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10 documents found
1: Title: A six-mRNA signature model for the prognosis of head and neck squamous cell carcinoma.
Authors: Guo, Wenna, et.al. .
Journal: Oncotarget, Vol. 8 (55): 94528-94538, 2017 .
Snippet: A model of six mRNAs (FRMD5, PCMT1, PDGFA, TMC8, YIPF4, ZNF324B) that could predict patient prognosis was identified in the training set using the Cox regression analysis.
Affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China. School of Life Sciences, Shanghai University, Shanghai, China. .
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2: Title: Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib.
Authors: Yeo, Astrid, et.al. .
Journal: PloS one, Vol. 12 (7): e0182115, 2017 .
Snippet: We replicated associations of published loci on baseline Lp-PLA2 activity (APOE, CELSR2, LPA, PLA2G7, LDLR and SCARB1) and identified three novel loci (TOMM5, FRMD5 and LPL) using the GWAS-significance threshold P≤5E-08.
Affiliation: Department of Genetics, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom. Department of Genetics, GlaxoSmithKline Medicines Research Centre, Research Triangle Park, North Carolina, United States of America. Clinical Statistics, GlaxoSmithKline Medicines Research Centre, Research Triangle Park, North Carolina, United States of America. Department of Vascular Biology & Thrombosis, GlaxoSmithKline Medicines Research Centre, King of Prussia, Pennsylvania, United States of America. Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline Medicines Research Centre, King of Prussia, Pennsylvania, United States of America. TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, United States of America. Green Lane Cardiovascular Service, Auckland City Hospital and University of Auckland, Auckland, New Zealand. Department of Medical Sciences, Cardiology & Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden. Department of Genetics, GlaxoSmithKline Medicines Research Centre, Upper Merion, Philadelphia, Pennsylvania, United States of America. .
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3: Title: Integrative variants, haplotypes and diplotypes of the CAPN3 and FRMD5 genes and several environmental exposures associate with serum lipid variables.
Authors: Guo, Tao, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7, 2017 .
Snippet: To determine whether the integrative variants, haplotypes and diplotypes of the calpain 3 (CAPN3) and the FERM domain containing 5 genes (FRMD5) and several environmental exposures are associated with an implication in lipid homeostasis, which are associated with cardiovascular risk.
Affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. .
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4: Title: Identification of FERM domain-containing protein 5 as a novel target of β-catenin/TCF7L2 complex.
Authors: Zhu, Chi, et.al. .
Journal: Cancer science (Cancer Sci), Vol. 108 (4): 612-619, 2017 .
Snippet: In this paper, we focused on FERM domain-containing protein 5 (FRMD5), and confirmed that it is regulated by both β-catenin and TCF7L2.
Affiliation: Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. .
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5: Title: Brucella melitensis and Mycobacterium tuberculosis depict overlapping gene expression patterns induced in infected THP-1 macrophages.
Authors: Masoudian, M, et.al. .
Journal: Iranian journal of veterinary research (Iran J Vet Res), Vol. 16 (4): 368-73, 2015 .
Snippet: EMP2, ST8SIA4, HCP5 and FRMD5 known to be involved in pathogenesis of Mycobacterium tuberculosis.
Affiliation: Ph.D. Student in Biotechnology, Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran; Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran; Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran and Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran. .
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6: Title: FERM domain-containing protein FRMD5 regulates cell motility via binding to integrin β5 subunit and ROCK1.
Authors: Hu, Jinxia, et.al. .
Journal: FEBS letters (Febs Lett), Vol. 588 (23): 4348-56, 2014 .
Snippet: Furthermore, FRMD5 interacts with ROCK1 and inhibits its activation that leads to the inhibition of myosin light chain phosphorylation and the actin stress fiber formation.
Affiliation: Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Health Science Center, Beijing 100191, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China; Laboratory of Molecular Cell Biology and Tumor Biology, Department of Anatomy, Histology and Embryology, Peking University Health Science Center, Beijing 100191, China; Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China; Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai 264000, Shandong, China. Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Health Science Center, Beijing 100191, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China; Laboratory of Molecular Cell Biology and Tumor Biology, Department of Anatomy, Histology and Embryology, Peking University Health Science Center, Beijing 100191, China. Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China. Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Health Science Center, Beijing 100191, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China; Laboratory of Molecular Cell Biology and Tumor Biology, Department of Anatomy, Histology and Embryology, Peking University Health Science Center, Beijing 100191, China. Electronic address: Hongquan.Zhang@bjmu.edu.cn. .
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7: Title: The postprandial chylomicron triacylglycerol response to dietary fat in healthy male adults is significantly explained by a combination of single nucleotide polymorphisms in genes involved in triacylglycerol metabolism.
Authors: Desmarchelier, Charles, et.al. .
Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab), Vol. 99 (3): E484-8, 2014 .
Snippet: RESULTS: Data obtained allowed us to generate a validated significant model (P = 1.3 × 10(-7)) that included 42 SNPs in 23 genes (ABCA1, APOA1, APOA5, APOB, BET1, CD36, COBLL1, ELOVL5, FRMD5, GPAM, INSIG2, IRS1, LDLR, LIPC, LPL, LYPLAL1, MC4R, NAT2, PARK2, SLC27A5, SLC27A6, TCF7L2, and ZNF664) and explained 88% of the variance.
Affiliation: Institut National de la Recherche Agronomique (INRA), Unité Mixte de Recherche (UMR) INRA1260, F-13005, Marseille, France; Inserm, UMR_S 1062, F-13005, Marseille, France; and Aix-Marseille Université, Nutrition, Obésité et Risques Thrombotiques, F-13005, Marseille, France. .
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8: Title: Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
Authors: Franceschini, Nora, et.al. .
Journal: American journal of human genetics (Am J Hum Genet), Vol. 91 (4): 744-53, 2012 .
Snippet: Through transethnic meta-analysis of European-ancestry and Japanese genome-wide association studies, we identified six loci at genome-wide significance (p < 5 × 10(-8)) for serum albumin (HPN-SCN1B, GCKR-FNDC4, SERPINF2-WDR81, TNFRSF11A-ZCCHC2, FRMD5-WDR76, and RPS11-FCGRT, in up to 53,190 European-ancestry and 9,380 Japanese individuals) and three loci for total protein (TNFRS13B, 6q21.3, and ELL2, in up to 25,539 European-ancestry and 10,168 Japanese individuals).
Affiliation: Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA. noraf@unc.edu .
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9: Title: FERM-containing protein FRMD5 is a p120-catenin interacting protein that regulates tumor progression.
Authors: Wang, Tao, et.al. .
Journal: FEBS letters (Febs Lett), Vol. 586 (19): 3044-50, 2012 .
Snippet: Here, we reported that FRMD5 localized at the cell adherens junction and formed a molecular complex with p120-catenin through its C-terminal region.
Affiliation: Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Health Science Center, Beijing, China. .
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10: Title: Modulation of gene expression in U251 glioblastoma cells by binding of mutant p53 R273H to intronic and intergenic sequences.
Authors: Brázdová, Marie, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 37 (5): 1486-500, 2009 .
Snippet: We identified the PPARGC1A and FRMD5 genes as p53(R273H) targets regulated by binding to intronic and intra-genic sequences.
Affiliation: Department of Tumor Virology, Heinrich-Pette-Institute for Experimental Virology and Immunology, D-20251 Hamburg, Germany. .
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