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138 documents found
1: Title: Immune signature profiling identified predictive and prognostic factors for esophageal squamous cell carcinoma.
Authors: Li, Yuan, et.al. .
Journal: Oncoimmunology, Vol. 6 (11): e1356147, 2017 .
Snippet: Moreover, nine immune related genes (ABL1, ATF2, ATG5, C6, CD38, HMGB1, ICOSLG, IL12RB2 and PLAU) were significantly associated with patients' overall survival, among which, prognostic model was built including three independent factors ABL1, CD38 and ICOSLG.
Affiliation: Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. .
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2: Title: ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses.
Authors: Lownik, Joseph C, et.al. .
Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol), Vol. 199 (7): 2305-2315, 2017 .
Snippet: This results in severe defects in T follicular helper development and TH2 polarization, as seen in a house dust mite exposure model.
Affiliation: Center for Clinical and Translational Research, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298. Department of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298. Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, United Kingdom. Department of Clinical and Chemical Pathology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Cairo 11562, Egypt; and. German Rheumatism Research Centre Berlin, 10117 Berlin, Germany. Department of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298; Daniel.Conrad@vcuhealth.org RKSmith@vcu.edu. .
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3: Title: TFH-derived dopamine accelerates productive synapses in germinal centres.
Authors: Papa, Ilenia, et.al. .
Journal: Nature, Vol. 547 (7663): 318-323, 2017 .
Snippet: Dopamine causes rapid translocation of intracellular ICOSL (inducible T-cell co-stimulator ligand, also known as ICOSLG) to the B-cell surface, which enhances accumulation of CD40L and chromogranin B granules at the human TFH cell synapse and increases the synapse area.
Affiliation: Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 2601, Australia. Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK. Ateneo Vita-Salute, Department of Pathology, IRCCS Scientific Institute San Raffaele, Milan 20132, Italy. Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, University of New South Wales, Sydney, New South Wales 2052, Australia. Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia 5000, Australia. OMNI-Biomarker Development, Genentech Inc., South San Francisco, California 94080, USA. Imaging and Cytometry Facility, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 2601, Australia. Department of Systems Immunology and Braunschweig Integrated Centre of Systems Biology, Helmholtz Centre for Infection Research, Braunschweig 38124, Germany. China-Australia Centre for Personalised Immunology, Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200085, China. .
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4: Title: Antigen-Presenting Human γδ T Cells Promote Intestinal CD4(+) T Cell Expression of IL-22 and Mucosal Release of Calprotectin.
Authors: Tyler, Christopher J, et.al. .
Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol), Vol. 198 (9): 3417-3425, 2017 .
Snippet: In human intestinal organ cultures, microbial activation of Vγ9/Vδ2 T cells promoted mucosal secretion of IL-22 and ICOSL/TNF-α-dependent release of the IL-22 inducible antimicrobial protein calprotectin without modulating IL-17 expression.
Affiliation: Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom. Centre for Immunobiology, The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, United Kingdom. Department of Gastroenterology, The Royal London Hospital, Barts Health NHS Trust, London E1 1BB, United Kingdom; and. Centre for Immunobiology, The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, United Kingdom; eberlm@cf.ac.uk a.stagg@qmul.ac.uk. Systems Immunity Research Institute, Cardiff University, Cardiff CF14 4XN, United Kingdom. Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom; eberlm@cf.ac.uk a.stagg@qmul.ac.uk. .
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5: Title: Smoking reduces circulating CD26(hi)CD161(hi) MAIT cells in healthy individuals and patients with multiple sclerosis.
Authors: Ammitzbøll, Cecilie, et.al. .
Journal: Journal of leukocyte biology (J Leukoc Biol), Vol. 101 (5): 1211-1220, 2017 .
Snippet: Upon chronic cigarette smoke exposure, inhaled antigens and irritants cause altered lung immune homeostasis.
Affiliation: Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark cecilie.ammitzboell@regionh.dk. Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. .
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6: Title: ICOS-Ligand Triggering Impairs Osteoclast Differentiation and Function In Vitro and In Vivo.
Authors: Gigliotti, Casimiro L, et.al. .
Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol), Vol. 197 (10): 3905-3916, 2016 .
Snippet: The results showed that ICOS-Fc inhibits RANKL-mediated differentiation of human monocyte-derived OC-like cells (MDOCs) by inhibiting the acquirement of the OC morphology, the CD14(-) cathepsin K(+) phenotype, and the expression of tartrate-resistant acid phosphatase, OSCAR, NFATc1, and DC-STAMP.
Affiliation: Department of Health Sciences and Interdisciplinary Research Center of Autoimmune Diseases, University of Piemonte Orientale, 28100 Novara, Italy. Department of Medical Sciences, University of Torino, 10126 Torino, Italy. Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy. Department of Microbiology and Immunology, Tokyo Women's Medical University, Tokyo 108-8639, Japan. Departamento de Medicina Celular y Molecular, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, 28006 Madrid, Spain; and. Department of Pharmaceutical Sciences, University of Piemonte Orientale, 28100 Novara, Italy. Department of Health Sciences and Interdisciplinary Research Center of Autoimmune Diseases, University of Piemonte Orientale, 28100 Novara, Italy; umberto.dianzani@med.uniupo.it. .
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7: Title: Assessment of CD37 B-cell antigen and cell of origin significantly improves risk prediction in diffuse large B-cell lymphoma.
Authors: Xu-Monette, Zijun Y, et.al. .
Journal: Blood, Vol. 128 (26): 3083-3100, 2016 .
Snippet: Gene expression profiling suggested that decreased CD20 and increased PD-1 levels in CD37(-) DLBCL, ICOSLG upregulation in CD37(+) GCB-DLBCL, and CD37 functions during R-CHOP treatment underlie the pivotal role of CD37 status in clinical outcomes.
Affiliation: Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX. Department of Oncology, The First Affiliated Hospital Zhengzhou University, Zhengzhou, China. Department of Hematology and Oncology, The Ohio State University, Columbus, OH. Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX. Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. University Hospital, Basel, Switzerland. San Bortolo Hospital, Vicenza, Italy. Aalborg University Hospital, Aalborg, Denmark. Memorial Sloan Kettering Cancer Center, New York, NY. Department of Pathology, Weill Medical College of Cornell University, New York, NY. Department of Pathology, The Methodist Hospital, Houston, TX. Department of Pathology, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY. Department of Hematology and Oncology, University of North Carolina School of Medicine, Chapel Hill, NC. Cleveland Clinic, Cleveland, OH. Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China. Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea. San Raffaele H. Scientific Institute, Milan, Italy. Odense University Hospital, Odense, Denmark. Gundersen Lutheran Health System, La Crosse, WI. Feinberg School of Medicine, Northwestern University, Chicago, IL. Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX. Hospital Universitario Marqués de Valdecilla, Santander, Spain. Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; and. Graduate School of Biomedical Sciences, The University of Texas School of Medicine, Houston, TX. .
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8: Title: Gene expression analysis of TIL rich HPV-driven head and neck tumors reveals a distinct B-cell signature when compared to HPV independent tumors.
Authors: Wood, Oliver, et.al. .
Journal: Oncotarget, Vol. 7 (35): 56781-56797, 2016 .
Snippet: A B-cell associated signature distinguished HPV(+) from HPV(-) tumors, and included the DEGs CD200, GGA2, ADAM28, STAG3, SPIB, VCAM1, BCL2 and ICOSLG; the immune signal relative to T-cells was qualitatively similar between TILs of both tumor cohorts.
Affiliation: Faculty of Medicine, University of Southampton & University Hospital Southampton, Southampton, UK. La Jolla Institute for Allergy & Immunology, La Jolla, CA, USA. Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK. .
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9: Title: Follicular B Lymphomas Generate Regulatory T Cells via the ICOS/ICOSL Pathway and Are Susceptible to Treatment by Anti-ICOS/ICOSL Therapy.
Authors: Le, Kieu-Suong, et.al. .
Journal: Cancer research (Cancer Res), Vol. 76 (16): 4648-60, 2016 .
Snippet: We analyzed 46 fresh lymph node biopsy samples, including FL (n = 20), diffuse large B-cell lymphoma (n = 10), classical Hodgkin lymphoma (n = 9), and reactive lymphadenitis (n = 7).
Affiliation: Centre de recherche en Cancérologie de Marseille, Inserm U1068/CNRS U7258, Marseille, France. Aix Marseille Université, Marseille, France. Centre de recherche en Cancérologie de Marseille, Inserm U1068/CNRS U7258, Marseille, France. Institut Paoli - Calmettes, Marseille, France. Institut Paoli - Calmettes, Marseille, France. Centre de recherche en Cancérologie de Marseille, Inserm U1068/CNRS U7258, Marseille, France. Centre de Recherche en Cancérologie de Lyon, Inserm U1052/CNRS 5286, Lyon, France. Institut Albert Bonniot, Grenoble, France. Centre de recherche en Cancérologie de Marseille, Inserm U1068/CNRS U7258, Marseille, France. Aix Marseille Université, Marseille, France. Institut Paoli - Calmettes, Marseille, France. Centre de recherche en Cancérologie de Marseille, Inserm U1068/CNRS U7258, Marseille, France. Aix Marseille Université, Marseille, France. Institut Paoli - Calmettes, Marseille, France. daniel.olive@inserm.fr. .
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10: Title: ICOS Promotes the Function of CD4+ Effector T Cells during Anti-OX40-Mediated Tumor Rejection.
Authors: Metzger, Todd C, et.al. .
Journal: Cancer research (Cancer Res), Vol. 76 (13): 3684-9, 2016 .
Snippet: Taken together, our results showed that ICOS signaling during antitumor responses acts on both Teff and Treg cells, which have opposing roles in promoting immune activation.
Affiliation: Rinat Laboratories, Pfizer Inc., South San Francisco, California. Todd.Metzger@pfizer.com Reid.Feldman@pfizer.com. Rinat Laboratories, Pfizer Inc., South San Francisco, California. Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. .
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11: Title: Altered immune parameters correlate with infection-related hospitalizations in children with Down syndrome.
Authors: Martínez, Elizabeth, et.al. .
Journal: Human immunology (Hum Immunol), Vol. 77 (7): 594-9, 2016 .
Snippet: As previously reported, numbers of lymphocytes, CD4(+) T cells, Treg cells, B cells, and levels of serum IgM were decreased, and levels of IgG and IgA were increased in children with DS.
Affiliation: Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Carrera 7 No. 43-82, Bogotá, Colombia. Grupo Parasitología y Medicina Tropical, Facultad de Salud, Universidad Surcolombiana, Avenida Pastrana Borrero Carrera 1, Neiva, Huila, Colombia. Instituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Carrera 7 No. 40-62, Bogotá, Colombia. Departamento de Matemáticas, Facultad de Ciencias, Pontificia Universidad Javeriana, Carrera 7 No. 43-82, Bogotá, Colombia. Hospital Universitario San Ignacio, Carrera 7 No. 40-62, Bogotá, Colombia. Departamento de Epidemiología Clínica y Bioestadística, Facultad de Medicina, Pontificia Universidad Javeriana, Carrera 7 No. 43-82, Bogotá, Colombia. Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Carrera 7 No. 43-82, Bogotá, Colombia. Electronic address: mmesa001@gmail.com. .
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12: Title: Development of a novel monoclonal antibody to human inducible co-stimulator ligand (ICOSL): Biological characteristics and application for enzyme-linked immunosorbent assay.
Authors: Hu, Xiaohan, et.al. .
Journal: International immunopharmacology (Int Immunopharmacol), Vol. 36, 2016 .
Snippet: Using the ELISA system, we found that sICOSL in the serum of healthy donors increases in an age-dependent manner and that the matrix metalloproteinase inhibitor (MMPI) could suppress sICOSL production.
Affiliation: Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China; Department of Immunology, Medical College of Soochow University, Suzhou 215006, China. Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China. Department of Immunology, Medical College of Soochow University, Suzhou 215006, China. Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China. Electronic address: liucuiping1980@126.com. Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China; Department of Immunology, Medical College of Soochow University, Suzhou 215006, China. Electronic address: xueguangzh@126.com. .
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13: Title: Effector function of CTLs is increased by irradiated colorectal tumor cells that modulate OX-40L and 4-1BBL and is reversed following dual blockade.
Authors: Kumari, Anita, et.al. .
Journal: BMC research notes (Bmc Res Notes), Vol. 9, 2016 .
Snippet: CONCLUSIONS: Overall, results of this study suggest that, beyond simply rendering tumor cells more sensitive to immune attack, radiation can be used to specifically modulate expression of genes that directly stimulate effector T cell activity.
Affiliation: Department of Biology, Georgia State University, 161 Jesse Hill Jr. Dr, Atlanta, GA, 30303, USA. akumari1@student.gsu.edu. Department of Biology, Georgia State University, 161 Jesse Hill Jr. Dr, Atlanta, GA, 30303, USA. cgarnettbenson@gsu.edu. .
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14: Title: Human mast cells costimulate T cells through a CD28-independent interaction.
Authors: Suurmond, Jolien, et.al. .
Journal: European journal of immunology (Eur J Immunol), Vol. 46 (5): 1132-41, 2016 .
Snippet: Mast cells are innate immune cells usually residing in peripheral tissues, where they are likely to activate T-cell responses.
Affiliation: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands. .
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15: Title: Different Gene Expression Signatures in Children and Adults with Celiac Disease.
Authors: Pascual, V, et.al. .
Journal: PloS one, Vol. 11 (2): e0146276, 2016 .
Snippet: Differences were observed in 13 genes: six genes being altered only in adults (IL1RL1, CD28, STAT3, TMEM187, VAMP3 and ZFP36L1) and two only in children (TNFSF18 and ICOSLG); and four genes showing a significantly higher alteration in adults (CCR4, IL6, IL18RAP and PLEK) and one in children (C1orf106).
Affiliation: Servicio de Inmunología Clínica, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Servicio de Aparato Digestivo, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Servicio de Pediatría, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Departamento de Estadística e Investigación Operativa I, Facultad de Matemáticas, Universidad Complutense de Madrid, Madrid, Spain. Departamento de Producción Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain. .
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16: Title: Development of a Novel Functional Monoclonal Antibody to Human CD275: Characterization and Biological Activity.
Authors: Hu, Xiaohan, et.al. .
Journal: Monoclonal antibodies in immunodiagnosis and immunotherapy (Monoclon Antib Immunodiagn Immunother), Vol. 35 (1): 18-24, 2016 .
Snippet: CD275 (B7-H2, ICOSL), a co-stimulatory molecule of the B7 superfamily, plays a critical role in immune response.
Affiliation: 1 Jiangsu Province Key Laboratory of Stem Cell Research, Soochow University , Suzhou, China . 2 Jiangsu Institute of Clinical Immunology, the First Affiliated Hospital of Soochow University , Suzhou, China . .
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17: Title: Association of polymorphisms in the ICOS and ICOSL genes with the pathogenesis of autoimmune thyroid diseases.
Authors: Yoshie, Namiki, et.al. .
Journal: Endocrine journal (Endocr J), Vol. 63 (1): 61-8, 2016 .
Snippet: The prognosis of autoimmune thyroid diseases (AITDs), including Graves' disease (GD) and Hashimoto's disease (HD), varies among patients.
Affiliation: Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan. .
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18: Title: Disease susceptibility genes shared by primary biliary cirrhosis and Crohn's disease in the Japanese population.
Authors: Aiba, Yoshihiro, et.al. .
Journal: Journal of human genetics (J Hum Genet), Vol. 60 (9): 525-31, 2015 .
Snippet: TNFSF15 and ICOSLG-CXCR5 might constitute a shared pathogenic pathway in the development of PBC and CD in the Japanese population, whereas IL12B-STAT4-NFKB1 might constitute an opposite pathogenic pathway, reflecting the different balance between Th1 and Th17 in the two diseases.
Affiliation: Clinical Research Center, National Hospital Organization, Nagasaki Medical Center, Omura, Japan. Laboratory for Genotyping Development, Center for Integrative Medical Science, Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan. Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Chiba, Japan. Japan Science and Technology Agency (JST), Tokyo, Japan. Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Tokyo, Japan. Department of Medicine, Division of Gastroenterology, Tokyo Yamate Medical Center, Tokyo, Japan. Department of Internal Medicine, Faculty of Medicine, Toho University, Chiba, Japan. Department of Gastroenterology, Sapporo Kosei Hospital, Sapporo, Japan. Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, Japan. Division of Gastroenterology, Department of Internal Medicine, Iwate Medical University, Iwate, Japan. Headquarters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ) and gp210 working in Research Program of Intractable Hepatoboliary Disease Study Group supported by the Ministry of Health, Labour, and Welfare of Japan, Clinical Research Center, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan. .
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19: Title: Downregulation of myeloma-induced ICOS-L and regulatory T cell generation by lenalidomide and dexamethasone therapy.
Authors: Scott, Gina B, et.al. .
Journal: Cellular immunology (Cell Immunol), Vol. 297 (1): 1-9, 2015 .
Snippet: Dexamethasone did not affect surface ICOS-L expression but did induce TReg cell apoptosis without impacting on TEff cell survival.
Affiliation: Transplant Immunology Group, Section of Experimental Haematology, Leeds Institute of Cancer & Pathology, University of Leeds, United Kingdom. Department of Clinical Immunology, Leeds Teaching Hospitals Trust, United Kingdom. Transplant Immunology Group, Section of Experimental Haematology, Leeds Institute of Cancer & Pathology, University of Leeds, United Kingdom. Electronic address: g.cook@leeds.ac.uk. .
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20: Title: Effect of TACI signaling on humoral immunity and autoimmune diseases.
Authors: Zhang, Yi, et.al. .
Journal: Journal of immunology research (J Immunol Res), Vol. 2015, 2015 .
Snippet: Transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) is one of the receptors of B cell activating factor of the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL).
Affiliation: Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. .
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