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11 documents found
1: Title: Dysregulation of PTEN caused by the underexpression of microRNA‑130b is associated with the severity of lupus nephritis.
Authors: Wu, Shupeng, et.al. .
Journal: Molecular medicine reports (Mol Med Report), 2018 .
Snippet: In addition, reverse transcription‑polymerase chain reaction and western blot analyses were performed to examine the mRNA and protein expression levels of PTEN among individuals with lupus nephritis (n=28) and those without lupus nephritis (n=31), and in mesangial cells treated with scramble control, miR‑130b mimics, PTEN small interfering (si)RNA and miR‑130b inhibitors.
Affiliation: Department of Rheumatism and Immunology, Tai'an Central Hospital, Tai'an, Shandong 271000, P.R. China. Department of Geriatric Diseases, Tai'an Central Hospital, Tai'an, Shandong 271000, P.R. China. .
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2: Title: miR-130b promotes bladder cancer cell proliferation, migration and invasion by targeting VGLL4.
Authors: Liu, Xiaowu, et.al. .
Journal: Oncology reports (Oncol Rep), 2018 .
Snippet: miR-130b overexpression promoted BCa cell proliferation, migration and invasion, whereas miR-130b inhibition had the opposite effects.
Affiliation: Department of Urology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China. .
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3: Title: Silencing of H19 inhibits the adipogenesis and inflammation response in ox-LDL-treated Raw264.7 cells by up-regulating miR-130b.
Authors: Han, Yong, et.al. .
Journal: Molecular immunology (Mol Immunol), Vol. 93, 2018 .
Snippet: Taken together, our research indicated a H19-miR130b pathway in regulating lipid metabolism and inflammation response in ox-LDL-treated Raw264.7 cells, providing new targets for AS treatment.
Affiliation: Department of Cardiovascular Diseases, Xi'an Honghui Hospital, Shaanxi, 710000, China. Department of Cardiovascular Diseases, Shaanxi Friendship Hospital, Shaanxi, 710000, China. Department of Cardiovascular Diseases, Xi'an Honghui Hospital, Shaanxi, 710000, China. Electronic address: wanglipingsxxa@yeah.net. .
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4: Title: Suppression of microRNA-130b inhibits glioma cell proliferation and invasion, and induces apoptosis by PTEN/AKT signaling.
Authors: Gu, Jian-Jun, et.al. .
Journal: International journal of molecular medicine (Int J Mol Med), Vol. 41 (1): 284-292, 2018 .
Snippet: Western blotting revealed that the miR-130b inhibitor upregulated the expression of PTEN, inhibited AKT pathway activation, upregulated the tumor suppressor gene p27, and suppressed cyclin D1, matrix metalloproteinase 2 and 9 expression.
Affiliation: Stroke Center, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan 450000, P.R. China. Department of Gastroenterology, Chinese PLA General Hospital, Beijing 100853, P.R. China. Department of Neurosurgery, Fuzhou General Hospital, Fuzhou, Fujian 350025, P.R. China. .
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5: Title: miR-130b regulates the proliferation, invasion and apoptosis of glioma cells via targeting of CYLD.
Authors: Xiao, Zhi-Qiang, et.al. .
Journal: Oncology reports (Oncol Rep), Vol. 38 (1): 167-174, 2017 .
Snippet: In the present study, miR-130b expression was upregulated in glioma tissues and cell lines.
Affiliation: Department of Neurosurgery, The First People's Hospital of Shangqiu, Shangqiu, Henan 476100, P.R. China. Department of Neurosurgery, Fuzong Clinical College, Fujian Medical University, Fuzhou, Fujian 350025, P.R. China. Department of Oncology, Taizhou People's Hospital Affiliated to the Medical College of Nantong University, Taizhou, Jiangsu 225300, P.R. China. Stroke Center, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan 450000, P.R. China. .
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6: Title: Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell.
Authors: Ofori, Jones K, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7, 2017 .
Snippet: Overexpression of any of the three microRNAs in the insulin-secreting INS-1 832/13 cell line resulted in altered dynamics of intracellular ATP/ADP ratio ultimately perturbing fundamental ATP-requiring beta cell processes such as glucose-stimulated insulin secretion, insulin biosynthesis and processing.
Affiliation: Islet Cell Exocytosis, Department of Clinical Sciences-Malmö, Lund University, Malmö, 205 02, Sweden. Lund University Diabetes Centre, Skåne University Hospital, Lund and Malmö, Sweden. Molecular Metabolism, Department of Clinical Sciences-Malmö, Lund University, Malmö, 20502, Sweden. Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, 1211, Switzerland. .
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7: Title: MicroRNA-130b promotes cell proliferation and invasion by inhibiting peroxisome proliferator-activated receptor-γ in human glioma cells.
Authors: Gu, Jian-Jun, et.al. .
Journal: International journal of molecular medicine (Int J Mol Med), Vol. 37 (6): 1587-93, 2016 .
Snippet: We found that the upregulation of miR-130b induced cell proliferation, decreased the percentage of cells in the G0/G1 phase and enhanced the invasiveness of U251 glioma cells whereas the downregulation of miR-130b exerted opposing effects.
Affiliation: Department of Neurosurgery, Fuzhou General Hospital, Xiamen University Medical College, Fuzhou, Fujian 350025, P.R. China. .
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8: Title: Identification of miR‑130b as an oncogene in renal cell carcinoma.
Authors: Li, Yifan, et.al. .
Journal: Molecular medicine reports (Mol Med Report), Vol. 13 (2): 1902-8, 2016 .
Snippet: MicroRNAs (miRNAs) have been found to be important in a wide range of biological and pathological processes, including cell differentiation, migration, growth, proliferation, apoptosis and metabolism.
Affiliation: Department of Urology, Peking University Shenzhen Hospital, Shenzhen PKU‑HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China. Department of Urology, Anhui Medical University, Hefei, Anhui 230032, P.R. China. Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU‑HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China. .
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9: Title: MiR130b-Regulation of PPARγ Coactivator- 1α Suppresses Fat Metabolism in Goat Mammary Epithelial Cells.
Authors: Chen, Zhi, et.al. .
Journal: PloS one, Vol. 10 (11): e0142809, 2015 .
Snippet: microRNAs (miRNAs) are a class of negative regulator of proteins and play crucial roles in many biological processes; including fat metabolism.
Affiliation: Shaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China. College of Life Sciences, Shenzhen University, Shenzhen, Guangzhou, China. College of Medicine, Shenzhen University, Shenzhen, Guangdong, China. .
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10: Title: NRP1 is targeted by miR-130a and miR-130b, and is associated with multidrug resistance in epithelial ovarian cancer based on integrated gene network analysis.
Authors: Chen, Changxian, et.al. .
Journal: Molecular medicine reports (Mol Med Report), Vol. 13 (1): 188-96, 2016 .
Snippet: In the present study, four public microarray datasets, including GSE41499, GSE33482, GSE15372 and GSE28739, available in Gene Expression Omnibus were downloaded, and 11 microRNAs (miRNA; miRs), including miR‑130a, miR‑214, let‑7i, miR‑125b, miR‑376c, miR‑199a, miR‑93, miR‑141, miR‑130b, miR‑193b* and miR‑200c, from previously published reports in PubMed were used to perform a comprehensive bioinformatics analysis through gene expression analysis, signaling pathway analysis, literature co‑occurrence and miRNA‑mRNA interaction networks.
Affiliation: Department of Gynecological Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China. Department of Bioinformatics, Medical Research Center, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China. .
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11: Title: A microRNA-based test improves endoscopic ultrasound-guided cytologic diagnosis of pancreatic cancer.
Authors: Brand, Randall E, et.al. .
Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association (Clin Gastroenterol Hepatol), Vol. 12 (10): 1717-23, 2014 .
Snippet: RESULTS: We developed a 5-miRNA expression classifier, consisting of MIR24, MIR130B, MIR135B, MIR148A, and MIR196, that could identify PDAC in well-characterized, formalin-fixed, paraffin-embedded specimens.
Affiliation: Department of Medicine, Division of Gastroenterology, Hepatology & Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Asuragen, Inc, Austin, Texas. Department of Pathology and Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida. Center for Pancreatic Disease, Brigham and Women's Hospital, Boston, Massachusetts. Department of Medicine, Division of Gastroenterology, University of Sherbrooke, Fleurimont, Quebec, Canada. Department of Endoscopy, Hospital of the Ministry of Internal Affairs and Administration, Szczecin, Poland. Department of Gastroenterology and Hepatology, Medical University of Silesia, Katowice, Poland. Institute of Pathology, Ruhr-University of Bochum, Bochum, Germany. Molecular GI-Oncology and Department of Pathology, Ruhr-University of Bochum, Bochum, Germany. Department of Medicine, Division of Radiology, Medical University of Łódź, Łódz, Poland. Department of Pathology and Department of Gasteroenterology and Hepatology, Dartmouth Hitchcock Medical Center and The Audrey and Theodor Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire. Asuragen, Inc, Austin, Texas. Electronic address: aschwarzbach@asuragen.com. .
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