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654 documents found
1: Title: Innate Lymphoid Cells Mediate Pulmonary Eosinophilic Inflammation, Airway Mucous Cell Metaplasia, and Type 2 Immunity in Mice Exposed to Ozone.
Authors: Kumagai, Kazuyoshi, et.al. .
Journal: Toxicologic pathology (Toxicol Pathol), 2017 .
Snippet: In the present study, we determined the role of innate lymphoid cells (ILCs) in the pathogenesis of ozone-induced nonatopic asthma by using lymphoid cell-sufficient C57BL/6 mice, ILC-sufficient Rag2(-/-) mice (devoid of T and B cells), and ILC-deficient Rag2(-/-)Il2rg(-/-) mice (depleted of all lymphoid cells including ILCs).
Affiliation: 1 Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, Michigan, USA. 2 Department of Medicine, University of California, San Francisco, California, USA. .
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2: Title: Viral load affects the immune response to HBV in mice with humanized immune system and liver.
Authors: Dusséaux, Mathilde, et.al. .
Journal: Gastroenterology, 2017 .
Snippet: METHODS: We performed studies with BALB/c Rag2(-/-)Il2rg(-/-)Sirpa(NOD)Alb-uPA(tg/tg) mice, stably engrafted with human hepatocytes (HUHEP) with or without a human immune system (HIS).
Affiliation: Innate Immunity Unit, Institut Pasteur, 75724 Paris, France; INSERM U1223, Paris, France. INSERM U1135, Faculté de Médecine, Université Pierre et Marie Curie Paris 6, Paris, France. INSERM U966, Université François Rabelais and CHRU de Tours, Tours, France. Unité des Hépacivirus et Immunité Innée, Institut Pasteur, 75724 Paris, France. Innate Immunity Unit, Institut Pasteur, 75724 Paris, France; INSERM U1223, Paris, France. Electronic address: helene.strick-marchand@pasteur.fr. .
3: Title: In vivo functional and morphological characterization of bone and striated muscle microcirculation in NSG mice.
Authors: Mussawy, Haider, et.al. .
Journal: PloS one, Vol. 12 (8): e0183186, 2017 .
Snippet: The full functional characterization of bone and striated muscle microcirculatory parameters in non-obese diabetic-severe combined immunodeficiency/y-chain; NOD-Prkds IL2rg (NSG) mice has not yet been reported.
Affiliation: Department of Orthopaedic Surgery, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. Department of Trauma-, Hand-, and Reconstructive Surgery, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. Department of Spine Surgery, Klinikum Bad Bramstedt, Bad Bramstedt, Germany. .
4: Title: CRISPR/Cas9-Mediated Deletion of Foxn1 in NOD/SCID/IL2rg(-/-) Mice Results in Severe Immunodeficiency.
Authors: Wei, Xinru, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7 (1): 7720, 2017 .
Snippet: In the present study, we generated a novel strain of nude NOD/SCID/IL2rg(-/-) (NSIN) mice by knocking out Foxn1 from NOD/SCID/IL2rg(-/-) (NSI) mice using the CRISPR/Cas9 system.
Affiliation: School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China. Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. Shenzhen InVivo Biomedicine Co. Ltd, Shenzhen, 518000, China. Department of Respiratory medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, England, UK. Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. yao_yao@gibh.ac.cn. Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. yao_yao@gibh.ac.cn. Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. li_peng@gibh.ac.cn. Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. li_peng@gibh.ac.cn. .
5: Title: Maternal T and B cell engraftment in two cases of X-linked severe combined immunodeficiency with IgG1 gammopathy.
Authors: Okano, Tsubasa, et.al. .
Journal: Clinical immunology (Orlando, Fla.) (Clin Immunol), 2017 .
Snippet: T cell dysfunction and impaired class-switch recombination of B cells mean that patients typically have defects in class-switched immunoglobulins (IgG, IgA, and IgE) with detectable IgM.
Affiliation: Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan. Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. Laboratory of Diagnostic Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. Department of Community Pediatrics, Perinatal and Maternal Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan. Department of Community Pediatrics, Perinatal and Maternal Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan. Electronic address: kimai.ped@tmd.ac.jp. Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan. Electronic address: hkanegane.ped@tmd.ac.jp. .
6: Title: T-Cell Lymphopenia Detected by Newborn Screening in Two Siblings with an Xq13.1 Duplication.
Authors: Rios, Xavier, et.al. .
Journal: Frontiers in pediatrics (Front Pediatr), Vol. 5, 2017 .
Snippet: The variant is downstream of the IL2RG gene with potential regulatory significance, suggesting a mechanism for the T-cell lymphopenia.
Affiliation: Center for Human Immunobiology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States. .
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7: Title: Tumor Xenografts of Human Clear Cell Renal Cell Carcinoma But Not Corresponding Cell Lines Recapitulate Clinical Response to Sunitinib: Feasibility of Using Biopsy Samples.
Authors: Dong, Yiyu, et.al. .
Journal: European urology focus (Eur Urol Focus), 2016 .
Snippet: DESIGN, SETTING, AND PARTICIPANTS: A total of 74 tumor specimens from 66 patients with RCC were implanted into immunocompromised NOD-SCID IL2Rg(-/-) mice.
Affiliation: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Computational Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Orthopedics Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Interventional Radiology Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: hsiehj@mskcc.org. .
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8: Title: Family History of Early Infant Death Correlates with Earlier Age at Diagnosis But Not Shorter Time to Diagnosis for Severe Combined Immunodeficiency.
Authors: Luk, Anderson Dik Wai, et.al. .
Journal: Frontiers in immunology (Front Immunol), Vol. 8, 2017 .
Snippet: RESULTS: A total of 88 different SCID gene mutations were identified in 94 patients, including 49 IL2RG mutations, 12 RAG1 mutations, 8 RAG2 mutations, 7 JAK3 mutations, 4 DCLRE1C mutations, 4 IL7R mutations, 2 RFXANK mutations, and 2 ADA mutations.
Affiliation: LKS Faculty of Medicine, Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, Hong Kong. Shenzhen Primary Immunodeficiency Diagnostic and Therapeutic Laboratory, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China. Guangzhou Children's Hospital, Guangzhou, China. Department of Allergy and Immunology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Beijing Children's Hospital, Capital Medical University, Beijing, China. Institut Pasteur d'Algérie, Algeria, North Africa. Allergy Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Guang Zhou Women and Children's Medical Center, Guangzhou, China. Children's Hospital of Chongqing Medical University, Chongqing, China. KK Women's and Children's Hospital, Singapore, Singapore. Department of Pediatrics, Siriraj Hospital Mahidol University, Bangkok, Thailand. Queen Sirikit National Institute of Child Health, Bangkok, Thailand. Monash University, Selangor, Malaysia. Mount Elizabeth Hospital, Singapore, Singapore. National University of Singapore, Singapore, Singapore. National Children's Hospital, Hanoi, Vietnam. Sarawak General Hospital Malaysia, Kuching, Malaysia. National Taiwan University Children's Hospital, Taipei, Taiwan. University Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia. Sichuan Second West China Hospital, Sichuan, China. Department of Paediatrics, Holy Family Hospital, New Delhi, India. Department of Immunology, Institut Pasteur de Tunis and University Tunis-El Manar, Tunis, Tunisia. Faculty of Medicine, Department of Paediatrics, University of Malaya, Kuala Lumpur, Malaysia. San Pedro Hospital, Davao, Philippines. Children's Hospital of Fudan University, Shanghai, China. The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Nanjing Children's Hospital, Nanjing, China. Queen Elizabeth Hospital, Hong Kong, Hong Kong. .
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9: Title: An Fc engineered CD19 antibody eradicates MRD in patient-derived MLL-rearranged acute lymphoblastic leukemia xenografts.
Authors: Schewe, Denis M, et.al. .
Journal: Blood, 2017 .
Snippet: Patient derived xenografts (PDX) of pediatric MLL-rearranged ALL were established in NOD.Cg-Prkdc(scid) Il2rg(tm1Wjl)/SzJ (NSG) mice.
Affiliation: Pediatric Hematology/Oncology, ALL-BFM Study Group, Christian Albrechts University Kiel and University Hospital Schleswig-Holstein, Campus Kiel, Germany; denis.schewe@uksh.de. Pediatric Hematology/Oncology, ALL-BFM Study Group, Christian Albrechts University Kiel and University Hospital Schleswig-Holstein, Campus Kiel, Germany. Division of Stem Cell Transplantation and Immunotherapy, Department of Medicine II, Christian Albrechts University Kiel and University Hospital Schleswig-Holstein, Campus Kiel, Germany. .
10: Title: A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism.
Authors: Barzi, Mercedes, et.al. .
Journal: Nature communications (Nat Commun), Vol. 8 (1): 39, 2017 .
Snippet: We therefore generated a conditional knock-out of the NADPH-P450 oxidoreductase (Por) gene combined with Il2rg (- /-) /Rag2 (- /-) /Fah (- /-) (PIRF) mice.
Affiliation: Center for Cell and Gene Therapy, Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX-77030, USA. Graduate Program, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX-77030, USA. Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX-77030, USA. Alkek Center for Molecular Discovery, Advanced Technology Core, Baylor College of Medicine, Houston, TX-77030, USA. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX-77030, USA. Program in Developmental Biology, Baylor College of Medicine, Houston, TX-77030, USA. Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX-77030, USA. McNair Medical Institute, Houston, TX-77030, USA. Center for Cell and Gene Therapy, Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX-77030, USA. bissig@bcm.edu. Graduate Program, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX-77030, USA. bissig@bcm.edu. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX-77030, USA. bissig@bcm.edu. Program in Developmental Biology, Baylor College of Medicine, Houston, TX-77030, USA. bissig@bcm.edu. Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX-77030, USA. bissig@bcm.edu. .
11: Title: MEMORY T CELLS EXPRESSING AN NKG2D-CAR EFFICIENTLY TARGET OSTEOSARCOMA CELLS.
Authors: Fernández, Lucía, et.al. .
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research (Clin Cancer Res), 2017 .
Snippet: In vitro cytotoxicity of NKG2D-CAR+ CD45RA- T cells against osteosarcoma was evaluated by performing conventional 4-hour europium-TDA release assays.
Affiliation: Hematology, CNIO. Hematology, St. Jude Children's Research Hospital. Paediatric Oncology Department, INGEMM, Hospital Universitario La Paz. Translational Research in Pediatric Oncology, Hematopoietic Trasplantation & Cell Therapy, IdiPAZ. Genetics, INGEMM, Hospital Universitario La Paz. Hematology and Hemotherapy, Hospital Universitario 12 De Octubre. Clinical Immunology, Hospital Universitario La Paz. Laboratory of Advanced Therapies for Pediatric Solid Tumors, University Clinic of Navarra. Servicio de Hematología y Hemoterapia, Hospital Universitario 12 de Octubre. Clinical Development, Miltenyi Biotec. Department of Pediatric Hemato-Oncology, Hospital Universitario La Paz aperezmartinez@salud.madrid.org. .
12: Title: Orthotopic Patient-Derived Pancreatic Cancer Xenografts Engraft Into the Pancreatic Parenchyma, Metastasize, and Induce Muscle Wasting to Recapitulate the Human Disease.
Authors: Go, Kristina L, et.al. .
Journal: Pancreas, 2017 .
Snippet: METHODS: Human PDX-derived PC tumors were implanted directly into the pancreas of NOD.Cg-Prkdc Il2rg/SzJ mice.
Affiliation: From the *Department of Surgery, College of Medicine; †Department of Physical Therapy; and ‡Department of Medicine, College of Medicine, University of Florida Health Science Center, Gainesville, FL. .
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13: Title: A Nationwide Study of Severe and Protracted Diarrhoea in Patients with Primary Immunodeficiency Diseases.
Authors: Lee, Wen-I, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7 (1): 3669, 2017 .
Snippet: Among 246 patients with predominantly paediatric-onset PIDs from 2003-2015, 21 [Btk (six), IL2RG (four), WASP, CD40L, gp91 (three each), gp47, RAG2 (one each)] and five [CVID (four), SCID (one)] without identified mutations had SD before prophylactic treatment.
Affiliation: Primary Immunodeficiency Care and Research (PICAR) Institute, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. wen2707@hotmail.com. Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. wen2707@hotmail.com. Division of Gastroenterology, Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, Taiwan. cgj2841@adm.cgmh.org.tw. Primary Immunodeficiency Care and Research (PICAR) Institute, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. Division of Hematology/Oncology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan. Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. Department of Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan. Primary Immunodeficiency Care and Research (PICAR) Institute, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. long@adm.cgmh.org.tw. Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. long@adm.cgmh.org.tw. .
14: Title: Orthotopic Patient-Derived Pancreatic Cancer Xenografts Engraft Into the Pancreatic Parenchyma, Metastasize, and Induce Muscle Wasting to Recapitulate the Human Disease.
Authors: Go, Kristina L, et.al. .
Journal: Pancreas, Vol. 46 (6): 813-819, 2017 .
Snippet: METHODS: Human PDX-derived PC tumors were implanted directly into the pancreas of NOD.Cg-Prkdc Il2rg/SzJ mice.
Affiliation: From the *Department of Surgery, College of Medicine; †Department of Physical Therapy; and ‡Department of Medicine, College of Medicine, University of Florida Health Science Center, Gainesville, FL. .
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15: Title: Novel RAG1 mutation and the occurrence of mycobacterial and Chromobacterium violaceum infections in a case of leaky SCID.
Authors: Khan, Taj Ali, et.al. .
Journal: Microbial pathogenesis (Microb Pathog), Vol. 109, 2017 .
Snippet: Severe combined immunodeficiency (SCID) is a potentially fatal primary immunodeficiency (PID) that is caused by mutations in genes such as IL2RG, JAK3, IL7RA, RAG1, RAG2, and ADA.
Affiliation: Department of Microbiology, Kohat University of Science and Technology, Kohat, Pakistan. Electronic address: microbiologist63@yahoo.com. Laboratory of Biochemistry and Biophysics, Butantan Institute, Sao Paulo, Brazil. Department of Microbiology, Abdul Wali Khan University of Mardan, Pakistan. Department of Rheumatology, University Lübeck, Lübeck, Germany. Basic Science Research Department, ShaukatKhanum Memorial Cancer Hospital & Research Centre, 7A, Block R-3, Johar Town, Lahore, Pakistan. Department of Biotechnology and Genetic Engineering, Kohat University of Science and Technology, Kohat, Pakistan. .
16: Title: HIF-1α-stabilizing agent FG-4497 rescues human CD34(+) cell mobilization in response to G-CSF in immunodeficient mice.
Authors: Nowlan, Bianca, et.al. .
Journal: Experimental hematology (Exp Hematol), Vol. 52, 2017 .
Snippet: To evaluate whether PHD inhibitors could be used to enhance mobilization of human HSPCs, we humanized nonobese, diabetic severe combined immune-deficient Il2rg(-/-) mice by transplanting them with human umbilical cord blood CD34(+) HSPCs and then treating them with G-CSF with and without co-administration of the PHD inhibitor FG-4497.
Affiliation: Stem Cell Therapies Laboratory, Translational Research Institute, Queensland University of Technology, Woolloongabba, Queensland, Australia; Mater Research Institute, Translational Research Institute, University of Queensland, Woolloongabba, Queensland, Australia. Stem Cell Therapies Laboratory, Translational Research Institute, Queensland University of Technology, Woolloongabba, Queensland, Australia. Mater Research Institute, Translational Research Institute, University of Queensland, Woolloongabba, Queensland, Australia. FibroGen, Inc., San Francisco, CA. Stem Cell Therapies Laboratory, Translational Research Institute, Queensland University of Technology, Woolloongabba, Queensland, Australia; Mater Research Institute, Translational Research Institute, University of Queensland, Woolloongabba, Queensland, Australia; Australian National Centre for the Public Awareness of Science - Australian National University, Australia. Electronic address: michael.doran@qut.edu.au. Mater Research Institute, Translational Research Institute, University of Queensland, Woolloongabba, Queensland, Australia. Electronic address: jp.levesque@mater.uq.edu.au. .
17: Title: Viability of Airborne Tumor Cells during Excision by Ultrasonic Device.
Authors: Hashimoto, Masakazu, et.al. .
Journal: Surgery research and practice (Surg Res Pract), Vol. 2017, 2017 .
Snippet: Flank tumors measuring about 2 cm were induced in male NOD-Cg-Rag1(tm1Mom)IL2rg(tm1wjl/SzJ) mice by subcutaneous injection of 1 × 10(6) HepG2 cells.
Affiliation: Department of Gastroenterological and Transplant Surgery, Hiroshima University Hospital, Hiroshima, Japan. .
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18: Title: Characterization of the anti-CD22 targeted therapy, moxetumomab pasudotox, for B-cell precursor acute lymphoblastic leukemia.
Authors: Kinjyo, Ichiko, et.al. .
Journal: Pediatric blood & cancer (Pediatr Blood Cancer), 2017 .
Snippet: Studies in NOD-scid IL2Rg(null) mice showed a modest survival benefit in mice engrafted with 697 cells but not in NALM6 or the two patient-derived xenograft models.
Affiliation: Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico. Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico. Division of Hematology/Oncology, Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, New Mexico. Translational Medicine Oncology, MedImmune, Gaithersburg, Maryland. Oncology Research, MedImmune, Gaithersburg, Maryland. .
19: Title: FLAG-tagged CD19-specific CAR-T cells eliminate CD19-bearing solid tumor cells in vitro and in vivo.
Authors: Berahovich, Robert, et.al. .
Journal: Frontiers in bioscience (Landmark edition) (Front Biosci), Vol. 22, 2017 .
Snippet: CD19-FLAG CAR-T cells also significantly reduced Raji tumor burden and extended mouse survival.
Affiliation: ProMab Biotechnologies, Richmond, CA. Department of Infectious Diseases, University of California, Berkeley, CA. ProMab Biotechnologies, Richmond, CA, vita.gol@promab.com. .
20: Title: Improving transplantation for IL2RG/JAK3 SCID.
Authors: Keller, Michael D .
Journal: Blood, Vol. 129 (15): 2049-2050, 2017 .
No Abstract available.
Affiliation: CHILDREN'S NATIONAL MEDICAL CENTER. .
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