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25 documents found
1: Title: QTL-Seq-based genetic analysis identifies a major genomic region governing dwarfness in rice (Oryza sativa L.).
Journal: Plant cell reports (Plant Cell Rep), 2018 .
Snippet: The sequencing of the QTL region and gene expression analysis predicted a gene that codes for IWS1 (C-terminus family protein).
Affiliation: Institute of Biotechnology, Acharya NG Ranga Agricultural University, Rajendranagar, Hyderabad, Andhra Pradesh, 500030, India. Institute of Biotechnology, Acharya NG Ranga Agricultural University, Rajendranagar, Hyderabad, Andhra Pradesh, 500030, India. drvlnreddy@gmail.com. Indian Institute of Rice Research, Rajendranagar, Hyderabad, Andhra Pradesh, 500030, India. .
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2: Title: Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif.
Authors: Tesina, Petr, et.al. .
Journal: Nature communications (Nat Commun), Vol. 6, 2015 .
Snippet: In addition, based on IBM conservation, we identify and validate IWS1 as a novel LEDGF/p75 interaction partner.
Affiliation: 1] Institute of Organic Chemistry and Biochemistry of the ASCR, v.v.i., Flemingovo nam. 2, 166 10 Prague, Czech Republic [2] Department of Genetics and Microbiology, Faculty of Science, Charles University in Prague, Vinicna 5, 128 44 Prague, Czech Republic [3] Institute of Molecular Genetics of the ASCR, v.v.i., Videnska 1083, 142 20 Prague, Czech Republic. KU Leuven, Molecular Virology and Gene Therapy, Kapucijnenvoer 33, B-3000 Leuven, Belgium. Institute of Molecular Genetics of the ASCR, v.v.i., Videnska 1083, 142 20 Prague, Czech Republic. Institute of Organic Chemistry and Biochemistry of the ASCR, v.v.i., Flemingovo nam. 2, 166 10 Prague, Czech Republic. 1] Institute of Organic Chemistry and Biochemistry of the ASCR, v.v.i., Flemingovo nam. 2, 166 10 Prague, Czech Republic [2] Institute of Molecular Genetics of the ASCR, v.v.i., Videnska 1083, 142 20 Prague, Czech Republic. .
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3: Title: HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma.
Authors: Gao, Kun, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 458 (4): 849-55, 2015 .
Snippet: Furthermore, we demonstrate HRP-2 interacts and co-localizes with RNA processing regulator IWS1, and positively regulated the mRNA level of Cyclin D1.
Affiliation: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China. Department of Urology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, PR China. State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China. Electronic address: longyu@fudan.edu.cn. State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China; Shanghai Cancer Center, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PR China. Electronic address: pzzhang@fudan.edu.cn. .
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4: Title: The integrase cofactor LEDGF/p75 associates with Iws1 and Spt6 for postintegration silencing of HIV-1 gene expression in latently infected cells.
Authors: Gérard, Annabelle, et.al. .
Journal: Cell host & microbe (Cell Host Microbe), Vol. 17 (1): 107-17, 2015 .
Snippet: Iws1 plays a role in the establishment of latent infection, whereas Spt6 functions to recruit Iws1 and LEDGF/p75 to the silenced provirus and maintains histone occupancy at the HIV promoter.
Affiliation: Inserm, U1016, Institut Cochin, 75014 Paris, France; CNRS, UMR8104, 75014 Paris, France; Université Paris Descartes, 75014 Paris, France. Electronic address: anabel.gerard@gmail.com. Inserm, U1016, Institut Cochin, 75014 Paris, France; CNRS, UMR8104, 75014 Paris, France; Université Paris Descartes, 75014 Paris, France. Hybrigenics, SA, Paris, 75014 France. Inserm, U1016, Institut Cochin, 75014 Paris, France; CNRS, UMR8104, 75014 Paris, France; Université Paris Descartes, 75014 Paris, France. Electronic address: stephane.emiliani@inserm.fr. .
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5: Title: Histone lysine methyltransferase SDG8 is involved in brassinosteroid-regulated gene expression in Arabidopsis thaliana.
Authors: Wang, Xiaolei, et.al. .
Journal: Molecular plant (Mol Plant), Vol. 7 (8): 1303-15, 2014 .
Snippet: BES1 interacts with SDG8, directly or indirectly through IWS1, a transcription elongation factor involved in BR-regulated gene expression.
Affiliation: State Key Laboratory of Plant Physiology and Biochemistry, Department of Agronomy, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, PR China Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA. Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA. Department of Agronomy, Iowa State University, Ames, IA 50011, USA Present address: Department of Plant Pathology, Kansas State University, Manhattan, KS 66506-5502, USA. Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA Present address: Du Pont Pioneer Inc., Johnston, IA, USA. State Key Laboratory of Plant Physiology and Biochemistry, Department of Agronomy, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, PR China. Department of Agronomy, Iowa State University, Ames, IA 50011, USA Data2Bio LLC, Ames, IA 50011-3650, USA. State Key Laboratory of Plant Physiology and Biochemistry, Department of Agronomy, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, PR China yin@iastate.edu lizhaohu@cau.edu.cn. Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA yin@iastate.edu lizhaohu@cau.edu.cn. .
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6: Title: AKT isoform-specific signals regulate RNA processing in lung cancer.
Journal: Cancer discovery (Cancer Discov), Vol. 4 (3): OF17, 2014 .
Snippet: IWS1 phosphorylation by AKT1 and AKT3 shifts splicing towards a tumorigenic FGFR2 isoform.
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7: Title: Akt-ivation of RNA splicing.
Authors: Lee, Gina, et.al. .
Journal: Molecular cell (Mol Cell), Vol. 53 (4): 519-20, 2014 .
Snippet: Cells must tightly control alternative splicing of RNA to maintain homeostasis; in this issue of Molecular Cell, Sanidas et al. (2014) provide new insights into the regulation of RNA splicing by Akt isoforms through phosphorylation of histone modification machinery.
Affiliation: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: john_blenis@hms.harvard.edu. .
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8: Title: Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.
Authors: Sanidas, Ioannis, et.al. .
Journal: Molecular cell (Mol Cell), Vol. 53 (4): 577-90, 2014 .
Snippet: H3K36me3-bound MRG15 and PTB regulate FGFR-2 splicing, which controls tumor growth and invasiveness downstream of IWS1 phosphorylation.
Affiliation: Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA. Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA; Division of Digestive Diseases, Center for Systems Biomedicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Department of Biostatistics and Computational Biology, Center for Cancer Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Cell Signaling Technology, Danvers, MA 01923, USA. Division of Digestive Diseases, Center for Systems Biomedicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA. Electronic address: ptsichlis@tuftsmedicalcenter.org. .
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9: Title: Spt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe.
Authors: Kiely, Christine M, et.al. .
Journal: Molecular and cellular biology (Mol Cell Biol), Vol. 31 (20): 4193-204, 2011 .
Snippet: We now show that Spt6 and its binding partner, Iws1, are required for heterochromatic silencing in Schizosaccharomyces pombe.
Affiliation: Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. .
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10: Title: High nitrogen insensitive 9 (HNI9)-mediated systemic repression of root NO3- uptake is associated with changes in histone methylation.
Authors: Widiez, Thomas, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 108 (32): 13329-34, 2011 .
Snippet: Here, we show that HNI9 encodes Arabidopsis INTERACT WITH SPT6 (AtIWS1), an evolutionary conserved component of the RNA polymerase II complex.
Affiliation: Biochimie et Physiologie Moléculaire des Plantes, Unité Mixte de Recherche 5004, Institut National de la Recherche Agronomique-Centre National de la Recherche Scientifique-Sup Agro-UM2, Institut de Biologie Intégrative des Plantes, F-34060 Montpellier, France. .
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11: Title: Recent advances in the regulation of brassinosteroid signaling and biosynthesis pathways.
Authors: Ye, Huaxun, et.al. .
Journal: Journal of integrative plant biology (J Integr Plant Biol), Vol. 53 (6): 455-68, 2011 .
Snippet: BES1 recruits histone demethylases ELF6 and REF6 as well as a transcription elongation factor IWS1 to regulate target gene expression.
Affiliation: Department of Genetics, Development and Cell Biology, Iowa State University, Ames, USA. .
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12: Title: The structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26.
Authors: Diebold, Marie-Laure, et.al. .
Journal: The EMBO journal (Embo J), Vol. 29 (23): 3979-91, 2010 .
Snippet: Binding of elongation factor Spt6 to Iws1 provides an effective means for coupling eukaryotic mRNA synthesis, chromatin remodelling and mRNA export.
Affiliation: Département de Biologie et Génomique Structurales, IGBMC (Institut de Génétique et Biologie Moléculaire et Cellulaire), UDS, CNRS, INSERM, Illkirch Cedex, France. .
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13: Title: The transcription factor Spn1 regulates gene expression via a highly conserved novel structural motif.
Authors: Pujari, Venugopal, et.al. .
Journal: Journal of molecular biology (J Mol Biol), Vol. 404 (1): 1-15, 2010 .
Snippet: Spn1/Iws1 plays essential roles in the regulation of gene expression by RNA polymerase II (RNAPII), and it is highly conserved in organisms ranging from yeast to humans.
Affiliation: Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1870, USA. .
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14: Title: Uniform transitions of the general RNA polymerase II transcription complex.
Authors: Mayer, Andreas, et.al. .
Journal: Nature structural & molecular biology (Nat Struct Mol Biol), Vol. 17 (10): 1272-8, 2010 .
Snippet: Paf1, Spt16 (part of the FACT complex), and the CTD kinases Bur1 and Ctk1 exit upstream of the polyadenylation site, whereas Spt4, Spt5, Spt6, Spn1 (also called Iws1) and Elf1 exit downstream.
Affiliation: Gene Center Munich and Department of Biochemistry, Center for Integrated Protein Science, Ludwig-Maximilians-Universität München, Munich, Germany. .
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15: Title: Arabidopsis IWS1 interacts with transcription factor BES1 and is involved in plant steroid hormone brassinosteroid regulated gene expression.
Authors: Li, Lei, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 107 (8): 3918-23, 2010 .
Snippet: By a forward genetic approach, we have discovered that Arabidopsis thaliana Interact-With-Spt6 (AtIWS1), an evolutionarily conserved protein implicated in RNA polymerase II (RNAPII) postrecruitment and transcriptional elongation processes, is required for BR-induced gene expression.
Affiliation: Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA. .
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16: Title: Crystallization and preliminary crystallographic analysis of eukaryotic transcription and mRNA export factor Iws1 from Encephalitozoon cuniculi.
Authors: Koch, Michael, et.al. .
Journal: Acta crystallographica. Section F, Structural biology and crystallization communications (Acta Crystallogr Sect F Struct Biol Cryst Commun), Vol. 66 (Pt 2): 207-10, 2010 .
Snippet: The essential protein Iws1 is at the interface of these processes through its interaction with histone chaperone and elongation factor Spt6 as well as with complexes involved in mRNA processing and export.
Affiliation: IGBMC (Institut de Génétique et Biologie Moléculaire et Cellulaire), Département de Biologie et Génomique Structurales, UDS, CNRS, INSERM, 1 Rue Laurent Fries, BP 10142, 67404 Illkirch CEDEX, France. .
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17: Title: The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation.
Authors: Yoh, Sunnie M, et.al. .
Journal: Genes & development (Gene Dev), Vol. 22 (24): 3422-34, 2008 .
Snippet: Interestingly, knockdown of either Iws1 or HYPB/Setd2 also enhanced H3K27me3 at the 5' end of the PABPC1 gene, and depletion of Iws1, but not HYPB/Setd2, increased histone acetylation across the coding regions at the HIV-1 and PABPC1 genes in vivo.
Affiliation: Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA. .
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18: Title: Uncoupling of the patterns of chromatin association of different transcription elongation factors by a histone H3 mutant in Saccharomyces cerevisiae.
Authors: Lloyd, Amanda, et.al. .
Journal: Eukaryotic cell (Eukaryot Cell), Vol. 8 (2): 257-60, 2009 .
Snippet: Using a histone H3 mutant, we now provide evidence that the mechanism of association of yFACT across genes is separable from that adopted by Spt4/Spt5 and Spt6/Iws1.
Affiliation: Biology Department, Hendrix College, 1600 Washington Avenue, Conway, AR 72032, USA. .
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19: Title: The multi-tasking P-TEFb complex.
Authors: Brès, Vanessa, et.al. .
Journal: Current opinion in cell biology (Curr Opin Cell Biol), Vol. 20 (3): 334-40, 2008 .
Snippet: Some functions of the P-TEFb/Ser2P CTD are executed by the Spt6 transcription elongation factor, which binds directly to the phosphorylated CTD and recruits the Iws1 ('interacts with Spt6') protein.
Affiliation: Regulatory Biology Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037-1099, USA. .
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20: Title: The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export.
Authors: Yoh, Sunnie M, et.al. .
Journal: Genes & development (Gene Dev), Vol. 21 (2): 160-74, 2007 .
Snippet: We cloned the human Spt6-interacting protein, hIws1 (interacts with Spt6), and found that it associates with the nuclear RNA export factor, REF1/Aly.
Affiliation: Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA. .
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