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10 documents found
1: Title: Hidden Genetic Variation in LCA9-Associated Congenital Blindness Explained by 5'UTR Mutations and Copy-Number Variations of NMNAT1.
Authors: Coppieters, Frauke, .
Journal: Human mutation (Hum Mutat), Vol. 36 (12): 1188-96, 2015 .
Snippet: Both 5'UTR variants resulted in decreased NMNAT1 mRNA abundance in patients' lymphocytes, and caused decreased luciferase activity in human retinal pigment epithelial RPE-1 cells.
Affiliation: Center for Medical Genetics Ghent, Ghent University, Ghent, Belgium. Institut Jacques Monod, UMR 7592 CNRS-Université Paris Diderot, Paris, France. Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan. Department of Ophthalmology, Mie University Graduate School of Medicine, Mie, Japan. Department of Ophthalmology, Queen Fabiola Children's University Hospital, Brussels, Belgium. Department of Ophthalmology, Ghent University Hospital, Ghent, Belgium. Division of Ophthalmology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. .
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2: Title: Inhibition of SCAMP1 suppresses cell migration and invasion in human pancreatic and gallbladder cancer cells.
Authors: Yang, Sera, .
Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol), Vol. 34 (5): 2731-9, 2013 .
Snippet: The expression of LZIC, FXR, SCAMP1, and SULT1E1 is significantly higher in pancreatic cancer tissues with LN metastasis than in pancreatic cancer tissues without LN metastasis.
Affiliation: Samsung Biomedical Research Institute, Seoul, South Korea. .
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3: Title: Proteome changes in platelets activated by arachidonic acid, collagen, and thrombin.
Authors: Májek, Pavel, .
Journal: Proteome science (Proteome Sci), Vol. 8, 2010 .
Snippet: Five proteins were found that had not previously been identified in platelets: protein CDV3 homolog, protein ETHE1, protein LZIC, FGFR1 oncogene partner 2, and guanine nucleotide-binding protein subunit beta-5.
Affiliation: Institute of Hematology and Blood Transfusion, Prague, Czech Republic. .
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4: Title: Gene expression profiling of alpha-radiation-induced rat osteosarcomas: identification of dysregulated genes involved in radiation-induced tumorigenesis of bone.
Authors: Daino, Kazuhiro, .
Journal: International journal of cancer (Int J Cancer), Vol. 125 (3): 612-20, 2009 .
Snippet: These included genes involved in the cell adhesion (e.g., Podxl, Col18a1, Cd93, Emcn and Vcl), differentiation, developmental processes (e.g., Hhex, Gata2, P2ry6, P2rx5, Cited2, Osmr and Igsf10), tumor-suppressor function (e.g., Nme3, Blcap and Rrm1), Src tyrosine kinase signaling (e.g., Hck, Shf, Arhgap29, Cttn and Akap12), and Wnt/beta-catenin signaling (e.g., Fzd6, Lzic, Dkk3 and Ctnna1) pathways.
Affiliation: Laboratoire de Cancérologie Expérimentale, iRCM, DSV, CEA, Fontenay-aux-Roses, France. .
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5: Title: Isolation and characterization of Wnt pathway-related genes from Porifera.
Authors: Adell, Teresa, .
Journal: Cell biology international (Cell Biol Int), Vol. 31 (9): 939-49, 2007 .
Snippet: In the present study we report the isolation and phylogenetic characterization of several Wnt pathway-related genes from the sponge Suberites domuncula: Sd-TCF/LEF, Sd-GSK3, a recently discovered molecule with a putative function as a Wnt regulator (Sd-LZIC), the small Rho GTPases Sd-RhoA, Sd-Cdc42, and their effector Sd-mrlc.
Affiliation: Institut für Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universität, Duesbergweg 6, D-55099 Mainz, Germany. .
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6: Title: Identification of a minimal region of loss on the short arm of chromosome 1 in Wilms tumor.
Authors: Tamimi, Yahya, .
Journal: Genes, chromosomes & cancer (Gene Chromosome Canc), Vol. 46 (4): 327-35, 2007 .
Snippet: This region of loss overlaps that found in neuroblastoma and harbors candidate genes highly expressed in fetal kidney i.e., LZIC, ICAT, and DNB5.
Affiliation: Department of Pediatrics and Experimental Oncology, Cross Cancer Institute and the University of Alberta, Edmonton, AB T6G 1Z2, Canada. .
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7: Title: Neuroblastoma tumors with favorable and unfavorable outcomes: Significant differences in mRNA expression of genes mapped at 1p36.2.
Authors: Fransson, Susanne, .
Journal: Genes, chromosomes & cancer (Gene Chromosome Canc), Vol. 46 (1): 45-52, 2007 .
Snippet: Here we report on a significant decrease in gene expression of the genes RERE, PIK3CD, LZIC, PGD, and PEX14 and an increase of SLC2A5 when comparing tumors of favorable biology to Stage 4 neuroblastomas.
Affiliation: Department of Clinical Genetics, University of Gothenburg, Sahlgrenska University Hospital-East, S-416 85 Gothenburg, Sweden. .
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8: Title: Analysis of fifteen positional candidate genes for Schnyder crystalline corneal dystrophy.
Authors: Aldave, Anthony J, .
Journal: Molecular vision (Mol Vis), Vol. 11, 2005 .
Snippet: METHODS: Mutation screening of fifteen genes (CORT, CLSTN1, CTNNBIP1, DFFA, ENO1, GPR157, H6PD, KIF1B, LOC440559, LZIC, MGC4399, PEX14, PGD, PIK3CD, and SSB1) that lie within the candidate gene region for SCCD was performed in members of two families affected with SCCD.
Affiliation: Cornea Service, Jules Stein Eye Institute, University of California, Los Angeles, CA, USA. .
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9: Title: LZIC regulates neuronal survival during zebrafish development.
Authors: Clements, Wilson K, .
Journal: Developmental biology (Dev Biol), Vol. 283 (2): 322-34, 2005 .
Snippet: LZIC is closely related to ICAT, a physiological inhibitor of the Wnt pathway that interacts physically and functionally with beta-catenin to prevent the transcription of Wnt target genes.
Affiliation: Department of Biochemistry, University of Washington, Seattle, 98195-7350, USA. .
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10: Title: Molecular cloning and characterization of LZIC, a novel gene encoding ICAT homologous protein with leucine zipper domain.
Authors: Katoh, M .
Journal: International journal of molecular medicine (Int J Mol Med), Vol. 8 (6): 611-5, 2001 .
Snippet: As LZIC contains ICAT homologous domain, LZIC might inhibit the interaction between beta-catenin and TCF transcription factors, just like ICAT, and, up-regulation of LZIC in gastric cancer might be due to a negative feed-back mechanism to inhibit the WNT - beta-catenin - TCF signaling pathway.
Affiliation: Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan. .
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