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Metallothionein 17
 
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23 documents found
1: Title: METALLOTHIONEIN genes encoding ROS scavenging enzymes are down-regulated in the root cortex during inducible aerenchyma formation in rice.
Authors: Yamauchi, Takaki, et.al. .
Journal: Plant signaling & behavior (Plant Signal Behav), Vol. 12 (11): e1388976, 2017 .
Snippet: In the root cortex, where aerenchyma forms exclusively, the expression of MT1a, MT1b and MT1Ld was reduced prior to aerenchyma formation.
Affiliation: a Graduate School of Bioagricultural Sciences , Nagoya University, Furo-cho , Chikusa, Nagoya , Japan. b UWA School of Agriculture and Environment , Faculty of Science, The University of Western Australia , 35 Stirling Highway, Crawley , Australia. .
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2: Title: Metallothionein Isoform Expression in Benign and Malignant Thyroid Lesions.
Authors: Wojtczak, Beata, et.al. .
Journal: Anticancer research (Anticancer Res), Vol. 37 (9): 5179-5185, 2017 .
Snippet: MATERIALS AND METHODS: mRNA expression of functional isoforms of MT genes (MT1A, MT1B, MT1E, MT1F, MT1G, MT1H, MT1X, MT2A, MT4) was studied in 17 nodular goiters (NG), 12 follicular adenomas (FA) and 26 papillary thyroid carcinomas (PTC).
Affiliation: First Department and Clinic of General, Gastroenterological and Endocrine Surgery, Wroclaw Medical University, Wroclaw, Poland beatawojtczak@wp.pl. Department of Histology and Embryology, Wroclaw Medical University, Wroclaw, Poland. First Department and Clinic of General, Gastroenterological and Endocrine Surgery, Wroclaw Medical University, Wroclaw, Poland. Department and Clinic of Endocrinology, Diabetology and Isotope Therapy, Wroclaw Medical University, Wroclaw, Poland. Department of Physiotherapy, Wroclaw University School of Physical Education, Wroclaw, Poland. .
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3: Title: Metallothionein polymorphisms in a Northern Spanish population with neovascular and dry forms of age-related macular degeneration.
Authors: García, Montserrat, et.al. .
Journal: Ophthalmic genetics (Ophthalmic Genet), 2017 .
Snippet: DNA was isolated from peripheral blood and genotyped for 14 SNPs located at 5 MT genes (MT1A: rs11076161, rs 11640851, rs8052394, and rs7196890; MT1B: rs8052334, rs964372, and rs7191779; MT1M: rs2270836 and rs9936741; MT2A: rs28366003, rs1610216, rs10636, and rs1580833; MT3: rs45570941) using TaqMan probes.
Affiliation: a Fernández-Vega University Institute, Foundation of Ophthalmological Investigation, University of Oviedo , Oviedo , Spain. b Department of Neurodegenerative Eye Disease, Fernández-Vega Ophthalmological Institute , Oviedo , Spain. c Laboratory of Human Molecular Genetics, Faculty of Medicine/Institute of Investigation in Neurological Disabilities (IDINE) , University of Castilla-La Mancha , Albacete , Spain. d Department of Ophthalmology and Visual Science , Yale University School of Medicine , New Haven , Connecticut , USA. .
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4: Title: Pharmacological advantages of melatonin in immunosenescence by improving activity of T lymphocytes.
Authors: Yoo, Yeong-Min, et.al. .
Journal: Journal of biomedical research (J Biomed Res), Vol. 30 (4): 314-21, 2016 .
Snippet: Splenocytes, CD4(+), and naïve CD4 T lymphocytes were isolated from the spleen of BALB/c mice and the cell population patterns and mRNA profiles associated with T cell activation (CD28 and p21) and the melatonin receptor (MT1A and MT1B) were assessed.
Affiliation: Department of Biomedical Engineering, College of Health Science, Yonsei University, Wonju, Gangwon-do 220-710, Republic of Korea. College of Life Science, Gangneung-Wonju National University, Gangneung, Gangwon-do 210-702, Republic of Korea. Industry-Academic Cooperation Foundation, Hanbat National University, Daejeon 305-719, Republic of Korea. College of Life Science, Gangneung-Wonju National University, Gangneung, Gangwon-do 210-702, Republic of Korea. ssj66@gwnu.ac.kr. .
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5: Title: Genetic variation in metallothionein and metal-regulatory transcription factor 1 in relation to urinary cadmium, copper, and zinc.
Authors: Adams, Scott V, et.al. .
Journal: Toxicology and applied pharmacology (Toxicol Appl Pharmacol), Vol. 289 (3): 381-8, 2015 .
Snippet: Minor alleles of rs8044719 and rs1599823, near MT1A and MT1B, were associated with lower urinary Cd and Zn, respectively.
Affiliation: Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA. Electronic address: sadams@fhcrc.org. Department of Plant and Environmental Sciences, New Mexico State University, Box 30003 MSC 3Q, Las Cruces, NM 88003, USA. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA. Environmental Chemistry and Technology, Wisconsin State Laboratory of Hygiene, University of Wisconsin, 2601 Agriculture Dr., Madison, WI 53718, USA. Public Health Science Biomarker Laboratory, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA. Border Epidemiology and Environmental Health Center, New Mexico State University, Box 30001 MSC 3BEC, Las Cruces, NM 88003, USA. .
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6: Title: Metallothionein gene expression is altered in oral cancer and may predict metastasis and patient outcomes.
Authors: Brazão-Silva, Marco T, et.al. .
Journal: Histopathology, Vol. 67 (3): 358-67, 2015 .
Snippet: All tissues were analysed for the following genes using TaqMan(®) reverse transcription-quantitative polymerase chain reaction (RT-qPCR) assays: MT1A, MT1B, MT1E, MT1F, MT1G, MT1H, MT1X, MT2A, MT3 and MT4.
Affiliation: PhD program in Estomatology and Basic and Applied Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil. Laboratory of Molecular Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil. Department of Pathology, Brazilian National Cancer Institute/INCA, Rio de Janeiro, Brazil. Department of Head and Neck Surgery, Brazilian National Cancer Institute/INCA, Rio de Janeiro, Brazil. National Tumor Bank, Brazilian National Cancer Institute/INCA, Rio de Janeiro, Brazil. Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil. Department of Histology and Morphology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Brazil. Department of Oral Pathology, School of Dentistry, Federal University of Uberlândia, Uberlândia, Brazil. .
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7: Title: Prognostic impact of tumor size eliminating the ground glass opacity component: modified clinical T descriptors of the tumor, node, metastasis classification of lung cancer.
Authors: Nakamura, Shota, et.al. .
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (J Thorac Oncol), Vol. 8 (12): 1551-7, 2013 .
Snippet: RESULTS: The 5-year survival rates were 88% and 82% in the patients with T1a and T1b tumors and 90% and 75% in the patients with mT1a and mT1b tumors, respectively.
Affiliation: *Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan; and †Center for Advanced Medicine and Clinical Research, Nagoya University Graduate School of Medicine, Nagoya, Japan. .
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8: Title: Changes in circadian rhythm for mRNA expression of melatonin 1A and 1B receptors in the hypothalamus under a neuropathic pain-like state.
Authors: Odo, Masahiko, et.al. .
Journal: Synapse (New York, N.Y.) (Synapse), Vol. 68 (4): 153-8, 2014 .
Snippet: In this study, we investigated the possible changes in circadian rhythm for the expression of MT receptors, especially MT1A and MT1B receptors, in the hypothalamus of mice with sciatic nerve ligation.
Affiliation: Department of Pharmacology, Hoshi University School of Pharmaceutical Sciences, Shinagawa-ku, Tokyo, 142-8501, Japan; Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, Tokyo, 113-8421, Japan. .
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9: Title: The stoichiometric transition from Zn6Cu1-metallothionein to Zn7-metallothionein underlies the up-regulation of metallothionein (MT) expression: quantitative analysis of MT-metal load in eye cells.
Authors: Alvarez, Lydia, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 287 (34): 28456-69, 2012 .
Snippet: All MT1 isoforms, with the exception of MT1B, were abundantly expressed in lens and corneal tissue.
Affiliation: Fundación de Investigación Oftalmológica, Instituto Oftalmológico Fernández-Vega, 33012 Oviedo, Spain. .
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10: Title: Functional characterization of four metallothionein genes in Daphnia pulex exposed to environmental stressors.
Authors: Asselman, J, et.al. .
Journal: Aquatic toxicology (Amsterdam, Netherlands) (Aquat Toxicol), Vol. 110-111, 2012 .
Snippet: The number of these elements and their positions relative to the start codon varied strongly among the four genes and even among two gene duplicates (Mt1A and Mt1B), suggesting different roles of the four proteins in the organisms' response to stress.
Affiliation: Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium. jana.asselman@ugent.be .
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11: Title: Immunohistochemical and biomolecular identification of melatonin 1a and 1b receptors in rat vestibular nuclei.
Authors: Ahn, Seong-Ki, et.al. .
Journal: Auris, nasus, larynx (Auris Nasus Larynx), Vol. 39 (5): 479-83, 2012 .
Snippet: The presences of the mRNAs of the MT1a and MT1b receptors were confirmed by RT-PCR in medial vestibular nuclei and trigeminal ganglia.
Affiliation: Department of Otolaryngology, School of Medicine, Gyeongsang National University, Jinju, South Korea. skahn@gnu.ac.kr .
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12: Title: DNA microarray analysis of human coronary artery endothelial cells exposed to cadmium.
Authors: Fujiwara, Yasuyuki, et.al. .
Journal: The Journal of toxicological sciences (J Toxicol Sci), Vol. 36 (1): 141-3, 2011 .
Snippet: Out of 35,035 human genes, Cd enhanced the expression of 3 metallothionein (MT)-I subisoform genes, including MT1E, MT1H and MT1B, and reduced the expression of 12 genes, including ISG20 and TK1, 2-fold or greater.
Affiliation: Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University, Chikusa-ku, Nagoya, Aichi, Japan. .
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13: Title: Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines.
Authors: Bigagli, Elisabetta, et.al. .
Journal: Chemico-biological interactions (Chem Biol Interact), Vol. 188 (1): 214-9, 2010 .
Snippet: Amongst these genes metallothioneins (MT1A and MT2A) were over-expressed at all copper concentrations, MT1M was up-regulated between 10(-6) and 10(-9)M, while MT1B, MT1E, MT1G and MT1H were up-regulated between 10(-6) and 10(-14)M.
Affiliation: Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy. .
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14: Title: Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction.
Authors: Wilson, Andrew J, et.al. .
Journal: Cancer research (Cancer Res), Vol. 70 (2): 609-20, 2010 .
Snippet: A robust and reproducible transcriptional response involving coordinate induction of multiple immediate-early (fos, jun, egr1, egr3, atf3, arc, nr4a1) and stress response genes (Ndrg4, Mt1B, Mt1E, Mt1F, Mt1H) was selectively induced in HDACi sensitive cells.
Affiliation: Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA. .
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15: Title: Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells.
Authors: Kim, Soohee, et.al. .
Journal: Toxicology in vitro : an international journal published in association with BIBRA (Toxicol In Vitro), Vol. 23 (6): 1076-84, 2009 .
Snippet: Metal-responsive metallothionein 1b (MT1b) mRNA expression was not induced in AgNP-treated cells, while it was induced in AgNO(3)-treated cells.
Affiliation: College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea. .
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16: Title: Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications.
Authors: Yang, Lina, et.al. .
Journal: American journal of physiology. Endocrinology and metabolism (Am J Physiol-endoc M), Vol. 294 (5): E987-92, 2008 .
Snippet: Using the PCR-based restriction fragment length polymorphism method, seven single nucleotide polymorphisms (SNPs) in MT genes (rs8052394 and rs11076161 in MT1A gene, rs8052334, rs964372, and rs7191779 in MT1B gene, rs708274 in MT1E gene, and rs10636 in MT2A gene) were detected in 851 Chinese people of Han descent (397 diabetes and 454 controls).
Affiliation: School of Public Health, Jilin University, Changchun, China. .
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17: Title: Metallothionein isoform 2A expression is inducible and protects against ROS-mediated cell death in rotenone-treated HeLa cells.
Authors: Reinecke, Fimmie, et.al. .
Journal: The Biochemical journal (Biochem J), Vol. 395 (2): 405-15, 2006 .
Snippet: To evaluate the role of MT2A expression, MT2A and MT1B were overexpressed in HeLa cells and treated with rotenone.
Affiliation: Division of Biochemistry, School for Chemistry and Biochemistry, North-West University, Potchefstroom 2531, South Africa. .
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18: Title: DBC1 re-expression alters the expression of multiple components of the plasminogen pathway.
Authors: Louhelainen, J P, et.al. .
Journal: Oncogene, Vol. 25 (16): 2409-19, 2006 .
Snippet: The cell clone with the lowest level of DBC1 expression showed induced expression of 26 genes including plasminogen activator inhibitor 2 (SERPINB5; 4.6-fold), heparin-binding EGF-like growth factor precursor (DTR; 4.2-fold), small proline-rich protein 2B (SPRR2B; 3.6-fold), metallothionein 1 isoforms (MT1B/MT1A/MT-1F; from 2.9- to 3.2-fold), tissue-type plasminogen activator precursor (PLAT; 2.8-fold) and urokinase-type plasminogen activator precursor (PLAU; 2.7-fold).
Affiliation: Cancer Research UK Clinical Centre, St James's University Hospital, Leeds, West Yorkshire, UK. .
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19: Title: The plant MT1 metallothioneins are stabilized by binding cadmiums and are required for cadmium tolerance and accumulation.
Authors: Zimeri, Anne Marie, et.al. .
Journal: Plant molecular biology (Plant Mol Biol), Vol. 58 (6): 839-55, 2005 .
Snippet: To understand why plants have such a diversity of MT sequences, the Arabidopsis MT1 class, comprised of three genes, MT1a, MT1b, and MT1c, was characterized in more detail in plants.
Affiliation: Department of Genetics, University of Georgia, Athens, GA 30602, USA. zimeri@uga.edu .
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20: Title: Expression of genes coding melatonin and serotonin receptors in rodent skin.
Authors: Slominski, Andrzej, et.al. .
Journal: Biochimica et biophysica acta (Biochim Biophys Acta), Vol. 1680 (2): 67-70, 2004 .
Snippet: Targeted search for expression of melatonin and serotonin receptors genes in the skin of C57BL/6J mice showed expression of MT1B (but not MT1A).
Affiliation: Department of Pathology, University of Tennessee Health Science Center, 930 Madison Ave., Room 519, Memphis, TN 38163, USA. aslominski@utmem.edu .
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