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397 documents found
1: Title: Punicalagin, an active pomegranate component, is a new inhibitor of PDIA3 reductase activity.
Authors: Giamogante, Flavia, et.al. .
Journal: Biochimie, 2018 .
Snippet: Considering the PDIA3 involvement in oxidative cellular stress response observed in neuroblastoma cells after treatment with hydrogen peroxide, a comparative study was conducted to evaluate the effect of punicalagin on wild type and PDIA3-silenced cells.
Affiliation: Department of Biochemical Sciences "A. Rossi Fanelli" and Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University ", P.le A. Moro 5, 00185, Rome, Italy. Department of Biochemical Sciences "A. Rossi Fanelli" and Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University ", P.le A. Moro 5, 00185, Rome, Italy. Electronic address: fabio.altieri@uniroma1.it. .
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2: Title: Decreased ERp57 Expression in WAG/Rij Rats Thalamus and Cortex; Possible Correlation with Absence Epilepsy.
Authors: Sahin, Deniz, et.al. .
Journal: Protein and peptide letters (Protein Pept Lett), 2018 .
Snippet: Among the six spots (DHRS9, BR44, HINT1, CREM, SPRE and PDIA3/ERp57) the highest mascot score was attributed to ERp57 a neuroprotective/neurodegenerative system associated protein.
Affiliation: Kocaeli University Medical School - Physiology Department Kocaeli. Turkey. Kocaeli University Medical School - Medical Biology and DEKART Proteomics Laboratory Kocaeli. Turkey. Sisli Hamidiye Etfal Research and Training Hospital, Department of Biochemistry, Istanbul. Turkey. Kocaeli University Medical School - Biochemistry Kocaeli. Turkey. .
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3: Title: Regulatory role of microRNA in mesenteric lymph nodes after Salmonella Typhimurium infection.
Authors: Herrera-Uribe, Juber, et.al. .
Journal: Veterinary research (Vet Res), Vol. 49 (1): 9, 2018 .
Snippet: Downregulation of miR-125a/b, miR-148 and miR-1 were identified as potential regulators of MHC-class I components PSMB8, HSP90B1 and PDIA3, respectively.
Affiliation: Grupo de Genómica y Mejora Animal, Departamento de Genética, Facultad de Veterinaria, Universidad de Córdoba, 14047, Córdoba, Spain. Grupo de Genómica y Mejora Animal, Departamento de Genética, Facultad de Veterinaria, Universidad de Córdoba, 14047, Córdoba, Spain. sara.zaldiv@gmail.com. Institute for Molecular Infection Biology, University of Würzburg, Würzburg, Germany. Plataforma Andaluza de Bioinformática, Universidad de Málaga, 29590, Málaga, Spain. Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, 24071, León, Spain. Departamento de Biología Molecular y Bioquímica, Universidad de Málaga, 29071, Málaga, Spain. .
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4: Title: Protein Disulfide Isomerases as potential therapeutic targets for Influenza A and B Viruses.
Authors: Kim, Yunjeong, et.al. .
Journal: Virus research (Virus Res), 2018 .
Snippet: Furthermore, siRNAs specific to three PDI family members (PDI1, PDIA3 or PDIA4) also significantly reduced the replication of influenza A and B viruses in cells.
Affiliation: Department of Pathobiology and Preventive Medicine, College of Veterinary Medicine, Kansas State University, Manhattan, KS, 66506, USA. Department of Pathobiology and Preventive Medicine, College of Veterinary Medicine, Kansas State University, Manhattan, KS, 66506, USA. Electronic address: kchang@vet.ksu.edu. .
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5: Title: Redundancy of protein disulfide isomerases in the catalysis of the inactivating disulfide switch in A Disintegrin and Metalloprotease 17.
Authors: Krossa, Sebastian, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 8 (1): 1103, 2018 .
Snippet: The affinities between PDIA1, PDIA3, PDIA6 and the targeted domain of ADAM17 are all in the nanomolar range and display no significant differences.
Affiliation: Centre of Biochemistry and Molecular Biology, Structural Biology, Kiel University, Am Botanischen Garten 9, 24118, Kiel, Germany. Institute of Biochemistry, Kiel University, Rudolf-Höber Str. 1, 24118, Kiel, Germany. Centre of Biochemistry and Molecular Biology, Structural Biology, Kiel University, Am Botanischen Garten 9, 24118, Kiel, Germany. ilorenzen@zbm.uni-kiel.de. Institute of Biochemistry, Kiel University, Rudolf-Höber Str. 1, 24118, Kiel, Germany. ilorenzen@zbm.uni-kiel.de. .
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6: Title: Clock mediates liver senescence by controlling ER stress.
Authors: Yuan, Gongsheng, et.al. .
Journal: Aging, Vol. 9 (12): 2647-2665, 2017 .
Snippet: Finally, ablation of Pdia3 with siRNA causes ER stress with sustained phosphorylation of PERK and eIF1α, resulting in exaggerated up-regulation of UPR target genes and increased apoptosis as well as ROS.
Affiliation: Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Shanghai Key Laboratory of Clinical Geriatric Medicine, Research Center on Aging and Medicine, Fudan University, Shanghai, 200032, China. Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. Department of Gastroenterology, Huadong Hospital, Shanghai Medical College of Fudan University, Shanghai, 200040, China. State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200032, China. .
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7: Title: Regulation of extracellular matrix vesicles via rapid responses to steroid hormones during endochondral bone formation.
Authors: Asmussen, Niels, et.al. .
Journal: Steroids, 2017 .
Snippet: 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3] acts through the vitamin D receptor (VDR) and a membrane associated receptor, protein disulfide isomerase A3 (PDIA3).
Affiliation: School of Integrative Life Sciences, Virginia Commonwealth University, Richmond, VA 23284, USA. Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA; Department of Periodontics, School of Dentistry, Virginia Commonwealth University, Richmond, VA 23284, USA. Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA. Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA; Department of Periodontics, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA. Electronic address: bboyan@vcu.edu. .
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8: Title: Combination of CALR and PDIA3 is a potential prognostic biomarker for non-small cell lung cancer.
Authors: Wang, Ke, et.al. .
Journal: Oncotarget, Vol. 8 (57): 96945-96957, 2017 .
Snippet: We confirmed that the candidate proteins, calreticulin (CALR) and protein disulfide isomerase family A member 3 (PDIA3) were overexpressed in NSCLC by real-time PCR using 20 paired samples and western blot using 5 paired samples.
Affiliation: Department of Cell Biology, National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an, P.R. China. Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, P.R. China. .
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9: Title: P4HB and PDIA3 are associated with tumor progression and therapeutic outcome of diffuse gliomas.
Authors: Zou, Hecun, et.al. .
Journal: Oncology reports (Oncol Rep), Vol. 39 (2): 501-510, 2018 .
Snippet: Protein disulfide isomerases (PDIs) such as P4HB and PDIA3 act as molecular chaperones for reconstructing misfolded proteins, and are involved in endoplasmic reticulum stress and the unfolded protein response.
Affiliation: Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, P.R. China. Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, P.R. China. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P.R. China. .
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10: Title: Diosgenin, an Activator of 1,25D3-MARRS Receptor/ERp57, Attenuates the Effects of TNF-α by Causing ADAM10-Dependent Ectodomain Shedding of TNF Receptor 1.
Authors: Yang, Won Seok, et.al. .
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology (Cell Physiol Biochem), Vol. 43 (6): 2434-2445, 2017 .
Snippet: METHODS: Tumor necrosis factor receptor 1 (TNFR1) was assessed by Western blot analysis.
Affiliation: Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Asan Institute for Life Sciences, Seoul, Republic of Korea. Department of Pediatrics, Dankook University College of Medicine, Cheonan, Republic of Korea. Division of Nephrology, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea. .
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11: Title: Kaempferia parviflora rhizome extract and Myristica fragrans volatile oil increase the levels of monoamine neurotransmitters and impact the proteomic profiles in the rat hippocampus: Mechanistic insights into their neuroprotective effects.
Authors: Plaingam, Waluga, et.al. .
Journal: Journal of traditional and complementary medicine (J Tradit Complement Med), Vol. 7 (4): 538-552, 2017 .
Snippet: In line with the proteomic data, the levels of GFAP, PDIA3, DPYSL2 and p-DPYSL2 were modified in the SD rat groups treated with K. parviflora, M. fragrans and fluoxetine as confirmed by Western blot.
Affiliation: Ph.D. Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand. Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand. National Laboratory Animal Center, Mahidol University, Nakhon Pathom, Thailand. .
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12: Title: Tat-protein disulfide-isomerase A3: a possible candidate for preventing ischemic damage in the spinal cord.
Authors: Yoo, Dae Young, et.al. .
Journal: Cell death & disease (Cell Death Dis), Vol. 8 (10): e3075, 2017 .
Snippet: Further, Tat-PDIA3 significantly ameliorated the ischemia-induced deficits in motor function, based on Tarlov's criteria, 24-72 h after ischemia/reperfusion, as well as the degeneration of motor neurons in the ventral horn 72 h after ischemia/reperfusion. Tat-PDIA3 administration also reduced the ischemia-induced activation of microglia and lipid peroxidation in the motor neurons 72 h after ischemia/reperfusion. PDIA3 also potentially ameliorated the ischemia-induced increase in oxidative markers in serum and decreased the activity of Cu,Zn-superoxide dismutase, Mn-superoxide dismutase, and glutathione peroxidase in spinal cord homogenates, 24 h and 72 h after ischemia/reperfusion.
Affiliation: Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul, South Korea. Department of Biomedical Sciences, and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon, South Korea. Departments of Thoracic and Cardiovascular Surgery, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon, South Korea. Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea. Department of Biochemistry and Molecular Biology, Research Institute of Oral Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung, Korea. Department of Neurosurgery, Dongtan Sacred Heart Hospital, College of Medicine, Hallym University, Hwaseong, South Korea. .
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13: Title: LncRNA EWSAT1 promotes ovarian cancer progression through targeting miR-330-5p expression.
Authors: Fu, Xin, et.al. .
Journal: American journal of translational research (Am J Transl Res), Vol. 9 (9): 4094-4103, 2017 .
Snippet: Furthermore, we identified Pdia3 was a direct target gene of miR-330-5p.
Affiliation: Department of Gynecology Cancer, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and HospitalTianjin 300060, China. Laboratory of Cancer Cell Biology, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and HospitalTianjin 300060, China. .
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14: Title: In vitro toxicoproteomic analysis of A549 human lung epithelial cells exposed to urban air particulate matter and its water-soluble and insoluble fractions.
Authors: Vuong, Ngoc Q, et.al. .
Journal: Particle and fibre toxicology (Part Fibre Toxicol), Vol. 14 (1): 39, 2017 .
Snippet: For example, the insoluble and soluble fractions differentially affected the secretion of pro-inflammatory cytokines such as MCP-1 and IL-8 and distinctly altered the expression of those proteins (e.g., TREM1, PDIA3 and ENO1) involved in an inflammatory response pathway in A549 cells.
Affiliation: Inhalation Toxicology Laboratory, Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, K1A 0K9, Canada. Department of Biochemistry, Faculty of Science, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. Biostatistics Section, Population Studies Division, Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, K1A 0K9, Canada. Analytical Biochemistry and Proteomics, Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, K1A 0K9, Canada. premkumari.kumarathasan@canada.ca. Inhalation Toxicology Laboratory, Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, K1A 0K9, Canada. renaud.vincent@canada.ca. Department of Biochemistry, Faculty of Science, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. renaud.vincent@canada.ca. .
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15: Title: Tetrazole-Based Probes for Integrated Phenotypic Screening, Affinity-Based Proteome Profiling and Sensitive Detection of a Cancer Biomarker.
Authors: Li, Zhengqiu, et.al. .
Journal: Angewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl), 2017 .
Snippet: Using this approach, we identified ANXA2, PDIA3/4, FLAD1 and NOS2 as primary cellular targets of two bioactive molecules that inhibit cancer cell proliferation.
Affiliation: Jinan University, Pharmacy, Huangpu west, 601, 510632, Guangzhou, CHINA. .
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16: Title: Differential expression of vitamin D-associated enzymes and receptors in brain cell subtypes.
Authors: Landel, Véréna, et.al. .
Journal: The Journal of steroid biochemistry and molecular biology (J Steroid Biochem Mol Biol), 2017 .
Snippet: With the idea of carrying out a comparative study in mind, we compared the transcript expression of Cyp27a1, Cyp27b1, Cyp24a1, Vdr and Pdia3 in purified cultures of astrocytes, endothelial cells, microglia, neurons and oligodendrocytes.
Affiliation: Aix Marseille Univ, CNRS, NICN, Marseille, France. Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Brisbane, Australia. Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Brisbane, Australia; Queensland Centre for Mental Health Research, Brisbane, QLD, Brisbane, Australia. Aix Marseille Univ, CNRS, NICN, Marseille, France. Electronic address: francois.feron@univ-amu.fr. .
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17: Title: Pseudogene PDIA3P1 promotes cell proliferation, migration and invasion, and suppresses apoptosis in hepatocellular carcinoma by regulating the p53 pathway.
Authors: Kong, Yang, et.al. .
Journal: Cancer letters (Cancer Lett), Vol. 407, 2017 .
Snippet: Pseudogenes play an important role in the pathogenesis of various tumors; however, the role of pseudogenes in hepatocellular carcinoma (HCC) is poorly understood.
Affiliation: Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, China; Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. State Key Laboratory & Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China. Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China. Electronic address: shusenzheng@zju.edu.cn. Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, China; State Key Laboratory & Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: wam@zju.edu.cn. .
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18: Title: Effect of Subcellular Translocation of Protein Disulfide Isomerase on Tetrachlorobenzoquinone-induced Signaling Shift from Endoplasmic Reticulum Stress to Apoptosis.
Authors: Liu, Zixuan, et.al. .
Journal: Chemical research in toxicology (Chem Res Toxicol), 2017 .
Snippet: Further mechanistic study illustrated that PDIs initially acted to restore cellular homeostasis to pro-survival, but constant ER stress promoted signaling switch to pro-apoptotic by the release of PDIA1/PDIA3 from ER lumen to induce Bak-dependent MOMP.
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19: Title: Multifunctional Molecule ERp57: From Cancer To Neurodegenerative Diseases.
Journal: Pharmacology & therapeutics (Pharmacol Ther), 2017 .
Snippet: The protein disulfide isomerase (PDI) gene family is a protein family classically characterized by endoplasmic reticulum (ER) localization and isomerase and redox activity.
Affiliation: Department of Orthopaedic Surgery, New York University Medical Center, New York, NY, 10003, USA. Department of Orthopaedic Surgery, New York University Medical Center, New York, NY, 10003, USA; Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA. Electronic address: chuanju.liu@med.nyu.edu. .
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20: Title: Vitamin D receptor regulates amyloid beta 1-42 production with protein disulfide isomerase A3.
Authors: Gezen-Ak, Duygu, et.al. .
Journal: ACS chemical neuroscience (Acs Chem Neurosci), 2017 .
Snippet: Based on our previous studies we have suggested that AD might be the consequence of a hormonal imbalance in which the critical hormone is vitamin D. The present study primarily focused on the creation of a condition that prevents the genomic or non-genomic action of vitamin D by disrupting vitamin D receptors (VDR or PDIA3/1,25MARRS); the effects of these disruptions on the series of proteins involved in secretases that play a crucial role in amyloid pathology and on amyloid beta (Aβ) production in primary cortical neurons were observed.
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