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20 documents found
1: Title: The major miR-31 target genes STK40 and LATS2 and their implications in the regulation of keratinocyte growth and hair differentiation.
Authors: Luan, Liming, et.al. .
Journal: Experimental dermatology (Exp Dermatol), Vol. 26 (6): 497-504, 2017 .
Snippet: LATS2 can regulate growth of keratinocytes and we have identified a function of STK40 that can promote the expression of key hair follicle programme regulators such as HR, DLX3 and HOXC13.
Affiliation: Division of Dermatology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA. State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China. Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA. .
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2: Title: Deletion of Stk40 impairs definitive erythropoiesis in the mouse fetal liver.
Authors: Wang, Lina, et.al. .
Journal: Cell death & disease (Cell Death Dis), Vol. 8 (3): e2722, 2017 .
Snippet: The serine threonine kinase Stk40 has been shown to involve in mouse embryonic stem cell differentiation, pulmonary maturation and adipocyte differentiation.
Affiliation: Laboratory of Molecular Developmental Biology, Shanghai JiaoTong University School of Medicine, Shanghai 200025, China. State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China. Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Tianjin, China. Key Laboratory of Stem Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Health Science, Chinese Academy of Sciences, Shanghai 200032, China. Department of Stem Cell & Regenerative Medicine, Peking Union Medical College, Tianjin, China. .
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3: Title: STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.
Authors: Durzynska, Izabela, et.al. .
Journal: Structure (London, England : 1993) (Structure), Vol. 25 (2): 287-294, 2017 .
Snippet: The structure, together with ATP-binding assay results, show that STK40 is a pseudokinase, in which substitutions of conserved residues within the kinase domain prevent ATP binding.
Affiliation: Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA. Electronic address: suljon@partners.org. Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA. Electronic address: stephen_blacklow@hms.harvard.edu. .
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4: Title: microRNA-130a Promotes Human Keratinocyte Viability and Migration and Inhibits Apoptosis Through Direct Regulation of STK40-Mediated NF-κB Pathway and Indirect Regulation of SOX9-Meditated JNK/MAPK Pathway: A Potential Role in Psoriasis.
Authors: Xiong, Ying, et.al. .
Journal: DNA and cell biology (Dna Cell Biol), Vol. 36 (3): 219-226, 2017 .
Snippet: MiR-130a regulates human keratinocyte HaCaT viability, migration and apoptosis might be by direct regulation of STK40-mediated NF-κB pathway and by indirect regulation of SOX9-mediated downstream JNK/MAPK signaling pathway.
Affiliation: Department of Dermatology, Linyi People's Hospital , Linyi, China . .
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5: Title: Serine/Threonine Kinase 40 (Stk40) Functions as a Novel Regulator of Skeletal Muscle Differentiation.
Authors: He, Ke, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 292 (1): 351-360, 2017 .
Snippet: Here we report the identification of serine/threonine kinase 40 (Stk40) as a novel positive regulator of skeletal myoblast differentiation in culture and fetal skeletal muscle formation in vivo We show that the expression level of Stk40 increases during skeletal muscle differentiation.
Affiliation: From the Laboratory of Molecular Developmental Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China. the Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200032, China. From the Laboratory of Molecular Developmental Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China, yjin@sibs.ac.cn. the Key Laboratory of Stem Cell Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Institute of Health Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China, and. .
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6: Title: MicroRNA dysregulation and esophageal cancer development depend on the extent of zinc dietary deficiency.
Authors: Fong, Louise Y, et.al. .
Journal: Oncotarget, Vol. 7 (10): 10723-38, 2016 .
Snippet: Additionally, Fbxw7, Pdcd4, and Stk40 (tumor-suppressor targets of miR-223, -21, and -31) were downregulated in marked-ZD cohort.
Affiliation: Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA. Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA. Animal Medicine, Production and Health Department, University of Padua, Padua, Italy. Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA. .
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7: Title: The Prediction of the Expected Current Selection Coefficient of Single Nucleotide Polymorphism Associated with Holstein Milk Yield, Fat and Protein Contents.
Authors: Lee, Young-Sup, et.al. .
Journal: Asian-Australasian journal of animal sciences (Asian Austral J Anim), Vol. 29 (1): 36-42, 2016 .
Snippet: They are phosphodiesterase 4B (PDE4B), serine/threonine kinase 40 (STK40), collagen, type XI, alpha 1 (COL11A1), ephrin-A1 (EFNA1), netrin 4 (NTN4), neuron specific gene family member 1 (NSG1), estrogen receptor 1 (ESR1), neurexin 3 (NRXN3), spectrin, beta, non-erythrocytic 1 (SPTBN1), ADP-ribosylation factor interacting protein 1 (ARFIP1), mutL homolog 1 (MLH1), transmembrane channel-like 7 (TMC7), carboxypeptidase X, member 2 (CPXM2) and ADAM metallopeptidase domain 12 (ADAM12).
Affiliation: Department of Natural Science, Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 151-747, Korea. Department of Agricultural Biotechnology, Animal Biotechnology, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Korea . National Livestock Research Institute, Cheonan 330-801, Korea . Genomic Informatics Center, Hankyong National University, Anseong 456-749, Korea . Department of Natural Science, Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 151-747, Korea ; Department of Agricultural Biotechnology, Animal Biotechnology, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Korea . .
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8: Title: MicroRNA-31 is a positive modulator of endothelial-mesenchymal transition and associated secretory phenotype induced by TGF-β.
Authors: Katsura, Akihiro, et.al. .
Journal: Genes to cells : devoted to molecular & cellular mechanisms (Genes Cells), Vol. 21 (1): 99-116, 2016 .
Snippet: Interestingly, TGF-β induces alternative polyadenylation (APA)-coupled miR-31-dependent Stk40 suppression without concomitant miR-31 induction, and APA-mediated exclusion of internal poly(A) sequence in Stk40 3'UTR enhances target efficiency of Stk40.
Affiliation: Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. Department of Anesthesiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, 76-417, Cambridge, MA, 02139, USA. Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji-city, Tokyo, 192-0392, Japan. .
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9: Title: Repression of Esophageal Neoplasia and Inflammatory Signaling by Anti-miR-31 Delivery In Vivo.
Authors: Taccioli, Cristian, et.al. .
Journal: Journal of the National Cancer Institute (J Natl Cancer Inst), Vol. 107 (11), 2015 .
Snippet: At the same time, the miR-31 target Stk40 was derepressed, thereby inhibiting the STK40-NF-κΒ-controlled inflammatory pathway, with resultant decreased cellular proliferation and activated apoptosis (caspase 3/7 activities, fold change = 10.7,
Affiliation: Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH (CT, MG, GDL, HA, PF, JM, CMC); Kimmel Cancer Center (HC, YJ, KJS, LYF) and Department of Pathology, Anatomy, and Cell Biology (YJ, JLF, LYF), Thomas Jefferson University, Philadelphia, PA; Center for Genome Research (CT, GMT), Department of Life Sciences (TS), University of Modena and Reggio Emilia, Modena, Italy (CT, GMT); Transcriptional Networks in Lung Cancer Group, Manchester Institute, University of Manchester, UK (MG, SN). Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH (CT, MG, GDL, HA, PF, JM, CMC); Kimmel Cancer Center (HC, YJ, KJS, LYF) and Department of Pathology, Anatomy, and Cell Biology (YJ, JLF, LYF), Thomas Jefferson University, Philadelphia, PA; Center for Genome Research (CT, GMT), Department of Life Sciences (TS), University of Modena and Reggio Emilia, Modena, Italy (CT, GMT); Transcriptional Networks in Lung Cancer Group, Manchester Institute, University of Manchester, UK (MG, SN). carlo.croce@osumc.edu louise.fong@jefferson.edu. .
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10: Title: Cardiac protein kinases: the cardiomyocyte kinome and differential kinase expression in human failing hearts.
Authors: Fuller, Stephen J, et.al. .
Journal: Cardiovascular research (Cardiovasc Res), Vol. 108 (1): 87-98, 2015 .
Snippet: MAP2K1, IRAK1, STK40) in human failing hearts.
Affiliation: School of Biological Sciences, University of Reading, Whiteknights Campus, Reading, Berkshire RG6 6AS, UK. Institut de Cardiologie de Montréal Centre de Recherche, Montréal, QC, Canada H1T 1C8 Département de Biochimie, Université de Montréal, Montréal, QC, Canada H3T 1J4. Institut de Cardiologie de Montréal Centre de Recherche, Montréal, QC, Canada H1T 1C8 Département de Biochimie, Université de Montréal, Montréal, QC, Canada H3T 1J4 Département de Médecine, Université de Montréal, Montréal, QC, Canada H3T 1J4. School of Biological Sciences, University of Reading, Whiteknights Campus, Reading, Berkshire RG6 6AS, UK a.clerk@reading.ac.uk. .
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11: Title: A New Genomewide Association Meta-Analysis of Alcohol Dependence.
Authors: Zuo, Lingjun, et.al. .
Journal: Alcoholism, clinical and experimental research (Alcohol Clin Exp Res), Vol. 39 (8): 1388-95, 2015 .
Snippet: They included 6 at SERINC2 (3.1 × 10(-8) ≤ p ≤ 9.6 × 10(-8) ), 1 at STK40 (p = 1.3 × 10(-7) ), 2 at KIAA0040 (3.3 × 10(-7) ≤ p ≤ 5.2 × 10(-7) ), and 1 at IPO11 (p = 6.9 × 10(-7) ).
Affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut. Biological Psychiatry Research Center , Beijing Huilongguan Hospital, Beijing, China. Menninger Department of Psychiatry and Behavioral Sciences , Baylor College of Medicine, Houston, Texas. Department of Neurology , First People's Hospital, Shanghai Jiaotong University, Shanghai, China. Department of Pharmacology , University of Colorado School of Medicine, Aurora, Colorado. Department of Neurosurgery , Renji Hospital, Shanghai Jiaotong University, Shanghai, China. .
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12: Title: Stk40 represses adipogenesis through translational control of CCAAT/enhancer-binding proteins.
Authors: Yu, Hongyao, et.al. .
Journal: Journal of cell science (J Cell Sci), Vol. 128 (15): 2881-90, 2015 .
Snippet: Genetic knockout (KO) or knockdown (KD) of Stk40 leads to increased protein levels of C/EBP proteins and adipocyte differentiation in mouse embryonic fibroblasts (MEFs), fetal liver stromal cells, and mesenchymal stem cells (MSCs).
Affiliation: Laboratory of Molecular Developmental Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China. Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China. Laboratory of Molecular Developmental Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China yjin@sibs.ac.cn. .
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13: Title: Tumor suppression by miR-31 in esophageal carcinoma is p21-dependent.
Authors: Ning, Zhifeng, et.al. .
Journal: Genes & cancer (Genes Cancer), Vol. 5 (11-12): 436-44, 2014 .
Snippet: In patient ESCC specimens, real-time RT-PCR analysis revealed that expression of E2F2 and STK40, two known miR-31 target oncogenes, was negatively correlated with the expression of miR-31 in a p21-dependent manner, supporting the conclusion that miR-31 only downregulates its target oncogenes when p21 levels are low.
Affiliation: Laboratory for Translational Oncology basic medicine college, Hubei University of Science and Technology, Xianning, Hubei province, China ; Department of Biotherapy and Gastrointestinal Medical Oncology, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China ; Cancer Research Center, Shantou University Medical College, Shantou, Guangdong, China. Department of Surgery, Davis Heart and Lung Research Institute, the Ohio State University Wexner Medical Center, Columbus, OH, USA. Department of Biotherapy and Gastrointestinal Medical Oncology, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China ; Cancer Research Center, Shantou University Medical College, Shantou, Guangdong, China. Department of Cell Biology, Shantou University Medical College, Shantou, Guangdong, China. Department of Thoracic Surgery, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China. Department of Biochemistry, Shantou University Medical College, Shantou, Guangdong, China. Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA. Department of Biotherapy and Gastrointestinal Medical Oncology, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China ; Tumor Tissue Bank, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China ; Cancer Research Center, Shantou University Medical College, Shantou, Guangdong, China. .
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14: Title: Analysis of transcription factor Stk40 expression and function during mouse pre-implantation embryonic development.
Authors: Zhang, Junqiang, et.al. .
Journal: Molecular medicine reports (Mol Med Report), Vol. 9 (2): 535-40, 2014 .
Snippet: Serine/threonine protein kinase 40 (Stk40) is a member of the serine/threonine kinase family.
Affiliation: Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210046, P.R. China. Department of Reproduction, Nanjing Maternity and Child Health Care Hospital, Affiliated to Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu 210004, P.R. China. Key Laboratory of Model Animals for Disease Study of Ministry of Education, Model Animal Research Centre, Nanjing University, Nanjing, Jiangsu 210093, P.R. China. .
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15: Title: Deletion of STK40 protein in mice causes respiratory failure and death at birth.
Authors: Yu, Hongyao, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 288 (8): 5342-52, 2013 .
Snippet: Consistently, Stk40 deficiency attenuates the ERK/MAPK activation, and inhibition of ERK/MAPK activities reduces surfactant protein gene expression in lung epithelial cells.
Affiliation: Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai JiaoTong University School of Medicine, 225 South Chongqing Road, Shanghai 200025, China. .
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16: Title: MicroRNA-31 is overexpressed in psoriasis and modulates inflammatory cytokine and chemokine production in keratinocytes via targeting serine/threonine kinase 40.
Authors: Xu, Ning, et.al. .
Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol), Vol. 190 (2): 678-88, 2013 .
Snippet: Among these genes, we identified serine/threonine kinase 40 (STK40), a negative regulator of NF-κB signaling, as a direct target for miR-31.
Affiliation: Molecular Dermatology Research Group, Unit of Dermatology and Venereology, Department of Medicine, Karolinska Institute, SE-17176 Stockholm, Sweden. ning.xu@ki.se .
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17: Title: Identification of biomarkers of human skin ageing in both genders. Wnt signalling - a label of skin ageing?
Authors: Makrantonaki, Evgenia, et.al. .
Journal: PloS one, Vol. 7 (11): e50393, 2012 .
Snippet: Only 4 overlapping genes (OR52N2, F6FR1OP2, TUBAL3 and STK40) showed differential regulation with age.
Affiliation: Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany. .
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18: Title: Genetic analysis of 16 NMR-lipoprotein fractions in humans, the GOLDN study.
Authors: Kraja, Aldi T, et.al. .
Journal: Lipids, Vol. 48 (2): 155-65, 2013 .
Snippet: Five proxy genes, (ACOXL, FAM84B, NXPH1, STK40 and VAPA) showed pleiotropic effects.
Affiliation: Division of Statistical Genomics, Washington University School of Medicine, 4444 Forest Park Ave, Campus Box 8506, St. Louis, MO 63108, USA. aldi@wustl.edu .
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19: Title: Octamer-binding factor 6 (Oct-6/Pou3f1) is induced by interferon and contributes to dsRNA-mediated transcriptional responses.
Authors: Hofmann, Elisabeth, et.al. .
Journal: BMC cell biology (Bmc Cell Biol), Vol. 11, 2010 .
Snippet: Using microarray and RT-qPCR, we furthermore show that Oct-6 is involved in the regulation of transcriptional responses to dsRNA, in particular in the gene regulation of serine/threonine protein kinase 40 (Stk40) and U7 snRNA-associated Sm-like protein Lsm10 (Lsm10).
Affiliation: Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria. .
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20: Title: Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation.
Authors: Li, Lingjie, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 107 (4): 1402-7, 2010 .
Snippet: Here, we report identification of a target gene of Oct4, serine/threonine kinase 40 (Stk40), which is able to activate the Erk/MAPK pathway and induce extraembryonic-endoderm (ExEn) differentiation in mouse ESCs.
Affiliation: Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai JiaoTong University School of Medicine, Shanghai 200025, China. .
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