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8 documents found
1: Title: Defective mitochondrial rRNA methyltransferase MRM2 causes MELAS-like clinical syndrome.
Authors: Garone, Caterina, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), 2017 .
Snippet: Targeted exome sequencing of genes encoding the mitochondrial proteome identified a damaging mutation, c.567G>A, affecting a highly conserved amino acid residue (p.Gly189Arg) of the MRM2 protein.
Affiliation: Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK. Department of Neurology, Columbia University Medical Center, New York, 10032, US. Department of Chemistry, Life Sciences and Environmental Sustainability - University of Parma, Parma, 43121, Italy. Graduate Program in Areas of Basic and Applied Biology (GABBA), University of Porto, 4099-002, Portugal. Metabolic Unit, A. Meyer Children's Hospital, Florence, 50139, Italy. Pediatric Neurology Unit and Laboratories, "A. Meyer" Children's Hospital, University of Florence, 50139 Italy. Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA. Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, and Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. .
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2: Title: Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16 S ribosomal RNA (rRNA).
Authors: Lee, Ken-Wing, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 289 (36): 24936-42, 2014 .
Snippet: In this study, we took advantage of the ability of 2'-O-ribose modification to block site-specific cleavage of RNA by DNAzymes to show that MRM1, MRM2, and RNMTL1 are responsible for modification of human large subunit rRNA at residues G(1145), U(1369), and G(1370), respectively.
Affiliation: From the Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York 11794-8651. From the Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York 11794-8651 daniel.bogenhagen@stonybrook.edu. .
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3: Title: MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome.
Authors: Rorbach, Joanna, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), Vol. 25 (17): 2542-55, 2014 .
Snippet: Here we investigate two methyltransferases, MRM2 (also known as RRMJ2, encoded by FTSJ2) and MRM3 (also known as RMTL1, encoded by RNMTL1), that are responsible for modification of nucleotides of the 16S rRNA A-loop, an essential component of the peptidyl transferase center.
Affiliation: MRC Mitochondrial Biology Unit, Cambridge CB2 0XY, United Kingdom. Gene Center Munich, Ludwig-Maximilians University, 81377 Munich, Germany. Gene Center Munich, Ludwig-Maximilians University, 81377 Munich, Germany Institute of Human Genetics, Helmholtz Zentrum Munich, 85764 Munich, Germany. MRC Mitochondrial Biology Unit, Cambridge CB2 0XY, United Kingdom michal.minczuk@mrc-mbu.cam.ac.uk. .
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4: Title: Mitochondrial ribosomal RNA (rRNA) methyltransferase family members are positioned to modify nascent rRNA in foci near the mitochondrial DNA nucleoid.
Authors: Lee, Ken-Wing, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 288 (43): 31386-99, 2013 .
Snippet: We have identified RNMTL1, MRM1, and MRM2 (FtsJ2) as members of the RNA methyltransferase family that may be responsible for the three known 2'-O-ribose modifications of the 16 S rRNA core of the large mitochondrial ribosome subunit.
Affiliation: From the Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York 11794-8651. .
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5: Title: The yeast GTPase Mtg2p is required for mitochondrial translation and partially suppresses an rRNA methyltransferase mutant, mrm2.
Authors: Datta, Kaustuv, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), Vol. 16 (2): 954-63, 2005 .
Snippet: Significantly, elevated levels of Mtg2p partially suppress the thermosensitive loss of mitochondrial DNA in a 21S rRNA methyltransferase mutant, mrm2.
Affiliation: Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-1048, USA. .
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6: Title: Functional redundancy of Spb1p and a snR52-dependent mechanism for the 2'-O-ribose methylation of a conserved rRNA position in yeast.
Authors: Bonnerot, Claire, et.al. .
Journal: Molecular cell (Mol Cell), Vol. 12 (5): 1309-15, 2003 .
Snippet: The equivalent position on the E. coli 23S rRNA is methylated by FtsJ/RrmJ which has three yeast homologs: Spb1, involved in biogenesis of LSU; Trm7, a tRNA methyltransferase; and Mrm2, a mitochondrial 21S rRNA methyltransferase.
Affiliation: Centre de Recherche en Biochimie Macromoléculaire, Centre National de la Recherche Scientifique, 1919 route de Mende, 34293 Montpellier, France. .
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7: Title: MRM2 encodes a novel yeast mitochondrial 21S rRNA methyltransferase.
Authors: Pintard, Lionel, et.al. .
Journal: The EMBO journal (Embo J), Vol. 21 (5): 1139-47, 2002 .
Snippet: We demonstrate here that the yeast nuclear genome encodes a mitochondrial protein, named Mrm2, which is required for methylating U(2791) of 21S rRNA, both in vivo and in vitro.
Affiliation: Centre de Recherche de Biochimie Macromoléculaire, CNRS, Montpellier, France. .
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8: Title: A self-perpetuating vicious cycle of tissue damage in human hibernating myocardium.
Authors: Elsässer, A, et.al. .
Journal: Molecular and cellular biochemistry (Mol Cell Biochem), Vol. 213 (1-2): 17-28, 2000 .
Snippet: The number of angiotensin converting enzyme (ACE) containing structures was increased (n/mrm2: control-11.4,
Affiliation: Department of Cardiology, University of Freiburg, Germany. .
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