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12 documents found
1: Title: Identification and Expression Analysis of the Complete Family of Zebrafish pkd Genes.
Authors: England, Samantha J, et.al. .
Journal: Frontiers in cell and developmental biology (Front Cell Dev Biol), Vol. 5, 2017 .
Snippet: However, in contrast to mammals and cartilaginous and holostei fish, teleosts lack pkd2l2, and pkdrej genes, suggesting that these have been lost in the teleost lineage.
Affiliation: Department of Biology, Syracuse University Syracuse, NY, USA. .
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2: Title: Genome-wide analysis of the nucleus accumbens identifies DNA methylation signals differentiating low/binge from heavy alcohol drinking.
Authors: Cervera-Juanes, Rita, et.al. .
Journal: Alcohol (Fayetteville, N.Y.) (Alcohol), Vol. 60, 2017 .
Snippet: Two of the DMRs, linked to PDE10A and PKD2L2, were also differentially methylated in H/VHDs, suggesting an alcohol-dose independent effect.
Affiliation: Division of Neurosciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, 97006, USA. Electronic address: cerveraj@ohsu.edu. Division of Neurosciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, 97006, USA. Department of Public Health and Preventive Medicine, Oregon Health & Science University, Portland, OR, 97239, USA. .
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3: Title: Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice.
Authors: Wu, Xudong, et.al. .
Journal: PloS one, Vol. 11 (5): e0155577, 2016 .
Snippet: We then characterized mice lacking functional Trpm2, Pkd2, Pkd2l1, Pkd2l2 and Pkd1l3, using scanning electron microscopy, auditory brainstem response, permeant dye accumulation, and single-cell electrophysiology.
Affiliation: Department of Neurobiology, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts, United States of America. Department of Medicine, Division of Nephrology, University of Maryland, Baltimore, Maryland, United States of America. Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America. Department of Physiology, McGill University Montréal, Québec, Canada. .
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4: Title: Direct recording and molecular identification of the calcium channel of primary cilia.
Authors: DeCaen, Paul G, et.al. .
Journal: Nature, Vol. 504 (7479): 315-8, 2013 .
Snippet: The polycystin proteins (PC and PKD), identified in linkage studies of polycystic kidney disease, are candidate channels divided into two structural classes: 11-transmembrane proteins (PKD1, PKD1L1 and PKD1L2) remarkable for a large extracellular amino terminus of putative cell adhesion domains and a G-protein-coupled receptor proteolytic site, and the 6-transmembrane channel proteins (PKD2, PKD2L1 and PKD2L2; TRPPs).
Affiliation: 1] Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital Boston, 320 Longwood Avenue, Boston, Massachusetts 02115, USA [2]. Department of Neuroscience, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts 02111, USA. 1] Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital Boston, 320 Longwood Avenue, Boston, Massachusetts 02115, USA [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA. .
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5: Title: Molecular evolution of PKD2 gene family in mammals.
Authors: Ye, Chun, et.al. .
Journal: Genetica, Vol. 137 (1): 77-86, 2009 .
Snippet: For the paralogs, our results implied that PKD2L2 genes evolved under a weaker purifying selection constraint than PKD2 and PKD2L1 genes.
Affiliation: State Key Laboratory of Biotherapy, West China Hospital, West China Medical School and College of Life Science, Sichuan University, 610041 Chengdu, Sichuan, People's Republic of China. .
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6: Title: Expression of Pkd2l2 in testis is implicated in spermatogenesis.
Authors: Chen, Ye, et.al. .
Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull), Vol. 31 (8): 1496-500, 2008 .
Snippet: Immunohistochemical analysis revealed that Pkd2l2 encoded a protein, polycystin-L2, which was predominantly detectable in the plasma membrane of spermatocytes and round spermatids, as well as in the head and tail of elongating spermatids within seminiferous tubules in mouse testis tissue sections of postnatal day 14 and adult mice.
Affiliation: Core Facility of Gene Engineered Mice, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Sichuan, China. .
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7: Title: Functional characterization of PKDREJ, a male germ cell-restricted polycystin.
Authors: Sutton, Keith A, et.al. .
Journal: Journal of cellular physiology (J Cell Physiol), Vol. 209 (2): 493-500, 2006 .
Snippet: These interactions, as well as polycystin-2 association with TRPC channels, are consistent with a role of this protein in the regulation of the acrosome reaction and in other aspects of sperm physiology.
Affiliation: Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA. keith.sutton@umassmed.edu .
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8: Title: Cellular and molecular function of mucolipins (TRPML) and polycystin 2 (TRPP2).
Authors: Qian, Feng, et.al. .
Journal: Pflügers Archiv : European journal of physiology (Pflug Arch Eur J Phy), Vol. 451 (1): 277-85, 2005 .
Snippet: Mutations of TRPP2 in humans result in autosomal dominant polycystic kidney disease.
Affiliation: Division of Nephrology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. fqjhupkd@jhmi.edu .
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9: Title: A polycystin-2-like large conductance cation channel in rat left ventricular myocytes.
Authors: Volk, Tilmann, et.al. .
Journal: Cardiovascular research (Cardiovasc Res), Vol. 58 (1): 76-88, 2003 .
Snippet: Single-cell RT-PCR analysis revealed that mRNA of PKD2 and PKD2L2, but not PKDL or PKD1 are expressed in individual rat left ventricular myocytes.
Affiliation: Institut für Physiologie, Universitätskrankenhaus Hamburg-Eppendorf, Universität Hamburg, Germany. volk@uke.uni.hamburg.de .
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10: Title: Identification of genes encoding mouse oocyte secretory and transmembrane proteins by a signal sequence trap.
Authors: Taft, Robert A, et.al. .
Journal: Biology of reproduction (Biol Reprod), Vol. 67 (3): 953-60, 2002 .
Snippet: A screen of an oocyte SST library identified three classes of oocyte-expressed sequences: known mouse genes, sequences homologous to known mammalian genes, and novel sequences of unknown function.
Affiliation: Jackson Laboratory, Bar Harbor, Maine 04609, USA. .
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11: Title: Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization.
Authors: Guo, L, et.al. .
Journal: Genomics, Vol. 64 (3): 241-51, 2000 .
Snippet: PKD2L2 was mapped to human chromosome 5q31 and Pkd2l2 to mouse chromosome 18 in band C.
Affiliation: Renal Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. .
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12: Title: Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2).
Authors: Veldhuisen, B, et.al. .
Journal: European journal of human genetics : EJHG (Eur J Hum Genet), Vol. 7 (8): 860-72, 1999 .
Snippet: To identify genes that code for related proteins we searched for homologous sequences in several databases and identified one partial cDNA and two genomic sequences with significant homology to both polycystin-1 and - 2. Further analysis revealed one novel gene, PKD2L2, located on chromosome band 5q31, and two recently described genes, PKD2L and PKDREJ, located on chromosome bands 10q31 and 22q13.3,
Affiliation: MGC Department of Human and Clinical Genetics, Leiden University Medical Center, The Netherlands. .
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