refine search
Interleukin Receptor Common gamma Subunit 395
 
Mice, Inbred NOD 224
 
Mice, SCID 227
 
X-Linked Combined Immunodeficiency Diseases 109
 
Mice, Knockout 191
 
Transplantation, Heterologous 159
 
Interleukin-2 147
 
stem cell development 179
 
nitric oxide dioxygenase activity 108
 
Killer Cells, Natural 114
 
Authors
Locations
Journals
Publication Dates
Find concepts in Knowledge Base
Explore current query
documentsstatisticstop authorclipboard
691 documents found
1: Title: Identification of IL2RG and CYBB mutations in two Chinese primary immunodeficiency patients by whole-exome sequencing.
Authors: Xu, Shanshan, et.al. .
Journal: Immunological investigations (Immunol Invest), 2018 .
Snippet: Sequencing analysis of IL2RG gene revealed a novel mutation (c.794T>A, p.I265N) and CYBB gene revealed a missense mutation (c.935T>A, p.M312K).
Affiliation: a Department of Pediatrics , The First Affiliated Hospital of Xiamen University , Xiamen , China. b Medical College of Xiamen University , Xiamen , China. c Joy Orient Translational Medicine Research Center Co., Ltd , Beijing , China. .
Related Products: order online
2: Title: EDAG promotes the expansion and survival of human CD34+ cells.
Authors: Zhao, Ke, et.al. .
Journal: PloS one, Vol. 13 (1): e0190794, 2018 .
Snippet: Gene expression profile analysis indicate that EDAG knockdown leads to down-regulation of various positive cell cycle regulators including cyclin A, B, D, and E. Together these data provides novel insights into EDAG in regulation of expansion and survival of human hematopoietic stem/progenitor cells.
Affiliation: State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China. Tianjin University, School of Chemical Engineering and Technology, Department of Pharmaceutical Engineering, Tianjin, China. An Hui Medical University, Hefei, China. Guang Dong Pharmaceutical University, School of Pharmacy, Guangzhou, China. Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital to Academy of Military Medical Sciences, Beijing, China. .
Related Products: order online
3: Title: A functional DC cross talk promotes human ILC homeostasis in humanized mice.
Authors: Lopez-Lastra, Silvia, et.al. .
Journal: Blood advances (Blood Adv), Vol. 1 (10): 601-614, 2017 .
Snippet: Here we show that novel dendritic cell (DC)-boosted BALB/c Rag2-/-Il2rg-/-SirpaNODFlk2-/- (BRGSF) HIS mice harbor abundant NK cells and tissue-resident ILC subsets in lymphoid and nonlymphoid mucosal sites.
Affiliation: Innate Immunity Unit, Institut Pasteur, Paris, France. INSERM U1223, Paris, France; and. Université Paris-Sud (Paris-Saclay), Ecole Doctorale-Structure et Dynamique des Systèmes Vivants n°577, Paris, France. .
Related Products: order online
4: Title: Advances in the understanding and management of T-cell prolymphocytic leukemia.
Authors: Laribi, Kamel, et.al. .
Journal: Oncotarget, Vol. 8 (61): 104664-104686, 2017 .
Snippet: In addition, molecular analysis shows that T-PLL exhibits substantial mutational activation of the IL2RG-JAK1-JAK3-, STAT5B axis.
Affiliation: Department of Hematology, Centre Hospitalier du Mans, Le Mans, France. Laboratory of Biology and Hematology, Centre Hospitalier du Mans, Le Mans, France. Laboratory of Anatomopathology, Centre Hospitalier du Mans, Le Mans, France. Department of Medicine, Clinique du Pré, Le Mans, France. .
Related Products: order online
5: Title: CD215+ Myeloid Cells Respond to Interleukin 15 Stimulation and Promote Tumor Progression.
Authors: Lin, Shouheng, et.al. .
Journal: Frontiers in immunology (Front Immunol), Vol. 8, 2017 .
Snippet: Here, we demonstrated that the in vivo injection of recombinant human IL-15 (200 µg/kg) or murine IL-15 (3 µg/kg) to tumor-bearing NOD-SCID-IL2Rg-/- (NSI) mice resulted in increased tumor progression and CD45+ CD11b+ Gr-1+ CD215+ cell expansion in the tumors and spleen.
Affiliation: Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. University of Chinese Academy of Sciences, Beijing, China. Department of Respiratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China. Department of Thoracic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China. Department of Thoracic Oncology, The Second Xiangya Hospital of Central South University, Changsha, China. Guangdong Zhaotai InVivo Biomedicine Co. Ltd., Guangzhou, China. Medical College, Institute of Hematology, Jinan University, Guangzhou, China. Guangdong Lung Cancer Institute, Medical Research Center, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. Wellcome Trust Sanger Institute, Hinxton, United Kingdom. International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China. .
Related Products: order online
6: Title: Genetic disorders of GH action pathway.
Authors: Domené, Horacio M, et.al. .
Journal: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society (Growth Horm Igf Res), 2017 .
Snippet: The genetic defects affecting GH and/or IGF-I action can be divided into five different groups: GH insensitivity by defects affecting the GH receptor (GHR), the intracellular GH signaling pathway (STAT5B, STAT3, IKBKB, IL2RG, PIK3R1), the synthesis of insulin-like growth factors (IGF1, IGF2), the transport/bioavailability of IGFs (IGFALS, PAPPA2), and defects affecting IGF-I sensitivity (IGF1R).
Affiliation: Centro de Investigaciones Endocrinológicas (CEDIE-CONICET), "Dr. César Bergadá", División de Endocrinología, Hospital de Niños R. Gutiérrez, Buenos Aires, Argentina. Electronic address: hdomene@cedie.org.ar. Escuela de Medicina, Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Quito, Ecuador. .
Related Products: order online
7: Title: Neddylation blockade diminishes hepatic metastasis by dampening cancer stem-like cells and angiogenesis in uveal melanoma.
Authors: Jin, Yanli, et.al. .
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research (Clin Cancer Res), 2017 .
Snippet: Liver metastasis was evaluated by use of a NOD-scid-IL2Rg-(NSI) mouse model.
Affiliation: Jinan University Institute of Tumor Pharmacology, College of Pharmacy, Jinan University. Department of Pathology, Zhongshan Ophthalmic Center, Sun Yat-sen University. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University. State Key Laboratory of Ophthalmology, Sun Yat-sen University Zhongshan Ophthalmic Center panjx2@mail.sysu.edu.cn. .
Related Products: order online
8: Title: Analysis of CTCL cell lines reveals important differences between mycosis fungoides/Sézary syndrome vs. HTLV-1+ leukemic cell lines.
Authors: Netchiporouk, Elena, et.al. .
Journal: Oncotarget, Vol. 8 (56): 95981-95998, 2017 .
Snippet: HTLV-1 is estimated to affect ~20 million people worldwide and in ~5% of carriers it produces Adult T-Cell Leukemia/Lymphoma (ATLL), which can often masquerade and present with classic erythematous pruritic patches and plaques that are typically seen in Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most recognized variants of Cutaneous T-Cell Lymphomas (CTCL).
Affiliation: Division of Dermatology, McGill University, Montréal, Québec, Canada. Division of Dermatology, University of Ottawa, Ottawa, Ontario, Canada. Université de Sherbrooke Rnomics Platform, Sherbrooke, Québec, Canada. Department of Pathology, McGill University Health Centre, Montreal, Québec, Canada. Department of International Health, Immunology, and Microbiology, University of Copenhagen, Copenhagen, Denmark. .
Related Products: order online
9: Title: Production and rearing of germ-free X-SCID pigs.
Authors: Hara, Hiromasa, et.al. .
Journal: Experimental animals (Exp Anim), 2017 .
Snippet: Pigs with X-linked severe combined immunodeficiency (X-SCID) caused by a mutation of the interleukin-2 receptor gamma chain gene (IL2RG) are of value for a wide range of studies.
Affiliation: Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University. Center for Development of Advanced Medical Technology, Jichi Medical University. Department of Life Sciences, School of Agriculture, Meiji University. Meiji University International Institute for Bio-Resource Research. Department of Biological Sciences, Graduate School of Science, The University of Tokyo. .
Related Products: order online
10: Title: Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy.
Authors: Wang, Minan, et.al. .
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (Faseb J), 2017 .
Snippet: HuNSG mice received human leukocyte antigen partially matched tumor implants from patient-derived xenografts [PDX; nonsmall cell lung cancer (NSCLC), sarcoma, bladder cancer, and triple-negative breast cancer (TNBC)] or from a TNBC cell line-derived xenograft (CDX).
Affiliation: Department of In Vivo Pharmacology Services, The Jackson Laboratory, Sacramento, California, USA; minan.wang@jax.org. Department of In Vivo Pharmacology Services, The Jackson Laboratory, Sacramento, California, USA. Department of Immunology, The Jackson Laboratory, Farmington, Connecticut, USA. Department of Urology, Davis Comprehensive Cancer Center, University of California, Davis, Davis, California, USA. Department of Biochemistry and Molecular Medicine, Davis Comprehensive Cancer Center, University of California, Davis, Davis, California, USA. Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA. Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts, USA; and. Department of Immunology, The Jackson Laboratory, Bar Harbor, Maine, USA. .
Related Products: order online
11: Title: Decitabine enhances targeting of AML cells by CD34+ progenitor-derived NK cells in NOD/SCID/IL2Rgnull mice.
Authors: Cany, Jeannette, et.al. .
Journal: Blood, Vol. 131 (2): 202-214, 2018 .
Snippet: Combining natural killer (NK) cell adoptive transfer with hypomethylating agents (HMAs) is an attractive therapeutic approach for patients with acute myeloid leukemia (AML).
Affiliation: Department of Laboratory Medicine, Laboratory of Hematology. Department of Hematology, and. Department of Gynecology, Radboud University Medical Center (Radboudumc), Nijmegen, The Netherlands; and. Department of Hematology, University Medical Center Groningen, Groningen, The Netherlands. .
Related Products: order online
12: Title: IL2RG, identified as overexpressed by RNA-seq profiling of pancreatic intraepithelial neoplasia, mediates pancreatic cancer growth.
Authors: Ayars, Michael, et.al. .
Journal: Oncotarget, Vol. 8 (48): 83370-83383, 2017 .
Snippet: CRISPR-mediated knockout of IL2RG in orthotopically implanted pancreatic cancer cells resulted in attenuated tumor growth in mice and reduced JAK3 expression in orthotopic tumors.
Affiliation: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Department of Medicine, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. .
Related Products: order online
13: Title: Humanized mouse model supports development, function, and tissue residency of human natural killer cells.
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 114 (45): E9626-E9634, 2017 .
Snippet: In contrast to nonobese diabetic severe combined immunodeficient Il2rg-/- (NSG) mice, human NK cells in SRG-15 mice did not require preactivation but infiltrated a Burkitt's lymphoma xenograft and efficiently inhibited tumor growth following treatment with the therapeutic antibody rituximab.
Affiliation: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519. Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06519. Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305. Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591. Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519; richard.flavell@yale.edu. Howard Hughes Medical Institute, New Haven, CT 06519. .
Related Products: order online
14: Title: Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways.
Authors: Saito, Yoriko, et.al. .
Journal: Science translational medicine (Sci Transl Med), Vol. 9 (413), 2017 .
Snippet: Through NOD.Cg-PrkdcscidIl2rgtmlWjl/Sz (NSG) xenotransplantation, we functionally identified preleukemic and leukemic stem cell populations present in FMS-like tyrosine kinase 3 internal tandem duplication-positive (FLT3-ITD)+ AML patient samples.
Affiliation: Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan. Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Department of Hematology, Toranomon Hospital, Tokyo 105-8470, Japan. RIKEN Program for Drug Discovery and Medical Technology Platforms, Yokohama, Kanagawa 230-0045, Japan. The Jackson Laboratory, Bar Harbor, ME 04609, USA. Kazusa DNA Research Institute, Kisarazu, Chiba 292-0818, Japan. Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan. fumihiko.ishikawa@riken.jp. .
Related Products: order online
15: Title: Molecular and Functional Characterization of Lymphoid Progenitor Subsets Reveals a Bipartite Architecture of Human Lymphopoiesis.
Authors: Alhaj Hussen, Kutaiba, et.al. .
Journal: Immunity, Vol. 47 (4): 680-696.e8, 2017 .
Snippet: Whereas CD127- ELPs comprised precursors of T cells, marginal zone B cells, and natural killer (NK) and innate lymphoid cells (ILCs), CD127+ ELPs supported production of all NK cell, ILC, and B cell populations but lacked T potential.
Affiliation: INSERM U1126, Université Paris-Diderot, École Pratique des Hautes Etudes/PSL Research University, Institut Universitaire d'Hématologie, Hôpital Saint-Louis, Paris, France. Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France. Service de Biologie du Développement, INSERM UMR 1141, Université Paris-Diderot, Hôpital Robert-Debré, AP-HP, Paris, France. Bioinformatique, Institut Universitaire d'Hématologie, Université Paris-Diderot, Paris, France. Institut de Systématique, Évolution, Biodiversité (ISYEB), UMR 7205, CNRS, Museum National d'Histoire Naturelle (MNHN), Université Pierre et Marie Curie, and École Pratique des Hautes Etudes (EPHE), Sorbonne Universités, Paris Sciences Lettres, Paris, France. Unité de Lymphopoïèse, Département d'Immunologie, Institut Pasteur; Université Paris-Diderot, Sorbonne Paris Cité, Cellule Pasteur; INSERM U1223, Paris, France. INSERM UMRS 1160, Institut Universitaire d'Hématologie, Université Paris-Diderot, Sorbonne Paris Cité; Laboratoire d'Immunologie et Histocompatibilité, AP-HP, Hôpital Saint-Louis, 75010 Paris, France. Plateforme d'Imagerie et de Tri Cellulaire, Institut Universitaire d'Hématologie, Hôpital Saint-Louis, Paris, France. APHP, Hôpital Saint-Louis, Unité de Thérapie Cellulaire; CIC de Biothérapies, Université Paris Diderot, Sorbonne Paris Cité, INSERM, F-75475 Paris, France. CIRI, International center for Infectiology Research, EVIR team, Université de Lyon, INSERM U1111, Lyon, France; and Centre Méditerranéen de Médecine Moléculaire (C3M), team "Contrôle métabolique des morts cellulaires" Inserm, U1065, 06204 Nice, France. INSERM U1126, Université Paris-Diderot, École Pratique des Hautes Etudes/PSL Research University, Institut Universitaire d'Hématologie, Hôpital Saint-Louis, Paris, France. Electronic address: bruno.canque@ephe.sorbonne.fr. .
Related Products: order online
16: Title: The Common Cytokine Receptor γ Chain Family of Cytokines.
Authors: Lin, Jian-Xin, et.al. .
Journal: Cold Spring Harbor perspectives in biology (Cold Spring Harbor Perspect Biol), 2017 .
Snippet: The IL2RG gene is located on the X chromosome and is mutated in humans with X-linked severe combined immunodeficiency (XSCID).
Affiliation: Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1674. .
Related Products: order online
17: Title: Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1.
Authors: Schiroli, Giulia, et.al. .
Journal: Science translational medicine (Sci Transl Med), Vol. 9 (411), 2017 .
Snippet: Finally, we optimized editing reagents and protocol for human HSPCs and attained the threshold of IL2RG editing in long-term repopulating cells predicted to safely rescue the disease, using clinically relevant HSPC sources and highly specific zinc finger nucleases or CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9).
Affiliation: San Raffaele Telethon Institute for Gene Therapy, 20132 Milan, Italy. Vita-Salute San Raffaele University, 20132 Milan, Italy. Sangamo Therapeutics, Richmond, CA 94804, USA. Pathology Unit, Department of Oncology, San Raffaele Scientific Institute, 20132 Milan, Italy. Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. MolMed S.p.A., 20132 Milan, Italy. Magenta Therapeutics, Cambridge, MA 02139, USA. Harvard Stem Cell Institute, Cambridge, MA 02138, USA. National Research Council, Institute of Genetic and Biomedical Research Milan Unit, 20138 Milan, Italy. San Raffaele Scientific Institute, 20132 Milan, Italy. San Raffaele Telethon Institute for Gene Therapy, 20132 Milan, Italy. genovese.pietro@hsr.it naldini.luigi@hsr.it. .
Related Products: order online
18: Title: Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Authors: Alzubi, Jamal, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7 (1): 12475, 2017 .
Snippet: X-linked severe combined immunodeficiency (X-SCID) is an immune disorder caused by mutations in the IL2RG gene and characterised by the absence of T and NK cells in patients.
Affiliation: Institute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, Freiburg, Germany. Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany. Institute of Child Health, University College London, London, United Kingdom. GlaxoSmithKline plc., Stevenage, Hertfordshire, United Kingdom. Great Ormond Street Hospital, NHS Foundation Trust, London, United Kingdom. Institute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, Freiburg, Germany. toni.cathomen@uniklinik-freiburg.de. Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany. toni.cathomen@uniklinik-freiburg.de. Faculty of Medicine, University of Freiburg, Freiburg, Germany. toni.cathomen@uniklinik-freiburg.de. .
Related Products: order online
19: Title: Production of immunodeficient rabbits by multiplex embryo transfer and multiplex gene targeting.
Authors: Song, Jun, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7 (1): 12202, 2017 .
Snippet: Next we microinjected forty-five embryos each with five sgRNAs targeting FOXN1, RAG1, RAG2, IL2RG and PRKDC, and transferred them to two recipients.
Affiliation: Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical Center, Ann Arbor, Michigan, 48109, USA. Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical Center, Ann Arbor, Michigan, 48109, USA. echenum@med.umich.edu. Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical Center, Ann Arbor, Michigan, 48109, USA. jiex@umich.edu. .
Related Products: order online
20: Title: Innate Lymphoid Cells Mediate Pulmonary Eosinophilic Inflammation, Airway Mucous Cell Metaplasia, and Type 2 Immunity in Mice Exposed to Ozone.
Authors: Kumagai, Kazuyoshi, et.al. .
Journal: Toxicologic pathology (Toxicol Pathol), 2017 .
Snippet: In the present study, we determined the role of innate lymphoid cells (ILCs) in the pathogenesis of ozone-induced nonatopic asthma by using lymphoid cell-sufficient C57BL/6 mice, ILC-sufficient Rag2(-/-) mice (devoid of T and B cells), and ILC-deficient Rag2(-/-)Il2rg(-/-) mice (depleted of all lymphoid cells including ILCs).
Affiliation: 1 Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, Michigan, USA. 2 Department of Medicine, University of California, San Francisco, California, USA. .
Related Products: order online
Page 1 2 3 … 35 
Documents per page: 20 | 50 | 100