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7 documents found
1: Title: Ct shift: A novel and accurate real-time PCR quantification model for direct comparison of different nucleic acid sequences and its application for transposon quantifications.
Authors: Kolacsek, Orsolya, et.al. .
Journal: Gene, Vol. 598, 2017 .
Snippet: The Ct shift method has been successfully applied for transposon gene copy measurements, as well as for comparison of different mRNAs in cDNA samples.
Affiliation: Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary. Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary. Electronic address: orban.tamas@ttk.mta.hu. .
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2: Title: CSB-PGBD3 Mutations Cause Premature Ovarian Failure.
Authors: Qin, Yingying, et.al. .
Journal: PLoS genetics (Plos Genet), Vol. 11 (7): e1005419, 2015 .
Snippet: The localization of the CSB-PGBD3 fusion protein to UVA-induced nuclear DNA repair foci further suggests that the CSB-PGBD3 fusion protein, like many other proteins that can cause POF, modulates or participates in DNA repair.
Affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China. State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China. Research and Global Programs March of Dimes Foundation, White Plains, New York, United States of America. Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China; Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. .
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3: Title: PGBD5: a neural-specific intron-containing piggyBac transposase domesticated over 500 million years ago and conserved from cephalochordates to humans.
Authors: Pavelitz, Thomas, et.al. .
Journal: Mobile DNA (Unknown Journal), Vol. 4 (1): 23, 2013 .
Snippet: In primates, a PGBD3 element inserted into the Cockayne syndrome group B (CSB) gene over 43 Mya serves as an alternative 3' terminal exon, enabling the CSB gene to generate both full length CSB and a conserved CSB-PGBD3 fusion protein that joins an N-terminal CSB domain to the C-terminal transposase domain.
Affiliation: Department of Biochemistry, School of Medicine, University of Washington, Seattle, WA 98195-7350, USA. amweiner@u.washington.edu. .
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4: Title: What role (if any) does the highly conserved CSB-PGBD3 fusion protein play in Cockayne syndrome?
Authors: Weiner, Alan M, et.al. .
Journal: Mechanisms of ageing and development (Mech Ageing Dev), Vol. 134 (5-6): 225-33, 2013 May-Jun .
Snippet: As a result of alternative splicing, the human CSB gene now encodes three proteins: CSB, a CSB-PGBD3 fusion protein that joins the N-terminal CSB domain to the C-terminal PGBD3 transposase domain, and PGBD3 transposase.
Affiliation: Department of Biochemistry, School of Medicine, University of Washington, Seattle, WA 98195-7350, USA. amweiner@uw.edu .
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5: Title: Tethering of the conserved piggyBac transposase fusion protein CSB-PGBD3 to chromosomal AP-1 proteins regulates expression of nearby genes in humans.
Authors: Gray, Lucas T, et.al. .
Journal: PLoS genetics (Plos Genet), Vol. 8 (9): e1002972, 2012 .
Snippet: Consistent with these data, the N-terminal CSB domain of the CSB-PGBD3 fusion protein interacts with the AP-1 transcription factor c-Jun and with RNA polymerase II, and a chimeric CSB-LacI construct containing only the N-terminus of CSB upregulates many of the genes induced by CSB-PGBD3.
Affiliation: Department of Biochemistry, School of Medicine, University of Washington, Seattle, Washington, United States of America. .
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6: Title: The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.
Authors: Bailey, Arnold D, et.al. .
Journal: DNA repair (Dna Repair (amst)), Vol. 11 (5): 488-501, 2012 .
Snippet: Interestingly, expression of CSB and the CSB-PGBD3 fusion protein together, but neither alone, upregulates the insulin growth factor binding protein IGFBP5 and downregulates IGFBP7, suggesting that the fusion protein may also confer a metabolic advantage, perhaps in the presence of DNA damage.
Affiliation: Department of Biochemistry, School of Medicine, University of Washington, Seattle, WA 98195-7350, USA. .
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7: Title: An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome.
Authors: Newman, John C, et.al. .
Journal: PLoS genetics (Plos Genet), Vol. 4 (3): e1000031, 2008 .
Snippet: The human genome contains over 600 nonautonomous PGBD3-related MER85 elements that were dispersed when the PGBD3 transposase was last active at least 37 Mya.
Affiliation: Department of Biochemistry, School of Medicine, University of Washington, Seattle, Washington, United States of America. .
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