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110 documents found
1: Title: The innate immune receptor NLRP12 maintains intestinal homeostasis by regulating microbiome diversity.
Authors: Lau, Jenny Moi-Fong, et.al. .
Journal: Cellular & molecular immunology (Cell Mol Immunol), 2017 .
No Abstract available.
Affiliation: Centre for Experimental Medicine, Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast BT9 7BL, UK. .
2: Title: Erratum: NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth.
Authors: Chen, Liang, et.al. .
Journal: Nature immunology (Nat Immunol), Vol. 18 (8): 951, 2017 .
No Abstract available.
3: Title: [Hyperuricemia and gene mutations: a case report].
Authors: Tattoli, Fabio, et.al. .
Journal: Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia (G Ital Nefrol), Vol. 34 (3): 38-43, 2017 .
Snippet: The NLRP12 gene encodes proteins called "Nalps", forming a subfamily of proteins "CATERPILLAR".
Affiliation: S.C. Nefrologia e Dialisi ASLCN1, Ospedali di Ceva, Mondoví, Savigliano e Saluzzo. S.C. Pediatria, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, Torino. S.C. Genetica Medica, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, Torino. .
4: Title: Neighborhood characteristics influence DNA methylation of genes involved in stress response and inflammation: The Multi-Ethnic Study of Atherosclerosis.
Authors: Smith, Jennifer A, et.al. .
Journal: Epigenetics, 2017 .
Snippet: Neighborhood social environment, a summary measure of aesthetic quality, safety, and social cohesion, was associated with methylation in four of the seven stress-related genes (AVP, BDNF, FKBP5, SLC6A4) and seven of the 11 inflammation-related genes (CCL1, CD1D, F8, KLRG1, NLRP12, SLAMF7, TLR1).
Affiliation: a Department of Epidemiology , School of Public Health, University of Michigan , Ann Arbor , MI , 48109. b Survey Research Center, Institute for Social Research, University of Michigan , Ann Arbor , MI , 48104. c Department of Epidemiology and Biostatistics , Dornsife School of Public Health, Drexel University , Philadelphia , PA , 19104. d Department of Biostatistics , School of Public Health, University of Michigan , Ann Arbor , MI , 48109. e Department of Epidemiology and Prevention , School of Medicine, Wake Forest University , Winston-Salem , NC , 27109. .
5: Title: Expression analysis of inflammasome sensors and implication of NLRP12 inflammasome in prostate cancer.
Authors: Karan, Dev, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7 (1): 4378, 2017 .
Snippet: These data suggest an increased expression of NLRP12 in association with prostate cancer and support the role of NLRP12 inflammasome complex regulating inflammatory cytokines in understanding the role of inflammation in the prostate cancer.
Affiliation: Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA. dev.karan@uscmed.sc.edu. Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA. Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA. .
6: Title: Ginsenoside Rg1 attenuates the inflammatory response in DSS-induced mice colitis.
Authors: Zhu, Guo, et.al. .
Journal: International immunopharmacology (Int Immunopharmacol), Vol. 50, 2017 .
Snippet: Our results showed that ginsenoside Rg1 markedly reduces proinflammatory cytokines release upon DSS stimulation of mouse dendritic cells, that ginsenoside Rg1 suppresses IL-1β (Interleukin 1 beta) and TNF-α (Tumor necrosis factor alpha) release via up-regulation of NLRP12 (NACHT, LRR and PYD domains-containing protein 12) expression, and that ginsenoside Rg1 significantly decreases the inflammatory response to DSS-induced mouse colitis, as evidenced by increased body weight, reduced colonic damage scores and disease activity index (DAI), and lowered proinflammatory cytokines levels.
Affiliation: Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China. Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: sfs@zju.edu.cn. .
7: Title: Transcriptional Responses in the Murine Spleen after Toxoplasma gondii Infection: Inflammasome and Mucus-Associated Genes.
Authors: Znalesniak, Eva B, et.al. .
Journal: International journal of molecular sciences (Int J Mol Sci), Vol. 18 (6), 2017 .
Snippet: The expression of the pattern-recognition receptors Nlrp3, Nlrp12, and Nlrp1a was significantly increased after infection.
Affiliation: Institute of Molecular Biology and Medicinal Chemistry, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany. eva.znalesniak@med.ovgu.de. Institute of Molecular Biology and Medicinal Chemistry, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany. ftketty@gmail.com. Institute of Molecular Biology and Medicinal Chemistry, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany. franz.salm@med.ovgu.de. Institute of Medical Microbiology and Hygiene, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany. ulrike.haendel@med.ovgu.de. Institute of Molecular Biology and Medicinal Chemistry, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany. werner.hoffmann@med.ovgu.de. .
8: Title: Inflammasome expression and cytomegalovirus viremia in critically ill patients with sepsis.
Authors: Singh, Nina, et.al. .
Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (J Clin Virol), Vol. 93, 2017 .
Snippet: Blood samples to evaluate mRNA levels of genes encoding CASP1, ASC, NLRP1, NLRP3, and NLRP12 were collected at the time of enrollment.
Affiliation: Department of Medicine, Division of Infectious Diseases, VA Pittsburgh Healthcare System and University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: nis5@pitt.edu. Department of Immunology, Duke University School of Medicine, Durham, NC, United States. Department of Medicine, Division of Infectious Diseases, VA Pittsburgh Healthcare System and University of Pittsburgh, Pittsburgh, PA, United States. Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, United States. .
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9: Title: Clinical Overlapping in Autoinflammatory Diseases: The Role of Gene Duplication.
Authors: Galozzi, Paola, et.al. .
Journal: Frontiers in immunology (Front Immunol), Vol. 8, 2017 .
No Abstract available.
Affiliation: Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padova, Italy. .
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10: Title: Clinical update on inflammasomopathies.
Authors: Sönmez, Hafize Emine, et.al. .
Journal: International immunology (Int Immunol), 2017 .
Snippet: The other rare inflammasomopathies will be briefly discussed based on clinical features; these diseases are pyogenic arthritis, pyoderma gangrenosum and acne (PAPA), NLRC4-related macrophage-activation syndrome of enterocolitis, mutations in NLRP12 that cause hereditary periodic fever syndromes (familial cold inflammatory syndrome 2), and NLRP1 associated autoinflammation with arthritis and dyskeratosis (NAIAD).
Affiliation: Department of Pediatric Rheumatology, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey. .
11: Title: Gut microbiota: NLRP12 regulates gut microbiota to suppress intestinal inflammation.
Authors: Ray, Katrina .
Journal: Nature reviews. Gastroenterology & hepatology (Nat Rev Gastroenterol Hepatol), Vol. 14 (5): 260-261, 2017 .
No Abstract available.
12: Title: NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth.
Authors: Chen, Liang, et.al. .
Journal: Nature immunology (Nat Immunol), Vol. 18 (5): 541-551, 2017 .
Snippet: In parallel, Nlrp12 deficiency in mice caused increased basal colonic inflammation, which led to a less-diverse microbiome and loss of protective gut commensal strains (of the family Lachnospiraceae) and a greater abundance of colitogenic strains (of the family Erysipelotrichaceae). Dysbiosis and susceptibility to colitis associated with Nlrp12 deficency were reversed equally by treatment with antibodies targeting inflammatory cytokines and by the administration of beneficial commensal Lachnospiraceae isolates.
Affiliation: Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA. Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. Department of Internal Medicine, Division of Infectious Diseases, University of Michigan, Ann Arbor, Michigan, USA. Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Division of Digestive and Liver Diseases, Columbia University Medical Center, New York, New York, USA. Department of Gastroenterology, Tel-Aviv Sourasky Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. UNC Neuroscience Center and Integrative Program for Biological Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Immunology Research and Development, Janssen Pharmaceuticals, Spring House, Pennsylvania, USA. Center for Gastrointestinal Biology and Disease and the Departments of Medicine, of Microbiology and of Immunology, University of North Carolina, Chapel Hill, North Carolina, USA. .
13: Title: Differential expressions of NOD-like receptors and their associations with inflammatory responses in rheumatoid arthritis.
Authors: Kim, Hye Won, et.al. .
Journal: Clinical and experimental rheumatology (Clin Exp Rheumatol), Vol. 35 (4): 630-637, 2017 Jul-Aug .
Snippet: METHODS: Gene expression and protein levels of various NLRs, including NOD1, NOD2, NLRP1, NLRP3, NLRP12, NLRX1, and NLRC3, were determined in FLS and synovial tissues from patients with RA and patients with osteoarthritis (OA) using quantitative real-time PCR and immunohistochemistry.
Affiliation: Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea. Chadwick International School, Songdo, Incheon, South Korea. Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea. mcpark@yuhs.ac. .
14: Title: NLRP12 Inflammasome Expression in the Rat Brain in Response to LPS during Morphine Tolerance.
Authors: Chang, Sulie L, et.al. .
Journal: Brain sciences (Unknown Journal), Vol. 7 (2), 2017 .
Snippet: In response to LPS, there was a significant increase in the expression of the pro-inflammatory cytokine/chemokine genes interleukin-1 beta (Il-1β), interleukin-6 (Il-6), C-C motif chemokine ligand 2 (Ccl2), C-C motif chemokine ligand 7 (Ccl7), C-X-C motif chemokine ligand 1 (Cxcl1), and C-X-C motif chemokine ligand 3 (Cxcl3) and a significant decrease in the anti-inflammatory NLRP12 gene in both morphine-tolerant and placebo-control rats compared to saline-treated rats, although the changes were greater in the placebo-control animals.
Affiliation: Institute of NeuroImmune Pharmacology, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA. sulie.chang@shu.edu. Department of Biological Sciences, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA. sulie.chang@shu.edu. Institute of NeuroImmune Pharmacology, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA. wenfei.huang@shu.edu. Institute of NeuroImmune Pharmacology, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA. ninnamao@yahoo.com.cn. Institute of NeuroImmune Pharmacology, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA. Sabroni.Sarkar@gmail.com. .
15: Title: Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis.
Authors: Linz, Brandon M L, et.al. .
Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol), Vol. 198 (6): 2426-2433, 2017 .
Snippet: Nlrp12(-/-) mice exhibited significantly greater mortality, an inability to fight bacterial infection, heightened levels of proinflammatory cytokines, overt granulocyte/monocyte progenitor cell apoptosis, and failure to reconstitute peripheral myeloid populations.
Affiliation: Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599. Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599. Human Vaccine Institute, Duke University, Durham, NC 27708; and. Host Defense Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, NC 27709. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; robmaile@med.unc.edu. .
16: Title: Autoinflammation in pyoderma gangrenosum and its syndromic form (pyoderma gangrenosum, acne and suppurative hidradenitis).
Authors: Marzano, A V, et.al. .
Journal: The British journal of dermatology (Br J Dermatol), Vol. 176 (6): 1588-1598, 2017 .
Snippet: Cases of PG and PASH showed mutations in the autoinflammatory genes MEFV, NLRP3, NLRP12, NOD2, LPIN2 and PSTPIP1.
Affiliation: IRCCS Cà Granda Foundation, Dermatology Unit, Department of Pathophysiology and Transplantation, University of Milan, Milan, 20122, Italy. Istituto Gaslini, Genetica Medica, Genoa, Italy. Internal Medicine, University of Milan, Milan, 20122, Italy. .
17: Title: NLRP12 negatively regulates proinflammatory cytokine production and host defense against Brucella abortus.
Authors: Silveira, Tatiana N, et.al. .
Journal: European journal of immunology (Eur J Immunol), Vol. 47 (1): 51-59, 2017 .
Snippet: We also observed that NLRP12 suppresses in vitro NF-κB and MAPK signaling in response to Brucella.
Affiliation: Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Programa de Pós-Graduação em Genética, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. .
18: Title: P2Y1 Receptor Signaling Contributes to High Salt-Induced Priming of the NLRP3 Inflammasome in Retinal Pigment Epithelial Cells.
Authors: Prager, Philipp, et.al. .
Journal: PloS one, Vol. 11 (10): e0165653, 2016 .
Snippet: High extracellular NaCl induced NLRP3 and pro-IL-1β gene expression, while the gene expression of further inflammasome-associated proteins (NLRP1, NLRP2, NLRP6, NLRP7, NLRP12, NLRC4, AIM2, ASC, procaspase-1, pro-IL-18) was not altered or below the detection threshold.
Affiliation: Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany. Helios Klinikum Aue, Aue, Germany. .
19: Title: Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment.
Authors: Ulland, Tyler K, et.al. .
Journal: Nature communications (Nat Commun), Vol. 7, 2016 .
Snippet: C57BL/6J and NLRP12-deficient macrophages have impaired CXCL1 production and the neutrophil defect observed in C57BL/6J and NLRP12-deficient mice is rescued by restoration of macrophage NLRP12.
Affiliation: Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA. Interdisciplinary Program in Molecular and Cellular Biology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA. Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA. Interdisciplinary Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA. Medical Scientist Training Program, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA. Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA. Department of Biostatistics, University of Iowa College of Public Health, Iowa City, Iowa 52242, USA. Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA. Department of Biochemistry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA. Protein Crystallography Facility, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA. Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA. Veterans Affairs Medical Center, Iowa City, Iowa 52246, USA. Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA. .
20: Title: The transcription factor, Nuclear factor, erythroid 2 (Nfe2), is a regulator of the oxidative stress response during Danio rerio development.
Authors: Williams, Larissa M, et.al. .
Journal: Aquatic toxicology (Amsterdam, Netherlands) (Aquat Toxicol), Vol. 180, 2016 .
Snippet: Across time and treatment, there were six genes (dhx40, cfap70, dnajb9b, slc35f4, spi-c, and gpr19) that were significantly up-regulated in KO compared to WT and four genes (fhad1, cyp4v7, nlrp12, and slc16a6a) that were significantly down-regulated.
Affiliation: Biology Department, Bates College, 44 Campus Avenue, Lewiston, ME 04240, USA; The MDI Biological Laboratory, 159 Old Bar Harbor Road, Bar Harbor, ME 04609 USA, USA. Electronic address: lwillia2@bates.edu. M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, Hamilton, ON L8S 4K1, Canada. Electronic address: lagoba@mcmaster.ca. M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, Hamilton, ON L8S 4K1, Canada. Electronic address: mcarthua@mcmaster.ca. M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, Hamilton, ON L8S 4K1, Canada. Electronic address: raphenar@mcmaster.ca. Biology Department, Bates College, 44 Campus Avenue, Lewiston, ME 04240, USA. Electronic address: pray.nicholas@gmail.com. Biology Department, Bates College, 44 Campus Avenue, Lewiston, ME 04240, USA; The MDI Biological Laboratory, 159 Old Bar Harbor Road, Bar Harbor, ME 04609 USA, USA. Electronic address: nabilsaleem@gmail.com. Biology Department, Bates College, 44 Campus Avenue, Lewiston, ME 04240, USA; The MDI Biological Laboratory, 159 Old Bar Harbor Road, Bar Harbor, ME 04609 USA, USA. Electronic address: sophia.salas2@gmail.com. Biology Department, Bates College, 44 Campus Avenue, Lewiston, ME 04240, USA; The MDI Biological Laboratory, 159 Old Bar Harbor Road, Bar Harbor, ME 04609 USA, USA. Electronic address: krpaulson@gmail.com. The MDI Biological Laboratory, 159 Old Bar Harbor Road, Bar Harbor, ME 04609 USA, USA; College of the Atlantic, 105 Eden Street, Bar Harbor, ME 04609, USA. Electronic address: rmangar@coa.edu. Department of Pediatrics and Communicable Diseases, University of Michigan, 8200 MSRB III 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: yangliu0302@gmail.com. Department of Pediatrics and Communicable Diseases, University of Michigan, 8200 MSRB III 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: Andy.Vo@northwestern.edu. Department of Pediatrics and Communicable Diseases, University of Michigan, 8200 MSRB III 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: jshavit@umich.edu. .
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