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1,766 documents found
1: Title: MMP-2 and Notch signal pathway regulate migration of adipose-derived stem cells and chondrocytes in co-culture systems.
Authors: Zhang, Qi, et.al. .
Journal: Cell proliferation (Cell Prolif), 2017 .
Snippet: Additionally, the expression level of MMP-2, Hey1 and Hes1 was examined to determine the mechanisms of co-culture-induced cell migration changes.
Affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Shanxi, China. Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Shanxi, China. .
2: Title: Notch system is differentially expressed and activated in pituitary adenomas of distinct histotype, tumor cell lines and normal pituitaries.
Authors: Perrone, Sofia, et.al. .
Journal: Oncotarget, Vol. 8 (34): 57072-57088, 2017 .
Snippet: In human pituitary adenomas we showed NOTCH1-4 receptors, JAGGED1 ligand and HES1 target gene expression with positive correlations between NOTCH1,2,4 and HES1, and NOTCH3 and JAGGED1 denoting Notch system activation in a subset of tumors.
Affiliation: Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires, CITNOBA (UNNOBA-CONICET), Universidad Nacional del Noroeste de la Provincia de Buenos Aires, Pergamino, 2700 Buenos Aires, Argentina. Instituto de Biología y Medicina Experimental, IBYME-CONICET, 1428 Buenos Aires, Argentina. Department of Development and Regeneration, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, B-3000 Leuven, Belgium. Servicio de Neurocirugía, Clínica Santa Isabel, C1406GZJ Buenos Aires, Argentina. .
3: Title: Expression of Wnt3a in hepatocellular carcinoma and its effects on cell cycle and metastasis.
Authors: Lu, Caijie, et.al. .
Journal: International journal of oncology (Int J Oncol), Vol. 51 (4): 1135-1145, 2017 .
Snippet: Intriguingly, the expression of Wnt3a, MMP‑7 and c‑Myc is significantly correlated with Notch3 and Hes1 expression.
Affiliation: Laboratory of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang Key Laboratory of Hepatobiliary Diseases, Zhanjiang, Guangdong 524001, P.R. China. Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China. .
4: Title: Organotypic pancreatoids with native mesenchyme develop Insulin producing endocrine cells.
Authors: Scavuzzo, Marissa A, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7 (1): 10810, 2017 .
Snippet: Protein kinase C activation also led to fewer Insulin+ cells, decreased Ins1 and Ins2 mRNA levels, and increased Pdx1 and Hes1 mRNA levels with a high number of DBA+ cells.
Affiliation: Program in Developmental Biology, Baylor College of Medicine, Houston, TX, 77030, USA. Molecular and Cellular Biology Department, Baylor College of Medicine, Houston, TX, 77030, USA. Program in Developmental Biology, Baylor College of Medicine, Houston, TX, 77030, USA. borowiak@bcm.edu. Molecular and Cellular Biology Department, Baylor College of Medicine, Houston, TX, 77030, USA. borowiak@bcm.edu. Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, and Houston Methodist Hospital, Houston, TX, 77030, USA. borowiak@bcm.edu. Stem Cell and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX, 77030, USA. borowiak@bcm.edu. McNair Medical Institute, Baylor College of Medicine, Houston, TX, 77030, USA. borowiak@bcm.edu. .
5: Title: A combination of valproic acid sodium salt, CHIR99021, E-616452, tranylcypromine, and 3-Deazaneplanocin A causes stem cell-like characteristics in cancer cells.
Authors: Sha, Shuang, et.al. .
Journal: Oncotarget, Vol. 8 (32): 53302-53312, 2017 .
Snippet: The A549 stem-like cells displayed resistance to the chemotherapeutic drugs etoposide and cisplatin, epithelial-to-mesenchymal transition properties, and increased protein expression levels of NOTCH1 and Hes Family bHLH Transcription Factor 1 (HES1).
Affiliation: Tongji University School of Life Sciences and Technology, Shanghai, China. Clinical Research Center, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, China. Department of Immunity, Tongji University School of Medicine, Shanghai, China. Center for Translational Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Center for Cancer Immunotherapy, Shanghai Biomed-Union Biotechnology Co. Ltd, Shanghai International Medical Zone, Shanghai, China. .
6: Title: Hedgehog Stimulation Suppresses Clonogenicity and Activates NOTCH Signalling in T-lymphoblastic Leukaemia Jurkat Cells.
Authors: Okuhashi, Yuki, et.al. .
Journal: Anticancer research (Anticancer Res), Vol. 37 (9): 5005-5009, 2017 .
Snippet: RESULTS: SHH stimulation did not affect cell growth but suppressed colony formation, increased the levels of cleaved NOTCH1 fragment characteristic for NOTCH1 activation, and upregulated mRNA expression of HES1, while decreasing that of MYC in Jurkat cells.
Affiliation: Department of Laboratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan. Department of Medical Technology, Tokyo University of Technology, Tokyo, Japan. Department of Laboratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan tohda.mlab@tmd.ac.jp. .
7: Title: Deletion of Dlk2 increases the vulnerability to anxiety-like behaviors and impairs the anxiolytic action of alprazolam.
Authors: Navarrete, Francisco, et.al. .
Journal: Psychoneuroendocrinology, Vol. 85, 2017 .
Snippet: Furthermore, relative gene expression analyses of corticotropin releasing hormone (Crh) in the paraventricular nucleus (PVN), glucocorticoid receptor (NR3C1) and FK506 binding protein 5 (FKBP5) in the hippocampus (HIPP), and the transcription factors Hes1, Hes5 and Hey1 in the PVN, HIPP and amygdala (AMY) were carried out in Dlk2(-/-) and WT mice under basal conditions and after exposure to restraint stress.
Affiliation: Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, Avda. de Ramón y Cajal s/n, San Juan de Alicante, 03550 Alicante, Spain; Red Temática de Investigación Cooperativa en Salud (RETICS), Red de Trastornos Adictivos, Instituto de Salud Carlos III, MICINN and FEDER, Madrid, Spain. Facultad de Farmacia, Centro Regional de Investigaciones Biomédicas (CRIB), Unidad de Biomedicina UCLM-CSIC, Albacete, Spain. Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, Avda. de Ramón y Cajal s/n, San Juan de Alicante, 03550 Alicante, Spain; Red Temática de Investigación Cooperativa en Salud (RETICS), Red de Trastornos Adictivos, Instituto de Salud Carlos III, MICINN and FEDER, Madrid, Spain. Electronic address: jorge.laborda@uclm.es. .
8: Title: Long nonding RNA UCA1 regulates neural stem cell differentiation by controlling miR-1/Hes1 expression.
Authors: Zheng, Jiaolin, et.al. .
Journal: American journal of translational research (Am J Transl Res), Vol. 9 (8): 3696-3704, 2017 .
Snippet: Furthermore, we demonstrated that knockdown of UCA1 increased the expression of miR-1 in the neural stem cell and suppressed the expresion of Hes1, which is one target gene of miR-1.
Affiliation: Department of Neruology, The Second Hospital of Harbin Medical UniversityHarbin 150086, Heilong Jiang, China. Department of Pharmacology, Rush University Medical CenterChicago IL 60612, USA. Department of Neurosurgery, The First Hospital of Harbin Medical UniversityHarbin 150001, Heilong Jiang, China. .
9: Title: Indirect immobilized Jagged1 suppresses cell cycle progression and induces odonto/osteogenic differentiation in human dental pulp cells.
Authors: Manokawinchoke, Jeeranan, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7 (1): 10124, 2017 .
Snippet: The indirect immobilized Jagged1 effectively activated Notch signaling in hDPs as confirmed by the upregulation of HES1 and HEY1 expression.
Affiliation: Excellence Center in Regenerative Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand. Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand. Office of Research Affairs, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand. Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai, 980-8575, Japan. Excellence Center in Regenerative Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand. thanaphum.o@chula.ac.th. Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand. thanaphum.o@chula.ac.th. Craniofacial Genetics and Stem Cells Research Group, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand. thanaphum.o@chula.ac.th. .
10: Title: [Mechanism of Chlorogenic Acid in Apoptotic Regulation through Notch1 
Pathway in Non-small Cell Lung Carcinoma in Animal Level].
Authors: Li, Wei, et.al. .
Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer (Zhongguo Fei Ai Za Zhi), Vol. 20 (8): 555-561, 2017 .
Snippet: 背景与目的 绿原酸类物质可通过调节细胞周期、诱导凋亡、抑制细胞生长等途径产生抗癌作用,Notch信号通路与人类许多肿瘤都存在密切的关系,本研究旨在探讨绿原酸通过Notch1信号通路控制非小细胞肺癌细胞凋亡的作用机制,为临床应用以及Notch1靶向药物的研究提供依据。方法 MTT法检测不同浓度的绿原酸对非小细胞肺癌细胞系A549细胞形态和细胞增殖的影响;流式细胞仪检测绿原酸对A549细胞的凋亡和细胞周期的影响;建立A549细胞的裸鼠荷瘤模型;测量肿瘤大小和重量;实时荧光定量PCR法检测Notch信号通路相关因子的mRNA表达水平;免疫印迹法检测Notch信号通路相关因子的蛋白表达水平。结果 绿原酸抑制A549细胞增殖,诱导A549细胞凋亡,增加细胞G2期/M期细胞百分比增加(P<0.05),并且呈现剂量依赖趋势。在A549细胞的裸鼠荷瘤模型中,实验组肿瘤大小和体积明显小于对照组,差异具有统计学意义(P<0.01)。试验组Notch1、VEGF、Delta4、HES1、HEY1
Affiliation: Department of Laboratory, First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Department of Oncology, General Hospital of Tianjin Medical University, Tianjin 300052, China. .
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11: Title: Genomic dissection of conserved transcriptional regulation in intestinal epithelial cells.
Authors: Lickwar, Colin R, et.al. .
Journal: PLoS biology (Plos Biol), Vol. 15 (8): e2002054, 2017 .
Snippet: Among the rare, highly sequence-conserved, IEC-specific regulatory regions, we discovered an ancient enhancer upstream from her6/HES1 that is active in a distinct population of Notch-positive cells in the intestinal epithelium.
Affiliation: Department of Molecular Genetics and Microbiology, Center for the Genomics of Microbial Systems, Duke University, Durham, North Carolina, United States of America. Department of Cell Biology and Physiology, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. Department of Developmental Biology, Stanford University, Stanford, California, United States of America. Departments of Genetics and Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. .
12: Title: STRAP promotes stemness of human colorectal cancer via epigenetic regulation of the NOTCH pathway.
Authors: Jin, Lin, et.al. .
Journal: Cancer research (Cancer Res), 2017 .
Snippet: Restoring the NOTCH pathway by lentiviral expression of NICD1 or HES1 in STRAP-depleted tumor cells reversed the CSC phenotype.
Affiliation: Medicine, University of Alabama at Birmingham. Medicine, University of Alabama at Birmingham prandatta@uabmc.edu. .
13: Title: Safflower Seed Oil, Containing Oleic Acid and Palmitic Acid, Enhances the Stemness of Cultured Embryonic Neural Stem Cells through Notch1 and Induces Neuronal Differentiation.
Authors: Ghareghani, Majid, et.al. .
Journal: Frontiers in neuroscience (Front Neurosci), Vol. 11, 2017 .
Snippet: Moreover, treatment of NSCs by safflower seed oil, but not LA, resulted in a significant increase in mRNA levels of notch1, hes1, and Ki-67, and protein levels of notch intracellular domain (NICD), in comparison to controls, indicating an enhancement of stemness.
Affiliation: Cellular and Molecular Research Center, Faculty of Medicine, Yasuj University of Medical SciencesYasuj, Iran. ER045, Laboratory of Stem Cells, DSST, Biology Department, Faculty of Sciences, Lebanese UniversityBeirut, Lebanon. Neural Stem Cell and Regenerative Neuroscience Laboratory, Department of Anatomical Sciences, Shiraz School of Medicine & Shiraz Stem Cell Institute, Shiraz University of Medical SciencesShiraz, Iran. Department of Biology, Payame Noor University (PNU)Tehran, Iran. Department of Pathology, Faculty of Medicine, Yasuj University of Medical SciencesYasuj, Iran. .
14: Title: The adaptor SASH1 acts through NOTCH1 and its inhibitor DLK1 in a 3D model of lumenogenesis involving CEACAM1.
Authors: Stubblefield, Kandis, et.al. .
Journal: Experimental cell research (Exp Cell Res), Vol. 359 (2): 384-393, 2017 .
Snippet: In agreement with the role of DLK1 as a NOTCH1 inhibitor, NOTCH1, as well as its regulated genes HES1 and HEY1, were down-regulated in CEACAM1/MCF7 cells by the action of DLK1 RNAi, and up-regulated by SASH1 RNAi.
Affiliation: Irell and Manella Graduate School of Biological Sciences of City of Hope, 1450 East Duarte Rd, Duarte CA 91010, United States. Department of Molecular Immunology, Beckman Research Institute of City of Hope, 1450 E Duarte, Rd, Duarte CA 91010, United States. Department of Molecular Immunology, Beckman Research Institute of City of Hope, 1450 E Duarte, Rd, Duarte CA 91010, United States. Electronic address: jshively@coh.org. .
15: Title: Nrf2 regulates cellular behaviors and Notch signaling in oral squamous cell carcinoma cells.
Authors: Fan, Hong, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), 2017 .
Snippet: Consistent with this observation, Nrf2 activation in Keap1(-/-) mice resulted in not only hyperproliferation of squamous epithelial cells in mouse tongue as evidenced by increased expression of PCNA, but also activation of Notch signaling in these cells as evidenced by increased expression of NICD1 and Hes1.
Affiliation: Department of Oral Medicine, Beijing Stomatological Hospital & School of Stomatology, Capital Medical University, Beijing 100050, China. Cancer Research Program, JLC-BBRI, North Carolina Central University, Durham, NC 27707, USA. Department of Immunology and Infectious Diseases, Montana State University, Bozeman, MT 59717, USA. Department of Oral Medicine, Beijing Stomatological Hospital & School of Stomatology, Capital Medical University, Beijing 100050, China. Electronic address: sunzheng12@vip.126.com. Cancer Research Program, JLC-BBRI, North Carolina Central University, Durham, NC 27707, USA. Electronic address: lchen@nccu.edu. .
16: Title: Notch Inhibitors from Calotropis gigantea That Induce Neuronal Differentiation of Neural Stem Cells.
Authors: Yoneyama, Tatsuro, et.al. .
Journal: Journal of natural products (J Nat Prod), 2017 .
Snippet: Hes1 and Hes5 are target genes of the Notch signaling pathway, and compound 1, called uscharin, decreased the protein levels of Hes1 and Hes5 in assay cells and MEB5 cells (mouse NSCs).
Affiliation: Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan. Pharmacy Discipline, Khulna University , Khulna 9208, Bangladesh. Department of Pharmaceutical Chemistry, University of Dhaka , Dhaka 1000, Bangladesh. Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University , 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. .
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17: Title: Deregulation of transcription factors controlling intestinal epithelial cell differentiation; a predisposing factor for reduced enteroendocrine cell number in morbidly obese individuals.
Authors: Wölnerhanssen, Bettina K, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7 (1): 8174, 2017 .
Snippet: Tissue morphology, abundance of chromogranin A, gut hormones, α-defensin, mucin 2, Na(+)/glucose co-transporter 1 (SGLT1) and transcription factors, Hes1, HATH1, NeuroD1, and Ngn3, were determined.
Affiliation: Department of Clinical Research, St. Claraspital Basel, 4058, Basel, Switzerland. Department of Biomedicine, University Hospital Basel, 4056, Basel, Switzerland. Institute of Integrative Biology, University of Liverpool, Liverpool, Merseyside, L69 7ZB, United Kingdom. Department of Surgery, St. Claraspital Basel, 4058, Basel, Switzerland. Department of Gastroenterology, St. Claraspital Basel, 4058, Basel, Switzerland. Department of Gastroenterology, University Hospital Basel, 4056, Basel, Switzerland. Institute of Integrative Biology, University of Liverpool, Liverpool, Merseyside, L69 7ZB, United Kingdom. spsb@liverpool.ac.uk. .
18: Title: HEPATITIS C VIRUS CORE PROTEIN MODULATES ENDOGLIN (CD105) SIGNALING PATHWAY FOR LIVER PATHOGENESIS.
Authors: Kwon, Young-Chan, et.al. .
Journal: Journal of virology (J Virol), 2017 .
Snippet: Further, follow-up from in vitro analysis suggested that anti-apoptosis Bcl2 protein, proliferation related Cyclin D1 protein, and CSC associated Hes1, Notch1, Nanog and Sox2 proteins are enhanced during infection or ectopic expression of HCV core protein.IMPORTANCE Endoglin plays a crucial role in fibrogenesis and angiogenesis, and is an important protein for tumor growth, survival, and cancer cell metastasis.
Affiliation: Departments of Internal Medicine, and Molecular Microbiology & Immunology, Saint Louis University, Missouri, USA. Departments of Internal Medicine, and Molecular Microbiology & Immunology, Saint Louis University, Missouri, USA rayr@slu.edu. .
19: Title: A mutation in NOTCH1 ligand binding region detected in patients with oral squamous cell carcinoma reduces NOTCH1 oncogenic effect.
Authors: Uchibori, Masahiro, et.al. .
Journal: Oncology reports (Oncol Rep), Vol. 38 (4): 2237-2242, 2017 .
Snippet: HES1 and HEY1 mRNA expression levels were lower in A465T than in WT cells.
Affiliation: Department of Oral and Maxillofacial Surgery, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan. Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan. .
20: Title: Short-term treatment with eicosapentaenoic acid improves inflammation and affects colonic differentiation markers and microbiota in patients with ulcerative colitis.
Authors: Prossomariti, Anna, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7 (1): 7458, 2017 .
Snippet: HES1, KLF4, STAT3, IL-10 and SOCS3 levels were determined using western blotting and qRT-PCR, while phospho-STAT3 levels were assessed by western blotting.
Affiliation: Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. Center for Applied Biomedical Research (CRBA), S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy. Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy. Institute of Biomedical Technologies-National Research Council (ITB-CNR), Segrate, Milan, Italy. Pathology Unit, S. Orsola-Malpighi Hospital, Bologna, Italy. Gastroenterology Unit, S. Orsola-Malpighi Hospital, Bologna, Italy. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. luigi.ricciardiello@unibo.it. .
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