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32 documents found
1: Title: Up-regulation of ceRNA TINCR by SP1 contributes to tumorigenesis in breast cancer.
Authors: Liu, Yun, et.al. .
Journal: BMC cancer, Vol. 18 (1): 367, 2018 .
Snippet: RESULTS: TINCR was aberrantly up-regulated by SP1, which in turn stimulated cell proliferation, anchorage-independent growth and suppressed cell apoptosis in breast cancer.
Affiliation: Department of ENT, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, People's Republic of China. Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, People's Republic of China. Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, People's Republic of China. huzhenxi973hust@outlook.com. .
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2: Title: Analysis of psoriasis-relevant gene expression and exon usage alterations after silencing of SR-rich splicing regulators.
Authors: Szlavicz, E, et.al. .
Journal: Experimental dermatology (Exp Dermatol), 2018 .
Snippet: Although immortalized keratinocytes express low levels of TINCR, a long non-coding RNA involved in terminal differentiation of keratinocytes, splicing alterations were successfully demonstrated for this RNA as well.
Affiliation: Department of Dermatology and Allergology, Faculty of Medicine, University of Szeged, Szeged, Hungary. Department of Dermatology, Venereology and Oncodermatology, Faculty of Medicine, University of Pécs, Pécs, Hungary. Department of Dermatology, University Hospital Düsseldorf, Düsseldorf, Germany. MTA-SZTE Dermatological Research Group, University of Szeged, Szeged, Hungary. International Centre for Genetic Engineering and Biotechnology, Trieste, Italy. Department of Medical Genetics, Faculty of Medicine, University of Szeged, Szeged, Hungary. .
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3: Title: TINCR facilitates non-small cell lung cancer progression through BRAF-activated MAPK pathway.
Authors: Zhu, Zhi-Jun, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), 2018 .
Snippet: Mechanistic study demonstrated that TINCR can interact with BRAF to facilitate its kinase activity, thereby leading to activation of oncogenic mitogen-activated protein kinase (MAPK) pathway.
Affiliation: Department of Cardiothoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China; Department of Cardiothoracic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China. Department of Cardiothoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. Electronic address: hejk_sh@sina.com. .
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4: Title: TINCR suppresses proliferation and invasion through regulating miR-544a/FBXW7 axis in lung cancer.
Authors: Liu, Xiaochun, et.al. .
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother), Vol. 99, 2018 .
Snippet: We further validated that miR-544a facilitated proliferation and invasion, and miR-544a could reverse TINCR-mediated anti-proliferation and anti-invasion effect in lung cancer cells.
Affiliation: Department of Respiratory, Huaihe Hospital of Henan University, Kaifeng, 475000, China. College of Nursing and Health Care, Henan University, Jinming Campus, Kaifeng, 475004, China. Electronic address: liligracely@163.com. .
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5: Title: The long noncoding RNA, TINCR, functions as a competing endogenous RNA to regulate PDK1 expression by sponging miR-375 in gastric cancer.
Authors: Chen, Zhaoliang, et.al. .
Journal: OncoTargets and therapy (Onco Targets Ther), Vol. 10, 2017 .
Snippet: CONCLUSION: The long noncoding RNA TINCR functions as a competing endogenous RNA to regulate PDK1 expression by sponging miR-375 in GC.
Affiliation: Department of Oncology, Binzhou Central Hospital, Binzhou, Shandong. Department of Hematology, Zhongda Hospital, Southeast University, Nanjing, China. .
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6: Title: Oncogenic long noncoding RNA landscape in breast cancer.
Authors: Xu, Shouping, et.al. .
Journal: Molecular cancer (Mol Cancer), Vol. 16 (1): 129, 2017 .
Snippet: Finally, the knockdown of TINCR, DSCAM-AS1 or HOTAIR inhibited breast cancer cell proliferation, increased apoptosis and inhibited cell cycle progression in vitro.
Affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, 150081, China. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China. Department of Breast Surgery, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, 150081, China. pangda@ems.hrbmu.edu.cn. Heilongjiang Academy of Medical Sciences, 157 Baojian Road, Harbin, 150086, China. pangda@ems.hrbmu.edu.cn. .
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7: Title: Long non-coding RNA C5orf66-AS1 is downregulated in pituitary null cell adenomas and is associated with their invasiveness.
Authors: Yu, Guoqiang, et.al. .
Journal: Oncology reports (Oncol Rep), Vol. 38 (2): 1140-1148, 2017 .
Snippet: We performed this study to determine the roles of C5orf66-AS1, NORAD, and TINCR in the pathogenesis and invasion of pituitary null cell adenomas.
Affiliation: Medical Center, Tsinghua University, Haidian, Beijing 100084, P.R. China. Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, P.R. China. Genome Wisdom Inc., Haidian, Beijing 100195, P.R. China. .
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8: Title: Computational prediction of lncRNA-mRNA interactionsby integrating tissue specificity in human transcriptome.
Authors: Iwakiri, Junichi, et.al. .
Journal: Biology direct (Biol Direct), Vol. 12 (1): 15, 2017 .
Snippet: Our predicted lncRNA-mRNA interactions were evaluated by comparisons with experimentally validated lncRNA-mRNA interactions (between the TINCR lncRNA and mRNAs), showing the improvement of prediction accuracy over previous prediction methods that did not account for tissue specificities of lncRNAs and mRNAs.
Affiliation: Graduate School of Frontier Sciences, University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba, 277-8562, Japan. iwakiri@cb.k.u-tokyo.ac.jp. INTEC Inc, 1-1-25 Shin-urashima-cho, Kanagawa-ku, Yokohama, Kanagawa, 221-8520, Japan. Department of Electrical Engineering and Bioscience, Faculty of Science and Engineering, Waseda University, 55N-06-10, 3-4-1, Okubo Shinjuku-ku Tokyo, 169-8555, Japan. Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), 2-41-6 Aomi, Koto-ku, Tokyo, 135-0064, Japan. AIST-Waseda University Computational Bio Big-Data Open Innovation Laboratory (CBBD-OIL), 3-4-1, Okubo Shinjuku-ku, Tokyo, 169-8555, Japan. Institute for Medical-oriented Structural Biology, Waseda University, 2-2, Wakamatsu-cho Shinjuku-ku, Tokyo, 162-8480, Japan. Graduate School of Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan. .
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9: Title: E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis.
Authors: Xu, Tong-Peng, et.al. .
Journal: Cell death & disease (Cell Death Dis), Vol. 8 (6): e2837, 2017 .
Snippet: Together, our findings suggest that E2F1/TINCR/STAU1/CDKN2B signaling axis contributes to the oncogenic potential of GC and may constitute a potential therapeutic target in this disease.
Affiliation: Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China. Department of Pathology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, P.R. China. State Key Laboratory of Microbial Metabolism, and School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, P.R. China. Department of Oncology, Jining No.1 People's Hospital, Jining City, China. Department of Medical Oncology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an City, P.R. China. Department of Medical Laboratory, Nanjing Chest Hospital, Nanjing, P.R. China. Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, P.R. China. .
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10: Title: LncRNA TINCR attenuates cardiac hypertrophy by epigenetically silencing CaMKII.
Authors: Shao, Mingjing, et.al. .
Journal: Oncotarget, Vol. 8 (29): 47565-47573, 2017 .
Snippet: Angiotensin II (Ang-II) was found to be associated with reduced TINCR expression and increased hypertrophy in cultured neonatal cardiomyocytes.
Affiliation: National Integrated Traditional and Western Medicine Center for Cardivascular Disease, China-Japan Friendship Hospital, Beijing, China. Department of Psychological Medicine, Wenzhou Seventh People's Hospital, Wenzhou, China. Department of Rehabilitation, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. Department of Psychological Medicine, Tianjin Anning Hospital, Tianjin, China. Department of Psychological Medicine, Tianjin Anding Hospital, Tianjin, China. Department of Psychological Medicine, Beijing Shijian Integrated Medicine Science Institute, Beijing, China. Department of Psychological Medicine, Chinese Land Force General Hospital, Beijing, China. Department of Psychological Medicine, Chinese People's Liberation Army General Hospital, Beijing, China. Department of Psychological Medicine, Chinese People's Liberation Army, Medical School, Beijing, China. .
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11: Title: TINCR expression is associated with unfavorable prognosis in patients with hepatocellular carcinoma.
Authors: Tian, Feng, et.al. .
Journal: Bioscience reports (Biosci Rep), Vol. 37 (4), 2017 .
Snippet: miR-137/miR-133a-TINCR pathway may serve as a promising target for tumor recurrence and prognosis of patients with HCC.
Affiliation: Department of Gastroenterology, Yishui Central Hospital of Linyi City, Yishui 276400, Shandong Province, P.R. China. Department of Gastroenterology, Yishui Central Hospital of Linyi City, Yishui 276400, Shandong Province, P.R. China yun_mmy@163.com. .
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12: Title: Genetic variation of long non-coding RNA TINCR contribute to the susceptibility and progression of colorectal cancer.
Authors: Zheng, Yongbin, et.al. .
Journal: Oncotarget, Vol. 8 (20): 33536-33543, 2017 .
Snippet: Herein, we explored effect of genetic variants of Tissue differentiation-inducing non-protein coding RNA (TINCR), a key lncRNA required for somatic tissue differentiation and tumor progression, on risk and progression of CRC.
Affiliation: Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, PR China. .
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13: Title: Research Techniques Made Simple: Identification and Characterization of Long Noncoding RNA in Dermatological Research.
Authors: Antonini, Dario, et.al. .
Journal: The Journal of investigative dermatology (J Invest Dermatol), Vol. 137 (3): e21-e26, 2017 .
Snippet: As with protein-coding RNA transcripts, lncRNAs are differentially regulated in disease, and can serve as novel biomarkers for the diagnosis and prognosis of skin diseases.
Affiliation: IRCSS SDN, Napoli, Italy. CEINGE Biotecnologie Avanzate, Center for Genetic Engineering, Napoli, Italy. CEINGE Biotecnologie Avanzate, Center for Genetic Engineering, Napoli, Italy; Department of Biology, University of Naples Federico II, Napoli, Italy. Electronic address: missero@ceinge.unina.it. .
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14: Title: Host genetic variation in mucosal immunity pathways influences the upper airway microbiome.
Authors: Igartua, Catherine, et.al. .
Journal: Microbiome, Vol. 5 (1): 16, 2017 .
Snippet: The most significant association was between the RA of Dermacoccus (phylum Actinobacteria) and a variant 8 kb upstream of TINCR (rs117042385; p = 1.61 × 10(-8); q = 0.002), a long non-coding RNA that binds to peptidoglycan recognition protein 3 (PGLYRP3) mRNA, a gene encoding a known antimicrobial protein.
Affiliation: Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA. cigartua@uchicago.edu. Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA. Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, 14853, USA. Department of Medicine, University of Chicago, Chicago, IL, 60637, USA. Department of Statistics, University of Chicago, Chicago, IL, 60637, USA. Section of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Chicago, Chicago, IL, 60637, USA. Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA. c-ober@bsd.uchicago.edu. .
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15: Title: Genome-Wide lncRNA Microarray Profiling Identifies Novel Circulating lncRNAs for Detection of Gastric Cancer.
Authors: Zhang, Kecheng, et.al. .
Journal: Theranostics, Vol. 7 (1): 213-227, 2017 .
Snippet: As a result, we identified five novel plasma lncRNAs (TINCR, CCAT2, AOC4P, BANCR and LINC00857), which, when combined in the lncRNA-based Index I, outperformed the CEA-based Index II (P < 0.001) and could distinguish GC patients from healthy controls with an area under the receiver-operating curve (AUC) of 0.91 (95% confidence interval (CI): 0.88-0.95).
Affiliation: Department of General Surgery & Institute of General Surgery, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing 100853, P.R. China. Department of General Surgery, General Hospital of Armed Police Force, Yongding Road 69, Beijing 100039, P.R. China. .
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16: Title: Tag SNPs of long non-coding RNA TINCR affect the genetic susceptibility to gastric cancer in a Chinese population.
Authors: Ma, Xiang, et.al. .
Journal: Oncotarget, Vol. 7 (52): 87114-87123, 2016 .
Snippet: These results suggest that long non-coding RNA TINCR polymorphisms may be implicated in GC development.
Affiliation: Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Jiangsu Province Academy of Clinical Medicine, Institute of Tumor Biology, Nanjing, China. Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. .
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17: Title: ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma.
Authors: Hazawa, M, et.al. .
Journal: Oncogene, Vol. 36 (16): 2243-2254, 2017 .
Snippet: Notably, ZNF750 promoted the expression of a long non-coding RNA (TINCR), which mediated both cancer-inhibition and differentiation-induction effects of ZNF750.
Affiliation: Cancer Science Institute of Singapore, National University of Singapore, Singapore. Cell-Bionomics Research Unit, Innovative Integrated Bio-Research Core, Institute for Frontier Science Initiative, Kanazawa University, Kanazawa, Japan. Division of Hematology/Oncology, Cedars-Sinai Medical Center, University of California, Los Angeles School of Medicine, Los Angeles, California, USA. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, National University of Singapore, Singapore. National University Cancer Institute, National University Health System and National University of Singapore, Singapore. .
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18: Title: Theophylline controllable RNAi-based genetic switches regulate expression of lncRNA TINCR and malignant phenotypes in bladder cancer cells.
Authors: Chen, Zhicong, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 6, 2016 .
Snippet: Silencing TINCR expression inhibited cell proliferation and promoted apoptosis in vitro, indicating that TINCR may be the potential therapeutic target for treating bladder urothelial carcinoma.
Affiliation: Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518039, Guangdong Province, People's Republic of China. Shantou University Medical College, Shantou 515041, Guangdong Province, People's Republic of China. Anhui Medical University, Hefei 230601, Anhui Province, People's Republic of China. Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai 200000, Shanghai, China. Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Centre, Beijing, 100034, China. .
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19: Title: Genetic Relationship between Schizophrenia and Nicotine Dependence.
Authors: Chen, Jingchun, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 6, 2016 .
Snippet: Based on this shared liability, we identified multiple long non-coding RNAs and RNA binding protein genes (DA376252, BX089737, LOC101927273, LINC01029, LOC101928622, HY157071, DA902558, RBFOX1 and TINCR), protein modification genes (MANBA, UBE2D3, and RANGAP1) and energy production genes (XYLB, MTRF1 and ENOX1) that were associated with both conditions.
Affiliation: Nevada Institute of Personalized Medicine, University of Nevada at Las Vegas, 4505 S. Maryland Parkway, Las Vegas, NV 89154, USA. Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E. Leigh Street, Richmond, VA 23298, USA. Department of Psychiatry Virginia, Commonwealth University, 800 E. Leigh Street, Richmond, VA 23298, USA. Departments of Biomedical Informatics and Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37203, USA. Department of Psychiatry, University of Pennsylvania Perelman School of Medicine and VISN4 MIRECC, Philadelphia VA Medical Center, Philadelphia, PA, USA. Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, and VA CT Healthcare Center, New Haven, CT 06516, USA. Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA. Department of Biological Psychology, VU University, Amsterdam, Netherlands. Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands. Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada. MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands. Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands. University of Helsinki, Department of Public Health, P.O.Box 41 (Mannerheimintie 172), 00014 Helsinki, Finland. National Institute for Health and Welfare, Department of Mental Health and Substance Abuse Services, P.O. Box 30 (Mannerheimintie 166), 00300 Helsinki, Finland. University of Helsinki, Institute for Molecular Medicine, P.O. Box 20 (Tukholmankatu 8), 00014 Helsinki, Finland. UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, University of Bristol, Bristol, UK. Department of Psychology, University of Nevada, Las Vegas, 4505 S. Maryland Parkway, Las Vegas, NV 89154, USA. .
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20: Title: Epidermal differentiation gene regulatory networks controlled by MAF and MAFB.
Authors: Labott, Andrew T, et.al. .
Journal: Cell cycle (Georgetown, Tex.) (Cell Cycle), Vol. 15 (11): 1405-9, 2016 .
Snippet: Lopez-Pajares and collaborators integrated 42 published regulator gene sets and the MAF:MAFB gene set into the dynamic differentiation gene expression landscape and found that lncRNAs TINCR and ANCR act as upstream regulators of MAF:MAFB.
Affiliation: a Program in Epithelial Biology, Stanford University , Stanford , CA , USA. .
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