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Polymorphism, Single Nucleotide 7
 
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activation of phospholipase A2 3
 
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17 documents found
1: Title: Detection of genetic variants between different Polish Landrace and Puławska pigs by means of RNA-seq analysis.
Authors: Piórkowska, K, et.al. .
Journal: Animal genetics (Anim Genet), 2018 .
Snippet: Interesting missense gene variants and mutations located in regulatory regions were found in a few genes related to fatty acid metabolism and lipid storage such as ACSL5, ALDH3A2, FADS1, SCD, PLA2G12A and ATGL.
Affiliation: Department of Animal Molecular Biology, National Research Institute of Animal Production, 32-083, Balice, Poland. Department of Cattle Breeding, National Research Institute of Animal Production, 32-083, Balice, Poland. Department of Pig Breeding, National Research Institute of Animal Production, 32-083, Balice, Poland. .
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2: Title: A genome-wide association study of growth and fatness traits in two pig populations with different genetic backgrounds.
Authors: Jiang, Y, et.al. .
Journal: Journal of animal science (J Anim Sci), Vol. 96 (3): 806-816, 2018 .
Snippet: PITX2 has a crucial role in skeletal muscle tissue development and animal organ morphogenesis, and PLA2G12A plays a role in the lipid catabolic and phospholipid catabolic processes, which both are involved in the body weight pathway.
Affiliation: National Engineering Laboratory for Animal Breeding, Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, P.R. China. Beijing Station of Animal Husbandry, Beijing, P.R. China. Beijing LM Pig Breeding Technology Co., Ltd., Beijing, P.R. China. Beijing Shunxin Agricultural Co., Ltd., Beijing, P.R. China. .
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3: Title: Association between PLA2G12A polymorphism and patients with schizophrenia in a southern Chinese Han population.
Authors: Hui, Li, et.al. .
Journal: Human psychopharmacology (Hum Psychopharmacol), Vol. 33 (2): e2654, 2018 .
Snippet: CONCLUSIONS: Our results indicated that even though PLA2G12A rs3087494 polymorphism did not influence age at onset in patients with schizophrenia, it may play an important role in the susceptibility to schizophrenia in a southern Chinese Han population.
Affiliation: Institute of Mental Health, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu, China. Kangning Hospital attached to Wenzhou Medical University, Wenzhou, Zhejiang, China. School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang, China. Institute of Mental Health, Peking University, Beijing, China. .
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4: Title: Quantitative trait locus mapping in mice identifies phospholipase Pla2g12a as novel atherosclerosis modifier.
Authors: Nicolaou, Alexandros, et.al. .
Journal: Atherosclerosis, Vol. 265, 2017 .
Snippet: RESULTS: Fine-mapping of the Chr3 locus revealed two overlapping, yet independent subloci for female atherosclerosis susceptibility: when transmitted by grandfathers to granddaughters, the B6 risk allele increased atherosclerosis and downregulated the expression of the secreted phospholipase Pla2g12a (2.6 and 2.2 fold, respectively); when inherited by grandmothers, the B6 risk allele induced vascular cell adhesion molecule 1 (Vcam1).
Affiliation: Institute of Laboratory Medicine, Ludwig Maximilians University Munich, Munich, Germany. Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany. Interdisciplinary Center for Clinical Research Leipzig (IZKF), Core-Unit DNA Technologies, University of Leipzig, Leipzig, Germany. Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland. Institute of Laboratory Medicine, Ludwig Maximilians University Munich, Munich, Germany. Electronic address: lesca.holdt@med.uni-muenchen.de. .
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5: Title: Integration of liver gene co-expression networks and eGWAs analyses highlighted candidate regulators implicated in lipid metabolism in pigs.
Authors: Ballester, Maria, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7, 2017 .
Snippet: The eGWAS identified 92 eSNPs located in seven chromosomal regions and associated with eight genes: CROT, CYP2U1, DGAT1, EGF, FABP1, FABP5, PLA2G12A, and PPARA.
Affiliation: Departament de Ciència Animal i dels Aliments, Facultat de Veterinària, Campus UAB, Bellaterra, 08193, Barcelona, Spain. Plant and Animal Genomics, Centre de Recerca en Agrigenòmica (Consorci CSIC-IRTA-UAB-UB), Edifici CRAG, Campus UAB, Bellaterra, 08193, Barcelona, Spain. IRTA, Genètica i Millora Animal, Torre Marimon, 08140 Caldes de Montbui, Spain. Génétique Animale et Biologie Intégrative, Institut National de la Recherche Agronomique, AgroParisTech, Université Paris-Saclay, 78350, Jouy-en-Josas, France. Departamento de Mejora Genética Animal, INIA, Ctra. de la Coruña km. 7, 28040, Madrid, Spain. .
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6: Title: Expression-based GWAS identifies variants, gene interactions and key regulators affecting intramuscular fatty acid content and composition in porcine meat.
Authors: Puig-Oliveras, Anna, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 6, 2016 .
Snippet: In addition, strong candidate genes regulating ACSM5, FOS, PPARA, PIK3R1, PLA2G12A and HIF1AN gene expression were also seen.
Affiliation: Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Spain. Plant and Animal Genomics, Centre de Recerca en Agrigenòmica (CRAG), 08193 Bellaterra, Spain. Departamento de Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), 28040 Madrid, Spain. Departament de Genètica i Millora Animal, Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Torre Marimon, 08140 Caldes de Montbui, Spain. .
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7: Title: The rs251684 Variant of PLA2G4C Is Associated with Autism Spectrum Disorder in the Northeast Han Chinese Population.
Authors: Liu, Shicheng, et.al. .
Journal: Genetic testing and molecular biomarkers (Genet Test Mol Biomarkers), Vol. 20 (12): 747-752, 2016 .
Snippet: AIM: To investigate the association between autism spectrum disorder (ASD) and the phospholipase A2 group IVC (PLA2G4C) and phospholipase A2 group XIIA (PLA2G12A) polymorphisms in the Northeast Han Chinese population.
Affiliation: 1 Department of Pediatrics, The First Hospital of Jilin University , Changchun, China . 2 Department of Epidemiology and Biostatistics, School of Public Health, Jilin University , Changchun, China . 3 The Key Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Cytology and Genetics, Northeast Normal University , Changchun, China . 4 The Second Department of Pediatrics, The First Hospital of Jilin University , Changchun, China . .
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8: Title: Association between PLA2G12A Polymorphisms and Schizophrenia in a Han Chinese Population from Northeast China.
Authors: Yang, Guang, et.al. .
Journal: PloS one, Vol. 11 (7): e0159584, 2016 .
Snippet: OBJECTIVE: The purpose of this study was to explore the association between single nucleotide polymorphisms (SNPs) in the phospholipase A2 (PLA2), group XIIA gene (PLA2G12A) and schizophrenia.
Affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, 1163 Xinmin Street, Changchun, 130021, Jilin province, China. Department of Hepatology, First Hospital of Jilin University, Jilin University, Changchun, Jilin, 130021, China. Department of Psychiatry, Yale University School of Medicine, New Haven, United States of America. VA Medical Center, VA Connecticut Healthcare System, West Haven, United States of America. Division of Clinical Epidemiology, First Hospital of Jilin University, Changchun, Jilin, 130021, China. .
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9: Title: Age-Related Macular Degeneration-Associated Genes in Alzheimer Disease.
Authors: Williams, Michael A, et.al. .
Journal: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry (Am J Geriatr Psychiatry), Vol. 23 (12): 1290-6, 2015 .
Snippet: MEASUREMENTS: Polymorphisms in the following genes were studied: CFH, ARMS2, C2/CFB, C3, CFI/PLA2G12a, SERPING1, TLR3, TLR4, CRP, APOE, and TOMM40.
Affiliation: Centre for Medical Education, Queen's University of Belfast, UK. Electronic address: m.williams@qub.ac.uk. Centre for Public Health, Queen's University of Belfast, UK. Centre for Experimental Medicine (GS), Queen's University of Belfast, UK. .
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10: Title: Population history and genomic signatures for high-altitude adaptation in Tibetan pigs.
Authors: Ai, Huashui, et.al. .
Journal: BMC genomics, Vol. 15, 2014 .
Snippet: These genes, such as PLA2G12A, RGCC, C9ORF3, GRIN2B, GRID1 and EPAS1, are involved in high-altitude physiology including angiogenesis, pulmonary hypertension, oxygen intake, defense response and erythropoiesis.
Affiliation: Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang 330045, P, R China. renjunjxau@hotmail.com. .
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11: Title: Investigation of Japanese-specific alleles: most are of Jomon lineage.
Authors: Yuasa, Isao, et.al. .
Journal: Legal medicine (Tokyo, Japan) (Leg Med (tokyo)), Vol. 17 (1): 52-5, 2015 .
Snippet: In this study, three single nucleotide polymorphisms (SNPs) in the GALNT11, H19, and PLA2G12A genes were analyzed in 2396 DNA samples from 25 global populations, and the derived alleles suggested that Japanese-specific alleles exist on autosomes.
Affiliation: Division of Legal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan. Electronic address: yuasai@med.tottori-u.ac.jp. Department of Forensic Medicine, Yamagata University School of Medicine, Yamagata, Japan. Department of Legal Medicine, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Chuo, Yamanashi, Japan. Department of Forensic Medicine, Fukuoka University School of Medicine, Fukuoka, Japan. Department of Legal Medicine, Iwate Medical University School of Medicine, Shiwa-gun, Iwate, Japan. Department of Legal Medicine, Faculty of Medicine, Shimane University, Izumo, Japan. Department of Legal Medicine, Kansai Medical University, Moriguchi, Japan. Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan. Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. Division of Legal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan. .
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12: Title: Gene profiling of human VEGF signaling pathways in human endothelial and retinal pigment epithelial cells after anti VEGF treatment.
Authors: Golan, Shani, et.al. .
Journal: BMC research notes (Bmc Res Notes), Vol. 7, 2014 .
Snippet: In comparison between drugs, more genes were up-regulated (NFATc2 and KDR) and more were down-regulated (Pla2g12a, Pla2g1b, Ppp3r2, Rac2) by bevacizumab than by ranibizumab.
Affiliation: Departments of Ophthalmology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, 64239, Israel. shanigol2@walla.com. .
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13: Title: Suggestive association between PLA2G12A single nucleotide polymorphism rs2285714 and response to anti-vascular endothelial growth factor therapy in patients with exudative age-related macular degeneration.
Authors: Wang, Vinson M, et.al. .
Journal: Molecular vision (Mol Vis), Vol. 18, 2012 .
Snippet: For rs2285714 (PLA2G12A), the frequency of minor allele T was 40.1% for good responders compared to 51.7% for poor responders (odds ratio: 1.60, 95% confidence interval of odds ratio: 0.87-2.94,
Affiliation: Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA. .
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14: Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin treatment alters eicosanoid levels in several organs of the mouse in an aryl hydrocarbon receptor-dependent fashion.
Authors: Bui, Peter, et.al. .
Journal: Toxicology and applied pharmacology (Toxicol Appl Pharmacol), Vol. 259 (2): 143-51, 2012 .
Snippet: TCDD increased the mRNA levels of Cyp1a1, Cyp1a2, Cyp1b1 and the Pla2g12a form of phospholipase A(2) to varying degrees in the different organs, and these increases correlated with some but not all the changes in eicosanoids levels in the organs, suggesting that other enzymes may also be involved.
Affiliation: Molecular Toxicology Program, University of California, Los Angeles, California 90095, USA. .
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15: Title: Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 mice.
Authors: Kopec, Anna K, et.al. .
Journal: Toxicology and applied pharmacology (Toxicol Appl Pharmacol), Vol. 256 (2): 154-67, 2011 .
Snippet: Statistical modeling of quantitative real-time PCR analysis of Pla2g12a, Serpinb6a, Nqo1, Srxn1, and Dysf verified non-additive expression following MIX treatment compared to TCDD and PCB153 alone.
Affiliation: Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI 48824-1319, USA. .
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16: Title: Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci.
Authors: Berg, Marianne, et.al. .
Journal: Molecular cancer (Mol Cancer), Vol. 9, 2010 .
Snippet: Seven of these genes, CLC, EIF4E, LTBP4, PLA2G12A, PPAT, RG9MTD2, and ZNF574, had significantly different mRNA expression comparing median expression levels across the transcriptome between the two groups.
Affiliation: Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, Norwegian Radium Hospital, Oslo, Norway. .
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17: Title: Distinct expression pattern of the full set of secreted phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as a biomarker candidate.
Authors: Mounier, C M, et.al. .
Journal: British journal of cancer (Brit J Cancer), Vol. 98 (3): 587-95, 2008 .
Snippet: In normal colon, PLA2G2A and PLA2G12A were expressed at high levels, PLA2G2D, PLA2G5, PLA2G10 and PLA2G12B at moderate levels, and PLA2G1B, PLA2G2F and PLA2G3 at low levels.
Affiliation: Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UNSA UMR6097, Sophia Antipolis, Valbonne, France. .
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