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593 documents found
1: Title: Potent SGLT1/2 Dual Inhibition Improves Glycemic Control Without Marked Gastrointestinal Adaptation or Colonic Microbiota Changes in Rodents.
Authors: Du, Fuyong, et.al. .
Journal: The Journal of pharmacology and experimental therapeutics (J Pharmacol Exp Ther), 2018 .
Snippet: Therefore, this was evaluated in slc5a1-/- mice or using a potent dual inhibitor (cmpd 8; SGLT1 Ki = 1.5±0.5nM 100 fold > potency than phlorizin; SGLT2 Ki = 0.4±0.2
Affiliation: CVM Janssen R&D LLC. Janssen R&D LLC. Baylor College of Medicine. Janssen R&D LLC; phornby@its.jnj.com. .
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2: Title: Effects of Preovulatory Estradiol on Uterine Environment and Conceptus Survival from Fertilization to Maternal Recognition of Pregnancy.
Authors: Northrop, Emmalee J, et.al. .
Journal: Biology of reproduction (Biol Reprod), 2018 .
Snippet: Animals with elevated preovulatory estradiol had greater endometrial abundance of SLC2A1 (P = 0.05) and SLC5A1 (P = 0.04) in both INCAR and CAR tissue.
Affiliation: Department of Animal Science, South Dakota State University, Brookings SD. USDA, ARS, Roman L. Hruska US Meat Animal Research Center, Clay Center NE. Animal Science Department, Federal University of Santa Maria, Santa Maria, RS, Brazil. Division of Animal Sciences, University of Missouri, Colombia MO. .
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3: Title: Sugar sensor genes in the murine gastrointestinal tract display a cephalocaudal axis of expression and a diurnal rhythm.
Authors: O'Brien, Patrick, et.al. .
Journal: Physiological genomics (Physiol Genomics), 2018 .
Snippet: Sweet taste receptor (tas1r2/tas1r3/gnat3/ gnat1) sugar transporter (slc5a1, slc2a2, slc2a5) and putative sugar sensor (slc5a4a and slc5a4b) gene expression levels were highest in tongue, proximal and distal small intestine, respectively.
Affiliation: Diabetes and Nutritional sciences, Kings college Lodon. Department of Nutritional sciences, Kings college London, United Kingdom. .
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4: Title: Transcriptional changes detected in fecal RNA of neonatal dairy calves undergoing a mild diarrhea are associated with inflammatory biomarkers.
Authors: Rosa, Fernanda, et.al. .
Journal: PloS one, Vol. 13 (1): e0191599, 2018 .
Snippet: A time effect was observed for the cell membrane sodium-dependent glucose transporter SLC5A1, for the major carbohydrate facilitated transporter SLC2A2, and water transport function AQP3, where SLC5A1 and AQP3 had a negative quadratic effect over time.
Affiliation: Department of Animal and Rangeland Sciences, Oregon State University, Corvallis, Oregon, United States of America. Escuela Agrícola Panamericana El Zamorano, El Zamorano, Francisco Morazán, Honduras. Department of Dairy and Food Sciences, South Dakota State University, Brookings, South Dakota, United States of America. Istituto di Zootecnica, Facoltà di Scienze Agrarie, Alimentari e Ambientali, Università Cattolica del Sacro Cuore, Piacenza, Italy. .
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5: Title: Micromanaging the gut: unravelling the regulatory pathways that mediate the intestinal adaptive response.
Journal: Annals of the Royal College of Surgeons of England (Ann R Coll Surg Engl), 2018 .
Snippet: RNA interference and luciferase assays demonstrated that PER1 transcriptionally regulates SGLT1, linking for the first time clock genes and intestinal glucose absorption.
Affiliation: Cambridge Hepatopancreatobiliary Unit and MRC Cancer Unit, Addenbrooke's Hospital and University of Cambridge , Cambridge , UK. .
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6: Title: A family-based genome-wide association study of chronic rhinosinusitis with nasal polyps implicates several genes in the disease pathogenesis.
Authors: Bohman, Anton, et.al. .
Journal: PloS one, Vol. 12 (12): e0185244, 2017 .
Snippet: Comparisons with data from expression quantitative trait loci showed the most skewed allelic distributions in cases with chronic rhinosinusitis with nasal polyps compared with controls for the genes HLCS, HLA-DRA, BICD2, VSIR and SLC5A1.
Affiliation: Department of Otorhinolaryngology, Uppsala University Hospital, Uppsala, Sweden. Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Department of Otorhinolaryngology, Skaraborg Hospital, Skövde, Sweden. Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. .
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7: Title: Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations.
Authors: Andersson, Emma R, et.al. .
Journal: Gastroenterology, 2017 .
Snippet: Whole-transcriptome sequence analyses of liver tissues from mice and patients with Alagille syndrome identified dysregulated genes encoding proteins enriched at the apical side of cholangiocytes, including CFTR and SLC5A1, as well as reduced expression of IGF1.
Affiliation: Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden;; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden;. Electronic address: emma.andersson@ki.se. Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden;; Ludwig Institute for Cancer Research, Karolinska Institutet, Stockholm, Sweden; Current affiliation: Integrated Cardio Metabolic Centre (ICMC), Karolinska Institutet, Huddinge, Sweden. Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden;; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden;; Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic. Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden. Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden. Rheumatology Unit, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México City, México. Karolinska University Hospital, CLINTEC, Karolinska Institutet, Stockholm, Sweden. Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic. Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht, Netherlands;; Present address: The Wellcome Trust/CRUK Gurdon Institute, Tennis Court Road, CB2, 1QN, Cambridge, UK. Karolinska University Hospital, Department of Pediatrics, CLINTEC, Karolinska Institutet, Stockholm, Sweden. Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht, Netherlands. Ludwig Institute for Cancer Research, Karolinska Institutet, Stockholm, Sweden. Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden;. Electronic address: urban.lendahl@ki.se. .
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8: Title: Genetic determinants of circulating GIP and GLP-1 concentrations.
Authors: Almgren, Peter, et.al. .
Journal: JCI insight, Vol. 2 (21), 2017 .
Snippet: We identified 6 genome-wide significant functional loci associated with plasma incretin concentrations in or near the SLC5A1 (encoding SGLT1), GIPR, ABO, GLP2R, F13A1, and HOXD1 genes and studied the effect of these variants on mRNA expression in pancreatic islet and on metabolic phenotypes.
Affiliation: Lund University Diabetes Centre, Department of Clinical Sciences, Malmö, Lund University, Skåne University Hospital, Malmö, Sweden. Endocrinology, Abdominal Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Diabetes and Obesity Research Program, University of Helsinki and Folkhälsan Research Center, Helsinki, Finland. Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland. Novo Nordisk Foundation Center for Basic Metabolic Research and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. Clinical Research Unit Medicine, Department of Internal Medicine, and Department of Clinical Sciences, Malmö, Lund University, Skåne University Hospital, Malmö, Sweden. .
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9: Title: Comparative study of expression and activity of glucose transporters between stem cell-derived brain microvascular endothelial cells and hCMEC/D3 cells.
Journal: American journal of physiology. Cell physiology (Am J Physiol Cell Physiol), Vol. 313 (4): C421-C429, 2017 .
Snippet: In this study, we investigated the expression of glucose transporters and glucose diffusion across brain microvascular endothelial cells (BMECs) derived from healthy patient-derived induced pluripotent stem cells (iPSCs).
Affiliation: Texas Tech University Health Sciences Center, School of Pharmacy, Department of Pharmaceutical Sciences, Amarillo, Texas abraham.al-ahmad@ttuhsc.edu. .
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10: Title: Loss of Endometrial Sodium Glucose Cotransporter SGLT1 is Detrimental to Embryo Survival and Fetal Growth in Pregnancy.
Authors: Salker, Madhuri S, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7 (1): 12612, 2017 .
Snippet: Ussing chamber experiments revealed electrogenic glucose transport across the endometrium in wild type (Slc5a1 (+/+)) but not in SGLT1 deficient (Slc5a1 (-/-)) mice.
Affiliation: Department of Physiology I, Eberhard-Karls Universität Tübingen, Tübingen, D-72076, Germany. msalker@gmail.com. Obstetrics, Gynecology, Eberhard-Karls Universität Tübingen, Tübingen, D-72076, Germany. msalker@gmail.com. Department of Physiology I, Eberhard-Karls Universität Tübingen, Tübingen, D-72076, Germany. Institute of Pathology and Comprehensive Cancer Centre, Eberhard-Karls Universität Tübingen, Tübingen, D-72076, Germany. Division of Biomedical Sciences, Warwick Medical School, and Tommy's National Centre for Miscarriage Research, University Hospitals Coventry and Warwickshire NHS Trust, Clifford Bridge Rd, Coventry, CV2 2DX, UK. Warwick Systems Biology Centre, University of Warwick, Coventry, CV4 7AL, UK. Obstetrics, Gynecology, Eberhard-Karls Universität Tübingen, Tübingen, D-72076, Germany. Molecular Toxicology Unit, Institute for Medical Research and Occupational Health, 10000, Zagreb, Croatia. Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Würzburg, D-97082, Germany. Department of Physiology I, Eberhard-Karls Universität Tübingen, Tübingen, D-72076, Germany. florian.lang@uni-tuebingen.de. .
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11: Title: Duodenal sodium/glucose co-transporter 1 expression under fasting conditions is associated with post-load hyperglycemia.
Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab), 2017 .
Snippet: Context: Type 2 diabetes (T2DM) is associated with a higher intestinal expression of the glucose transporters sodium/glucose co-transporter 1 (SGLT-1) and glucose transporter 2 (GLUT-2).
Affiliation: Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy. Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy. .
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12: Title: Expression profiling and immunolocalization of Na(+)-D-glucose-cotransporter 1 in mice employing knockout mice as specificity control indicate novel locations and differences between mice and rats.
Authors: Madunić, Ivana Vrhovac, et.al. .
Journal: Pflugers Archiv : European journal of physiology (Pflugers Arch), 2017 .
Snippet: The expression and localization of sodium-D-glucose cotransporter SGLT1 (SLC5A1), which is involved in small intestinal glucose absorption and renal glucose reabsorption, is of high biomedical relevance because SGLT1 inhibitors are currently tested for antidiabetic therapy.
Affiliation: Molecular Toxicology Unit, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000, Zagreb, Croatia. Department of Molecular Plant Physiology and Biophysics, University of Würzburg, Würzburg, Germany. Molecular Toxicology Unit, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000, Zagreb, Croatia. sabolic@imi.hr. .
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13: Title: EPA blocks TNF-α-induced inhibition of sugar uptake in Caco-2 cells via GPR120 and AMPK.
Authors: Castilla-Madrigal, Rosa, et.al. .
Journal: Journal of cellular physiology (J Cell Physiol), 2017 .
Snippet: The aim of the present work was to investigate in Caco-2 cells whether eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid, could block the inhibitory effect of tumor necrosis factor-α (TNF-α) on sugar transport, and identify the intracellular signaling pathways involved.
Affiliation: University of Navarra, Dept. Nutrition, Food Science and Physiology, Irunlarrea 1, 31008 Pamplona, Spain. University of Navarra, Nutrition Research Centre, Irunlarrea 1, 31008 Pamplona, Spain. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain. CIBERobn, Physiopathology of Obesity and Nutrition, Institute of Health Carlos III (ISCIII), Madrid, Spain. .
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14: Title: Clinical relevance of the selectivity of sodium-glucose cotransporter-2 inhibitors.
Authors: Morales-Olivas, Francisco J .
Journal: Medicina clinica (Med Clin (barc)), Vol. 147 Suppl 1, 2016 .
Snippet: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are able to inhibit renal SGLT2 without modifying intestinal SGLT1, whose inhibition could produce gastrointestinal adverse reactions.
Affiliation: Departamento de Farmacología, Facultad de Medicina y Odontología, Universitat de València, Valencia, España. Electronic address: sfrancisco.morales@uv.es. .
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15: Title: SLC5A1 Mutations in Saudi Arabian Patients with Congenital Glucose-Galactose Malabsorption.
Authors: Al-Suyufi, Yasir, et.al. .
Journal: Journal of pediatric gastroenterology and nutrition (J Pediatr Gastroenterol Nutr), 2017 .
Snippet: Congenital glucose-galactose malabsorption (cGGM) is a rare autosomal recessive disorder, caused by mutations in the SLC5A1 gene, encoding the sodium/glucose co-transporter 1 (SGLT1) which may result in severe life-threatening osmotic diarrhea due to the accumulation of unabsorbed sugars in the intestinal lumen.
Affiliation: *Department of Pediatric Gastroenterology, King Faisal Specialist Hospital & Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia †Department of Genetics, King Faisal Specialist Hospital & Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia. .
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16: Title: SGLT1 Deficiency Turns Listeria Infection into a Lethal Disease in Mice.
Authors: Sharma, Piyush, et.al. .
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology (Cell Physiol Biochem), Vol. 42 (4): 1358-1365, 2017 .
Snippet: Bacterial titers were determined by colony forming assay, SGLT1, TNF-α, IL-6 and IL-12a transcript levels were determined by qRT-PCR, as well as SGLT1 protein abundance and localization by immunohistochemistry. RESULTS: Genetic knockout of SGLT1 (Slc5a10-/- mice) significantly compromised bacterial clearance following Listeria monocytogenes infection with significantly enhanced bacterial load in liver, spleen, kidney and lung, and significantly augmented hepatic expression of TNF-α and IL-12a.
Affiliation: Institute of Immunology, University of Duisburg-Essen, Essen, Germany. Molecular Toxicology Unit, Institute for Medical Research and Occupational Health, Zagreb, Croatia. Department of Internal Medicine III, University of Tuebingen, Tuebingen, Germany. Institute of Anatomy and Cell Biology, University of Wuerzburg, Wuerzburg, Germany. Department of Physiology I, University of Tuebingen, Tuebingen, Germany. Department of Molecular Medicine II, Heinrich Heine University Duesseldorf, Duesseldorf, Germany. .
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17: Title: SGLT-2 Inhibitors in Heart Failure: Implications for the Kidneys.
Authors: Verbrugge, Frederik H, et.al. .
Journal: Current heart failure reports (Curr Heart Fail Rep), Vol. 14 (4): 331-337, 2017 .
Snippet: Afferent arteriolar vasoconstriction is promoted through tubulo-glomerular feedback and reduces glomerular capillary hydrostatic pressure, relieving podocyte stress and explaining renal preservation.
Affiliation: Department of Cardiology, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600, Genk, Belgium. frederik.verbrugge@zol.be. Department of Cardiology, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600, Genk, Belgium. .
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18: Title: Antidiabetic Properties of an Apple/Kale Extract In Vitro, In Situ, and in Mice Fed a Western-Type Diet.
Authors: Schloesser, Anke, et.al. .
Journal: Journal of medicinal food (J Med Food), Vol. 20 (9): 846-854, 2017 .
Snippet: Body weight, food and energy intake, body composition, and blood glucose level were recorded in addition to the postprandial rise in blood glucose concentration after a single administration of glucose (oral glucose tolerance test, OGTT).
Affiliation: 1 Institute of Human Nutrition and Food Science, University of Kiel , Kiel, Germany . 2 Animal Welfare Officer, University of Kiel , Kiel, Germany . 3 BioActive Food GmbH , Bad Segeberg, Germany . .
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19: Title: Genome-wide association study of 1,5-anhydroglucitol identifies novel genetic loci linked to glucose metabolism.
Authors: Li, Man, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7 (1): 2812, 2017 .
Snippet: Seven loci in/near EFNA1/SLC50A1, MCM6/LCT, SI, MGAM, MGAM2, SLC5A10, and SLC5A1 showed genome-wide significant associations (P < 5 × 10(-8)) among EA participants, five of which were novel.
Affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. Division of Nephrology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA. Department of Medicine, Division of General Internal Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. The Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University, Baltimore, Maryland, USA. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA. Department of Data Science, School of Population Health, University of Mississippi Medical Center, Jackson, Mississippi, USA. Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA. Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. anna.koettgen@uniklinik-freiburg.de. Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de. .
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20: Title: A 9-Day-Old With Weight Loss and Diarrhea.
Authors: Rajbhandari, Prabi, et.al. .
Journal: Pediatrics, Vol. 139 (5), 2017 .
Snippet: Laboratory data on hospital admission showed a normal complete blood cell count, but her chemistry analysis revealed significant hypernatremia, hyperkalemia, metabolic acidosis, and acute kidney injury.
Affiliation: Akron Children's Hospital, Akron, Ohio; and prajbhandari@chmca.org. Cleveland Clinic Children's, Cleveland, Ohio. .
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