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406 documents found
1: Title: Cell- and Tissue-based Proteome Profiling and Dual Imaging of Apoptosis Markers with Probes Derived from Venetoclax and Idasanutlin.
Authors: Li, Zhengqiu, et.al. .
Journal: Angewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl), 2018 .
Snippet: A series of protein hits, including ITPR1, GSR, RER1, PDIA3, Apoa1 and Tnfrsf17 were simultaneously identified by pull-down/LC-MS/MS with the two sets of affinity-based probes.
Affiliation: Jinan University, Pharmacy, Huangpu west, 601, 510632, Guangzhou, CHINA. CHINA. .
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2: Title: Amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) are characterised by differential activation of ER stress pathways: focus on UPR target genes.
Authors: Montibeller, L, et.al. .
Journal: Cell stress & chaperones (Cell Stress Chaperones), 2018 .
Snippet: In AD cases, a distinct pattern emerged, where targets involved in protein folding were more prominent, such as CANX, PDIA3 and PDIA6.
Affiliation: Neurogenetics Group, Division of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK. Neurogenetics Group, Division of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK. j.belleroche@imperial.ac.uk. .
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3: Title: Oxidatively modified PDIA3 promotes DKC1-mediated malignancy and survival of hepatocellular carcinoma cells.
Authors: Ko, Eunkyong, et.al. .
Journal: Hepatology (Baltimore, Md.) (Hepatology), 2018 .
Snippet: We found that protein-disulfide isomerase-associated 3 (PDIA3) interacted with the DKC1 regulatory DNA in HCC cells, but not in HCC cells with elevated reactive oxygen species (ROS) levels, using liquid chromatography tandem-mass spectrometry analysis after isolating the DKC1 regulatory region binding proteins.
Affiliation: Department of Biological Sciences, College of Natural Sciences, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea. Center for RNA Research, Institute of Basic Science (IBS), Seoul, 08826, Republic of Korea. School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, Republic of Korea. .
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4: Title: Hippocampal Subcellular Organelle Proteomic Alteration of Copper-treated Mice.
Authors: Yu, Haitao, et.al. .
Journal: Toxicological sciences : an official journal of the Society of Toxicology (Toxicol Sci), 2018 .
Snippet: Bioinformatic analysis indicated that these differentially expressed proteins are mainly involved energy metabolism (NDUV1, COX5B, IDH3A, PGAM1), synapses (complexin-2, synapsin-2), DNA damage (PDIA3), apoptosis (GRP75) and oxidative stress (SODC, PRDX3).
Affiliation: Key Laboratory of Modern Toxicology of Shenzhen, Institute of Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China. Department of Geriatrics, The Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, Guangdong, China. Institute of New Drug Research and Guangzhou, Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou 510632, China. .
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5: Title: Secretome analysis of rat osteoblasts during icariin treatment induced osteogenesis.
Authors: Qian, Weiqing, et.al. .
Journal: Molecular medicine reports (Mol Med Report), Vol. 17 (5): 6515-6525, 2018 .
Snippet: A total of 56 DEPs were identified, including serpin family F member 1 (PEDF), protein disulfide isomerase family A, member 3 (PDIA3), nuclear protein, co‑activator of histone transcription (NPAT), c‑Myc and heat shock protein 70 (HSP70).
Affiliation: Department of Orthopedics, The 3rd Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210001, P.R. China. Reproductive Center, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210023, P.R. China. Laboratory Center, The 3rd Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China. Cardiovascular Department, The 3rd Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China. School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China. .
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6: Title: Role of the ERp57 protein (1,25D3-MARRS receptor) in murine mammary gland growth and development.
Authors: Wilkin, Allison M, et.al. .
Journal: Steroids, 2018 .
Snippet: The protein disulfide isomerase ERp57 (GRp58/PDIA3/1,25D3-MARRS) has been implicated in a multitude of signaling pathways throughout the entire body.
Affiliation: Department of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Rd E, Guelph, ON, N1G 2W1, Canada. Electronic address: awilkin@uoguelph.ca. Department of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Rd E, Guelph, ON, N1G 2W1, Canada. Electronic address: aharnett@uwo.ca. Department of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Rd E, Guelph, ON, N1G 2W1, Canada. Electronic address: michael.underschultz@gmail.com. Department of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Rd E, Guelph, ON, N1G 2W1, Canada. Electronic address: ccragg@uoguelph.ca. Department of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Rd E, Guelph, ON, N1G 2W1, Canada. Electronic address: kmecklin@uoguelph.ca. .
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7: Title: Punicalagin, an active pomegranate component, is a new inhibitor of PDIA3 reductase activity.
Authors: Giamogante, Flavia, et.al. .
Journal: Biochimie, 2018 .
Snippet: Considering the PDIA3 involvement in oxidative cellular stress response observed in neuroblastoma cells after treatment with hydrogen peroxide, a comparative study was conducted to evaluate the effect of punicalagin on wild type and PDIA3-silenced cells.
Affiliation: Department of Biochemical Sciences "A. Rossi Fanelli" and Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University ", P.le A. Moro 5, 00185, Rome, Italy. Department of Biochemical Sciences "A. Rossi Fanelli" and Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University ", P.le A. Moro 5, 00185, Rome, Italy. Electronic address: fabio.altieri@uniroma1.it. .
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8: Title: Decreased ERp57 Expression in WAG/Rij Rats Thalamus and Cortex; Possible Correlation with Absence Epilepsy.
Authors: Sahin, Deniz, et.al. .
Journal: Protein and peptide letters (Protein Pept Lett), 2018 .
Snippet: Among the six spots (DHRS9, BR44, HINT1, CREM, SPRE and PDIA3/ERp57) the highest mascot score was attributed to ERp57 a neuroprotective/neurodegenerative system associated protein.
Affiliation: Kocaeli University Medical School - Physiology Department Kocaeli. Turkey. Kocaeli University Medical School - Medical Biology and DEKART Proteomics Laboratory Kocaeli. Turkey. Sisli Hamidiye Etfal Research and Training Hospital, Department of Biochemistry, Istanbul. Turkey. Kocaeli University Medical School - Biochemistry Kocaeli. Turkey. .
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9: Title: ERp57 is protective against mutant SOD1-induced cellular pathology in Amyotrophic Lateral Sclerosis.
Authors: Parakh, Sonam, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), 2018 .
Snippet: We previously established that protein disulphide isomerase (PDIA1) is protective against ER stress and apoptosis in neuronal cells expressing mutant SOD1, recently mutations in PDIA1 and related PDI family member endoplasmic reticulum protein 57 (ERp57/PDIA), were associated with ALS.
Affiliation: Centre for MND Research, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, 2109, Australia. 3 Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Vic, 3086, Australia. Department of Physiology, Anatomy and Microbiology. .
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10: Title: Regulatory role of microRNA in mesenteric lymph nodes after Salmonella Typhimurium infection.
Authors: Herrera-Uribe, Juber, et.al. .
Journal: Veterinary research (Vet Res), Vol. 49 (1): 9, 2018 .
Snippet: Downregulation of miR-125a/b, miR-148 and miR-1 were identified as potential regulators of MHC-class I components PSMB8, HSP90B1 and PDIA3, respectively.
Affiliation: Grupo de Genómica y Mejora Animal, Departamento de Genética, Facultad de Veterinaria, Universidad de Córdoba, 14047, Córdoba, Spain. Grupo de Genómica y Mejora Animal, Departamento de Genética, Facultad de Veterinaria, Universidad de Córdoba, 14047, Córdoba, Spain. sara.zaldiv@gmail.com. Institute for Molecular Infection Biology, University of Würzburg, Würzburg, Germany. Plataforma Andaluza de Bioinformática, Universidad de Málaga, 29590, Málaga, Spain. Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, 24071, León, Spain. Departamento de Biología Molecular y Bioquímica, Universidad de Málaga, 29071, Málaga, Spain. .
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11: Title: Protein Disulfide Isomerases as potential therapeutic targets for Influenza A and B Viruses.
Authors: Kim, Yunjeong, et.al. .
Journal: Virus research (Virus Res), 2018 .
Snippet: Furthermore, siRNAs specific to three PDI family members (PDI1, PDIA3 or PDIA4) also significantly reduced the replication of influenza A and B viruses in cells.
Affiliation: Department of Pathobiology and Preventive Medicine, College of Veterinary Medicine, Kansas State University, Manhattan, KS, 66506, USA. Department of Pathobiology and Preventive Medicine, College of Veterinary Medicine, Kansas State University, Manhattan, KS, 66506, USA. Electronic address: kchang@vet.ksu.edu. .
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12: Title: Redundancy of protein disulfide isomerases in the catalysis of the inactivating disulfide switch in A Disintegrin and Metalloprotease 17.
Authors: Krossa, Sebastian, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 8 (1): 1103, 2018 .
Snippet: The affinities between PDIA1, PDIA3, PDIA6 and the targeted domain of ADAM17 are all in the nanomolar range and display no significant differences.
Affiliation: Centre of Biochemistry and Molecular Biology, Structural Biology, Kiel University, Am Botanischen Garten 9, 24118, Kiel, Germany. Institute of Biochemistry, Kiel University, Rudolf-Höber Str. 1, 24118, Kiel, Germany. Centre of Biochemistry and Molecular Biology, Structural Biology, Kiel University, Am Botanischen Garten 9, 24118, Kiel, Germany. ilorenzen@zbm.uni-kiel.de. Institute of Biochemistry, Kiel University, Rudolf-Höber Str. 1, 24118, Kiel, Germany. ilorenzen@zbm.uni-kiel.de. .
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13: Title: Endoplasmic reticulum-resident protein 57 (ERp57) oxidatively inactivates human transglutaminase 2.
Authors: Yi, Michael C, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), 2018 .
Snippet: Moreover, its specificity for TG2 was also markedly higher than those of other secreted redox proteins, including protein disulfide isomerase (PDI), ERp72, TRX, and quiescin sulfhydryl oxidase 1 (QSOX1).
Affiliation: Stanford University, United States. .
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14: Title: Clock mediates liver senescence by controlling ER stress.
Authors: Yuan, Gongsheng, et.al. .
Journal: Aging, Vol. 9 (12): 2647-2665, 2017 .
Snippet: Finally, ablation of Pdia3 with siRNA causes ER stress with sustained phosphorylation of PERK and eIF1α, resulting in exaggerated up-regulation of UPR target genes and increased apoptosis as well as ROS.
Affiliation: Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Shanghai Key Laboratory of Clinical Geriatric Medicine, Research Center on Aging and Medicine, Fudan University, Shanghai, 200032, China. Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. Department of Gastroenterology, Huadong Hospital, Shanghai Medical College of Fudan University, Shanghai, 200040, China. State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200032, China. .
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15: Title: Regulation of extracellular matrix vesicles via rapid responses to steroid hormones during endochondral bone formation.
Authors: Asmussen, Niels, et.al. .
Journal: Steroids, 2017 .
Snippet: 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3] acts through the vitamin D receptor (VDR) and a membrane associated receptor, protein disulfide isomerase A3 (PDIA3).
Affiliation: School of Integrative Life Sciences, Virginia Commonwealth University, Richmond, VA 23284, USA. Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA; Department of Periodontics, School of Dentistry, Virginia Commonwealth University, Richmond, VA 23284, USA. Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA. Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA; Department of Periodontics, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA. Electronic address: bboyan@vcu.edu. .
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16: Title: Combination of CALR and PDIA3 is a potential prognostic biomarker for non-small cell lung cancer.
Authors: Wang, Ke, et.al. .
Journal: Oncotarget, Vol. 8 (57): 96945-96957, 2017 .
Snippet: We confirmed that the candidate proteins, calreticulin (CALR) and protein disulfide isomerase family A member 3 (PDIA3) were overexpressed in NSCLC by real-time PCR using 20 paired samples and western blot using 5 paired samples.
Affiliation: Department of Cell Biology, National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an, P.R. China. Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, P.R. China. .
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17: Title: P4HB and PDIA3 are associated with tumor progression and therapeutic outcome of diffuse gliomas.
Authors: Zou, Hecun, et.al. .
Journal: Oncology reports (Oncol Rep), Vol. 39 (2): 501-510, 2018 .
Snippet: Protein disulfide isomerases (PDIs) such as P4HB and PDIA3 act as molecular chaperones for reconstructing misfolded proteins, and are involved in endoplasmic reticulum stress and the unfolded protein response.
Affiliation: Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, P.R. China. Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, P.R. China. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P.R. China. .
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18: Title: Structure of the human MHC-I peptide-loading complex.
Authors: Blees, Andreas, et.al. .
Journal: Nature, Vol. 551 (7681): 525-528, 2017 .
Snippet: Sampling of different MHC-I allomorphs requires the precise coordination of seven different subunits in a single macromolecular assembly, including the transporter associated with antigen processing (TAP1 and TAP2, jointly referred to as TAP), the oxidoreductase ERp57, the MHC-I heterodimer, and the chaperones tapasin and calreticulin.
Affiliation: Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Max-von-Laue Strasse 9, 60438 Frankfurt/Main, Germany. Department of Structural Biology, Max Planck Institute of Biophysics, Max-von-Laue Strasse 3, 60438 Frankfurt/Main, Germany. Interdisciplinary Research Center HALOmen, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Strasse 3, 06120 Halle/Saale, Germany. .
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19: Title: Diosgenin, an Activator of 1,25D3-MARRS Receptor/ERp57, Attenuates the Effects of TNF-α by Causing ADAM10-Dependent Ectodomain Shedding of TNF Receptor 1.
Authors: Yang, Won Seok, et.al. .
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology (Cell Physiol Biochem), Vol. 43 (6): 2434-2445, 2017 .
Snippet: METHODS: Tumor necrosis factor receptor 1 (TNFR1) was assessed by Western blot analysis.
Affiliation: Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Asan Institute for Life Sciences, Seoul, Republic of Korea. Department of Pediatrics, Dankook University College of Medicine, Cheonan, Republic of Korea. Division of Nephrology, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea. .
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20: Title: Kaempferia parviflora rhizome extract and Myristica fragrans volatile oil increase the levels of monoamine neurotransmitters and impact the proteomic profiles in the rat hippocampus: Mechanistic insights into their neuroprotective effects.
Authors: Plaingam, Waluga, et.al. .
Journal: Journal of traditional and complementary medicine (J Tradit Complement Med), Vol. 7 (4): 538-552, 2017 .
Snippet: In line with the proteomic data, the levels of GFAP, PDIA3, DPYSL2 and p-DPYSL2 were modified in the SD rat groups treated with K. parviflora, M. fragrans and fluoxetine as confirmed by Western blot.
Affiliation: Ph.D. Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand. Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand. National Laboratory Animal Center, Mahidol University, Nakhon Pathom, Thailand. .
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