit, BioTherapeutics Research and Development, Pfizer Inc. Cambridge, Massachusetts (Q.W., S.P.A., D.M.R., N.J.B., M.D.E.); Center of Chemistry Innovation and Excellence, Pfizer Inc., Groton, Connecticut (M.M.H.); Neuroscience Medicinal Chemistry, Pfizer Inc., Cambridge, Massachusetts (B.L.K., P.R.V.);and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts (L.X.) Qi.Wang@azneuro.com Michael.Ehlers@pfizer.com. Neuroscience & Pain Research Unit, BioTherapeutics Research and Development, Pfizer Inc. Cambridge, Massachusetts (Q.W., S.P.A., D.M.R., N.J.B., M.D.E.); Center of Chemistry Innovation and Excellence, Pfizer Inc., Groton, Connecticut (M.M.H.); Neuroscience Medicinal Chemistry, Pfizer Inc., Cambridge, Massachusetts (B.L.K., P.R.V.);and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts (L.X.). .
12: Title: Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer.
Authors: Masuda, Mari, et.al. .
Journal: Pharmacology & therapeutics (Pharmacol Ther), Vol. 156, 2015 .
Snippet: TNIK regulates Wnt signaling in the most downstream part of the pathway, and its inhibition is expected to block the signal even in colorectal cancer cells with APC gene mutation.
Affiliation: Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo 104-0045, Japan. Carna Biosciences, Inc., Kobe 650-0047, Japan. Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo 104-0045, Japan. Electronic address: tyamada@ncc.go.jp. .
13: Title: From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.
Authors: Colombrita, Claudia, et.al. .
Journal: Biochimica et biophysica acta (Biochim Biophys Acta), Vol. 1849 (12): 1398-410, 2015 .
Snippet: In particular, TDP-43 and FUS were found to regulate splicing and expression of genes related to neuronal (SEPT6, SULT4A1, TNIK) and RNA metabolism (DICER, ELAVL3/HuC, POLDIP3).
Affiliation: Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center - Università degli Studi di Milano, Milan 20122, Italy; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan 20149, Italy. Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan 20149, Italy. International Centre for Genetic Engineering and Biotechnology (ICGEB), AREA Science Park, Trieste 34149, Italy. GenoSplice, Hopital Pitié-Salpêtrière, Paris 75013, France. Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center - Università degli Studi di Milano, Milan 20122, Italy; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan 20149, Italy. Electronic address: antonia.ratti@unimi.it. .
14: Title: Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer.
Authors: Takahashi, Hidenori, et.al. .
Journal: BMC cancer, Vol. 15, 2015 .
Snippet: Thus, we identified seventeen candidate genes, and selected Traf2- and Nck-interacting kinase (TNIK), which was known to be associated with progression in CRC through Wnt signaling pathways.
Affiliation: Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. htsrg2@tmd.ac.jp. Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. ishi.srg2@tmd.ac.jp. Department of Translational Oncology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan. ishiguro.srg2@tmd.ac.jp. Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. okazaki3332@gmail.com. Department of Systems Biology, Graduate School of Biochemical Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan. kmogushi@juntendo.ac.jp. Center for Minimally Invasive Surgery, Division of Colorectal Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. h-kobayashi.srg2@tmd.ac.jp. Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. s-iida@ohta-hp.or.jp. Center for Public Health Informatics, National Institute of Public Health, 2-3-6 Minami, Wako-shi, Saitama, 351-0197, Japan. hmizushi@niph.go.jp. Department of Systems Biology, Graduate School of Biochemical Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan. tanaka@cim.tmd.ac.jp. Department of Translational Oncology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan. h-uetake.srg2@tmd.ac.jp. Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. sugi.srg2@gmail.com. .
15: Title: Targeting the Wnt signaling pathway in colorectal cancer.
Authors: Sawa, Masaaki, et.al. .
Journal: Expert opinion on therapeutic targets (Expert Opin Ther Targets), Vol. 20 (4): 419-29, 2016 .
Snippet: TRAF2 and NCK-interacting protein kinase (TNIK) was identified as the most downstream regulator of Wnt signaling by two independent research groups, and several classes of small-molecule inhibitors targeting this protein kinase have been developed.
Affiliation: a 1 Carna Biosciences, Inc. , BMA 3F 1-5-5 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. b 2 National Cancer Center Research Institute, Division of Chemotherapy and Clinical Research , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. c 3 National Cancer Center Research Institute, Division of Chemotherapy and Clinical Research , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan ; tyamada@ncc.go.jp. .
16: Title: Association studies of genomic variants with treatment response to risperidone, clozapine, quetiapine and chlorpromazine in the Chinese Han population.
Authors: Xu, Q, et.al. .
Journal: The pharmacogenomics journal (Pharmacogenomics J), Vol. 16 (4): 357-65, 2016 .
Snippet: Also, we found several new candidate genes (TNIK, RELN, NOTCH4 and SLC6A2) and combinations (haplotype rs1544325-rs5993883-rs6269-rs4818 in COMT) that are associated with treatment response to the four drugs.
Affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China. Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Broad Institute of Harvard and MIT, Cambridge, MA, USA. Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. Shanghai Institute of Mental Health, Shanghai, China. Nanjing Medical University Affiliated Wuxi Mental Health Center, Wuxi, China. Institutes of Biomedical Sciences, Fudan University, Shanghai, China. Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China. .
17: Title: Epigenetic regulation of traf2- and Nck-interacting kinase (TNIK) in polycystic ovary syndrome.
Authors: Li, Da, et.al. .
Journal: American journal of translational research (Unknown Journal), Vol. 7 (6): 1152-60, 2015 .
Snippet: Mechanistically, hypermethylated cg10180092 site-mediated loss of holocarboxylase synthetase (HLCS)-related H3K9me enrichment activated TNIK transcription in PCOS ovarian tissues.
Affiliation: Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University Shenyang 110004, China. Department of Medicine, Brigham and Women's Hospital, Harvard Institutes of Medicine, Harvard Medical School Boston, MA 02115, USA. .
18: Title: TNIK serves as a novel biomarker associated with poor prognosis in patients with pancreatic cancer.
Authors: Zhang, Yong, et.al. .
Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol), Vol. 37 (1): 1035-40, 2016 .
Snippet: Traf-2 and Nck interacting kinase (TNIK) is one of the STE20/MAP4K family members implicated in carcinogenesis and progression of several human malignancies.
Affiliation: Department of Gastrointestinal Surgery, Inner Mongolia People's Hospital, No. 20 Zhao Wuda Road, Inner Mongolia, Hohhot, 010017, China. Nankai Hospital of Tianjin Medical University, No. 122, San Wei Road, Nankai District, Tianjin, China. Department of Gastrointestinal Surgery, Inner Mongolia People's Hospital, No. 20 Zhao Wuda Road, Inner Mongolia, Hohhot, 010017, China. wangju_86@163.com. .
19: Title: Organization of TNIK in dendritic spines.
Authors: Burette, Alain C, et.al. .
Journal: The Journal of comparative neurology (J Comp Neurol), Vol. 523 (13): 1913-24, 2015 .
Snippet: Tumor necrosis factor receptor-associated factor 2 (TRAF2)- and noncatalytic region of tyrosine kinase (NCK)-interacting kinase (TNIK) has been identified as an interactor in the psychiatric risk factor, Disrupted in Schizophrenia 1 (DISC1).
Affiliation: Department of Cell Biology & Physiology, University of North Carolina, Chapel Hill, North Carolina, 27599. Shenogen Pharma Group, Beijing, People's Republic of China 102206. Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer, Andover, Massachusetts 01810. Clinical Research Unit, Pfizer, New Haven, Connecticut 06511. Biomarker and Personalized Medicine Group, Eisai Product Creation Systems, Eisai, Andover, Massachusetts 01810. Neuroscience Research Unit, Pfizer, Cambridge, Massachusetts 02139. AstraZeneca Neuroscience IMED, Cambridge, Massachusetts 02139. Centers for Therapeutic Innovation, Pfizer, Boston, Massachusetts 02115. Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina, 27599. .
20: Title: A novel aminothiazole KY-05009 with potential to inhibit Traf2- and Nck-interacting kinase (TNIK) attenuates TGF-β1-mediated epithelial-to-mesenchymal transition in human lung adenocarcinoma A549 cells.
Authors: Kim, Jiyeon, et.al. .
Journal: PloS one, Vol. 9 (10): e110180, 2014 .
Snippet: Traf2- and Nck-interacting kinase (TNIK) has recently been considered as a first-in-class anti-cancer target molecule to regulate Wnt signaling pathway, but pharmacologic inhibition of its EMT activity has not yet been studied.
Affiliation: Department of Biomedical Laboratory Science, School of Medicine, Eulji University, Jung-gu, Daejeon, Republic of Korea. Laboratory of Translational Therapeutics, Korea Research Institute of Chemical Technology, Yuseong-gu, Daejeon, Republic of Korea. Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, Yuseong-gu, Daejeon, Republic of Korea. Drug Discovery Platform Technology Team, Korea Research Institute of Chemical Technology, Yuseong-gu, Daejeon, Republic of Korea. .
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