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53 documents found
1: Title: Development of potent and proteolytically stable human neuromedin U receptor agonists.
Authors: De Prins, An, et.al. .
Journal: European journal of medicinal chemistry (Eur J Med Chem), Vol. 144, 2017 .
Snippet: Selectivity towards NMUR1 was observed when the Phe residue in position 4 was modified, whereas higher potencies at NMUR2 were found when substitutions of the Pro residue in position 6 were executed.
Affiliation: Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium; Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neurosciences (C4N), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium. Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neurosciences (C4N), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark. Biological Research Centre, Institute of Biochemistry, Laboratory of Chemical Biology, 6726 Szeged, Temesvári krt. 62, Hungary. In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; Department of Nuclear Medicine, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium. Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark. Electronic address: rosenkilde@sund.ku.dk. Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neurosciences (C4N), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address: ilse.smolders@vub.be. Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium. Electronic address: steven.ballet@vub.be. .
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2: Title: Characterization of neuromedin U (NMU), neuromedin S (NMS) and their receptors (NMUR1, NMUR2) in chickens.
Authors: Wan, Yiping, et.al. .
Journal: Peptides, Vol. 101, 2017 .
Snippet: Neuromedin U (NMU) and its structurally-related peptide, neuromedin S (NMS), are reported to regulate many physiological processes and their actions are mediated by two NMU receptors (NMUR1, NMUR2) in mammals.
Affiliation: Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, PR China. Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, PR China. Electronic address: lijuanscuhk@163.com. Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, PR China. Electronic address: cdwyjhk@gmail.com. .
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3: Title: Neuromedin U potentiates ADP- and epinephrine-induced human platelet activation.
Authors: Grippi, C, et.al. .
Journal: Thrombosis research (Thromb Res), Vol. 159, 2017 .
Snippet: It acts via both a Gαq/11-coupled receptor (NMUR1) and a Gαi-coupled receptor (NMUR2) in different cell types.
Affiliation: Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, Pozzilli, IS, Italy. Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, Pozzilli, IS, Italy; Department of Medicine and Surgery, University of Insubria, Varese, Italy. Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy. Centre for Neurogenetics and Rare Diseases, IRCCS Istituto Neurologico Mediterraneo NEUROMED, Pozzilli, IS, Italy. Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium. Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, Pozzilli, IS, Italy. Electronic address: chiara.cerletti@neuromed.it. .
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4: Title: Genomic Programming of Human Neonatal Dendritic Cells in Congenital Systemic and In Vitro Cytomegalovirus Infection Reveal Plastic and Robust Immune Pathway Biology Responses.
Authors: Dantoft, Widad, et.al. .
Journal: Frontiers in immunology (Front Immunol), Vol. 8, 2017 .
Snippet: Functional siRNA viral growth screen targeting 516-GPCRs and subsequent validation identified novel GPCR-dependent antiviral (ADORA1) and proviral (GPR146, RGS16, PTAFR, SCTR, GPR84, GPR85, NMUR2, FZ10, RDS, CCL17, and SORT1) roles.
Affiliation: Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom. Immunology Unit, Department of Biomedical Sciences, Medical School, University of Barcelona, Barcelona, Spain. Quantitative Proteomics, Institute of Molecular Biology, Mainz, Germany. Synexa Life Sciences, Cape Town, South Africa. SynthSys-Centre for Synthetic and Systems Biology, School of Engineering, University of Edinburgh, Edinburgh, United Kingdom. Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom. NSilico Life Science and Department of Computing, Institute of Technology, Cork, Ireland. Institute for Medical Immunology, Université Libre de Bruxelles, Charleroi, Belgium. .
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5: Title: A potent neuromedin U receptor 2-selective alkylated peptide.
Authors: Nishizawa, Naoki, et.al. .
Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett), Vol. 27 (20): 4626-4629, 2017 .
Snippet: Neuromedin U (NMU) mediates various physiological functions via NMUR1 and NMUR2 receptors.
Affiliation: Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, Fujisawa 251-8555, Japan. Electronic address: naoki.nishizawa@takeda.com. Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, Fujisawa 251-8555, Japan. Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, Fujisawa 251-8555, Japan. Electronic address: taiji.asami.1@gmail.com. .
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6: Title: Changes in expression of neuropeptides and their receptors in the hypothalamus and gastrointestinal tract of calorie restricted hens.
Authors: Simon, Ádám, et.al. .
Journal: Acta biologica Hungarica (Acta Biol Hung), Vol. 68 (3): 237-247, 2017 .
Snippet: We aimed to investigate plasma level and mRNA expression of the pituitary adenylate cyclase-activating polypeptide (PACAP), gene expression of its receptor (PAC1), furthermore the gene expression of galanin (GAL), neuromedin U (NMU), and its two receptors (NMUR1 and NMUR2) in the hypothalamus, proventriculus, and jejunum of hens exposed to 40% calorie restriction.
Affiliation: 1 Department of Animal Science, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen , H-4027 Debrecen, Böszörményi út 138 , Hungary. 2 Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen , H-4032 Debrecen, Nagyerdei körút 98 , Hungary. 3 Department of Anatomy, University of Pécs Medical School , H-7624 Pécs, Szigeti út 12 , Hungary. .
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7: Title: Effects of peripheral administration of a Neuromedin U receptor 2-selective agonist on food intake and body weight in obese mice.
Authors: Kaisho, T, et.al. .
Journal: International journal of obesity (2005) (Int J Obes (lond)), 2017 .
Snippet: It is reported that the NMU signaling system regulates food intake and body weight via NMUR2, suggesting that an NMUR2 agonist exhibiting anorectic effects would be a potential therapy for obesity.
Affiliation: Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan. .
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8: Title: Potent Body Weight-Lowering Effect of a Neuromedin U Receptor 2-selective PEGylated Peptide.
Authors: Kanematsu-Yamaki, Yoko, et.al. .
Journal: Journal of medicinal chemistry (J Med Chem), Vol. 60 (14): 6089-6097, 2017 .
Snippet: Compound 37, an NMUR2-selective PEG20k analogue containing piperazin-1-ylacetyl linker, exhibited a potent body weight-lowering effect with concomitant inhibition of food intake in a dose-dependent manner (body weight loss of 12.4% at 30 nmol/kg) by once-daily repeated dosing for 2 weeks in mice with diet-induced obesity.
Affiliation: Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd. , Fujisawa, 251-8555, Japan. .
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9: Title: Discovery of a Human Neuromedin U Receptor 1-Selective Hexapeptide Agonist with Enhanced Serum Stability.
Authors: Takayama, Kentaro, et.al. .
Journal: Journal of medicinal chemistry (J Med Chem), Vol. 60 (12): 5228-5234, 2017 .
Snippet: Neuromedin U (NMU) activates two NMU receptors (NMUR1 and NMUR2) and is a useful antiobesity drug lead.
Affiliation: Department of Medicinal Chemistry, Tokyo University of Pharmacy and Life Sciences , 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute , 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan. Department of Biopharmaceutics, Kyoto Pharmaceutical University , 5 Misasaginakauchi-cho, Yamashina, Kyoto 607-8414, Japan. Laboratory of Pharmaceutical Technology, Kobe Pharmaceutical University , 4-19-1 Motoyamakitamachi, Higashinada, Kobe, Hyogo 658-8558, Japan. Omics Research Center, National Cerebral and Cardiovascular Center , 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan. .
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10: Title: Cloning and expression patterns of neuromedin U and its receptors in pigs.
Authors: Li, Xiang, et.al. .
Journal: Neuropeptides, Vol. 64, 2017 .
Snippet: Neuromedin U (NMU) is a highly conserved neuropeptide that performs a variety of physiological functions in animals via neuromedin U receptor-1 (NMUR1) and neuromedin U receptor-2 (NMUR2).
Affiliation: College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, Jiangsu, PR China; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, Henan, PR China. College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, Henan, PR China. College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, Jiangsu, PR China. College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, Jiangsu, PR China. Electronic address: leizh@njau.edu.cn. .
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11: Title: Oncogenic features of neuromedin U in breast cancer are associated with NMUR2 expression involving crosstalk with members of the WNT signaling pathway.
Authors: Garczyk, Stefan, et.al. .
Journal: Oncotarget, Vol. 8 (22): 36246-36265, 2017 .
Snippet: Using an in silico dataset comprising 1,195 samples, high NMU expression was identified as an indicator of poor outcome in breast tumors showing strong NMUR2 expression.
Affiliation: Molecular Oncology Group, Institute of Pathology, Medical Faculty of the RWTH Aachen University, D-52074 Aachen, Germany. IZKF Aachen, Medical Faculty of the RWTH Aachen University, D-52074 Aachen, Germany. .
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12: Title: Postnatal developmental of Neuromedin S and its receptor in the male Xiaomeishan pig reproductive axis.
Authors: Ma, Zhiyu, et.al. .
Journal: Animal reproduction science (Anim Reprod Sci), Vol. 181, 2017 .
Snippet: Neuromedin S (NMS) has been identified as an endogenous ligand for FM-3/GPR66 and FM-4/TGR-1 which are NMU receptors NMUR1 and NMUR2, respectively.
Affiliation: College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China. Nanjing Institute of Zootechnics and Poultry Science, Nanjing 210036, PR China. College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China. Electronic address: sujuan@njau.edu.cn. .
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13: Title: A PEGylated analog of short-length Neuromedin U with potent anorectic and anti-obesity effects.
Authors: Inooka, Hiroshi, et.al. .
Journal: Bioorganic & medicinal chemistry (Bioorg Med Chem), Vol. 25 (8): 2307-2312, 2017 .
Snippet: Integrated evaluation of NMUR1 and NMUR2 binding affinities in vitro and anorectic activity in mice revealed that the introduction of a linker with a rigid ring group, e.g., 2-(piperazin-1-yl)acetic acid (PipAc), yielded a highly potent anorectic peptide, PEG30k-PipAc-NMU-8 (14), possessing improved receptor binding affinity.
Affiliation: Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd., Fujisawa 251-8555, Japan. Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd., Fujisawa 251-8555, Japan. Electronic address: yasushi.masuda@takeda.com. Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd., Fujisawa 251-8555, Japan. Electronic address: taiji.asami@takeda.com. .
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14: Title: Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes.
Authors: Romanov, Roman A, et.al. .
Journal: Nature neuroscience (Nat Neurosci), Vol. 20 (2): 176-188, 2017 .
Snippet: We identified dopamine neurons that uniquely coexpress the Onecut3 and Nmur2 genes, and placed these in the periventricular nucleus with many synaptic afferents arising from neuromedin S(+) neurons of the suprachiasmatic nucleus.
Affiliation: Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria. Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. Department of Bioengineering &CNC Program, Stanford University, Stanford, California, USA. MTA-SE NAP Research Group of Experimental Neuroanatomy and Developmental Biology, Hungarian Academy of Sciences, Budapest, Hungary. Department of Anatomy, Semmelweis University, Budapest, Hungary. Science for Life Laboratories, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. Laboratory of Neural Differentiation, Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium. Synaptic Systems GmbH, Göttingen, Germany. Microscopy Labs Munich, Global Sales Support-Life Sciences, Carl Zeiss Microscopy GmbH, Munich, Germany. The Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary. Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Maebashi, Japan. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. Science for Life Laboratory, Albanova University Center, Royal Institute of Technology, Stockholm, Sweden. Institute of Physiology, Christian Albrechts University, Kiel, Germany. Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. .
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15: Title: Effects of sex steroid hormones on neuromedin S and neuromedin U2 receptor expression following experimental traumatic brain injury.
Authors: Khaksari, Mohammad, et.al. .
Journal: Iranian journal of basic medical sciences (Iran J Basic Med Sci), Vol. 19 (10): 1080-1089, 2016 .
Snippet: Two of these peptides are including the regulatory peptides neuromedin U (NMU) and neuromedin S (NMS), and their common receptor neuromedin U2 receptor (NMUR2).
Affiliation: Endocrinology and Metabolism Research, and Physiology Research Centers, Kerman University of Medical Sciences, Kerman, Iran. Neuroscience Research Center, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran. .
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16: Title: Gamma-Aminobutyric Acidergic Projections From the Dorsal Raphe to the Nucleus Accumbens Are Regulated by Neuromedin U.
Authors: Kasper, James M, et.al. .
Journal: Biological psychiatry (Biol Psychiatry), Vol. 80 (11): 878-887, 2016 .
Snippet: While NMU and its receptor, NMU receptor 2 (NMUR2), have been studied for the ability to regulate food reward, NMU has not been studied in the context of drugs of abuse (e.g., cocaine).
Affiliation: Center for Addiction Research, Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, Texas. Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, Illinois. Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas. Center for Addiction Research, Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, Texas. Electronic address: jdhommel@utmb.edu. .
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17: Title: NMU signaling promotes endometrial cancer cell progression by modulating adhesion signaling.
Authors: Lin, Ting-Yu, et.al. .
Journal: Oncotarget, Vol. 7 (9): 10228-42, 2016 .
Snippet: We identified that NMU and one of its receptors, NMUR2, are not only present in normal uterine endometrium but also co-expressed in endometrial cancer tissues, where the NMU level is correlated with the malignant grades and survival of patients.
Affiliation: Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan. Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Kweishan, Taoyuan 333, Taiwan. .
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18: Title: Identifying a Neuromedin U Receptor 2 Splice Variant and Determining Its Roles in the Regulation of Signaling and Tumorigenesis In Vitro.
Authors: Lin, Ting-Yu, et.al. .
Journal: PloS one, Vol. 10 (8): e0136836, 2015 .
Snippet: Neuromedin U (NMU) activates two G protein-coupled receptors, NMUR1 and NMUR2; this signaling not only controls many physiological responses but also promotes tumorigenesis in diverse tissues.
Affiliation: Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan. .
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19: Title: Genome-wide pathway analysis for diabetic nephropathy in type 1 diabetes.
Authors: Lee, Young Ho, et.al. .
Journal: Endocrine research (Endocr Res), Vol. 41 (1): 21-7, 2016 .
Snippet: This next most strongly supported hypothesis was the modulation of NMUR2 by rs982715, rs4958531, 4958532, rs1895245, and rs4958535 to affect its role in various pathways and processes, including calcium-mediated signaling and peptide receptor activity, and G-protein activity (p < 0.001, 0.002; FDR = 0.005, 0.049, respectively).
Affiliation: a Division of Rheumatology , Department of Internal Medicine, Korea University College of Medicine , Seoul , Korea. .
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20: Title: Neuromedin U inhibits food intake partly by inhibiting gastric emptying.
Authors: Dalbøge, Louise S, et.al. .
Journal: Peptides, Vol. 69, 2015 .
Snippet: Neuromedin U (NMU) is a gut-brain peptide, implicated in energy and glucose homeostasis via the peripherally expressed NMU receptor 1 (NMUR1) and the central NMUR2.
Affiliation: Gubra ApS, Agern Alle 1, 2970 Hørsholm, Denmark; University of Copenhagen, The Novo Nordisk Foundation Center for Basic Metabolic Research, Blegdamsvej 3B, 2200 Copenhagen N, Denmark. Gubra ApS, Agern Alle 1, 2970 Hørsholm, Denmark. University of Copenhagen, The Novo Nordisk Foundation Center for Basic Metabolic Research, Blegdamsvej 3B, 2200 Copenhagen N, Denmark. Gubra ApS, Agern Alle 1, 2970 Hørsholm, Denmark. Electronic address: jacob@gubra.dk. .
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