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97 documents found
1: Title: Identification of Novel Potentially Pleiotropic Variants Associated With Osteoporosis and Obesity Using the cFDR Method.
Authors: Hu, Yuan, et.al. .
Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab), Vol. 103 (1): 125-138, 2018 .
Snippet: Results: We identified seven potentially pleiotropic loci-rs3759579 (MARK3), rs2178950 (TRPS1), rs1473 (PUM1), rs9825174 (XXYLT1), rs2047937 (ZNF423), rs17277372 (DNM3), and rs335170 (PRDM6)-associated with osteoporosis and obesity.
Affiliation: Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China. Center for Bioinformatics and Genomics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana. .
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2: Title: MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.
Authors: Sandí, María-José, et.al. .
Journal: Science signaling (Sci Signal), Vol. 10 (503), 2017 .
Snippet: We showed in mammalian cells that liver kinase B1 (LKB1) activated the microtubule affinity-regulating kinase 3 (MARK3), which in turn phosphorylated ARHGEF2 at Ser151 This modification disrupted the interaction between ARHGEF2 and DYNLT1 by generating a 14-3-3 binding site in ARHGEF2, thus causing ARHGEF2 to dissociate from microtubules.
Affiliation: Princess Margaret Cancer Centre, University Health Network, 101 College Street, Princess Margaret Cancer Research Tower, Toronto, Ontario M5G 1L7, Canada. Department of Medical Biophysics, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada. Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. Department of Biostatistics, Princess Margaret Cancer Centre, Toronto, Ontario, Canada. Princess Margaret Cancer Centre, University Health Network, 101 College Street, Princess Margaret Cancer Research Tower, Toronto, Ontario M5G 1L7, Canada. rottapel@uhnresearch.ca. Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Division of Rheumatology, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada. .
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3: Title: Plasma Membrane Protein Profiling in Beta-Amyloid-Treated Microglia Cell Line.
Authors: Correani, Virginia, et.al. .
Journal: Proteomics, Vol. 17 (17-18), 2017 .
Snippet: Among these, we proposed as reliable biomarkers of the inflammatory microglia phenotype in AD damaged tissues MAP/microtubule affinity-regulating kinase 3 (MARK3), Interferon-induced transmembrane protein 3 (IFITM3), Annexins A5 and A7 (ANXA5, ANXA7) and Neuropilin-1 (NRP1), all proteins known to be involved in the inflammation processes and in microtubule network assembly rate.
Affiliation: Dipartimento di Scienze Biochimiche, Sapienza Università di Roma, Rome, Italy. Dipartimento di Scienze Anatomiche Istologiche, Medico-Legali e dell'Apparato Locomotore, Sapienza Università di Roma, Rome, Italy. Dipartimento di Scienze, Università Roma Tre, Rome, Italy. .
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4: Title: Combining affinity propagation clustering and mutual information network to investigate key genes in fibroid.
Authors: Chen, Qian-Song, et.al. .
Journal: Experimental and therapeutic medicine (Exp Ther Med), Vol. 14 (1): 251-259, 2017 .
Snippet: A total of 9 clusters and exemplars were identified based on mAP-KL, which were comprised of CALCOCO2, COL4A2, COPS8, SNCG, PA2G4, C17orf70, MARK3, BTNL3 and TBC1D13.
Affiliation: Department of Gynaecology, Tangshan Maternal and Child Healthcare Hospital, Tangshan, Hebei 063000, P.R. China. Department of Reproductive Genetics, Tangshan Maternal and Child Healthcare Hospital, Tangshan, Hebei 063000, P.R. China. .
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5: Title: MARK2 inhibits the growth of HeLa cells through AMPK and reverses epithelial-mesenchymal transition.
Authors: Xu, Ge, et.al. .
Journal: Oncology reports (Oncol Rep), Vol. 38 (1): 237-244, 2017 .
Snippet: Microtubule affinity-regulating kinases (MARKs; MARK1, MARK2, MARK3 and MARK4) act directly downstream of LKB1, the multitasking tumor-suppressor kinase, and thereby mediate its biological effects.
Affiliation: Institute of Life Science, Chongqing Medical University, Chongqing 400016, P.R. China. Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China. Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China. .
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6: Title: First report on the safety and efficacy of an extended half-life glycoPEGylated recombinant FVIII for major surgery in severe haemophilia A.
Authors: Hampton, K, et.al. .
Journal: Haemophilia : the official journal of the World Federation of Hemophilia (Haemophilia), Vol. 23 (5): 689-696, 2017 .
Snippet: BACKGROUND: N8-GP (turoctocog alfa pegol) is an extended half-life glycoPEGylated recombinant factor VIII (FVIII) product developed for the prevention and treatment of bleeds in haemophilia A patients.
Affiliation: Department of Cardiovascular Science, University of Sheffield, Sheffield, UK. KD Haemophilia Centre and Thrombosis Unit, Royal Free Hospital, London, UK. Institute of Haematology, Royal Prince Alfred Hospital, Camperdown,Sydney, New South Wales, Australia. Novo Nordisk, Søborg, Denmark. Vanderbilt University Medical Center, Nashville, TN, USA. Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Ca' Granda Foundation, Maggiore Hospital Policlinico, Milan, Italy. Department of Haematology, Ampang Hospital, Selangor, Malaysia. Department of Joint Surgery, Research Hospital, Institute of Medical Science, University of Tokyo, Tokyo, Japan. Division of Pediatric Hematology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Hemostasis and Thrombosis Unit, Louis Pradel Hospital, Université Claude Bernard, Lyon, France. .
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7: Title: An evaluation of wearable sensors and their placements for analyzing construction worker's trunk posture in laboratory conditions.
Authors: Lee, Wonil, et.al. .
Journal: Applied ergonomics (Appl Ergon), Vol. 65, 2017 .
Snippet: Measurements of upper-body thoracic bending posture during the lifting and lowering of raised deck materials in a laboratory setting were compared against video-captured observations of posture.
Affiliation: Department of Construction Management, College of Built Environments, University of Washington, Seattle, WA 98195, USA; Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA 98195, USA. Electronic address: wonillee@uw.edu. Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA 98195, USA. Department of Construction Management, College of Built Environments, University of Washington, Seattle, WA 98195, USA. .
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8: Title: DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.
Authors: Kwan, Julian, et.al. .
Journal: Genes & development (Genes Dev), Vol. 30 (24): 2696-2709, 2016 .
Snippet: Dlg5 also interacts genetically with Hippo effectors Yap1/Taz Mechanistically, we show that DLG5 inhibits the association between MST1/2 and large tumor suppressor homologs 1/2 (LATS1/2), uses its scaffolding function to link MST1/2 with MARK3, and inhibits MST1/2 kinase activity.
Affiliation: Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada. Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario M5G 1X5, Canada. Department of Pathology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98195, USA. .
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9: Title: Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module.
Authors: Calabrese, Gina M, et.al. .
Journal: Cell systems (Cell Syst), Vol. 4 (1): 46-59.e4, 2017 .
Snippet: We experimentally confirmed that two of the genes predicted to be causal, SPTBN1 and MARK3, are potentially responsible for the effects of GWAS loci on chromosomes 2p16.2 and 14q32.32,
Affiliation: Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA. Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT 06520-8071, USA. Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA. Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA; Departments of Public Health Sciences and Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: crf2s@virginia.edu. .
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10: Title: Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors.
Authors: Katz, Jason D, et.al. .
Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett), Vol. 27 (1): 114-120, 2017 .
Snippet: Information gleaned from ligand co-crystal structures allowed for rapid refinements in both MARK potency and kinase selectivity.
Affiliation: Department of Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: jason_katz2@merck.com. Department of Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, USA. Department of Structural Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, USA. Department of In Vitro Sciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, USA. Department of Drug Metabolism, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, USA. Department of Neuroscience, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, USA. Department of Structural Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. .
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11: Title: Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties.
Authors: Sloman, David L, et.al. .
Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett), Vol. 26 (17): 4362-6, 2016 .
Snippet: A unique cylcyclohexyldiamine scaffold was identified that led to remarkable improvements in potency, opening up opportunities to reduce MW, Pgp efflux and improve pharmacokinetic properties while also conferring improved solubility.
Affiliation: Discovery Chemistry, Merck and Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02215, United States. Chemistry Modeling and Informatics, Merck and Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02215, United States. Drug Metabolism and Pharmacokinetics, Merck and Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02215, United States. CNS Pharmacology, Merck and Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02215, United States. Core Pharmacology, Merck and Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02215, United States. Neuroscience Drug Discovery, Merck and Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02215, United States. Pharmaceutical Research and Development, Merck and Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02215, United States. Structural Biology, 770 Sumneytown Pike, West Point, PA 19486, United States. .
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12: Title: Nonacog beta pegol (N9-GP) in haemophilia B: A multinational phase III safety and efficacy extension trial (paradigm™4).
Authors: Young, Guy, et.al. .
Journal: Thrombosis research (Thromb Res), Vol. 141, 2016 .
Snippet: INTRODUCTION: Paradigm™4 was an international extension trial investigating the safety and efficacy of nonacog beta pegol, a recombinant glycoPEGylated factor IX (FIX) with extended half-life, in haemophilia B patients (FIX activity ≤2%; aged 13-70years) who had previously participated in phase III pivotal (paradigm™2) or surgery (paradigm™3) trials.
Affiliation: Hemostasis and Thrombosis Center, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, United States. Electronic address: gyoung@chla.usc.edu. Arthur Bloom Haemophilia Centre, Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom. Novo Nordisk A/S, Søborg, Denmark. Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Department of Hematology, Ogikubo Hospital, Tokyo, Japan. Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, United States. Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, NHLS and University of the Witwatersrand, Johannesburg, South Africa. Van Creveldkliniek, University Medical Centre, Utrecht, The Netherlands. Hôpital Edouard Herriot, University Claude Bernard Lyon 1, Lyon, France. Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Bonn, Germany. Erciyes University Medical Faculty, Kayseri, Turkey. Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Ca' Granda Foundation, Maggiore Hospital Policlinico, Milan, Italy. Haemophilia Center, National Blood Centre, Kuala Lumpur, Malaysia. .
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13: Title: Development of a Stable Cell Line, Overexpressing Human T-cell Immunoglobulin Mucin 1.
Authors: Ebrahimi, Mina, et.al. .
Journal: Iranian journal of biotechnology (Iran J Biotechnol), Vol. 13 (4): 25-31, 2015 .
Snippet: BACKGROUND: Recent researches have demonstrated that human T-cell immunoglobulin mucin 1 (TIM-1) glycoprotein plays important roles in regulation of autoimmune and allergic diseases, as well as in tumor immunity and response to viral infections.
Affiliation: Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Tabriz University of Medical Sciences, Tabriz, Iran. Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Department of Genetic and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. .
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14: Title: Atypical PKC phosphorylates microtubule affinity-regulating kinase 4 in vitro.
Authors: Naz, Farha, et.al. .
Journal: Molecular and cellular biochemistry (Mol Cell Biochem), Vol. 410 (1-2): 223-8, 2015 .
Snippet: The interaction of MARK2 and MARK3 with aPKC and their negative regulation by aPKC is already known.
Affiliation: Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India. Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India. mihassan@jmi.ac.in. .
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15: Title: KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage.
Authors: Gong, Eun-Yeung, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 5, 2015 .
Snippet: Modelling indicates a high probability that this region of Chk1 contains a kinase-associated 1 (KA1) domain, a small, compact protein fold found in multiple protein kinases including SOS2, AMPK and MARK3.
Affiliation: Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, U.K. Unidad de Investigación, Hospital Universitario de Canarias, Instituto de Tecnologías Biomédicas, Ofra s/n, La Cuesta, La Laguna 38320, Tenerife, Spain. Instituto de Tecnologías Biomédicas, Centro de Investigaciones Biomédicas de Canarias, Facultad de Medicina, Campus Ciencias de la Salud, Universidad de La Laguna, La Laguna 38071, Tenerife, Spain. .
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16: Title: Physical activity and sedentary behavior in bariatric patients long-term post-surgery.
Authors: Reid, Ryan E R, et.al. .
Journal: Obesity surgery (Obes Surg), Vol. 25 (6): 1073-7, 2015 .
Snippet: Healthcare workers should be taking physical activity and sedentary time into account when creating post-surgical guidelines for this population to ensure the best long-term weight loss maintenance and health outcomes.
Affiliation: Department of Kinesiology and Physical Education, McGill University, 475 avenue des Pins Ouest, Montreal, QC, H2W 1S4, Canada, ryan.reid@mail.mcgill.ca. .
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17: Title: Glucagon directly interacts with vagal afferent nodose ganglion neurons to induce Ca(2+) signaling via glucagon receptors.
Authors: Ayush, Enkh-Amar, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 456 (3): 727-32, 2015 .
Snippet: In vivo study showed that intraperitoneal injection of glucagon induced phosphorylation of extracellular signal regulated kinase 1 and 2 (ERK1/2), cellular activation makers, in NG neurons.
Affiliation: Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 320-0498, Japan. Division of Human Genetics, Center of Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 320-0498, Japan. Health Science Service Center, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan. First Department of Medicine, Saitama Medical Center, Jichi Medical University School of Medicine, Omiya 1-847, Saitama 337-8503, Japan. Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 320-0498, Japan; Division of Adaptation Development, Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki, Aichi 444-8585, Japan. Electronic address: tyada@jichi.ac.jp. .
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18: Title: Italian translation, cultural adaptation and validation of the PedsQL™ 3.0 Diabetes Module questionnaire in children with type 1 diabetes and their parents.
Authors: d'Annunzio, Giuseppe, et.al. .
Journal: Health and quality of life outcomes (Health Qual Life Outcomes), Vol. 12, 2014 .
Snippet: Discriminant validity was satisfied for 71% of children and adolescents and for 82% of parents.
Affiliation: Pediatric Clinic, IRCCS - Istituto Giannina Gaslini, Genoa, Italy. giuseppedannunzio@ospedale-gaslini.ge.it. Pediatric Clinic, IRCCS - Istituto Giannina Gaslini, Genoa, Italy. saragialetti@ospedale-gaslini.ge.it. Endocrinology-Diabetology Unit, Department of Pediatrics of the University and Hospital, Bambino Gesù Pediatric Hospital, Rome, Italy. chiara.carducci@opbg.net. Endocrinology-Diabetology Unit, Department of Science of Public Health and Pediatric, University of Turin, Turin, Italy. ivana.rabbone@unito.it. Pediatric Clinic Unit, AOU Policlinico Vittorio Emanuele, Catania, Italy. donatellalopresti@yahoo.it. Diabetologic Unit, Meyer's Children Hospital, Florence, Italy. s.toni@meyer.it. Department of Pediatrics, Federico II University, Naples, Italy. e.zito@unina.it. Pediatric Clinic, IRCCS - Istituto Giannina Gaslini, Genoa, Italy. sarabolloli@ospedale-gaslini.ge.it. Pediatric Clinic, IRCCS - Istituto Giannina Gaslini, Genoa, Italy. renatalorini@ospedale-gaslini.ge.it. Clinical Pharmacology & Clinical Trial Unit, Scientific Direction, IRCCS - Istituto Giannina Gaslini, via G. Gaslini, 3-5, 16147, Genoa, Italy. ornelladellacasa@ospedale-gaslini.ge.it. .
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19: Title: Regulation of protein phosphatase 1I by Cdc25C-associated kinase 1 (C-TAK1) and PFTAIRE protein kinase.
Authors: Platholi, Jimcy, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 289 (34): 23893-900, 2014 .
Snippet: We studied the effects of two protein kinases identified previously in purified brain PP-1I by mass spectrometry, Cdc25C-associated kinase 1 (C-TAK1) and PFTAIRE (PFTK1) kinase, for their ability to regulate PP-1I.
Affiliation: From the Departments of Anesthesiology and Pharmacology, Weill Cornell Medical College, New York, New York 10065. From the Departments of Anesthesiology and. From the Departments of Anesthesiology and Pharmacology, Weill Cornell Medical College, New York, New York 10065 hchemmi@med.cornell.edu. .
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20: Title: MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies.
Authors: Lund, Harald, et.al. .
Journal: Acta neuropathologica communications (Acta Neuropathol Commun), Vol. 2, 2014 .
Snippet: These results suggest that in AD, phosphorylated MARK3 and MARK4 are sequestered and proteolysed in GVDs.
Affiliation: Department of Neuroscience, iMed, CNS and Pain Södertälje, AstraZeneca Research and Development, Södertälje, Sweden. gabriel.von.euler@ki.se. .
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